JP5684145B2 - Gタンパク質共役受容体活性化の測定 - Google Patents
Gタンパク質共役受容体活性化の測定 Download PDFInfo
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- JP5684145B2 JP5684145B2 JP2011546532A JP2011546532A JP5684145B2 JP 5684145 B2 JP5684145 B2 JP 5684145B2 JP 2011546532 A JP2011546532 A JP 2011546532A JP 2011546532 A JP2011546532 A JP 2011546532A JP 5684145 B2 JP5684145 B2 JP 5684145B2
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- Prior art keywords
- protein
- subunit
- coupled receptor
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- receptor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
- G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Mycology (AREA)
- Wood Science & Technology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14827109P | 2009-01-29 | 2009-01-29 | |
| US61/148,271 | 2009-01-29 | ||
| PCT/AU2010/000080 WO2010085844A1 (en) | 2009-01-29 | 2010-01-28 | Measuring g protein coupled receptor activation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012516429A JP2012516429A (ja) | 2012-07-19 |
| JP2012516429A5 JP2012516429A5 (cg-RX-API-DMAC7.html) | 2013-03-14 |
| JP5684145B2 true JP5684145B2 (ja) | 2015-03-11 |
Family
ID=42395049
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011546532A Expired - Fee Related JP5684145B2 (ja) | 2009-01-29 | 2010-01-28 | Gタンパク質共役受容体活性化の測定 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8647887B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2382470B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5684145B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101834574B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN102439444B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2010207880B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2748500C (cg-RX-API-DMAC7.html) |
| IL (1) | IL213771A0 (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ593294A (cg-RX-API-DMAC7.html) |
| SG (1) | SG172321A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2010085844A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011067202A1 (en) * | 2009-12-02 | 2011-06-09 | Unilever Nv | Improved method for screening a potential modulator compound of a taste receptor |
| CA2833578A1 (en) | 2011-04-22 | 2012-10-26 | 3M Innovative Properties Company | Luminescence detection method |
| ITMI20112038A1 (it) * | 2011-11-10 | 2013-05-11 | Arterra Bioscience S R L | "nuovi recettori gpcr chimerici, loro usi per lo screening di fitofarmaci, e metodi di screening relativi" |
| AU2013204332B2 (en) * | 2012-04-16 | 2015-07-16 | Commonwealth Scientific And Industrial Research Organisation | Methods and systems for detecting an analyte or classifying a sample |
| CN102839193A (zh) * | 2012-08-22 | 2012-12-26 | 海狸(广州)生物科技有限公司 | 一种g蛋白偶联受体对化合物特异性的检测方法 |
| CN103149111A (zh) * | 2013-02-26 | 2013-06-12 | 浙江大学 | 一种基于嗅觉受体传感器检测气味物质丁二酮的方法 |
| WO2014169336A1 (en) * | 2013-04-16 | 2014-10-23 | Commonwealth Scientific And Industrial Research Organisation | G protein coupled receptor libraries |
| WO2014176700A1 (en) * | 2013-05-01 | 2014-11-06 | Université de Montréal | Biosensors for ras-dependent signaling pathways and use thereof |
| US10101319B2 (en) | 2013-11-28 | 2018-10-16 | Commonwealth Scientific And Industrial Research Organisation | Methods of detecting plasmodium infection |
| WO2016007886A1 (en) * | 2014-07-11 | 2016-01-14 | Northwestern University | Yeast-based biosensor |
| AU2015318567B2 (en) | 2014-09-19 | 2020-11-05 | The Royal Institution For The Advancement Of Learning/Mcgill University | Biosensors for monitoring biomolecule localization and trafficking in cells |
