JP5667989B2 - 血液凝固分析装置 - Google Patents
血液凝固分析装置 Download PDFInfo
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- JP5667989B2 JP5667989B2 JP2011544235A JP2011544235A JP5667989B2 JP 5667989 B2 JP5667989 B2 JP 5667989B2 JP 2011544235 A JP2011544235 A JP 2011544235A JP 2011544235 A JP2011544235 A JP 2011544235A JP 5667989 B2 JP5667989 B2 JP 5667989B2
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
- G01N21/51—Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
- G01N21/53—Scattering, i.e. diffuse reflection within a body or fluid within a flowing fluid, e.g. smoke
- G01N21/532—Scattering, i.e. diffuse reflection within a body or fluid within a flowing fluid, e.g. smoke with measurement of scattering and transmission
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/82—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a precipitate or turbidity
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/18—Water
- G01N33/1826—Water organic contamination in water
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/4905—Determining clotting time of blood
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N2021/4704—Angular selective
- G01N2021/4711—Multiangle measurement
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/82—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a precipitate or turbidity
- G01N2021/825—Agglutination
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/18—Water
Description
たとえば特許文献1記載の技術によると、複数の波長の光を照射し、被測定検体に応じ干渉物質の影響の少ない波長のデータを選択して凝固時間の算出に用いる技術が開示されている。
応が終了したとして、散乱光測定を終了する。このとき、測定終了までに第1検出器103aおよび第2検出器103bからの信号が、ともに信号強度上限値Smaxを予め設定された一定時間(例えば3秒間)連続で超えたことを判断部106が検出した場合、即時、測定を終了し、制御部109に希釈再検依頼のフラグを送信する。
102…単一波長光源
103a〜103b…検出器
104…増幅部
105…A/D変換部
106…判断部
107…記憶部
108…演算部
109…制御部
110…出力部
502a〜502b…単一波長光源
503…検出器
Claims (3)
- 試料と試薬を混合し反応させるための反応容器(101)と、前記反応容器(101)に光を照射するための単一波長の光源(102)と、前記反応容器(101)周辺に前記光源(102)の光軸に対し異なる角度で配置され試料と試薬の混合液から発せられる散乱光を検出する複数の検出器(103a、103b)と、前記検出器(103a、103b)から得られる複数の経時的な光強度変化データを取り込み記憶する記憶部(107)と、前記記憶部(107)に保管された各々の光強度変化データから光強度変化量に基づき血液凝固時間の算出に用いる光強度変化データを選択する判断部(106)と、前記判断部(106)により選択された光強度変化データから血液凝固時間を算出する演算部(108)を備えた血液凝固分析装置において、
前記検出器(103a、103b)に予め優先順位が設定されており、前記検出器(103a、103b)で優先順位の高い検出器(103a、103b)からの光強度変化データの変化量が予め設定された閾値以下の場合、次の優先順位の検出器(103a、103b)からの光強度データを血液凝固時間の算出に用いることを特徴とする血液凝固分析装置。 - 請求項1記載の血液凝固分析装置において、
前記検出器(103a、103b)で優先順位の高い検出器からの光強度変化データがノイズ等の影響で血液凝固時間の算出が困難な場合に、次の優先順位の検出器からのデータを血液凝固時間の算出に用いることを特徴とする血液凝固分析装置。 - 試料と試薬の混合液を反応させる反応容器(101)と、前記反応容器(101)に単一波長光を照射する光源(102)と、照射した前記反応容器(101)から散乱する散乱光を検出する検出器(103a、103b)とを備え、前記検出器(103a、103b)により検出される経時的な光強度変化データより血液凝固時間を算出する血液凝固分析装置において、
前記検出器(103a、103b)を前記光源(102)の光軸に対し異なる角度で複数配置して複数の光強度変化データを取得し、前記複数の光強度変化データより血液凝固分析におけるダイナミックレンジ確保と高感度化に適する方を択一することを特徴とする血液凝固分析装置。
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JP2011544235A JP5667989B2 (ja) | 2009-12-04 | 2010-11-19 | 血液凝固分析装置 |
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PCT/JP2010/070741 WO2011068049A1 (ja) | 2009-12-04 | 2010-11-19 | 血液凝固分析装置 |
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US (1) | US9395298B2 (ja) |
EP (1) | EP2508891B1 (ja) |
JP (2) | JP5667989B2 (ja) |
CN (1) | CN102640004B (ja) |
