JP5725605B2 - 軽度認知障害を処置するためのフェノチアジン化合物 - Google Patents

軽度認知障害を処置するためのフェノチアジン化合物 Download PDF

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Publication number
JP5725605B2
JP5725605B2 JP2010512761A JP2010512761A JP5725605B2 JP 5725605 B2 JP5725605 B2 JP 5725605B2 JP 2010512761 A JP2010512761 A JP 2010512761A JP 2010512761 A JP2010512761 A JP 2010512761A JP 5725605 B2 JP5725605 B2 JP 5725605B2
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unsubstituted
substituted
alkyl
carboaryl
aliphatic
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Japanese (ja)
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JP2010530403A (ja
JP2010530403A5 (https=
Inventor
ヴィスシック，クロード・ミシェル
ハーバラン，ドミニク・ヴェネイ
リーデル，ゲルノート
ディアーナ，セレーナ
ゴートマン，エリザベス・アン
ウィズシック，デイモン・ジュード
マレー，アリソン・ドロシー
スタッフ，ロジャー・トッド
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Wista Laboratories Ltd
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Wista Laboratories Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2010512761A 2007-06-19 2008-06-17 軽度認知障害を処置するためのフェノチアジン化合物 Active JP5725605B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94500607P 2007-06-19 2007-06-19
US60/945,006 2007-06-19
PCT/GB2008/002066 WO2008155533A2 (en) 2007-06-19 2008-06-17 Phenothiazine compounds for treating mild cognitive impairment

Publications (3)

Publication Number Publication Date
JP2010530403A JP2010530403A (ja) 2010-09-09
JP2010530403A5 JP2010530403A5 (https=) 2011-08-04
JP5725605B2 true JP5725605B2 (ja) 2015-05-27

Family

ID=39943003

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010512761A Active JP5725605B2 (ja) 2007-06-19 2008-06-17 軽度認知障害を処置するためのフェノチアジン化合物

Country Status (16)

Country Link
US (1) US9211294B2 (https=)
EP (1) EP2167095B1 (https=)
JP (1) JP5725605B2 (https=)
CN (1) CN101820884B (https=)
AU (1) AU2008265045B2 (https=)
BR (1) BRPI0813670A2 (https=)
CA (1) CA2690746C (https=)
DK (1) DK2167095T3 (https=)
ES (1) ES2739546T3 (https=)
HR (1) HRP20191513T1 (https=)
HU (1) HUE045460T2 (https=)
MY (1) MY177001A (https=)
PL (1) PL2167095T3 (https=)
PT (1) PT2167095T (https=)
SI (1) SI2167095T1 (https=)
WO (1) WO2008155533A2 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2013191B3 (en) 2006-03-29 2019-02-27 Wista Laboratories Ltd. 3,7-diamino-10h-phenothiazine salts and their use
CA3027974C (en) * 2007-10-03 2022-03-15 Wista Laboratories Ltd. Therapeutic use of diaminophenothiazines
US8828986B2 (en) 2011-04-20 2014-09-09 Prosetta Antiviral Inc. Antiviral compounds
CN102958525B (zh) 2010-04-30 2017-05-24 普罗瑟塔抗病毒股份有限公司 抗病毒化合物
EA025033B1 (ru) * 2011-02-11 2016-11-30 Уиста Лэборэтэриз Лтд. Диаминиевые соли фенотиазина и их применение
EP2951149B1 (en) * 2013-01-30 2018-10-10 Ecolab USA Inc. Hydrogen sulfide scavengers
US10304006B2 (en) * 2013-02-15 2019-05-28 The Charles Stark Draper Laboratory, Inc. Method for integrating and fusing heterogeneous data types to perform predictive analysis
WO2016133995A1 (en) * 2015-02-17 2016-08-25 Arizona Board Of Regents On Behalf Of Arizona State University Phenothiazine analogues as mitochondrial therapeutic agents
KR102592614B1 (ko) * 2016-07-25 2023-10-24 위스타 레보레이토리스 리미티드 디아미노페노티아진 (diaminophenothiazines)의 투여 및 투여량 (dosage)
GB201614834D0 (en) * 2016-09-01 2016-10-19 Wista Lab Ltd Treatment of dementia
DK3826639T3 (da) 2018-07-26 2024-09-23 Wista Lab Ltd Optimeret dosering af diaminophenothiaziner i populationer
MY209608A (en) * 2019-04-10 2025-07-24 Genting Taurx Diagnostic Centre Sdn Bhd Adaptive neurological testing method
GB201909493D0 (en) 2019-07-01 2019-08-14 Wista Lab Ltd Therapeutic interactions
GB201909454D0 (en) 2019-07-01 2019-08-14 Wista Lab Ltd Enhancers
GB201909506D0 (en) 2019-07-02 2019-08-14 Wista Lab Ltd Synaptopathies
WO2023232764A1 (en) 2022-05-31 2023-12-07 Wista Laboratories Ltd. Treatment of neurodegenerative disorders utilising methylthioninium (mt)-containing compounds
AU2024231880A1 (en) 2023-03-03 2025-09-11 Taurx Therapeutics Management Ltd. Diaminophenothiazine for the treatment of microvascular brain disease disease

