JP2012526822A5 - - Google Patents
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- Publication number
- JP2012526822A5 JP2012526822A5 JP2012510929A JP2012510929A JP2012526822A5 JP 2012526822 A5 JP2012526822 A5 JP 2012526822A5 JP 2012510929 A JP2012510929 A JP 2012510929A JP 2012510929 A JP2012510929 A JP 2012510929A JP 2012526822 A5 JP2012526822 A5 JP 2012526822A5
- Authority
- JP
- Japan
- Prior art keywords
- fluorescent phospholipid
- ether compound
- phospholipid ether
- tissue
- malignant tumor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 phospholipid ether compound Chemical class 0.000 claims 38
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 29
- 201000011510 cancer Diseases 0.000 claims 23
- 238000000034 method Methods 0.000 claims 17
- 206010028980 Neoplasm Diseases 0.000 claims 10
- 238000009825 accumulation Methods 0.000 claims 5
- 230000001575 pathological effect Effects 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 210000000130 stem cell Anatomy 0.000 claims 4
- 238000001574 biopsy Methods 0.000 claims 2
- 210000003238 esophagus Anatomy 0.000 claims 2
- 230000003211 malignant effect Effects 0.000 claims 2
- 238000002271 resection Methods 0.000 claims 2
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 claims 1
- 210000000683 abdominal cavity Anatomy 0.000 claims 1
- 210000000621 bronchi Anatomy 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 210000001953 common bile duct Anatomy 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 210000001198 duodenum Anatomy 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 210000000664 rectum Anatomy 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 210000000813 small intestine Anatomy 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 210000000115 thoracic cavity Anatomy 0.000 claims 1
- 210000003932 urinary bladder Anatomy 0.000 claims 1
- 210000004291 uterus Anatomy 0.000 claims 1
- ORGHESHFQPYLAO-UHFFFAOYSA-N vinyl radical Chemical compound C=[CH] ORGHESHFQPYLAO-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/463,970 | 2009-05-11 | ||
| US12/463,970 US7811548B1 (en) | 2009-05-11 | 2009-05-11 | Fluorescent phospholipid ether compounds and compositions |
| US12/463,978 | 2009-05-11 | ||
| US12/463,998 US20100284931A1 (en) | 2009-05-11 | 2009-05-11 | Fluorescent phospholipid ether compounds, compositions, and methods of use |
| US12/463,990 US20100284930A1 (en) | 2009-05-11 | 2009-05-11 | Fluorescent imaging of skin cancers using phospholipid ether compounds |
| US12/463,983 US20100286510A1 (en) | 2009-05-11 | 2009-05-11 | Use of fluorescent phospholipid ether compounds in biopsies |
| US12/463,978 US20100284929A1 (en) | 2009-05-11 | 2009-05-11 | Fluorescent imaging of tumors using phospholipid ether compounds |
| US12/463,990 | 2009-05-11 | ||
| US12/463,983 | 2009-05-11 | ||
| US12/463,998 | 2009-05-11 | ||
| PCT/US2010/034361 WO2010132428A1 (en) | 2009-05-11 | 2010-05-11 | Fluorescent phospholipid ether compounds, compositions, and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014183841A Division JP6006271B2 (ja) | 2009-05-11 | 2014-09-10 | 蛍光リン脂質エーテル化合物、組成物、及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012526822A JP2012526822A (ja) | 2012-11-01 |
| JP2012526822A5 true JP2012526822A5 (https=) | 2013-06-27 |
| JP5702366B2 JP5702366B2 (ja) | 2015-04-15 |
Family
ID=43085298
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012510929A Active JP5702366B2 (ja) | 2009-05-11 | 2010-05-11 | 蛍光リン脂質エーテル化合物、組成物、及びその使用 |
| JP2014183841A Active JP6006271B2 (ja) | 2009-05-11 | 2014-09-10 | 蛍光リン脂質エーテル化合物、組成物、及びその使用 |
| JP2015098391A Active JP6073961B2 (ja) | 2009-05-11 | 2015-05-13 | 蛍光リン脂質エーテル化合物、組成物、及びその使用 |
