CA2723226A1 - Products and methods for stimulating an immune response - Google Patents
Products and methods for stimulating an immune response Download PDFInfo
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- CA2723226A1 CA2723226A1 CA2723226A CA2723226A CA2723226A1 CA 2723226 A1 CA2723226 A1 CA 2723226A1 CA 2723226 A CA2723226 A CA 2723226A CA 2723226 A CA2723226 A CA 2723226A CA 2723226 A1 CA2723226 A1 CA 2723226A1
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- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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| US61/049,814 | 2008-05-02 | ||
| PCT/GB2009/001111 WO2009133378A2 (en) | 2008-05-02 | 2009-05-05 | Products and methods for stimulating an immune response |
Publications (1)
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| CA2723226A1 true CA2723226A1 (en) | 2009-05-11 |
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| JP (3) | JP5721620B2 (enExample) |
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| AU (1) | AU2009241645B2 (enExample) |
| CA (1) | CA2723226A1 (enExample) |
| ES (1) | ES2570973T3 (enExample) |
| WO (1) | WO2009133378A2 (enExample) |
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| CA2723226A1 (en) * | 2008-05-02 | 2009-05-11 | Cancer Research Technology Ltd | Products and methods for stimulating an immune response |
| WO2012088414A1 (en) * | 2010-12-23 | 2012-06-28 | Ludwig Institute For Cancer Research Ltd. | Liposomal formulation of nonglycosidic ceramides and uses thereof |
| US9675561B2 (en) | 2011-04-28 | 2017-06-13 | President And Fellows Of Harvard College | Injectable cryogel vaccine devices and methods of use thereof |
| JP6100762B2 (ja) | 2011-06-02 | 2017-03-22 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 膜で被包されたナノ粒子および使用方法 |
| TW201442739A (zh) * | 2013-02-27 | 2014-11-16 | Riken | 過敏疾病治療藥 |
| GB2514591A (en) * | 2013-05-30 | 2014-12-03 | Mologen Ag | Predictive biomarker for cancer therapy |
| WO2015013673A1 (en) | 2013-07-25 | 2015-01-29 | Aurasense Therapeutics, Llc | Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use |
| WO2015021390A2 (en) | 2013-08-08 | 2015-02-12 | The Regents Of The University Of California | Nanoparticles leverage biological membranes to target pathogens for disease treatment and diagnosis |
| WO2015084677A1 (en) * | 2013-12-02 | 2015-06-11 | Arytha Biosciences, Llc | Toxoid preparation and uses thereof |
| CN106163504B (zh) | 2014-03-20 | 2021-02-09 | 加利福尼亚大学董事会 | 水凝胶毒素-吸收或结合纳米颗粒 |
| US10682400B2 (en) | 2014-04-30 | 2020-06-16 | President And Fellows Of Harvard College | Combination vaccine devices and methods of killing cancer cells |
| US10434064B2 (en) | 2014-06-04 | 2019-10-08 | Exicure, Inc. | Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications |
| JP7094533B2 (ja) * | 2015-04-10 | 2022-07-04 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 免疫細胞捕捉デバイスおよびその製造および使用方法 |
| US10610493B2 (en) | 2015-04-29 | 2020-04-07 | The Regents Of The University Of California | Detoxification using nanoparticles |
| CN107708740A (zh) * | 2015-06-10 | 2018-02-16 | 萨尔布吕肯大学 | 用于治疗b细胞恶性肿瘤的手段和方法 |
| EP3411475B1 (en) | 2016-02-06 | 2025-08-27 | President and Fellows of Harvard College | Recapitulating the hematopoietic niche to reconstitute immunity |