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9506197D0 (en) 1995-03-27 1995-05-17 Hoffmann La Roche Inhibition of tau-tau association.
GB0017060D0 (en) * 2000-07-11 2000-08-30 Hunter Fleming Ltd Production, stabilisation and use of reduced forms of pharmaceutical compounds
GB0101049D0 (en) 2001-01-15 2001-02-28 Univ Aberdeen Materials and methods relating to protein aggregation in neurodegenerative disease
WO2004087160A1 (en) * 2003-04-03 2004-10-14 Prana Biotechnology Ltd Treatment of neurological conditions
AU2005286235C1 (en) 2004-09-23 2013-08-22 TauRx Therapeutics Management Ltd Methods of chemical synthesis and purification of diaminophenothiazinium compounds including Methylthioninium Chloride (MTC)
CN101084204B (zh) * 2004-09-23 2012-12-05 卫思道制药有限公司 包括亚甲蓝(mtc)在内的二氨基吩噻嗪鎓化合物的化学合成和纯化方法
WO2006091728A2 (en) * 2005-02-24 2006-08-31 The Trustees Of The University Of Pennsylvania Microtubule stabilizing compounds and methods of their use
EP2013191B3 (en) 2006-03-29 2019-02-27 Wista Laboratories Ltd. 3,7-diamino-10h-phenothiazine salts and their use
MY162640A (en) * 2006-03-29 2017-06-30 Wista Lab Ltd Thioninium compounds and their use
PL2004155T3 (pl) 2006-03-29 2018-08-31 Wista Laboratories Ltd. Inhibitory agregacji białek
DK3121169T3 (da) * 2006-07-11 2022-02-28 Wista Lab Ltd Fremgangsmåder til syntese og/eller oprensning af diaminophenothiaziniumforbindelser

Also Published As

Publication number Publication date
US9211294B2 (en) 2015-12-15
BRPI0813670A2 (pt) 2014-12-30
ES2739546T3 (es) 2020-01-31
JP2010530403A (ja) 2010-09-09
EP2167095B1 (en) 2019-05-29
PT2167095T (pt) 2019-08-06
HRP20191513T1 (hr) 2019-11-29
PL2167095T3 (pl) 2019-11-29
US20100184752A1 (en) 2010-07-22
CA2690746C (en) 2018-01-02
WO2008155533A3 (en) 2009-02-19
CA2690746A1 (en) 2008-12-24
AU2008265045B2 (en) 2014-02-27
DK2167095T3 (da) 2019-07-29
EP2167095A2 (en) 2010-03-31
CN101820884A (zh) 2010-09-01
CN101820884B (zh) 2013-08-28
AU2008265045A1 (en) 2008-12-24
MY177001A (en) 2020-09-01
WO2008155533A2 (en) 2008-12-24
SI2167095T1 (sl) 2019-09-30
HUE045460T2 (hu) 2019-12-30

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