JP5721620B2 - 免疫応答を刺激するための作製物および方法 - Google Patents

免疫応答を刺激するための作製物および方法 Download PDF

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JP5721620B2
JP5721620B2 JP2011506772A JP2011506772A JP5721620B2 JP 5721620 B2 JP5721620 B2 JP 5721620B2 JP 2011506772 A JP2011506772 A JP 2011506772A JP 2011506772 A JP2011506772 A JP 2011506772A JP 5721620 B2 JP5721620 B2 JP 5721620B2
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antigen
cells
cell
specific
hel
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JP2011519847A5 (enExample
JP2011519847A (ja
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バティスタ，ファクンド
エックル−ドルナ，ジュリア
バラール，パトリシア
セルンドロ，ヴィンチェンツォ
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Cancer Research Technology Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2011506772A 2008-05-02 2009-05-05 免疫応答を刺激するための作製物および方法 Expired - Fee Related JP5721620B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4981408P 2008-05-02 2008-05-02
US61/049,814 2008-05-02
PCT/GB2009/001111 WO2009133378A2 (en) 2008-05-02 2009-05-05 Products and methods for stimulating an immune response

Related Child Applications (2)

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JP2014160906A Division JP2015028023A (ja) 2008-05-02 2014-08-07 免疫応答を刺激するための作製物および方法
JP2014160907A Division JP5853068B2 (ja) 2008-05-02 2014-08-07 免疫応答を刺激するための作製物および方法

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JP2011519847A JP2011519847A (ja) 2011-07-14
JP2011519847A5 JP2011519847A5 (enExample) 2012-06-07
JP5721620B2 true JP5721620B2 (ja) 2015-05-20

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JP2011506772A Expired - Fee Related JP5721620B2 (ja) 2008-05-02 2009-05-05 免疫応答を刺激するための作製物および方法
JP2014160906A Pending JP2015028023A (ja) 2008-05-02 2014-08-07 免疫応答を刺激するための作製物および方法
JP2014160907A Expired - Fee Related JP5853068B2 (ja) 2008-05-02 2014-08-07 免疫応答を刺激するための作製物および方法

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JP2014160906A Pending JP2015028023A (ja) 2008-05-02 2014-08-07 免疫応答を刺激するための作製物および方法
JP2014160907A Expired - Fee Related JP5853068B2 (ja) 2008-05-02 2014-08-07 免疫応答を刺激するための作製物および方法

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US (1) US20110280930A1 (enExample)
EP (3) EP2288381A2 (enExample)
JP (3) JP5721620B2 (enExample)
CN (1) CN102170903B (enExample)
AU (1) AU2009241645B2 (enExample)
CA (1) CA2723226A1 (enExample)
ES (1) ES2570973T3 (enExample)
WO (1) WO2009133378A2 (enExample)

Cited By (1)

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JP2015028023A (ja) * 2008-05-02 2015-02-12 キャンサー・リサーチ・テクノロジー・リミテッドＣａｎｃｅｒ Ｒｅｓｅａｒｃｈ Ｔｅｃｈｎｏｌｏｇｙ Ｌｉｍｉｔｅｄ 免疫応答を刺激するための作製物および方法

