JP5689055B2 - 鳥皮由来スフィンゴミエリン含有物を有効成分とする抗高血糖及び/又は抗高脂血症剤 - Google Patents
鳥皮由来スフィンゴミエリン含有物を有効成分とする抗高血糖及び/又は抗高脂血症剤 Download PDFInfo
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- JP5689055B2 JP5689055B2 JP2011513379A JP2011513379A JP5689055B2 JP 5689055 B2 JP5689055 B2 JP 5689055B2 JP 2011513379 A JP2011513379 A JP 2011513379A JP 2011513379 A JP2011513379 A JP 2011513379A JP 5689055 B2 JP5689055 B2 JP 5689055B2
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- chicken skin
- sphingomyelin
- deoiled
- antihyperglycemic
- mass
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/688—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols both hydroxy compounds having nitrogen atoms, e.g. sphingomyelins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Organic Chemistry (AREA)
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- Hematology (AREA)
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- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2011513379A JP5689055B2 (ja) | 2009-05-13 | 2010-05-13 | 鳥皮由来スフィンゴミエリン含有物を有効成分とする抗高血糖及び/又は抗高脂血症剤 |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009116929 | 2009-05-13 | ||
JP2009116929 | 2009-05-13 | ||
JP2011513379A JP5689055B2 (ja) | 2009-05-13 | 2010-05-13 | 鳥皮由来スフィンゴミエリン含有物を有効成分とする抗高血糖及び/又は抗高脂血症剤 |
PCT/JP2010/058131 WO2010131718A1 (fr) | 2009-05-13 | 2010-05-13 | Agent anti-hyperglycémique et/ou anti-hyperlipidémique comprenant une matière contenant de la sphingomyéline issue de la peau d'oiseau comme ingrédient actif |
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Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006516280A (ja) * | 2003-01-20 | 2006-06-29 | ネーデルランドセ オルガニサティエ フォール トエゲパストナトールヴェテンシャッペリク オンデルゾエク ティエヌオー | 血漿コレステロール及びトリアシルグリセロールレベルを減少するためにスフィンゴ脂質を使用する方法 |
JP2006232967A (ja) * | 2005-02-24 | 2006-09-07 | Umeda Jimusho:Kk | 複合脂質画分、それから単離されたヒト型スフィンゴミエリンとプラズマローゲンならびにこれらを含む機能性食品素材、医薬品素材および化粧品素材 |
JP2007529507A (ja) * | 2004-03-16 | 2007-10-25 | ネーデルランドセ オルガニサティエ フォール トエゲパストナトールヴェテンシャッペリク オンデルゾエク ティエヌオー | 2型糖尿病、インスリン抵抗性及びメタボリック症候群の治療及び予防においてスフィンゴ脂質を使用する方法 |
JP2008179588A (ja) * | 2007-01-26 | 2008-08-07 | Umeda Jimusho:Kk | スフィンゴミエリンおよびプラズマローゲン型グリセロリン脂質の製造方法 |
WO2008108236A1 (fr) * | 2007-02-21 | 2008-09-12 | Umeda Jimusho Ltd. | Procédé de fabrication d'un matériau fonctionnel, matériau fonctionnel et appareil de chauffage continu pour obtenir celui-ci |
WO2009055867A1 (fr) * | 2007-10-31 | 2009-05-07 | The University Of Sydney | Traitement de maladies métaboliques |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR0310099A (pt) * | 2002-05-17 | 2007-03-20 | Esperion Therapeutics Inc | método para tratar dislipidemia ou uma doença associada com a dislipidemia |
JP5077982B2 (ja) * | 2006-04-07 | 2012-11-21 | 雪印メグミルク株式会社 | 脂肪蓄積抑制剤 |
-
2010
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- 2010-05-13 WO PCT/JP2010/058131 patent/WO2010131718A1/fr active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006516280A (ja) * | 2003-01-20 | 2006-06-29 | ネーデルランドセ オルガニサティエ フォール トエゲパストナトールヴェテンシャッペリク オンデルゾエク ティエヌオー | 血漿コレステロール及びトリアシルグリセロールレベルを減少するためにスフィンゴ脂質を使用する方法 |
JP2007529507A (ja) * | 2004-03-16 | 2007-10-25 | ネーデルランドセ オルガニサティエ フォール トエゲパストナトールヴェテンシャッペリク オンデルゾエク ティエヌオー | 2型糖尿病、インスリン抵抗性及びメタボリック症候群の治療及び予防においてスフィンゴ脂質を使用する方法 |
JP2006232967A (ja) * | 2005-02-24 | 2006-09-07 | Umeda Jimusho:Kk | 複合脂質画分、それから単離されたヒト型スフィンゴミエリンとプラズマローゲンならびにこれらを含む機能性食品素材、医薬品素材および化粧品素材 |
JP2008179588A (ja) * | 2007-01-26 | 2008-08-07 | Umeda Jimusho:Kk | スフィンゴミエリンおよびプラズマローゲン型グリセロリン脂質の製造方法 |
WO2008108236A1 (fr) * | 2007-02-21 | 2008-09-12 | Umeda Jimusho Ltd. | Procédé de fabrication d'un matériau fonctionnel, matériau fonctionnel et appareil de chauffage continu pour obtenir celui-ci |
WO2009055867A1 (fr) * | 2007-10-31 | 2009-05-07 | The University Of Sydney | Traitement de maladies métaboliques |
Non-Patent Citations (2)
Title |
---|
JPN6010040633; 佐々木 一: '7.ミルクレシチンの特徴と生理作用' Milk Science Vol.51, No.2, 2002, p.93-94 * |
JPN6010040634; 佐々木 一ら: 'ミルクリン脂質の脂質代謝調節作用' Milk Science Vol.51, No.3, 2002, p.173-177 * |
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JPWO2010131718A1 (ja) | 2012-11-08 |
WO2010131718A1 (fr) | 2010-11-18 |
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