JP5750675B2 - 口腔用組成物 - Google Patents
口腔用組成物 Download PDFInfo
- Publication number
- JP5750675B2 JP5750675B2 JP2011032882A JP2011032882A JP5750675B2 JP 5750675 B2 JP5750675 B2 JP 5750675B2 JP 2011032882 A JP2011032882 A JP 2011032882A JP 2011032882 A JP2011032882 A JP 2011032882A JP 5750675 B2 JP5750675 B2 JP 5750675B2
- Authority
- JP
- Japan
- Prior art keywords
- composition
- oral
- catechins
- catechin
- oral cavity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
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- 239000000203 mixture Substances 0.000 title claims description 56
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 claims description 56
- 235000005487 catechin Nutrition 0.000 claims description 56
- 150000001765 catechin Chemical class 0.000 claims description 35
- -1 polyoxyethylene Polymers 0.000 claims description 31
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 claims description 23
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 21
- 229950001002 cianidanol Drugs 0.000 claims description 21
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- WMBWREPUVVBILR-UHFFFAOYSA-N GCG Natural products C=1C(O)=C(O)C(O)=CC=1C1OC2=CC(O)=CC(O)=C2CC1OC(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-UHFFFAOYSA-N 0.000 claims description 13
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- LVJJFMLUMNSUFN-UHFFFAOYSA-N gallocatechin gallate Natural products C1=C(O)C=C2OC(C=3C=C(O)C(O)=CC=3)C(O)CC2=C1OC(=O)C1=CC(O)=C(O)C(O)=C1 LVJJFMLUMNSUFN-UHFFFAOYSA-N 0.000 claims description 4
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- 235000010413 sodium alginate Nutrition 0.000 description 1
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000004320 sodium erythorbate Substances 0.000 description 1
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- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
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- 235000011008 sodium phosphates Nutrition 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
- RBWSWDPRDBEWCR-RKJRWTFHSA-N sodium;(2r)-2-[(2r)-3,4-dihydroxy-5-oxo-2h-furan-2-yl]-2-hydroxyethanolate Chemical compound [Na+].[O-]C[C@@H](O)[C@H]1OC(=O)C(O)=C1O RBWSWDPRDBEWCR-RKJRWTFHSA-N 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