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WO2014133106A1 (ja) * 2013-02-27 2014-09-04 独立行政法人理化学研究所 アレルギー疾患治療薬
GB2514591A (en) 2013-05-30 2014-12-03 Mologen Ag Predictive biomarker for cancer therapy
CA2919268C (en) 2013-07-25 2023-09-05 Exicure, Inc. Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use
WO2015021390A2 (en) 2013-08-08 2015-02-12 The Regents Of The University Of California Nanoparticles leverage biological membranes to target pathogens for disease treatment and diagnosis
WO2015084677A1 (en) * 2013-12-02 2015-06-11 Arytha Biosciences, Llc Toxoid preparation and uses thereof
WO2015143295A2 (en) 2014-03-20 2015-09-24 The Regents Of The University Of California Hydrogel compositions containing toxin-absorbing or binding nanoparticles and uses thereof
CN107073090A (zh) 2014-04-30 2017-08-18 哈佛学院董事会 结合的疫苗装置和杀死癌细胞的方法
AU2015269412B2 (en) * 2014-06-04 2020-03-12 Exicure Operating Company Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications
US11150242B2 (en) * 2015-04-10 2021-10-19 President And Fellows Of Harvard College Immune cell trapping devices and methods for making and using the same
US10610493B2 (en) 2015-04-29 2020-04-07 The Regents Of The University Of California Detoxification using nanoparticles
AU2016277471A1 (en) * 2015-06-10 2018-01-04 Astrid TSCHIERSCH-PFREUNDSCHUH Means and methods for treatment of B-cell malignancies
WO2017136837A1 (en) 2016-02-06 2017-08-10 President And Fellows Of Harvard College Recapitulating the hematopoietic niche to reconstitute immunity
NL2017204B1 (en) * 2016-06-08 2017-12-18 Kei International Ltd Solid substrate comprising antigens immobilised thereto, biosensor comprising said solid substrate and method for detecting the presence of mycobacterial material in a sample
WO2017211314A1 (en) 2016-06-08 2017-12-14 Kei International Limited Method for detecting presence of mycobacterial material in sample using immobilised mannosyl phosphoketide antigen
AU2017295704B2 (en) 2016-07-13 2023-07-13 President And Fellows Of Harvard College Antigen-presenting cell-mimetic scaffolds and methods for making and using the same
CN110418651A (zh) 2016-08-02 2019-11-05 哈佛学院院长等 用于调节免疫应答的生物材料
CN110114468A (zh) * 2016-08-17 2019-08-09 奥比思健康解决方案有限责任公司 靶向肿瘤的珠载体及其使用方法
AU2018316253A1 (en) * 2017-08-10 2020-01-16 Dana-Farber Cancer Institute, Inc. LMP1-expressing cells and methods of use thereof
NL2021443B1 (en) 2018-08-08 2020-02-20 Kei International Ltd Synthetic antigens for tuberculosis detection
WO2020061129A1 (en) 2018-09-19 2020-03-26 President And Fellows Of Harvard College Compositions and methods for labeling and modulation of cells in vitro and in vivo
EP3650466A1 (en) * 2018-11-12 2020-05-13 Consejo Superior De Investigaciones Científicas In vitro production of high affinity monoclonal antibodies
CN111229023B (zh) * 2018-11-29 2022-01-28 内蒙古东盛硅藻土科技创新产业园有限公司 一种化学降解添加剂
JP2022514568A (ja) 2018-12-17 2022-02-14 プレジデント アンド フェローズ オブ ハーバード カレッジ 免疫系のモジュレーションのための生物工学的スキャフォールドおよびその使用
JP2022549270A (ja) 2019-09-23 2022-11-24 プレジデント アンド フェローズ オブ ハーバード カレッジ バイオマテリアルベースの無抗原ワクチンおよびその使用
CN112300987B (zh) * 2020-10-16 2022-04-29 中国农业大学 单个浆细胞的筛选方法及其在小分子单克隆抗体制备中的应用
CN116286631A (zh) * 2023-02-15 2023-06-23 上海长征医院 一种利用CD79b单克隆抗体诱导构建B细胞免疫无能模型及其构建方法

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Also Published As

Publication number Publication date
EP2711020A1 (en) 2014-03-26
EP2711021B1 (en) 2016-03-09
CA2723226A1 (en) 2009-05-11
HK1190942A1 (en) 2014-07-18
WO2009133378A3 (en) 2009-12-23
JP2011519847A (ja) 2011-07-14
HK1191548A1 (en) 2014-08-01
EP2288381A2 (en) 2011-03-02
JP2015028023A (ja) 2015-02-12
EP2711021A1 (en) 2014-03-26
US20110280930A1 (en) 2011-11-17
JP2015038066A (ja) 2015-02-26
HK1161542A1 (zh) 2012-07-27
CN102170903B (zh) 2016-04-06
EP2711020B1 (en) 2016-08-10
ES2570973T3 (es) 2016-05-23
AU2009241645B2 (en) 2014-07-17
AU2009241645A1 (en) 2009-11-05
WO2009133378A2 (en) 2009-11-05
CN102170903A (zh) 2011-08-31
JP5853068B2 (ja) 2016-02-09

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