| WO2017211316A1 (en) | 2016-06-08 | 2017-12-14 | Kei International Limited | Method for detecting the presence of mycobacterial material in a sample using at least two antigens |
| NL2017204B1 (en) | 2016-06-08 | 2017-12-18 | Kei International Ltd | Solid substrate comprising antigens immobilised thereto, biosensor comprising said solid substrate and method for detecting the presence of mycobacterial material in a sample |
| CN115537372A (zh) | 2016-07-13 | 2022-12-30 | 哈佛学院院长等 | 抗原呈递细胞模拟支架及其制备和使用方法 |
| EP3493842A4 (en) | 2016-08-02 | 2020-07-29 | President and Fellows of Harvard College | BIOMATERIALS TO MODULATE IMMUNE RESPONSES |
| WO2018035303A1 (en) * | 2016-08-17 | 2018-02-22 | Orbis Health Solutions Llc | Tumor-targeting bead vectors and methods of using the same |
| WO2019032862A1 (en) * | 2017-08-10 | 2019-02-14 | Dana-Farber Cancer Institute, Inc. | CELLS EXPRESSING LMP1 AND METHODS OF USE |
| NL2021443B1 (en) | 2018-08-08 | 2020-02-20 | Kei International Ltd | Synthetic antigens for tuberculosis detection |
| WO2020061129A1 (en) | 2018-09-19 | 2020-03-26 | President And Fellows Of Harvard College | Compositions and methods for labeling and modulation of cells in vitro and in vivo |
| EP3650466A1 (en) * | 2018-11-12 | 2020-05-13 | Consejo Superior De Investigaciones Científicas | In vitro production of high affinity monoclonal antibodies |
| CN111229023B (zh) * | 2018-11-29 | 2022-01-28 | 内蒙古东盛硅藻土科技创新产业园有限公司 | 一种化学降解添加剂 |
| CN112300987B (zh) * | 2020-10-16 | 2022-04-29 | 中国农业大学 | 单个浆细胞的筛选方法及其在小分子单克隆抗体制备中的应用 |
Family Cites Families (24)
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| DK590288D0 (da) | 1988-10-24 | 1988-10-24 | Symbicom Ab | Kemiske forbindelser |
| ES2092560T5 (es) | 1989-12-22 | 2004-09-16 | Mikrogen Molekularbiologische Entwicklungs-Gmbh | Proteinas inmunologicamente activas de borrelia burgdorferi, estuches de ensayo relacionados y vacuna. |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| JP3215109B2 (ja) | 1991-02-15 | 2001-10-02 | ユーエイビー リサーチ ファウンデーション | 肺炎球菌タンパクの構造遺伝子 |
| EP0598816B1 (en) | 1991-08-15 | 1999-06-23 | SMITHKLINE BEECHAM BIOLOGICALS s.a. | Osp a proteins of borrelia burgdorferi subgroups, encoding genes and vaccines |
| ES2194010T3 (es) | 1991-10-22 | 2003-11-16 | Symbicom Ab | Mejoras en el diagnostico y profilaxis de la borrelia burgdorferi. |
| US5776427A (en) | 1992-03-05 | 1998-07-07 | Board Of Regents, The University Of Texas System | Methods for targeting the vasculature of solid tumors |
| FR2695563B1 (fr) * | 1992-09-11 | 1994-12-02 | Pasteur Institut | Microparticules portant des antigènes et leur utilisation pour l'induction de réponses humorales ou cellulaires. |
| US6004763A (en) * | 1992-09-11 | 1999-12-21 | Institut Pasteur | Antigen-carrying microparticles and their use in the induction of humoral or cellular responses |
| AU711183B2 (en) | 1994-08-19 | 1999-10-07 | Biotransplant Incorporated | Genetically engineered swine cells |
| CA2453880A1 (en) | 2001-07-25 | 2003-02-06 | New York University | Use of glycosylceramides as adjuvants for vaccines against infections and cancer |
| DE10164309A1 (de) * | 2001-12-28 | 2003-07-10 | Fraunhofer Ges Forschung | Verbesserte strukturiert-funktionale Bindematrices für Biomoleküle |
| US20070104726A1 (en) * | 2002-08-14 | 2007-05-10 | Avidis Sa | Multimeric complexes of antigens and adjuvants |