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- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 description 1
- 235000019202 steviosides Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- 229960001367 tartaric acid Drugs 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- CRDAMVZIKSXKFV-UHFFFAOYSA-N trans-Farnesol Natural products CC(C)=CCCC(C)=CCCC(C)=CCO CRDAMVZIKSXKFV-UHFFFAOYSA-N 0.000 description 1
- 239000012780 transparent material Substances 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
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Images
Landscapes
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Description
[1]カテキン類及び非イオン性界面活性剤を含み、pHが2〜6である、口腔用組成物、
[2]前記カテキン類が、エピガロカテキン、カテキン、エピガロカテキンガレート、エピカテキン、ガロカテキンガレート、エピカテキンガレート、又はカテキンガレートである、[1]の口腔用組成物、
[3]非イオン性界面活性剤がポリオキシエチレン硬化ヒマシ油である、[1]又は[2]の口腔用組成物
に関する。
なお、サンフェノン(太陽化学株式会社製)、テアフラン(株式会社伊藤園製)、ウーロン茶エキスM(丸善製薬株式会社製)、ポリフェノン(三井農林株式会社製)、テアビゴ(DSMニュートリションジャパン株式会社製)等、市販のカテキン類含有素材も使用できる。特に、サンフェノンEGCg(太陽化学株式会社製)は、カテキン類中でも高力価のエピガロカテキンガレートを90%以上含むため、好ましい。
グリセリルモノステアレート、グリセリルモノオレエート等の(モノ,ジ,トリ)グリセリン脂肪酸エステル;
ポリグリセリルモノステアレート、ポリグリセリルモノラウレート等のポリグリセリン脂肪酸エステル;
ソルビタンモノステアレート、ソルビタントリステアレート等のソルビタン脂肪酸エステル;
ポリオキシエチレンソルビタンモノステアレート、ポリオキシエチレンソルビタントリオレエート等のポリオキシエチレンソルビタン脂肪酸エステル;
テトラオレイン酸ポリオキシエチレンソルビット、テトラステアリン酸ポリオキシエチレンソルビット等のポリオキシエチレンソルビット脂肪酸エステル;
ポリオキシエチレン硬化ヒマシ油;
ポリオキシエチレンラウリルエーテル、ポリオキシエチレンオレイルエーテル等のポリオキシエチレンアルキルエーテル;
ポリオキシアルキレンアルキルエーテル;
ポリオキシエチレンポリオキシプロピレンセチルエーテル、ポリオキシエチレンポリオキシプロピレンデシルテトラデシルエーテル等のポリオキシエチレンポリオキシプロピレンアルキルエーテル;
ポリエチレングリコールモノステアレート、ポリエチレングリコールモノラウレート等のポリエチレングリコール脂肪酸エステル;
アルキルアルカノールアミド;
等が挙げられる。これらを単独で又は2種以上組み合わせて使用しても良い。
本実施例では、集中治療患者の感染症起炎菌として重要なメチシリン耐性黄色ブドウ球菌(Methicillin-resistant Staphylococcus aureus (MRSA) IID 1677株)と緑膿菌(Pseudomonas aeruginosa NBRC 13275株)を用いて、以下の手順に従って、本発明の口腔用組成物の静菌効力試験を行った。本実施例で用いた本発明の口腔用組成物(ポリオキシエチレン硬化ヒマシ油含有のカテキン水溶液;実施例A)の組成と、比較用のカテキン水溶液(非イオン性界面活性剤を含まない;比較例a)の組成を表1に示す。カテキン類としては、エピガロカテキンガレートを90%以上含む緑茶抽出物(サンフェノンEGCg;太陽化学株式会社製)を使用し、ポリオキシエチレン硬化ヒマシ油としては、エチレンオキサイドの平均付加モル数が60であるもの(NIKKOL HCO−60;日光ケミカルズ株式会社/日本サーファクタント工業株式会社製)を使用した。
実施例A 比較例a
カテキン類(エピガロカテキンガレート) 0.5% 0.5%
ポリオキシエチレン硬化ヒマシ油60 6.0% −
濃グリセリン 15.0% −
香料 0.2% −
エデト酸ナトリウム 0.2% −
キシリトール 0.5% −
クエン酸 0.05% −
カラギーナン 0.3% −
メチルパラベン 0.3% −
安息香酸ナトリウム 0.1% −
精製水 76.85% 99.5%
合計 100.0% 100.0%