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Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
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JP5216051B2 (ja) * | 2010-06-23 | 2013-06-19 | 株式会社日立ハイテクノロジーズ | 自動分析装置および自動分析方法 |
JP5822534B2 (ja) * | 2011-05-13 | 2015-11-24 | 株式会社日立ハイテクノロジーズ | 自動分析装置 |
US8772039B2 (en) * | 2011-05-26 | 2014-07-08 | The General Hospital Corporation | Optical thromboelastography system and method for evaluation of blood coagulation metrics |
JP6013796B2 (ja) * | 2012-06-25 | 2016-10-25 | 株式会社日立ハイテクノロジーズ | 自動分析装置及び試料測定方法 |
JP6073117B2 (ja) * | 2012-11-26 | 2017-02-01 | 株式会社日立ハイテクノロジーズ | 自動分析装置、自動分析方法 |
ES2848673T3 (es) | 2012-12-19 | 2021-08-11 | Massachusetts Gen Hospital | Sensor óptico de coagulación sanguínea |
WO2015098473A1 (ja) * | 2013-12-25 | 2015-07-02 | 株式会社日立ハイテクノロジーズ | 自動分析装置及び分析方法 |
JP5920409B2 (ja) * | 2014-06-18 | 2016-05-18 | 栗田工業株式会社 | 凝集モニタリング装置、凝集モニタリング方法および凝集システム |
FR3030048B1 (fr) * | 2014-12-15 | 2016-12-23 | Immunodiagnostic Systems France | Procede et dispositif de determination du temps de coagulation d’un echantillon sanguin, et cuvette de reaction |
JP6696963B2 (ja) * | 2015-02-27 | 2020-05-20 | 学校法人東日本学園 | 凝固時間の延長原因に関する情報を取得する方法とそれを実施するための装置及びプログラム |
JP6871673B2 (ja) * | 2015-03-31 | 2021-05-12 | 学校法人東日本学園 | 血液検体を判定するための方法、装置及びコンピュータプログラム、並びに血液検体分析装置 |
CN104897615A (zh) * | 2015-06-03 | 2015-09-09 | 何祖玲 | 智能血凝仪 |
JP6812577B2 (ja) * | 2017-12-26 | 2021-01-13 | 株式会社日立ハイテク | 自動分析装置および自動分析方法 |
JP6952668B2 (ja) * | 2018-09-28 | 2021-10-20 | シスメックス株式会社 | 血液凝固分析方法、血液凝固分析装置、プログラム |
EP3882628A4 (en) * | 2018-11-15 | 2022-08-10 | Sekisui Medical Co., Ltd. | ANALYTICAL METHOD, ANALYTICAL DEVICE AND ANALYTICAL PROGRAM |
JP7241209B2 (ja) * | 2020-01-17 | 2023-03-16 | 株式会社エイアンドティー | 血液凝固測定装置、血液凝固時間の測定方法、血液凝固反応の完了判定方法、および血液自動遠心分離装置 |
WO2021207896A1 (zh) * | 2020-04-13 | 2021-10-21 | 深圳迈瑞生物医疗电子股份有限公司 | 一种样本分析装置及方法 |
CN113686735B (zh) * | 2021-09-16 | 2023-11-07 | 北京信息科技大学 | 测量血液凝固属性的方法及装置 |
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JPS58172537A (ja) * | 1982-04-04 | 1983-10-11 | Wako Pure Chem Ind Ltd | 光散乱測定装置 |
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- 2010-11-19 US US13/509,661 patent/US9395298B2/en active Active
- 2010-11-19 WO PCT/JP2010/070741 patent/WO2011068049A1/ja active Application Filing
- 2010-11-19 EP EP10834501.8A patent/EP2508891B1/en active Active
- 2010-11-19 CN CN201080054740.3A patent/CN102640004B/zh active Active
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Patent Citations (5)
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JPS58172537A (ja) * | 1982-04-04 | 1983-10-11 | Wako Pure Chem Ind Ltd | 光散乱測定装置 |
JPS6113136A (ja) * | 1984-06-19 | 1986-01-21 | バイエルコーポレーション | 光学的に不均一な試料から拡散反射される光の測定装置及び測定方法 |
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CN102640004A (zh) | 2012-08-15 |
JPWO2011068049A1 (ja) | 2013-04-18 |
WO2011068049A1 (ja) | 2011-06-09 |
EP2508891A1 (en) | 2012-10-10 |
EP2508891A4 (en) | 2017-11-29 |
JP5955934B2 (ja) | 2016-07-20 |
US20120282139A1 (en) | 2012-11-08 |
CN102640004B (zh) | 2015-04-15 |
EP2508891B1 (en) | 2019-08-07 |
JP2015111123A (ja) | 2015-06-18 |
US9395298B2 (en) | 2016-07-19 |
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