| JP2016089336A Pending JP2016193907A (ja) | 2009-05-11 | 2016-04-27 | 蛍光リン脂質エーテル化合物、組成物、及びその使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014183841A Active JP6006271B2 (ja) | 2009-05-11 | 2014-09-10 | 蛍光リン脂質エーテル化合物、組成物、及びその使用 |
| JP2015098391A Active JP6073961B2 (ja) | 2009-05-11 | 2015-05-13 | 蛍光リン脂質エーテル化合物、組成物、及びその使用 |
| JP2016089336A Pending JP2016193907A (ja) | 2009-05-11 | 2016-04-27 | 蛍光リン脂質エーテル化合物、組成物、及びその使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9616140B2 (https=) |
| EP (1) | EP2429591B1 (https=) |
| JP (4) | JP5702366B2 (https=) |
| ES (1) | ES2549459T3 (https=) |
| WO (1) | WO2010132428A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2549459T3 (es) * | 2009-05-11 | 2015-10-28 | Cellectar, Inc. | Compuestos de éter de fosfolípido fluorescentes, composiciones y procedimientos de uso |
| SI3708192T1 (sl) * | 2009-06-12 | 2023-12-29 | Cellectar, Inc. | Eter fosfolipidne spojine za zdravljenje raka in slikanje in detekcijo rakavih izvornih celic |
| JP2013032297A (ja) * | 2011-08-01 | 2013-02-14 | Univ Of Tsukuba | バイオイメージングのための近赤外発光物質及びその合成方法 |
| JP6260259B2 (ja) * | 2013-12-24 | 2018-01-17 | 日油株式会社 | ボロン酸含有ホスホリルコリン化合物及びその製造方法、並びにヨード基含有化合物修飾剤 |
| CN107708702A (zh) | 2014-11-17 | 2018-02-16 | 塞勒克塔生物科学有限公司 | 磷脂醚类似物作为靶向癌症的药物载体 |
| CN108430520B (zh) | 2015-11-06 | 2021-08-13 | 威斯康星校友研究基金会 | 长效钆基肿瘤靶向成像与治疗剂 |
| JP7136770B2 (ja) * | 2016-06-14 | 2022-09-13 | セレクター・バイオサイエンシズ・インコーポレイテッド | 循環腫瘍細胞を同定及び単離するためのリン酸化エーテル類似体 |
| KR102148067B1 (ko) * | 2016-09-02 | 2020-08-26 | 주식회사 엘지화학 | 화합물 및 이를 포함하는 색변환필름 |
| JP2020066637A (ja) * | 2017-02-27 | 2020-04-30 | 富士フイルム株式会社 | 病理診断用染色剤、細胞核染色方法、病理標本の製造方法、及び色素 |
| JP6495989B1 (ja) | 2017-10-02 | 2019-04-03 | 株式会社アマダホールディングス | プログラム作成装置、溶接システム、及びプログラム作成方法 |
| KR102821508B1 (ko) | 2018-04-10 | 2025-06-16 | 셀렉타 바이오사이언시스, 인코퍼레이티드 | 인지질-플라베글린 접합체 및 표적화된 암 치료를 위해 이를 사용하는 방법 |
| WO2019230963A1 (ja) | 2018-06-01 | 2019-12-05 | 富士フイルム株式会社 | 蛍光性化合物及びこれを用いた蛍光標識生体物質 |
| CA3154192A1 (en) | 2019-10-10 | 2021-04-15 | Cellectar Biosciences, Inc. | Phospholipid-flavagline conjugates and methods of using the same for targeted cancer therapy |
| KR102400464B1 (ko) * | 2020-07-28 | 2022-05-19 | 부산대학교 산학협력단 | 암 줄기세포 검출용 바이오 마커 조성물 |
| JP7423855B2 (ja) * | 2020-09-05 | 2024-01-29 | カウンシル オブ サイエンティフィック アンド インダストリアル リサーチ | フォトニックインクとしての熱応答性自己組織化有機材料及びその製造方法 |
| CN114957330A (zh) * | 2022-07-06 | 2022-08-30 | 南京师范大学 | 一种新型花菁染料中间体及其制备方法 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4925649A (en) | 1987-06-12 | 1990-05-15 | The University Of Michigan | Radioiodinated diacylglycerol analogues and methods of use |
| US5087721A (en) | 1987-10-23 | 1992-02-11 | The University Of Michigan | Radioiodinated phosphate esters |
| US4965391A (en) | 1987-10-23 | 1990-10-23 | The University Of Michigan | Radioiodinated phospholipid ether analogues |
| US5347030A (en) | 1987-10-23 | 1994-09-13 | The Board Of Regents Of The University Of Michigan | Radioiodinated phospholipid ether analogues and methods of using same |
| US5369097A (en) | 1991-04-25 | 1994-11-29 | The University Of British Columbia | Phosphonates as anti-cancer agents |
| US5728529A (en) * | 1995-06-23 | 1998-03-17 | Baylor College Of Medicine | Alternative dye-labeled ribonucleotides, deoxyribonucleotides, and dideoxyribonucleotides for automated DNA analysis |
| US5626654A (en) | 1995-12-05 | 1997-05-06 | Xerox Corporation | Ink compositions containing liposomes |
| US6255519B1 (en) | 1996-12-04 | 2001-07-03 | Regents Of The University Of Michigan | Radioiodinated phospholipid ether analogs and methods of using the same |
| CA2276284C (en) | 1996-12-04 | 2006-10-10 | The Regents Of The University Of Michigan | Radioiodinated phospholipid ether analogs and methods of using the same |
