DK2167095T3 - Phenothiazin-forbindelser til behandling af let kognitiv svækkelse - Google Patents

Phenothiazin-forbindelser til behandling af let kognitiv svækkelse Download PDF

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Publication number
DK2167095T3
DK2167095T3 DK08762390.6T DK08762390T DK2167095T3 DK 2167095 T3 DK2167095 T3 DK 2167095T3 DK 08762390 T DK08762390 T DK 08762390T DK 2167095 T3 DK2167095 T3 DK 2167095T3
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DK
Denmark
Prior art keywords
phenothiazin
compounds
treatment
low cognitive
cognitive disability
Prior art date
Application number
DK08762390.6T
Other languages
English (en)
Inventor
Claude Michel Wischik
Dominic Venay Harbaran
Gernot Riedel
Serena Deiana
Elizabeth Anne Goatman
Damon Jude Wischik
Alison Dorothy Murray
Roger Todd Staff
Original Assignee
Wista Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wista Lab Ltd filed Critical Wista Lab Ltd
Application granted granted Critical
Publication of DK2167095T3 publication Critical patent/DK2167095T3/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
DK08762390.6T 2007-06-19 2008-06-17 Phenothiazin-forbindelser til behandling af let kognitiv svækkelse DK2167095T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94500607P 2007-06-19 2007-06-19
PCT/GB2008/002066 WO2008155533A2 (en) 2007-06-19 2008-06-17 Phenothiazine compounds for treating mild cognitive impairment

Publications (1)

Publication Number Publication Date
DK2167095T3 true DK2167095T3 (da) 2019-07-29

Family

ID=39943003

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08762390.6T DK2167095T3 (da) 2007-06-19 2008-06-17 Phenothiazin-forbindelser til behandling af let kognitiv svækkelse

Country Status (16)

Country Link
US (1) US9211294B2 (da)
EP (1) EP2167095B1 (da)
JP (1) JP5725605B2 (da)
CN (1) CN101820884B (da)
AU (1) AU2008265045B2 (da)
BR (1) BRPI0813670A2 (da)
CA (1) CA2690746C (da)
DK (1) DK2167095T3 (da)
ES (1) ES2739546T3 (da)
HR (1) HRP20191513T1 (da)
HU (1) HUE045460T2 (da)
MY (1) MY177001A (da)
PL (1) PL2167095T3 (da)
PT (1) PT2167095T (da)
SI (1) SI2167095T1 (da)
WO (1) WO2008155533A2 (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE478058T3 (de) 2006-03-29 2010-09-15 Wista Lab Ltd 3,7-diamino-10h-phenothiazinsalze und ihre verwendung
MY161656A (en) * 2007-10-03 2017-04-28 Wista Lab Ltd Therapeutic use of diaminophenothiazines
JP5868955B2 (ja) 2010-04-30 2016-02-24 プロセッタ アンチバイラル インコーポレイテッド 抗ウイルス化合物
CN105853439A (zh) * 2011-02-11 2016-08-17 维斯塔实验室有限公司 吩噻嗪二胺鎓盐和其用途
EP2699241B1 (en) 2011-04-20 2016-07-27 Prosetta Antiviral Inc. Antiviral compounds
EP2951149B1 (en) * 2013-01-30 2018-10-10 Ecolab USA Inc. Hydrogen sulfide scavengers
US10304006B2 (en) * 2013-02-15 2019-05-28 The Charles Stark Draper Laboratory, Inc. Method for integrating and fusing heterogeneous data types to perform predictive analysis
JP6807337B2 (ja) 2015-02-17 2021-01-06 アリゾナ ボード オブ リージェンツ オン ビハーフ オブ アリゾナ ステート ユニバーシティ ミトコンドリア治療剤としてのフェノチアジン類似体
KR20230058533A (ko) * 2016-07-25 2023-05-03 위스타 레보레이토리스 리미티드 디아미노페노티아진 (diaminophenothiazines)의 투여 및 투여량 (dosage)
GB201614834D0 (en) * 2016-09-01 2016-10-19 Wista Lab Ltd Treatment of dementia
CA3134588A1 (en) * 2019-04-10 2020-10-15 Genting Taurx Diagnostic Centre Sdn Bhd Adaptive neurological testing method
GB201909454D0 (en) 2019-07-01 2019-08-14 Wista Lab Ltd Enhancers
GB201909493D0 (en) 2019-07-01 2019-08-14 Wista Lab Ltd Therapeutic interactions
GB201909506D0 (en) 2019-07-02 2019-08-14 Wista Lab Ltd Synaptopathies
WO2023232764A1 (en) 2022-05-31 2023-12-07 Wista Laboratories Ltd. Treatment of neurodegenerative disorders utilising methylthioninium (mt)-containing compounds

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9506197D0 (en) 1995-03-27 1995-05-17 Hoffmann La Roche Inhibition of tau-tau association.
GB0017060D0 (en) * 2000-07-11 2000-08-30 Hunter Fleming Ltd Production, stabilisation and use of reduced forms of pharmaceutical compounds
GB0101049D0 (en) * 2001-01-15 2001-02-28 Univ Aberdeen Materials and methods relating to protein aggregation in neurodegenerative disease
EP1617844A4 (en) * 2003-04-03 2009-07-22 Prana Biotechnology Ltd TREATMENT OF NEUROLOGICAL DISEASES
AU2005286235C1 (en) 2004-09-23 2013-08-22 Wista Laboratories Ltd. Methods of chemical synthesis and purification of diaminophenothiazinium compounds including Methylthioninium Chloride (MTC)
JP5186212B2 (ja) * 2004-09-23 2013-04-17 ウィスタ ラボラトリーズ リミテッド メチルチオニニウム塩化物（ｍｔｃ）などのジアミノフェノチアジニウム化合物を化学合成および精製する方法
WO2006091728A2 (en) * 2005-02-24 2006-08-31 The Trustees Of The University Of Pennsylvania Microtubule stabilizing compounds and methods of their use
DK2004155T3 (da) * 2006-03-29 2018-04-30 Wista Lab Ltd Inhibitorer af protein-aggregation
CA2645919C (en) 2006-03-29 2016-05-31 Wista Laboratories Ltd. Thioninium compounds and their use
ATE478058T3 (de) 2006-03-29 2010-09-15 Wista Lab Ltd 3,7-diamino-10h-phenothiazinsalze und ihre verwendung
CN102718730B (zh) * 2006-07-11 2018-06-05 维斯塔实验室有限公司 二氨基吩噻嗪*化合物的合成和/或纯化方法

Also Published As

Publication number Publication date
HRP20191513T1 (hr) 2019-11-29
JP5725605B2 (ja) 2015-05-27
WO2008155533A2 (en) 2008-12-24
PL2167095T3 (pl) 2019-11-29
CA2690746A1 (en) 2008-12-24
AU2008265045A1 (en) 2008-12-24
SI2167095T1 (sl) 2019-09-30
WO2008155533A3 (en) 2009-02-19
BRPI0813670A2 (pt) 2014-12-30
US20100184752A1 (en) 2010-07-22
ES2739546T3 (es) 2020-01-31
EP2167095A2 (en) 2010-03-31
US9211294B2 (en) 2015-12-15
CA2690746C (en) 2018-01-02
JP2010530403A (ja) 2010-09-09
EP2167095B1 (en) 2019-05-29
HUE045460T2 (hu) 2019-12-30
AU2008265045B2 (en) 2014-02-27
CN101820884A (zh) 2010-09-01
PT2167095T (pt) 2019-08-06
MY177001A (en) 2020-09-01
CN101820884B (zh) 2013-08-28

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