JP5687777B2 - Ｃ−４”位置換マクロライド誘導体 - Google Patents

Ｃ−４”位置換マクロライド誘導体 Download PDF

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Publication number
JP5687777B2
JP5687777B2 JP2013554176A JP2013554176A JP5687777B2 JP 5687777 B2 JP5687777 B2 JP 5687777B2 JP 2013554176 A JP2013554176 A JP 2013554176A JP 2013554176 A JP2013554176 A JP 2013554176A JP 5687777 B2 JP5687777 B2 JP 5687777B2
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JP
Japan
Prior art keywords
group
formula
compound
substituted
alkyl group
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JP2013554176A
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English (en)
Japanese (ja)
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JP2014505723A (ja
JP2014505723A5 (es
Inventor
杉本　智洋
智洋 杉本
直樹 笹本
直樹 笹本
淳 黒坂
淳 黒坂
真知 林
真知 林
加奈子 山本
加奈子 山本
樫村　政人
政人 樫村
康信 宇敷
康信 宇敷
荻田　晴久
晴久 荻田
知明 三浦
知明 三浦
憲一 兼本
憲一 兼本
興 久村
興 久村
諭 吉田
諭 吉田
圭司 田村
圭司 田村
設楽　永紀
永紀 設楽
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Meiji Seika Kaisha Ltd
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Meiji Seika Kaisha Ltd
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Application filed by Meiji Seika Kaisha Ltd filed Critical Meiji Seika Kaisha Ltd
Priority to JP2013554176A priority Critical patent/JP5687777B2/ja
Publication of JP2014505723A publication Critical patent/JP2014505723A/ja
Publication of JP2014505723A5 publication Critical patent/JP2014505723A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
JP2013554176A 2011-02-21 2012-02-20 Ｃ−４”位置換マクロライド誘導体 Expired - Fee Related JP5687777B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2013554176A JP5687777B2 (ja) 2011-02-21 2012-02-20 Ｃ−４”位置換マクロライド誘導体

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2011034578 2011-02-21
JP2011034578 2011-02-21
PCT/JP2012/054677 WO2012115256A1 (en) 2011-02-21 2012-02-20 C-4" position substituted macrolide derivative
JP2013554176A JP5687777B2 (ja) 2011-02-21 2012-02-20 Ｃ−４”位置換マクロライド誘導体

Publications (3)

Publication Number Publication Date
JP2014505723A JP2014505723A (ja) 2014-03-06
JP2014505723A5 JP2014505723A5 (es) 2014-07-10
JP5687777B2 true JP5687777B2 (ja) 2015-03-18

Family

ID=46721028

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013554176A Expired - Fee Related JP5687777B2 (ja) 2011-02-21 2012-02-20 Ｃ−４”位置換マクロライド誘導体

Country Status (34)

Country Link
US (1) US9139609B2 (es)
EP (1) EP2678349B1 (es)
JP (1) JP5687777B2 (es)
KR (1) KR20140008388A (es)
CN (1) CN103492404B (es)
AR (1) AR085286A1 (es)
AU (1) AU2012222267B2 (es)
BR (1) BR112013020118A2 (es)
CA (1) CA2827474A1 (es)
CL (1) CL2013002313A1 (es)
CO (1) CO6801737A2 (es)
CY (1) CY1117381T1 (es)
DK (1) DK2678349T3 (es)
ES (1) ES2566368T3 (es)
HR (1) HRP20160252T1 (es)
HU (1) HUE028245T2 (es)
IL (1) IL227663A (es)
IN (1) IN2013CN07459A (es)
ME (1) ME02475B (es)
MX (1) MX2013009585A (es)
MY (1) MY161451A (es)
NZ (1) NZ613956A (es)
PE (1) PE20140649A1 (es)
PL (1) PL2678349T3 (es)
RS (1) RS54635B1 (es)
RU (1) RU2599718C2 (es)
SA (1) SA112330287B1 (es)
SG (1) SG192655A1 (es)
SI (1) SI2678349T1 (es)
SM (1) SMT201600106B (es)
TW (1) TWI513704B (es)
UA (1) UA111191C2 (es)
WO (1) WO2012115256A1 (es)
ZA (1) ZA201305983B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014058509A (ja) * 2012-08-20 2014-04-03 Taisho Pharmaceutical Co Ltd Ｃ−４”位置換マクロライド誘導体を含有する医薬