| US5830701A (en) * | 1997-03-28 | 1998-11-03 | Tao Medical Electronics Co., Ltd. | Method of detecting hematopoietic progenitor cells |
| US6939985B1 (en) | 1997-04-09 | 2005-09-06 | Commonwealth Scientific And Industrial Research Organisation | Aryl borates |
| CA2461654A1 (en) * | 2002-07-18 | 2004-01-29 | Protein Express Co., Ltd. | Non-natural labeled amino acid and method for producing a conjugate of said amino acid and trna |
| JP4004385B2 (ja) * | 2002-11-07 | 2007-11-07 | 独立行政法人科学技術振興機構 | 二重染色法によるガン検出方法 |
| WO2005063774A1 (en) | 2003-12-22 | 2005-07-14 | Johns Hopkins University | Boronic acid aryl analogs |
| US7700075B2 (en) | 2004-07-08 | 2010-04-20 | Cellectar, Llc | Virtual colonoscopy with radiolabeled phospholipid ether analogs |
| US8540968B2 (en) * | 2004-03-02 | 2013-09-24 | Cellectar, Inc. | Phospholipid ether analogs as agents for detecting and locating cancer, and methods thereof |
| KR20070015518A (ko) * | 2004-03-02 | 2007-02-05 | 셀렉타, 엘엘씨 | 암의 진단 및 치료를 위한 포스포리피드 유사체 |
| US7041859B1 (en) | 2004-09-09 | 2006-05-09 | University Of Tennessee Research Foundation | Method for halogenating or radiohalogenating a chemical compound |
| KR20080005178A (ko) * | 2004-12-20 | 2008-01-10 | 셀렉타, 엘엘씨 | 암 검출 및 치료용 인지질 에테르 동족체 |
| JP2007143624A (ja) * | 2005-11-24 | 2007-06-14 | Hamamatsu Photonics Kk | 蛍光観察装置 |
| US20070297988A1 (en) * | 2006-06-21 | 2007-12-27 | Bin Wu | Optical probes for in vivo imaging |
| AU2007355882A1 (en) * | 2006-08-15 | 2009-01-08 | Cellectar, Inc. | Near infrared-fluorescence using phospholipid ether analog dyes in endoscopic applications |
| US8022235B2 (en) | 2007-06-01 | 2011-09-20 | Cellectar, Inc. | Compositions of phospholipid ether boronic acids and esters and methods for their synthesis and use |
| ES2326458B1 (es) * | 2008-04-04 | 2010-07-26 | Consejo Superior De Investigaciones Cientificas (Csic) (85%) | Compuestos fluorescentes para diagnostico de infecciones, procedimiento de obtencion y sus aplicaciones. |
| US20100284931A1 (en) | 2009-05-11 | 2010-11-11 | Pinchuk Anatoly | Fluorescent phospholipid ether compounds, compositions, and methods of use |
| US20100286510A1 (en) | 2009-05-11 | 2010-11-11 | Pinchuk Anatoly | Use of fluorescent phospholipid ether compounds in biopsies |
| US20100284930A1 (en) | 2009-05-11 | 2010-11-11 | Pinchuk Anatoly | Fluorescent imaging of skin cancers using phospholipid ether compounds |
| US7811548B1 (en) | 2009-05-11 | 2010-10-12 | Cellectar, Inc. | Fluorescent phospholipid ether compounds and compositions |
| US20100284929A1 (en) | 2009-05-11 | 2010-11-11 | Pinchuk Anatoly | Fluorescent imaging of tumors using phospholipid ether compounds |
| ES2549459T3 (es) * | 2009-05-11 | 2015-10-28 | Cellectar, Inc. | Compuestos de éter de fosfolípido fluorescentes, composiciones y procedimientos de uso |
| US8871181B2 (en) | 2009-05-11 | 2014-10-28 | Cellectar, Inc. | Fluorescent phospholipid ether compounds, compositions, and methods of use |
| SI3708192T1 (sl) | 2009-06-12 | 2023-12-29 | Cellectar, Inc. | Eter fosfolipidne spojine za zdravljenje raka in slikanje in detekcijo rakavih izvornih celic |
-
2010
- 2010-05-11 ES ES10775385.7T patent/ES2549459T3/es active Active
- 2010-05-11 WO PCT/US2010/034361 patent/WO2010132428A1/en not_active Ceased
- 2010-05-11 EP EP10775385.7A patent/EP2429591B1/en active Active
- 2010-05-11 JP JP2012510929A patent/JP5702366B2/ja active Active
-
2014
- 2014-09-10 JP JP2014183841A patent/JP6006271B2/ja active Active
- 2014-09-23 US US14/493,489 patent/US9616140B2/en active Active
-
2015
- 2015-05-13 JP JP2015098391A patent/JP6073961B2/ja active Active
-
2016
- 2016-04-27 JP JP2016089336A patent/JP2016193907A/ja active Pending
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