JP5758499B2 - ホモセリンアセチルトランスフェラーゼ活性を有する変異型ポリペプチド及びそれを発現する微生物 - Google Patents

ホモセリンアセチルトランスフェラーゼ活性を有する変異型ポリペプチド及びそれを発現する微生物 Download PDF

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JP5758499B2
JP5758499B2 JP2013546021A JP2013546021A JP5758499B2 JP 5758499 B2 JP5758499 B2 JP 5758499B2 JP 2013546021 A JP2013546021 A JP 2013546021A JP 2013546021 A JP2013546021 A JP 2013546021A JP 5758499 B2 JP5758499 B2 JP 5758499B2
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amino acid
polypeptide
microorganism
homoserine
activity
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JP2014502843A (ja
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ヨン キム,ソ
ヨン キム,ソ
ウク シン,ヨン
ウク シン,ヨン
イル ソ,チャン
イル ソ,チャン
ギョン ホ,イン
ギョン ホ,イン
ウン キム,チュ
ウン キム,チュ
ア キム,ヒョン
ア キム,ヒョン
ジン イ,ハン
ジン イ,ハン
ホ ナ,クァン
ホ ナ,クァン
グァン ソン,ソン
グァン ソン,ソン
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CJ CheilJedang Corp
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1025Acyltransferases (2.3)
    • C12N9/1029Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
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    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
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    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/04Alpha- or beta- amino acids
    • C12P13/06Alanine; Leucine; Isoleucine; Serine; Homoserine
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y203/00Acyltransferases (2.3)
    • C12Y203/01Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01031Homoserine O-acetyltransferase (2.3.1.31)

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  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2013546021A 2010-12-21 2011-12-21 ホモセリンアセチルトランスフェラーゼ活性を有する変異型ポリペプチド及びそれを発現する微生物 Active JP5758499B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
KR10-2010-0131953 2010-12-21
KR20100131953 2010-12-21
PCT/KR2011/009966 WO2012087039A2 (ko) 2010-12-21 2011-12-21 호모세린 아세틸 트랜스퍼라제 활성을 가지는 변이형 폴리펩티드 및 이를 발현하는 미생물
KR10-2011-0139228 2011-12-21
KR1020110139228A KR101335841B1 (ko) 2010-12-21 2011-12-21 호모세린 아세틸 트랜스퍼라제 활성을 가지는 변이형 폴리펩티드 및 이를 발현하는 미생물

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JP2014502843A JP2014502843A (ja) 2014-02-06
JP5758499B2 true JP5758499B2 (ja) 2015-08-05

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US (1) US9127257B2 (enExample)
EP (1) EP2657250B1 (enExample)
JP (1) JP5758499B2 (enExample)
KR (1) KR101335841B1 (enExample)
CN (1) CN103797027B (enExample)
DK (1) DK2657250T3 (enExample)
ES (1) ES2650451T3 (enExample)
MY (1) MY173933A (enExample)
NO (1) NO2657250T3 (enExample)
PL (1) PL2657250T3 (enExample)
RU (1) RU2557411C2 (enExample)
WO (1) WO2012087039A2 (enExample)

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US9834491B2 (en) 2013-03-20 2017-12-05 Cj Cheiljedang Corporation Method for producing bio-based homoserine lactone and bio-based organic acid from O-acyl homoserine produced by microorganisms
KR101565213B1 (ko) * 2013-10-23 2015-11-03 씨제이제일제당 (주) O-숙시닐호모세린 생산 미생물 및 이를 이용한 o-숙시닐호모세린의 생산방법
KR101555749B1 (ko) * 2013-10-23 2015-09-25 씨제이제일제당 (주) O-숙시닐호모세린 생산 미생물 및 이를 이용한 o-숙시닐호모세린의 생산방법
AU2014386892B2 (en) * 2014-03-20 2017-11-23 Cj Cheiljedang Corporation Method for preparing biobased homoserine lactone hydrochloride and biobased organic acid from microorganism-derived O-acyl homoserine
KR101825777B1 (ko) * 2014-06-05 2018-02-07 씨제이제일제당 (주) O-아세틸-호모세린을 생산하는 미생물 및 이를 이용하여 o-아세틸-호모세린을 생산하는 방법
KR101641770B1 (ko) * 2014-06-23 2016-07-22 씨제이제일제당 (주) O-아세틸 호모세린을 생산하는 미생물 및 상기 미생물을 이용하여 o-아세틸 호모세린을 생산하는 방법
PL3305808T3 (pl) 2015-06-04 2022-04-04 Cj Cheiljedang Corporation Mikroorganizm wytwarzający o-acetylohomoserynę i sposób wytwarzania o-acetylohomoseryny z jego zastosowaniem
US11034985B2 (en) 2015-11-27 2021-06-15 Evonik Operations Gmbh Method for producing L-methionine
KR20200026874A (ko) * 2017-06-06 2020-03-11 지머젠 인코포레이티드 대장균 개량을 위한 htp 게놈 공학 플랫폼
RU2747493C1 (ru) * 2017-06-30 2021-05-05 СиДжей ЧеилДжеданг Корпорейшн Новый вариант О-сукцинилгомосеринтрансферазы и способ получения О-сукцинилгомосерина с использованием этого варианта
EP3647415B1 (en) * 2017-06-30 2025-12-03 CJ Cheiljedang Corporation Novel o-succinyl homoserine transferase mutant and method for producing o-succinyl homoserine using same
CN110129294B (zh) * 2018-02-02 2021-12-24 中国科学院天津工业生物技术研究所 高丝氨酸乙酰基转移酶突变体及其宿主细胞和应用
KR101947959B1 (ko) 2018-05-28 2019-02-13 씨제이제일제당 (주) 변이형 호모세린 디하이드로게나제 및 이를 이용한 호모세린 또는 호모세린 유래 l-아미노산의 생산 방법
CN112673091B (zh) * 2018-07-09 2025-04-25 科德克希思公司 工程化泛酸激酶变体酶
KR101996769B1 (ko) 2018-12-21 2019-10-01 씨제이제일제당 (주) 변이형 호모세린 디하이드로게나제 및 이를 이용한 호모세린 또는 호모세린 유래 l-아미노산의 생산 방법
US12146167B2 (en) 2021-04-01 2024-11-19 Evonik Operations Gmbh Enzymatic method for producing L-glufosinate and its phosphoesters
JP2025531377A (ja) 2022-09-21 2025-09-19 エボニック オペレーションズ ゲーエムベーハー L-グルホシネート及びそのホスホエステルを製造するための酵素法

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Publication number Publication date
EP2657250A4 (en) 2015-02-18
KR20120070531A (ko) 2012-06-29
WO2012087039A3 (ko) 2012-08-23
ES2650451T3 (es) 2018-01-18
BR112013015991A2 (pt) 2018-07-10
JP2014502843A (ja) 2014-02-06
NO2657250T3 (enExample) 2018-02-03
RU2557411C2 (ru) 2015-07-20
CN103797027A (zh) 2014-05-14
WO2012087039A2 (ko) 2012-06-28
US20130273615A1 (en) 2013-10-17
EP2657250A2 (en) 2013-10-30
KR101335841B1 (ko) 2013-12-02
MY173933A (en) 2020-02-27
PL2657250T3 (pl) 2018-02-28
EP2657250B1 (en) 2017-09-06
DK2657250T3 (en) 2017-12-11
CN103797027B (zh) 2017-05-17
RU2013133626A (ru) 2015-01-27
US9127257B2 (en) 2015-09-08

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