本実施例では、表2に示す組成からなる本発明の口腔用組成物(ポリオキシエチレン硬化ヒマシ油含有のカテキン水溶液;実施例B)と、比較用のカテキン水溶液(非イオン性界面活性剤を含まない;比較例b)を調製し、被検者10人による呈味試験を実施した。結果を表2に示す。
実施例B 比較例b
カテキン類(エピガロカテキンガレート) 0.5% 0.5%
ポリオキシエチレン硬化ヒマシ油60 6.0% −
メチルパラベン 0.3% 0.3%
精製水 93.2% 99.2%
合計 100.0% 100.0%
苦味あり 0人 10人
渋味あり 0人 10人
収斂味あり 0人 10人
本実施例では、表1に示す実施例A、表3に示す組成からなる本発明の口腔用組成物(ポリオキシエチレン硬化ヒマシ油含有のカテキン水溶液;実施例C、D)、比較用のカテキン水溶液(非イオン性界面活性剤を含まない;比較例c)を調製し、それぞれバイアル瓶に移した後、プラスチック蓋で密封し、室温、5℃、40℃で1か月間静置した後、水溶液の状態を観察した。結果を表4に示す。
実施例C 実施例D 比較例c
カテキン類 0.5% 0.5% 0.5%
(エピガロカテキンガレート)
ポリオキシエチレン
硬化ヒマシ油60 4.0% 5.0% −
濃グリセリン 15.0% 15.0% 15.0%
香料 0.2% 0.2% 0.2%
エデト酸ナトリウム 0.2% 0.2% 0.2%
キシリトール 0.5% 0.5% 0.5%
クエン酸 0.05% 0.05% 0.05%
カラギーナン 0.3% 0.3% 0.3%
メチルパラベン 0.3% 0.3% 0.3%
安息香酸ナトリウム 0.1% 0.1% 0.1%
精製水 78.85% 77.85% 82.85%
合計 100.0% 100.0% 100.0%
実施例A 実施例D 実施例C 比較例c
カテキン類 0.5% 0.5% 0.5% 0.5%
(エピガロカテキンガレート)
ポリオキシエチレン
硬化ヒマシ油60 6.0% 5.0% 4.0% −
調製直後 透明に溶解 透明に溶解 透明に溶解 透明に溶解
1か月後(室温) 透明のまま 透明のまま 透明のまま 透明のまま
1か月後(5℃) 透明のまま 透明のまま 透明のまま 結晶物の析出
1か月後(40℃) 透明のまま 透明のまま 不透明に変化 褐色に変化
本実施例では、異なるpHにおける安定性を評価するために、表5に示す組成からなる本発明の口腔用組成物(実施例A、E)と、比較用の口腔用組成物(比較例d、e)を調製し、それぞれ、バイアル瓶に移した後、プラスチック蓋で密封し、室温又は50℃で1週間静置した後、水溶液の状態を観察した。結果を表5に示す。
実施例E 実施例A 比較例d 比較例e
カテキン類 0.5% 0.5% 0.5% 0.5%
(エピガロカテキンガレート)
ポリオキシエチレン
硬化ヒマシ油60 6.0% 6.0% 6.0% 6.0%
濃グリセリン 15.0% 15.0% 15.0% 15.0%
香料 0.2% 0.2% 0.2% 0.2%
エデト酸ナトリウム 0.2% 0.2% 0.2% 0.2%
キシリトール 0.5% 0.5% 0.5% 0.5%
クエン酸 1.6% 0.05% 0.05% 0.05%
クエン酸ナトリウム − − 6.0% 18.0%
カラギーナン 0.3% 0.3% 0.3% 0.3%
メチルパラベン 0.3% 0.3% 0.3% 0.3%
安息香酸ナトリウム 0.1% 0.1% 0.1% 0.1%
精製水 75.3% 76.85% 70.85% 58.85%
合計 100.0% 100.0% 100.0% 100.0%
pH 2.5 4.5 6.5 6.8
調製直後 透明に溶解 透明に溶解 透明に溶解 浮遊物を確認
1週間後(室温) 透明のまま 透明のまま 透明のまま −
1週間後(50℃)透明のまま 透明のまま 褐色に変化 −
Claims (5)
- カテキン類及び非イオン性界面活性剤を含み、口腔用組成物に含まれる非イオン性界面活性剤の含量が2〜60重量%であり、pHが2〜6である、口腔用組成物。
- カテキン類に対する非イオン性界面活性剤の配合比が8〜30倍である、請求項1に記載の口腔用組成物。
- 口腔用組成物に含まれるカテキン類の含量が0.01〜3重量%である、請求項1又は2に記載の口腔用組成物。
- 前記カテキン類が、ガロカテキン、エピガロカテキン、カテキン、エピガロカテキンガレート、エピカテキン、ガロカテキンガレート、エピカテキンガレート、又はカテキンガレートである、請求項1〜3のいずれか一項に記載の口腔用組成物。
- 非イオン性界面活性剤がポリオキシエチレン硬化ヒマシ油である、請求項1〜4のいずれか一項に記載の口腔用組成物。
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CN110721095B (zh) * | 2019-11-22 | 2022-05-24 | 北京中蜜科技发展有限公司 | 一种含蜂胶的草本口腔抑菌喷剂及其制备方法 |
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CN107898705B (zh) * | 2017-12-21 | 2021-01-12 | 滨州医学院附属医院 | 一种可预防龋齿和口腔溃疡的漱口水及其制备方法 |
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