JP5702366B2 - 蛍光リン脂質エーテル化合物、組成物、及びその使用 - Google Patents

蛍光リン脂質エーテル化合物、組成物、及びその使用 Download PDF

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JP5702366B2
JP5702366B2 JP2012510929A JP2012510929A JP5702366B2 JP 5702366 B2 JP5702366 B2 JP 5702366B2 JP 2012510929 A JP2012510929 A JP 2012510929A JP 2012510929 A JP2012510929 A JP 2012510929A JP 5702366 B2 JP5702366 B2 JP 5702366B2
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fluorescent phospholipid
ether compound
phospholipid ether
tissue
fluorescent
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JP2012526822A5 (https=
JP2012526822A (ja
Inventor
ピンチュク アナトリー
ピンチュク アナトリー
ピー．ウェイチャート ジェイミー
ピー．ウェイチャート ジェイミー
ロンギーノ マルク
ロンギーノ マルク
カンデラ イラワティ
カンデラ イラワティ
アール．クラーク ウィリアム
アール．クラーク ウィリアム
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セレクター，インコーポレイティド
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Priority claimed from US12/463,970 external-priority patent/US7811548B1/en
Priority claimed from US12/463,998 external-priority patent/US20100284931A1/en
Priority claimed from US12/463,990 external-priority patent/US20100284930A1/en
Priority claimed from US12/463,983 external-priority patent/US20100286510A1/en
Priority claimed from US12/463,978 external-priority patent/US20100284929A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052—Small organic molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Endoscopes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2012510929A 2009-05-11 2010-05-11 蛍光リン脂質エーテル化合物、組成物、及びその使用 Active JP5702366B2 (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US12/463,970 2009-05-11
US12/463,970 US7811548B1 (en) 2009-05-11 2009-05-11 Fluorescent phospholipid ether compounds and compositions
US12/463,978 2009-05-11
US12/463,998 US20100284931A1 (en) 2009-05-11 2009-05-11 Fluorescent phospholipid ether compounds, compositions, and methods of use
US12/463,990 US20100284930A1 (en) 2009-05-11 2009-05-11 Fluorescent imaging of skin cancers using phospholipid ether compounds
US12/463,983 US20100286510A1 (en) 2009-05-11 2009-05-11 Use of fluorescent phospholipid ether compounds in biopsies
US12/463,978 US20100284929A1 (en) 2009-05-11 2009-05-11 Fluorescent imaging of tumors using phospholipid ether compounds
US12/463,990 2009-05-11
US12/463,983 2009-05-11
US12/463,998 2009-05-11
PCT/US2010/034361 WO2010132428A1 (en) 2009-05-11 2010-05-11 Fluorescent phospholipid ether compounds, compositions, and methods of use

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JP2012526822A JP2012526822A (ja) 2012-11-01
JP2012526822A5 JP2012526822A5 (https=) 2013-06-27
JP5702366B2 true JP5702366B2 (ja) 2015-04-15

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JP2014183841A Active JP6006271B2 (ja) 2009-05-11 2014-09-10 蛍光リン脂質エーテル化合物、組成物、及びその使用
JP2015098391A Active JP6073961B2 (ja) 2009-05-11 2015-05-13 蛍光リン脂質エーテル化合物、組成物、及びその使用
JP2016089336A Pending JP2016193907A (ja) 2009-05-11 2016-04-27 蛍光リン脂質エーテル化合物、組成物、及びその使用

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JP2015098391A Active JP6073961B2 (ja) 2009-05-11 2015-05-13 蛍光リン脂質エーテル化合物、組成物、及びその使用
JP2016089336A Pending JP2016193907A (ja) 2009-05-11 2016-04-27 蛍光リン脂質エーテル化合物、組成物、及びその使用

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US (1) US9616140B2 (https=)
EP (1) EP2429591B1 (https=)
JP (4) JP5702366B2 (https=)
ES (1) ES2549459T3 (https=)
WO (1) WO2010132428A1 (https=)

