CN102414198B - 3-{[(2r)-1-甲基吡咯烷-2-基]甲基}-5-[2-(苯基磺酰基)乙基]-1h-吲哚的合成 - Google Patents

3-{[(2r)-1-甲基吡咯烷-2-基]甲基}-5-[2-(苯基磺酰基)乙基]-1h-吲哚的合成 Download PDF

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Publication number
CN102414198B
CN102414198B CN200980158923.7A CN200980158923A CN102414198B CN 102414198 B CN102414198 B CN 102414198B CN 200980158923 A CN200980158923 A CN 200980158923A CN 102414198 B CN102414198 B CN 102414198B
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salt
eletriptan
formula
hydrobromate
solvent
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CN102414198A (zh
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希洛·塞拉菲尼
安德里·卡斯特林
克劳迪奥·达尔桑托
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Fabbrica Italiana Sintetici SpA (FIS)
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
CN200980158923.7A 2009-04-22 2009-11-09 3-{[(2r)-1-甲基吡咯烷-2-基]甲基}-5-[2-(苯基磺酰基)乙基]-1h-吲哚的合成 Active CN102414198B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI2009A000678 2009-04-22
ITMI2009A000678A IT1393700B1 (it) 2009-04-22 2009-04-22 Sintesi di 3-{[(2r)-1-metilpirrolidin-2-il]metil}-5-[2-(fenilsulfonil)etil]-1h-indolo
PCT/EP2009/064850 WO2010121673A1 (en) 2009-04-22 2009-11-09 Synthesis of 3-{[(2r)-1-methylpyrrolidin-2-yl]methyl}-5-[2-(phenylsulfonyl)ethyl]-1h-indole

Publications (2)

Publication Number Publication Date
CN102414198A CN102414198A (zh) 2012-04-11
CN102414198B true CN102414198B (zh) 2014-11-12

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CN200980158923.7A Active CN102414198B (zh) 2009-04-22 2009-11-09 3-{[(2r)-1-甲基吡咯烷-2-基]甲基}-5-[2-(苯基磺酰基)乙基]-1h-吲哚的合成

Country Status (8)

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US (1) US8426612B2 (enExample)
EP (1) EP2421853B1 (enExample)
JP (1) JP5663559B2 (enExample)
CN (1) CN102414198B (enExample)
CA (1) CA2756234C (enExample)
ES (1) ES2432066T3 (enExample)
IT (1) IT1393700B1 (enExample)
WO (1) WO2010121673A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102786514B (zh) * 2012-07-26 2014-01-29 武汉人福医药集团股份有限公司 依来曲普坦的制备方法
CN104341397A (zh) * 2013-07-31 2015-02-11 上海威智医药科技有限公司 具晶型的依来曲普坦自由碱及其制法和应用
CN105175397B (zh) * 2015-09-15 2017-10-10 上海现代哈森（商丘）药业有限公司 一种氢溴酸依立曲坦合成方法
WO2017125351A1 (en) * 2016-01-21 2017-07-27 Laboratorios Lesvi Sl Process for preparing (( r)-3-[(-1-methylpyrrolidin-2-yl)methyl]-5-(2-phenylsulfonylethyl)-1h-indole

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
US5607951A (en) * 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
CN1290697A (zh) * 1999-10-01 2001-04-11 辉瑞大药厂 酰化作用方法
CN1487932A (zh) * 2000-12-20 2004-04-07 新方法
CN1823060A (zh) * 2003-07-23 2006-08-23 辉瑞大药厂 制备α－多晶型氢溴酸依来曲普坦的改良方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0179053B1 (ko) * 1990-10-15 1999-03-20 알렌 제이.스피겔 인돌 유도체
GB9417310D0 (en) 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
US20030166704A1 (en) 2000-12-20 2003-09-04 Pfizer Inc. New process
BRPI0409127A (pt) 2003-04-11 2006-03-28 Pfizer combinação farmacêutica compreendendo eletriptano e bicarbonato de sódio
US6927296B2 (en) * 2003-07-23 2005-08-09 Pfizer Inc. Process
EP2046777A2 (en) 2007-05-01 2009-04-15 Plus Chemicals B.V. Amorphous eletriptan hydrobromide and process for preparing it and other forms of eletriptan hydrobromide
WO2008150500A1 (en) * 2007-05-29 2008-12-11 Plus Chemicals, S.A. A process for preparing 5-bromo-3-[(r)-1-methyl-pyrrolidin-2-ylmethyl]-1h-indole
EP2225224A2 (en) * 2007-12-17 2010-09-08 Actavis Group PTC EHF Novel hemioxalate salt of eletriptan
US20090299077A1 (en) 2008-05-22 2009-12-03 Vinod Kumar Kansal Salts of (R)-5-(2phenylsulphonylethenyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole, 5-bromo-3-[(R)-1-methyl-pyrrolidin-2-ylmethyl]-1H-indole and of eletriptan

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
US5607951A (en) * 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
CN1290697A (zh) * 1999-10-01 2001-04-11 辉瑞大药厂 酰化作用方法
CN1487932A (zh) * 2000-12-20 2004-04-07 新方法
CN1823060A (zh) * 2003-07-23 2006-08-23 辉瑞大药厂 制备α－多晶型氢溴酸依来曲普坦的改良方法

Also Published As

Publication number Publication date
WO2010121673A1 (en) 2010-10-28
ITMI20090678A1 (it) 2010-10-23
JP2012524736A (ja) 2012-10-18
CA2756234A1 (en) 2010-10-28
CN102414198A (zh) 2012-04-11
CA2756234C (en) 2017-01-03
IT1393700B1 (it) 2012-05-08
ES2432066T3 (es) 2013-11-29
EP2421853A1 (en) 2012-02-29
JP5663559B2 (ja) 2015-02-04
EP2421853B1 (en) 2013-07-24
US20110166364A1 (en) 2011-07-07
US8426612B2 (en) 2013-04-23

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