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103965273B (zh) * 2013-08-23 2016-05-25 普莱柯生物工程股份有限公司 一种大环内酯类化合物
CN105669798B (zh) * 2013-08-23 2019-07-26 普莱柯生物工程股份有限公司 一种大环内酯类化合物
CN103588833B (zh) * 2013-10-30 2016-08-17 北京科技大学 动物抗菌素泰拉霉素的制备方法
CN109748942A (zh) * 2014-05-16 2019-05-14 普莱柯生物工程股份有限公司 一种大环内酯类化合物
AR102810A1 (es) * 2014-08-18 2017-03-29 Taisho Pharmaceutical Co Ltd Derivado de macrólido sustituido en la posición c-4
WO2017142002A1 (ja) * 2016-02-17 2017-08-24 大正製薬株式会社 Ｃ－４"位置換マクロライド化合物フリー体及び塩の結晶形並びにそれらの製造方法
CN108610388B (zh) * 2016-12-12 2020-11-06 浙江京新药业股份有限公司 一种大环内酯的制备方法
CN109425666B (zh) * 2017-08-28 2022-07-08 广东东阳光药业有限公司 一种酰氯衍生物的lc-ms分析方法
KR20230170813A (ko) 2018-09-12 2023-12-19 노파르티스 아게 항바이러스 피리도피라진디온 화합물
US11667613B2 (en) 2019-09-26 2023-06-06 Novartis Ag Antiviral pyrazolopyridinone compounds
CN111423482B (zh) * 2020-04-26 2023-01-17 梯尔希（南京）药物研发有限公司 一种同位素标记的红霉胺的合成方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI8110592A8 (en) 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4474768A (en) 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
US5393743A (en) 1993-07-06 1995-02-28 Abbott Laboratories Erythromycin derivatives
FR2719587B1 (fr) 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
RU2144541C1 (ru) * 1995-12-08 2000-01-20 Руссель Юклаф Производные эритромицина, способ их получения, промежуточный продукт, фармацевтическая композиция
KR100576988B1 (ko) 1996-09-04 2006-05-10 아보트 러보러터리즈 항균 활성을 지닌 6-ｏ-치환된 케톨라이드
UA51730C2 (uk) 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
US5804565A (en) 1996-09-24 1998-09-08 Taisho Pharmaceutical Co., Ltd. Erythromycin A derivatives
HN1998000074A (es) 1997-06-11 1999-01-08 Pfizer Prod Inc Derivados de macrolidos c-4 sustituidos
US6407074B1 (en) 1997-06-11 2002-06-18 Pfizer Inc C-4″-substituted macrolide derivatives
US5972898A (en) * 1998-03-27 1999-10-26 Abbott Laboratories 3',3-N-bis-substituted macrolide LHRH antagonists
WO2000071557A1 (en) 1999-05-24 2000-11-30 Pfizer Products Inc. 13-methyl-erythromycin derivatives
UY26964A1 (es) 2000-10-16 2002-06-20 Abbott Lab Derivados de eritromicina 6-0-sustituidos con mayor tolerancia gastrointestinal
WO2008106225A1 (en) * 2007-02-28 2008-09-04 Rib-X Pharmaceuticals, Inc. Macrolide compounds and methods of making and using the same
US20080203485A1 (en) 2007-02-28 2008-08-28 International Business Machines Corporation Strained metal gate structure for cmos devices with improved channel mobility and methods of forming the same

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014058509A (ja) * 2012-08-20 2014-04-03 Taisho Pharmaceutical Co Ltd Ｃ−４”位置換マクロライド誘導体を含有する医薬

Also Published As

Publication number Publication date
MY161451A (en) 2017-04-14
WO2012115256A1 (en) 2012-08-30
US20140046043A1 (en) 2014-02-13
AR085286A1 (es) 2013-09-18
UA111191C2 (uk) 2016-04-11
EP2678349A1 (en) 2014-01-01
EP2678349B1 (en) 2016-01-13
RU2599718C2 (ru) 2016-10-10
ZA201305983B (en) 2014-11-26
RS54635B1 (en) 2016-08-31
PE20140649A1 (es) 2014-06-25
IL227663A0 (en) 2013-09-30
BR112013020118A2 (pt) 2017-07-18
SMT201600106B (it) 2016-04-29
NZ613956A (en) 2014-07-25
TWI513704B (zh) 2015-12-21
CN103492404A (zh) 2014-01-01
IN2013CN07459A (es) 2015-04-24
CL2013002313A1 (es) 2014-08-08
IL227663A (en) 2017-09-28
SI2678349T1 (sl) 2016-04-29
ES2566368T3 (es) 2016-04-12
JP2014505723A (ja) 2014-03-06
SA112330287B1 (ar) 2015-10-11
CO6801737A2 (es) 2013-11-29
AU2012222267A1 (en) 2013-08-22
SG192655A1 (en) 2013-09-30
ME02475B (me) 2017-02-20
CA2827474A1 (en) 2012-08-30
DK2678349T3 (en) 2016-03-07
CY1117381T1 (el) 2017-04-26
PL2678349T3 (pl) 2016-06-30
HUE028245T2 (en) 2016-12-28
CN103492404B (zh) 2016-09-07
US9139609B2 (en) 2015-09-22
AU2012222267B2 (en) 2016-07-07
HRP20160252T1 (hr) 2016-04-22
RU2013142898A (ru) 2015-03-27
MX2013009585A (es) 2014-06-05
KR20140008388A (ko) 2014-01-21
TW201247693A (en) 2012-12-01
EP2678349A4 (en) 2014-07-30

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