| WO2016058094A1 (en) * | 2014-10-14 | 2016-04-21 | Université de Montréal | BIOSENSOR BASED ON GβΥ-INTERACTING PROTEINS TO MONITOR G-PROTEIN ACTIVATION |
| US10273463B2 (en) * | 2014-10-16 | 2019-04-30 | International Paper Company | Chemiluminescent wetness indicator for absorbent products |
| CN105018564B (zh) * | 2015-07-22 | 2017-03-08 | 华东师范大学 | 一种g蛋白‑偶联受体活体示踪方法及应用 |
| WO2017147323A1 (en) * | 2016-02-24 | 2017-08-31 | Aromyx Corporation | Biosensor detecting smell. scent and taste |
| CN105671119A (zh) * | 2016-03-02 | 2016-06-15 | 昆明理工大学 | 一种基于组胺受体3分子探针的药物活性成分筛选方法 |
| US11952612B2 (en) | 2016-11-14 | 2024-04-09 | Commonwealth Scientific And Industrial Research Organisation | Protease sensor molecules |
| JP7215999B2 (ja) * | 2016-12-21 | 2023-01-31 | エフ.ホフマン-ラ ロシュ アーゲー | 抗体またはリガンドの結合および機能を決定するためのアッセイ法 |
| US20190342356A1 (en) * | 2017-01-02 | 2019-11-07 | Koninklijke Kpn N.V. | Selectively updating a dynamic manifest file |
| CN106872435B (zh) * | 2017-04-14 | 2019-07-16 | 重庆大学 | 基于苝酰亚胺多臂聚合物的蛋白质生物发光成像传感器 |
| SG11202001121WA (en) | 2017-08-08 | 2020-03-30 | Commw Scient Ind Res Org | Carbohydrate sensors |
| US10209239B1 (en) * | 2017-08-16 | 2019-02-19 | Aromyx Corporation | Method of making an aromagraph comprising ectopic olfactory receptors |
| CN113501881B (zh) * | 2017-09-27 | 2023-07-28 | 北京大学 | 融合蛋白 |
| US20190194573A1 (en) * | 2017-12-21 | 2019-06-27 | Aromyx Corporation | Scent, Smell and Odor Creation from an Aromagraph |
| CN108586620B (zh) * | 2018-05-10 | 2021-11-23 | 山东大学 | 筛选昆虫性信息素受体的配体的传感器分子以及筛选方法 |
| US11078200B2 (en) | 2018-06-29 | 2021-08-03 | International Paper Company | Synthesis of coelenterazine |
| US11008326B2 (en) | 2018-06-29 | 2021-05-18 | International Paper Company | Synthesis of coelenterazine |
| CN110252079B (zh) * | 2019-05-08 | 2022-03-15 | 天津大学 | 一种气味远程传输的方法 |
| KR102264116B1 (ko) * | 2019-06-19 | 2021-06-14 | 한국과학기술연구원 | 세포 소포체 내 g-단백질 연결 수용체(gpcr)의 실시간 활성 상태 분석 방법 및 컴퓨터 프로그램 |
| CN110577593B (zh) * | 2019-07-01 | 2021-09-14 | 华中农业大学 | 一种小分子近红外光荧光蛋白及其融合蛋白 |
| CN115362263A (zh) * | 2020-02-11 | 2022-11-18 | Absci公司 | 邻近测定 |
| DE102023204533B4 (de) * | 2023-05-15 | 2025-03-27 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eingetragener Verein | Verfahren für die Durchführung von biochemischen Untersuchungen an Proben |
| CN118501118B (zh) * | 2024-07-16 | 2024-10-29 | 汉王科技股份有限公司 | 一种基于细胞的生物荧光能量共振转移检测系统及应用 |
| CN119409840B (zh) * | 2025-01-06 | 2025-07-01 | 北京大学 | 基于g蛋白偶联受体构建的比率型荧光探针及其构建方法 |
Family Cites Families (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5196524A (en) | 1989-01-06 | 1993-03-23 | Eli Lilly And Company | Fusion reporter gene for bacterial luciferase |
| US5219737A (en) | 1990-03-27 | 1993-06-15 | Kikkoman Corporation | Mutant luciferase of a firefly, mutant luciferase genes, recombinant dnas containing the genes and a method of producing mutant luciferase |
| US5229285A (en) | 1991-06-27 | 1993-07-20 | Kikkoman Corporation | Thermostable luciferase of firefly, thermostable luciferase gene of firefly, novel recombinant dna, and process for the preparation of thermostable luciferase of firefly |
| JP3466765B2 (ja) | 1994-07-27 | 2003-11-17 | キッコーマン株式会社 | ビオチン化ホタルルシフェラーゼ、ビオチン化ホタルルシフェラーゼ遺伝子、新規な組み換え体dna、ビオチン化ホタルルシフェラーゼの製造法及び生物発光分析法 |
| US5670356A (en) | 1994-12-12 | 1997-09-23 | Promega Corporation | Modified luciferase |
| US6008373A (en) | 1995-06-07 | 1999-12-28 | Carnegie Mellon University | Fluorescent labeling complexes with large stokes shift formed by coupling together cyanine and other fluorochromes capable of resonance energy transfer |
| GB9517926D0 (en) | 1995-09-01 | 1995-11-01 | Biocine Spa | Binding protein |