| AU2004215125B2 (en) | 2003-02-26 | 2011-01-06 | Institute For Research In Biomedicine | Monoclonal antibody production by EBV transformation of B cells |
| EP1694301A4 (en) * | 2003-12-02 | 2009-11-18 | Cytimmune Sciences Inc | METHOD AND COMPOSITIONS FOR THE PRODUCTION OF MONOCLONAL ANTIBODIES |
| EP1767216B1 (en) | 2004-06-11 | 2012-07-11 | Riken | Drug having regulatory cell ligand contained in liposome |
| WO2006002642A2 (en) * | 2004-07-07 | 2006-01-12 | Statens Serum Institut | Compositions and methods for stabilizing lipid based adjuvant formulations using glycolipids |
| JP5117191B2 (ja) * | 2004-10-01 | 2013-01-09 | ミダテック リミテッド | 抗原及びアジュバントを含むナノ粒子、並びに免疫原性構造 |
| JP2008531672A (ja) * | 2005-03-02 | 2008-08-14 | イギリス国 | 医薬組成物 |
| WO2007050668A1 (en) | 2005-10-25 | 2007-05-03 | Ludwig Institute For Cancer Research | Analogs of alpha galactosylceramide and uses thereof |
| WO2007051004A2 (en) | 2005-10-28 | 2007-05-03 | The Brigham And Women's Hospital, Inc. | Conjugate vaccines for non-proteinaceous antigens |
| US20070231344A1 (en) | 2005-10-28 | 2007-10-04 | The Brigham And Women's Hospital, Inc. | Conjugate vaccines for non-proteinaceous antigens |
| CA2723226A1 (en) * | 2008-05-02 | 2009-05-11 | Cancer Research Technology Ltd | Products and methods for stimulating an immune response |
| JP5782775B2 (ja) | 2011-03-29 | 2015-09-24 | ソニー株式会社 | 情報表示装置および情報表示方法、並びにプログラム |
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2009
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- 2009-05-05 EP EP13189439.6A patent/EP2711021B1/en not_active Not-in-force
- 2009-05-05 WO PCT/GB2009/001111 patent/WO2009133378A2/en not_active Ceased
- 2009-05-05 JP JP2011506772A patent/JP5721620B2/ja not_active Expired - Fee Related
- 2009-05-05 EP EP13189438.8A patent/EP2711020B1/en not_active Not-in-force
- 2009-05-05 US US12/736,706 patent/US20110280930A1/en not_active Abandoned
- 2009-05-05 CN CN200980125581.9A patent/CN102170903B/zh not_active Expired - Fee Related
- 2009-05-05 AU AU2009241645A patent/AU2009241645B2/en not_active Ceased
- 2009-05-05 ES ES13189439T patent/ES2570973T3/es active Active
- 2009-05-05 EP EP09738408A patent/EP2288381A2/en not_active Withdrawn
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2014
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- 2014-08-07 JP JP2014160907A patent/JP5853068B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
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| AU2009241645B2 (en) | 2014-07-17 |
| CN102170903A (zh) | 2011-08-31 |
| EP2711021A1 (en) | 2014-03-26 |
| US20110280930A1 (en) | 2011-11-17 |
| EP2711020A1 (en) | 2014-03-26 |
| WO2009133378A3 (en) | 2009-12-23 |
| JP5853068B2 (ja) | 2016-02-09 |
| JP2015038066A (ja) | 2015-02-26 |
| ES2570973T3 (es) | 2016-05-23 |
| EP2711020B1 (en) | 2016-08-10 |
| EP2288381A2 (en) | 2011-03-02 |
| WO2009133378A2 (en) | 2009-11-05 |
| HK1190942A1 (en) | 2014-07-18 |
| JP2015028023A (ja) | 2015-02-12 |
| AU2009241645A1 (en) | 2009-11-05 |
| JP5721620B2 (ja) | 2015-05-20 |
| EP2711021B1 (en) | 2016-03-09 |
| JP2011519847A (ja) | 2011-07-14 |
| HK1191548A1 (en) | 2014-08-01 |
| HK1161542A1 (zh) | 2012-07-27 |
| CN102170903B (zh) | 2016-04-06 |
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