JP5663559B2 - ３−｛［（２ｒ）−１−メチルピロリジン−２−イル］メチル｝−５−［２−（フェニルスルホニル）エチル］１ｈ−インドールの合成 - Google Patents

３−｛［（２ｒ）−１−メチルピロリジン−２−イル］メチル｝−５−［２−（フェニルスルホニル）エチル］１ｈ−インドールの合成 Download PDF

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JP5663559B2
JP5663559B2 JP2012506351A JP2012506351A JP5663559B2 JP 5663559 B2 JP5663559 B2 JP 5663559B2 JP 2012506351 A JP2012506351 A JP 2012506351A JP 2012506351 A JP2012506351 A JP 2012506351A JP 5663559 B2 JP5663559 B2 JP 5663559B2
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salt
eletriptan
formula
acid
solvent
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Japanese (ja)
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JP2012524736A (ja
JP2012524736A5 (enExample
Inventor
シロ セラフィニ、
シロ セラフィニ、
アンドレア カステリン、
アンドレア カステリン、
サント、 クラウディオ ダル
サント、 クラウディオ ダル
Original Assignee
エッフェ．イー．エッセ． ファブリカ イタリアーナ シンテーティチ エッセ．ペー．アー．
エッフェ．イー．エッセ． ファブリカ イタリアーナ シンテーティチ エッセ．ペー．アー．
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
JP2012506351A 2009-04-22 2009-11-09 ３−｛［（２ｒ）−１−メチルピロリジン−２−イル］メチル｝−５−［２−（フェニルスルホニル）エチル］１ｈ−インドールの合成 Active JP5663559B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI2009A000678 2009-04-22
ITMI2009A000678A IT1393700B1 (it) 2009-04-22 2009-04-22 Sintesi di 3-{[(2r)-1-metilpirrolidin-2-il]metil}-5-[2-(fenilsulfonil)etil]-1h-indolo
PCT/EP2009/064850 WO2010121673A1 (en) 2009-04-22 2009-11-09 Synthesis of 3-{[(2r)-1-methylpyrrolidin-2-yl]methyl}-5-[2-(phenylsulfonyl)ethyl]-1h-indole

Publications (3)

Publication Number Publication Date
JP2012524736A JP2012524736A (ja) 2012-10-18
JP2012524736A5 JP2012524736A5 (enExample) 2014-07-10
JP5663559B2 true JP5663559B2 (ja) 2015-02-04

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JP2012506351A Active JP5663559B2 (ja) 2009-04-22 2009-11-09 ３−｛［（２ｒ）−１−メチルピロリジン−２−イル］メチル｝−５−［２−（フェニルスルホニル）エチル］１ｈ−インドールの合成

Country Status (8)

Country Link
US (1) US8426612B2 (enExample)
EP (1) EP2421853B1 (enExample)
JP (1) JP5663559B2 (enExample)
CN (1) CN102414198B (enExample)
CA (1) CA2756234C (enExample)
ES (1) ES2432066T3 (enExample)
IT (1) IT1393700B1 (enExample)
WO (1) WO2010121673A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102786514B (zh) * 2012-07-26 2014-01-29 武汉人福医药集团股份有限公司 依来曲普坦的制备方法
CN104341397A (zh) * 2013-07-31 2015-02-11 上海威智医药科技有限公司 具晶型的依来曲普坦自由碱及其制法和应用
CN105175397B (zh) * 2015-09-15 2017-10-10 上海现代哈森（商丘）药业有限公司 一种氢溴酸依立曲坦合成方法
WO2017125351A1 (en) * 2016-01-21 2017-07-27 Laboratorios Lesvi Sl Process for preparing (( r)-3-[(-1-methylpyrrolidin-2-yl)methyl]-5-(2-phenylsulfonylethyl)-1h-indole

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL168919B1 (pl) 1990-10-15 1996-05-31 Pfizer Sposób wytwarzania nowych pochodnych indolu PL PL PL PL
US5545644A (en) 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
US5607951A (en) * 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
GB9417310D0 (en) 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
GB9923314D0 (en) * 1999-10-01 1999-12-08 Pfizer Ltd Acylation process
US20030166704A1 (en) 2000-12-20 2003-09-04 Pfizer Inc. New process
GB0031094D0 (en) * 2000-12-20 2001-01-31 Pfizer Ltd New Process
EP1615635A1 (en) 2003-04-11 2006-01-18 Pfizer Limited Pharmaceutical combination comprising eletriptan and sodium bicarbonate
US6927296B2 (en) * 2003-07-23 2005-08-09 Pfizer Inc. Process
GB0317229D0 (en) * 2003-07-23 2003-08-27 Pfizer Ltd Improved process
WO2008137134A2 (en) 2007-05-01 2008-11-13 Teva Pharmaceuticals Usa, Inc. Amorphous eletriptan hydrobromide and process for preparing it and other forms of eletriptan hydrobromide
EP2038273A1 (en) * 2007-05-29 2009-03-25 Plus Chemicals B.V. A process for preparing 5-bromo-3-[(r)-1-methyl-pyrrolidin-2-ylmethyl]-1h-indole
WO2009077858A2 (en) * 2007-12-17 2009-06-25 Actavis Group Ptc Ehf Novel hemioxalate salt of eletriptan
WO2009142771A2 (en) * 2008-05-22 2009-11-26 Plus Chemicals, S.A. Salts of (r)-5-(2-phenylsulphonylethenyl)-3-(n- methylpyrrolidin-2-ylmethyl)-1h-indole, 5-bromo-3-[(r)-1- methyl-pyrrolidin-2- ylmethyl]-1h-indole and of eletriptan

Also Published As

Publication number Publication date
EP2421853A1 (en) 2012-02-29
JP2012524736A (ja) 2012-10-18
US8426612B2 (en) 2013-04-23
CN102414198A (zh) 2012-04-11
IT1393700B1 (it) 2012-05-08
CN102414198B (zh) 2014-11-12
ES2432066T3 (es) 2013-11-29
CA2756234C (en) 2017-01-03
EP2421853B1 (en) 2013-07-24
ITMI20090678A1 (it) 2010-10-23
WO2010121673A1 (en) 2010-10-28
US20110166364A1 (en) 2011-07-07
CA2756234A1 (en) 2010-10-28

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