| US5792294A (en) | 1995-11-16 | 1998-08-11 | Otis Elevator Company | Method of replacing sheave liner |
| US6593135B2 (en) | 1996-08-16 | 2003-07-15 | The State Of Oregon, Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon | Long wavelength engineered fluorescent proteins |
| DE69840146D1 (de) | 1997-03-14 | 2008-12-04 | Univ California | Fluoreszenzprotein-sensoren zur erkennung von analyten |
| US6207392B1 (en) | 1997-11-25 | 2001-03-27 | The Regents Of The University Of California | Semiconductor nanocrystal probes for biological applications and process for making and using such probes |
| EP1064360B1 (en) | 1998-03-27 | 2008-03-05 | Prolume, Ltd. | Luciferases, gfp fluorescent proteins, their nucleic acids and the use thereof in diagnostics |
| GB9812596D0 (en) | 1998-06-11 | 1998-08-12 | Amersham Pharm Biotech Uk Ltd | Energy transfer assay method |
| EP1102977A1 (en) | 1998-08-08 | 2001-05-30 | Imperial Cancer Research Technology Limited | Fluorescence assay for biological systems |
| EP1109931A4 (en) | 1998-09-03 | 2004-12-15 | Univ Loma Linda | METHOD FOR STUDYING PROTEIN INTERACTIONS $i(IN VIVO) |
| GB2342651B (en) | 1998-09-18 | 2001-10-17 | Massachusetts Inst Technology | Biological applications of semiconductor nanocrystals |
| GB9823468D0 (en) | 1998-10-28 | 1998-12-23 | Secr Defence | Novel enzyme |
| US6207831B1 (en) | 1998-12-21 | 2001-03-27 | Novartis Ag | Fluorescent dyes (AIDA) for solid phase and solution phase screening |
| AU3488700A (en) | 1999-02-12 | 2000-08-29 | Ljl Biosystems, Inc. | Luminescent metal-ligand complexes |
| US6824990B1 (en) | 1999-10-05 | 2004-11-30 | Washington University | Methods of detecting and modulating oligomerization of G protein-coupled receptors |
| ATE320000T1 (de) | 1999-12-22 | 2006-03-15 | Perkinelmer Biosignal Inc | Ein biolumineszenz resonanz energie transfer (bret) system mit breitem spektralen resolution zwischen donator- und akzeptor-emission wellenlänge und ihre anwendung |
| US20040214227A1 (en) | 1999-12-22 | 2004-10-28 | Erik Joly | Bioluminescence resonance energy transfer (bret) fusion molecule and method of use |
| WO2001062919A1 (en) | 2000-02-23 | 2001-08-30 | Aurora Biosciences Corporation | Modified fluorescent proteins |
| US20010053848A1 (en) | 2000-03-10 | 2001-12-20 | Patel Yogesh C. | Hetero-oligomeric G protein-coupled receptors as novel drug targets |
| CA2403327C (en) | 2000-03-15 | 2012-05-29 | Prolume, Ltd. | Renilla reniformis fluorescent proteins, nucleic acids encoding the fluorescent proteins and the use thereof in diagnostics, high throughput screening and novelty items |
| WO2002008245A2 (en) | 2000-07-13 | 2002-01-31 | The Scripps Research Institute | Labeled peptides, proteins and antibodies and processes and intermediates useful for their preparation |
| DE10046215B4 (de) | 2000-09-19 | 2004-04-15 | Institut für Chemo- und Biosensorik Münster e.V. i.Ins. | Fluorochrome und deren Verwendung |
| US20020048811A1 (en) | 2000-10-16 | 2002-04-25 | Devreotes Peter N. | Receptor mediated activation of heterotrimeric G-proteins |
| WO2002042323A2 (en) | 2000-11-22 | 2002-05-30 | Devgen Nv | Fluorescent proteins |
| EP1340080A2 (en) | 2000-11-30 | 2003-09-03 | The Netherlands Cancer Institute | Membrane molecule indicator compositions and methods |
| US6949377B2 (en) | 2001-03-05 | 2005-09-27 | Ho Winston Z | Chemiluminescence-based microfluidic biochip |
| US20020168641A1 (en) | 2001-03-09 | 2002-11-14 | Bruce Mortensen | Fluorescein-cyanine 5 as a fluorescence resonance energy transfer pair |