Cited By (2)

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JP2015166372A (ja) * 2009-05-11 2015-09-24 セレクター，インコーポレイティド 蛍光リン脂質エーテル化合物、組成物、及びその使用
WO2022025625A1 (ko) * 2020-07-28 2022-02-03 부산대학교 산학협력단 암 줄기세포 검출용 바이오 마커 조성물

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JP2013032297A (ja) * 2011-08-01 2013-02-14 Univ Of Tsukuba バイオイメージングのための近赤外発光物質及びその合成方法
JP6260259B2 (ja) * 2013-12-24 2018-01-17 日油株式会社 ボロン酸含有ホスホリルコリン化合物及びその製造方法、並びにヨード基含有化合物修飾剤
CN107708702A (zh) 2014-11-17 2018-02-16 塞勒克塔生物科学有限公司 磷脂醚类似物作为靶向癌症的药物载体
CN108430520B (zh) 2015-11-06 2021-08-13 威斯康星校友研究基金会 长效钆基肿瘤靶向成像与治疗剂
JP7136770B2 (ja) * 2016-06-14 2022-09-13 セレクター・バイオサイエンシズ・インコーポレイテッド 循環腫瘍細胞を同定及び単離するためのリン酸化エーテル類似体
KR102148067B1 (ko) * 2016-09-02 2020-08-26 주식회사 엘지화학 화합물 및 이를 포함하는 색변환필름
JP2020066637A (ja) * 2017-02-27 2020-04-30 富士フイルム株式会社 病理診断用染色剤、細胞核染色方法、病理標本の製造方法、及び色素
JP6495989B1 (ja) 2017-10-02 2019-04-03 株式会社アマダホールディングス プログラム作成装置、溶接システム、及びプログラム作成方法
KR102821508B1 (ko) 2018-04-10 2025-06-16 셀렉타 바이오사이언시스, 인코퍼레이티드 인지질-플라베글린 접합체 및 표적화된 암 치료를 위해 이를 사용하는 방법
WO2019230963A1 (ja) 2018-06-01 2019-12-05 富士フイルム株式会社 蛍光性化合物及びこれを用いた蛍光標識生体物質
CA3154192A1 (en) 2019-10-10 2021-04-15 Cellectar Biosciences, Inc. Phospholipid-flavagline conjugates and methods of using the same for targeted cancer therapy
JP7423855B2 (ja) * 2020-09-05 2024-01-29 カウンシル オブ サイエンティフィック アンド インダストリアル リサーチ フォトニックインクとしての熱応答性自己組織化有機材料及びその製造方法
CN114957330A (zh) * 2022-07-06 2022-08-30 南京师范大学 一种新型花菁染料中间体及其制备方法

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JP2015166372A (ja) * 2009-05-11 2015-09-24 セレクター，インコーポレイティド 蛍光リン脂質エーテル化合物、組成物、及びその使用
WO2022025625A1 (ko) * 2020-07-28 2022-02-03 부산대학교 산학협력단 암 줄기세포 검출용 바이오 마커 조성물
KR20220014003A (ko) * 2020-07-28 2022-02-04 부산대학교 산학협력단 암 줄기세포 검출용 바이오 마커 조성물

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JP2016193907A (ja) 2016-11-17
JP6073961B2 (ja) 2017-02-01
ES2549459T3 (es) 2015-10-28
JP6006271B2 (ja) 2016-10-12
EP2429591B1 (en) 2015-08-26
JP2015007118A (ja) 2015-01-15
JP2012526822A (ja) 2012-11-01
JP2015166372A (ja) 2015-09-24
WO2010132428A1 (en) 2010-11-18
EP2429591A1 (en) 2012-03-21
EP2429591A4 (en) 2013-02-20
US9616140B2 (en) 2017-04-11
US20150044142A1 (en) 2015-02-12

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