DK2195428T3 - SIRNA SEQUENCE-INDEPENDENT MODIFICATION FORMS TO REDUCE TARGET-FAILING PHENOTYPIC EFFECTS OF RNAI, AND STABILIZED FORMS THEREOF - Google Patents

SIRNA SEQUENCE-INDEPENDENT MODIFICATION FORMS TO REDUCE TARGET-FAILING PHENOTYPIC EFFECTS OF RNAI, AND STABILIZED FORMS THEREOF Download PDF

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DK2195428T3
DK2195428T3 DK08831316.8T DK08831316T DK2195428T3 DK 2195428 T3 DK2195428 T3 DK 2195428T3 DK 08831316 T DK08831316 T DK 08831316T DK 2195428 T3 DK2195428 T3 DK 2195428T3
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format
sirna
sirnas
passenger
modification
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Irudaya Charles
Susan Magdaleno
Alexander Vlassov
Chris Burnett
Nitin Puri
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Applied Biosystems Llc
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/343—Spatial arrangement of the modifications having patterns, e.g. ==--==--==--
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    • C12N2320/00—Applications; Uses
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    • C12N2320/53—Methods for regulating/modulating their activity reducing unwanted side-effects

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK08831316.8T 2007-09-19 2008-09-17 SIRNA SEQUENCE-INDEPENDENT MODIFICATION FORMS TO REDUCE TARGET-FAILING PHENOTYPIC EFFECTS OF RNAI, AND STABILIZED FORMS THEREOF DK2195428T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97354807P 2007-09-19 2007-09-19
PCT/US2008/076675 WO2009039173A2 (en) 2007-09-19 2008-09-17 SiRNA SEQUENCE-INDEPENDENT MODIFICATION FORMATS FOR REDUCING OFF-TARGET PHENOTYPIC EFFECTS IN RNAi, AND STABILIZED FORMS THEREOF

Publications (1)

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DK2195428T3 true DK2195428T3 (en) 2014-03-03

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DK12189270.7T DK2548962T3 (en) 2007-09-19 2008-09-17 Sirna sequence-independent modification formats to reduce off-target phenotype effects in RNAI and stabilized forms thereof
DK08831316.8T DK2195428T3 (en) 2007-09-19 2008-09-17 SIRNA SEQUENCE-INDEPENDENT MODIFICATION FORMS TO REDUCE TARGET-FAILING PHENOTYPIC EFFECTS OF RNAI, AND STABILIZED FORMS THEREOF

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DK12189270.7T DK2548962T3 (en) 2007-09-19 2008-09-17 Sirna sequence-independent modification formats to reduce off-target phenotype effects in RNAI and stabilized forms thereof

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US (6) US8524681B2 (enExample)
EP (2) EP2195428B1 (enExample)
JP (2) JP5723154B2 (enExample)
CN (1) CN101849008A (enExample)
DK (2) DK2548962T3 (enExample)
WO (1) WO2009039173A2 (enExample)

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