| WO2002093129A2 (en) | 2001-05-15 | 2002-11-21 | University Of Medicine & Dentistry Of New Jersey | Methods for analyzing interactions between proteins in live and intact cells |
| JP3829252B2 (ja) | 2001-06-08 | 2006-10-04 | 独立行政法人理化学研究所 | 蛍光蛋白質 |
| CA2455962A1 (en) * | 2001-08-10 | 2003-02-20 | Wyeth | G protein-coupled receptor assay |
| US20030082547A1 (en) | 2001-08-27 | 2003-05-01 | Ewing Gregory J. | Non-fluorescent quencher compounds and biomolecular assays |
| WO2003033650A2 (en) | 2001-10-15 | 2003-04-24 | Stratagene | Recombinant renilla reniformis system for bioluminescence resonance energy transfer |
| DE10153829A1 (de) | 2001-11-05 | 2003-05-28 | Bayer Ag | Assay basierend auf dotierten Nanoteilchen |
| US7393934B2 (en) | 2001-12-21 | 2008-07-01 | Human Genome Sciences, Inc. | Human G-protein chemokine receptor (CCR5) HDGNR10 |
| FR2836475B1 (fr) * | 2002-02-26 | 2007-02-23 | Aventis Pharma Sa | Procede de detection de ligands du recepteur de la leptine |
| AU2003242182A1 (en) | 2002-06-10 | 2003-12-22 | Medical & Biological Laboratories Co., Ltd | Chromoprotein |
| US7504491B2 (en) | 2002-06-10 | 2009-03-17 | Riken | Pigment protein from Cnidopus japonicus |
| JP2004053416A (ja) | 2002-07-19 | 2004-02-19 | Zoegene Corp | C末端標識タンパク質を用いるタンパク質−分子間相互作用の解析方法 |
| AU2003252111A1 (en) | 2002-07-19 | 2004-02-09 | Diversa Corporation | Fluorescent proteins, nucleic acids encoding them and methods for making and using them |
| EP2314683B1 (en) | 2002-08-23 | 2012-10-24 | Riken | Fluorescent protein and chromoprotein |
| EP1554581A2 (en) | 2002-10-11 | 2005-07-20 | 7TM Pharma A/S | Method for enhancing and prolonging the bioluminescence resonance energy transfer (bret) signal in a bret assay and a substrate solution for use in a bret assay |
| EP1413584B1 (en) * | 2002-10-21 | 2005-03-02 | AXXAM S.r.l. | Photoprotein with improved bioluminescence |
| DE10258150A1 (de) | 2002-12-10 | 2004-07-08 | Dyomics Gmbh | Hydrophile Marker auf der Basis von Benzopyrylo-Polymethinen |
| EP1581811B1 (en) | 2002-12-20 | 2008-10-22 | Julius-Maximilians-Universität Würzburg | Millisecond activation switch for seven-transmembrane proteins |
| US8580517B2 (en) | 2003-02-05 | 2013-11-12 | Washington University In St. Louis | Biosensor and use thereof to identify therapeutic drug molecules and molecules binding orphan receptors |
| SG153714A1 (en) * | 2003-08-06 | 2009-07-29 | Senomyx Inc | T1r hetero-oligomeric taste receptors, cell lines that express said receptors, and taste compounds |
| GB0320236D0 (en) | 2003-08-29 | 2003-10-01 | Molecular Light Tech Res Ltd | Chemiluminescent compounds |
| CA2538797A1 (en) | 2003-09-12 | 2005-03-24 | Invitrogen Corporation | Multiplex binding and activity assays |
| US20050118619A1 (en) | 2003-09-22 | 2005-06-02 | Wensheng Xia | Dark quenchers for fluorescence resonance energy transfer (FRET) in bioassays |
| WO2005030930A2 (en) | 2003-09-23 | 2005-04-07 | Vanderbilt University | Variants of cyan fluorescent protein with improved fluorescent properties |
| US20080108128A1 (en) | 2003-11-19 | 2008-05-08 | Eidne Karin A | Resonance Energy Transfer Assay System for Multi-Component Detection |
| US20050211776A1 (en) | 2003-12-01 | 2005-09-29 | Morgan Ray H | Method and system for providing a mail stamp unit assembly with tracking code |
| EP2314682B1 (en) | 2003-12-03 | 2012-10-10 | Riken | Fluorescent protein |
| KR20070040329A (ko) | 2004-03-17 | 2007-04-16 | 유니버시티 오브 하와이 | 센서 구조물 및 검출방법 |
| CA2607015C (en) | 2004-05-04 | 2016-07-05 | Universite De Montreal | Double brilliance beta-arrestin: a biosensor for monitoring the activity of receptors and signalling molecules, and method of using same |
