JP5723154B2 - ＲＮＡｉにおけるオフターゲット表現型の影響を減少させるためのＳｉＲＮＡ配列非依存性修飾フォーマットおよびその安定化型 - Google Patents

ＲＮＡｉにおけるオフターゲット表現型の影響を減少させるためのＳｉＲＮＡ配列非依存性修飾フォーマットおよびその安定化型 Download PDF

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JP5723154B2
JP5723154B2 JP2010525916A JP2010525916A JP5723154B2 JP 5723154 B2 JP5723154 B2 JP 5723154B2 JP 2010525916 A JP2010525916 A JP 2010525916A JP 2010525916 A JP2010525916 A JP 2010525916A JP 5723154 B2 JP5723154 B2 JP 5723154B2
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oligonucleotide
sirna
modified
passenger
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JP2010538677A5 (enExample
JP2010538677A (ja
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ニティン パリ，
ニティン パリ，
イルダヤ チャールズ，
イルダヤ チャールズ，
スーザン マグダレノ，
スーザン マグダレノ，
アレキサンダー ブラッソフ，
アレキサンダー ブラッソフ，
クリス バーネット，
クリス バーネット，
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アプライド バイオシステムズ リミテッド ライアビリティー カンパニー
アプライド バイオシステムズ リミテッド ライアビリティー カンパニー
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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JP2010525916A 2007-09-19 2008-09-17 ＲＮＡｉにおけるオフターゲット表現型の影響を減少させるためのＳｉＲＮＡ配列非依存性修飾フォーマットおよびその安定化型 Active JP5723154B2 (ja)

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US97354807P 2007-09-19 2007-09-19
US60/973,548 2007-09-19
PCT/US2008/076675 WO2009039173A2 (en) 2007-09-19 2008-09-17 SiRNA SEQUENCE-INDEPENDENT MODIFICATION FORMATS FOR REDUCING OFF-TARGET PHENOTYPIC EFFECTS IN RNAi, AND STABILIZED FORMS THEREOF

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JP2014035378A Division JP2014097073A (ja) 2007-09-19 2014-02-26 ＲＮＡｉにおけるオフターゲット表現型の影響を減少させるためのＳｉＲＮＡ配列非依存性修飾フォーマットおよびその安定化型

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JP2010538677A JP2010538677A (ja) 2010-12-16
JP2010538677A5 JP2010538677A5 (enExample) 2012-10-11
JP5723154B2 true JP5723154B2 (ja) 2015-05-27

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JP2014035378A Withdrawn JP2014097073A (ja) 2007-09-19 2014-02-26 ＲＮＡｉにおけるオフターゲット表現型の影響を減少させるためのＳｉＲＮＡ配列非依存性修飾フォーマットおよびその安定化型

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US (6) US8524681B2 (enExample)
EP (2) EP2195428B1 (enExample)
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DK (2) DK2548962T3 (enExample)
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