| EP1774330A4 (en) | 2004-08-02 | 2008-10-15 | Cellumen Inc | METHODS FOR DETECTION OF MOLECULAR INTERACTIONS IN CELLS |
| WO2006024041A2 (en) | 2004-08-27 | 2006-03-02 | The Regents Of The University Of California | Monomeric and dimeric fluorescent protein variants and methods for making same |
| GB0421693D0 (en) | 2004-09-30 | 2004-11-03 | Amersham Biosciences Uk Ltd | Method for measuring binding of a test compound to a G-protein coupled receptor |
| WO2006037226A1 (en) | 2004-10-05 | 2006-04-13 | Mcgill University | Use of quantum dots for biological labels and sensors |
| WO2006042907A1 (en) | 2004-10-19 | 2006-04-27 | Wallac Oy | A novel probe and its use in bioaffinity assays |
| US20060115842A1 (en) | 2004-10-22 | 2006-06-01 | Wallac Oy | Highly sensitive homogeneous assay based on anti-Stokes' shift FRET measurement |
| JP4557685B2 (ja) | 2004-11-15 | 2010-10-06 | 独立行政法人理化学研究所 | 蛍光蛋白質 |
| US8031338B2 (en) | 2004-12-02 | 2011-10-04 | Vanderbilt University | Measuring Forster resonance energy transfer with polarized and depolarized light |
| US20060205015A1 (en) | 2005-02-14 | 2006-09-14 | Herve Ansanay | Method for detecting the interactions between a G protein-coupled receptor (GPCR) and one of the Galpha or Gbetagamma subunits |
| KR100704011B1 (ko) | 2005-02-16 | 2007-04-04 | 한국과학기술원 | 금속나노입자와 양자점의 fret에 의한 생체분자특이결합 검출 방법 |
| WO2006086883A1 (en) * | 2005-02-16 | 2006-08-24 | Universite De Montreal | Biosensors for monitoring receptor-mediated g-protein activation |
| JP2008529540A (ja) | 2005-02-17 | 2008-08-07 | ケムコム エス.エー. | 揮発性化合物を認識する受容体を試験するための新規なインビトロ方法 |
| US7507565B2 (en) | 2005-03-11 | 2009-03-24 | Stanford University | Bioluminescence resonance energy transfer (BRET) systems and methods of use thereof |
| WO2007019382A1 (en) | 2005-08-03 | 2007-02-15 | University Of Sydney | Photoactivatable chromo/fluorescent gfp-like proteins and imaging applications |
| JP4918489B2 (ja) | 2005-08-09 | 2012-04-18 | 独立行政法人科学技術振興機構 | タンパク質と他の分子との相互作用を検出するためのタンパク質プローブ |
| US8227572B2 (en) | 2005-08-19 | 2012-07-24 | Commonwealth Scientific And Industrial Research Organisation | Arachnocampa luciferases |
| FR2890446B1 (fr) | 2005-09-05 | 2008-04-18 | Cis Bio Internat Sa | Methode de detection d'interaction intracellulaire entre bio-molecules |
| DE102006029454A1 (de) | 2005-12-05 | 2007-06-06 | Dyomics Gmbh | Hydrophile Marker auf Basis von diasteromeren |
| CN1991364A (zh) * | 2005-12-26 | 2007-07-04 | 中国科学院上海生命科学研究院 | 预防和治疗阿尔兹海默症的g蛋白偶联受体拮抗剂 |
| JP2008058104A (ja) * | 2006-08-30 | 2008-03-13 | Sekisui Chem Co Ltd | Gタンパク質共役型受容体に対する結合性評価用組成物および結合性評価方法 |
| BRPI0807205A2 (pt) * | 2007-02-02 | 2014-07-22 | Novartis Ag | Moduladores de ligantes esclerostina para tratamento de distúrbios relacionados ao osso |
| KR20100017666A (ko) * | 2007-05-23 | 2010-02-16 | 파마콤 엘엘씨 | 리간드 친화성이 개질된 g단백질 공액형 수용체 및 그 용도 |
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|---|---|
| NZ593294A (en) | 2013-04-26 |
| KR101834574B1 (ko) | 2018-03-05 |
| CN102439444B (zh) | 2014-10-22 |
| CA2748500C (en) | 2017-10-17 |
| AU2010207880A1 (en) | 2010-08-05 |
| SG172321A1 (en) | 2011-07-28 |
| EP2382470A1 (en) | 2011-11-02 |
| CN102439444A (zh) | 2012-05-02 |
| HK1163254A1 (en) | 2012-09-07 |
| US20120077210A1 (en) | 2012-03-29 |
| US8647887B2 (en) | 2014-02-11 |
| AU2010207880B2 (en) | 2012-03-29 |
| JP2012516429A (ja) | 2012-07-19 |
| EP2382470A4 (en) | 2012-08-15 |
| IL213771A0 (en) | 2011-07-31 |
| CA2748500A1 (en) | 2010-08-05 |
| EP2382470B1 (en) | 2014-12-10 |
| KR20110125228A (ko) | 2011-11-18 |
| WO2010085844A1 (en) | 2010-08-05 |
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