JP5635905B2 - ミルタザピンの調製方法 - Google Patents

ミルタザピンの調製方法 Download PDF

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Publication number
JP5635905B2
JP5635905B2 JP2010502504A JP2010502504A JP5635905B2 JP 5635905 B2 JP5635905 B2 JP 5635905B2 JP 2010502504 A JP2010502504 A JP 2010502504A JP 2010502504 A JP2010502504 A JP 2010502504A JP 5635905 B2 JP5635905 B2 JP 5635905B2
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JP
Japan
Prior art keywords
compound
formula
mirtazapine
enantiomeric excess
reducing agent
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JP2010502504A
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English (en)
Japanese (ja)
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JP2010523620A5 (enExample
JP2010523620A (ja
Inventor
ケムペルマン，ヘラルドス・ヨハネス
Original Assignee
メルク・シャープ・エンド・ドーム・ベー・フェー
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Publication of JP2010523620A5 publication Critical patent/JP2010523620A5/ja
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2010502504A 2007-04-11 2008-04-10 ミルタザピンの調製方法 Active JP5635905B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07105985 2007-04-11
EP07105985.1 2007-04-11
PCT/EP2008/054316 WO2008125578A2 (en) 2007-04-11 2008-04-10 A method for the preparation of mirtazapine

Publications (3)

Publication Number Publication Date
JP2010523620A JP2010523620A (ja) 2010-07-15
JP2010523620A5 JP2010523620A5 (enExample) 2011-05-26
JP5635905B2 true JP5635905B2 (ja) 2014-12-03

Family

ID=38474342

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010502504A Active JP5635905B2 (ja) 2007-04-11 2008-04-10 ミルタザピンの調製方法

Country Status (8)

Country Link
EP (1) EP2146993B1 (enExample)
JP (1) JP5635905B2 (enExample)
CN (1) CN101679431B (enExample)
AR (1) AR066005A1 (enExample)
CA (1) CA2684021A1 (enExample)
MX (1) MX2009010967A (enExample)
WO (1) WO2008125578A2 (enExample)
ZA (1) ZA200907537B (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG191831A1 (en) 2011-03-31 2013-08-30 Kaneka Corp Process for preparing cyclic amine compounds
SI3261645T1 (sl) 2015-02-27 2021-08-31 Dechra Limited Stimulacija apetita, uravnavanje izgube mase in zdravljenje anoreksije pri psih in mačkah

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL189199C (nl) * 1975-04-05 1993-02-01 Akzo Nv Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten.
CA2309744A1 (en) 1997-11-14 1999-05-27 Akzo Nobel N.V. Use of mirtazapine for treating sleep apneas
PL366289A1 (en) 1999-04-19 2005-01-24 Teva Pharmaceutical Industries Ltd. Novel synthesis and crystallization of piperazine ring-containing compounds
AU6476300A (en) 1999-09-30 2001-05-10 Sumika Fine Chemicals Co., Ltd. Process for the preparation of a piperazine derivative
WO2001042239A1 (en) 1999-12-13 2001-06-14 Sumika Fine Chemicals Co., Ltd. Process for the preparation of a pyridinemethanol compound
KR20020069371A (ko) 2000-02-11 2002-08-30 악조 노벨 엔.브이. 수면 장애의 치료를 위한 미르타자핀의 용도
DE60133674D1 (de) 2001-09-14 2008-05-29 Medichem Sa Zwischenprodukte für die herstellung von mirtazapin und verfahren zu deren herstellung
US6806283B2 (en) * 2002-05-06 2004-10-19 Virginia Commonwealth University Selective serotonin receptor antagonists and therapeutic applications thereof
UA83666C2 (ru) * 2003-07-10 2008-08-11 Н.В. Органон Способ получения энантиомерно чистого миртазапина
LT2896397T (lt) * 2003-08-01 2017-11-27 Mitsubishi Tanabe Pharma Corporation Nauji junginiai, turintys inhibitorinį aktyvumą prieš nuo natrio priklausomą gliukozės transporterį
JP2007284358A (ja) 2006-04-13 2007-11-01 Sumitomo Chemical Co Ltd 光学活性なピペラジン化合物の製造方法
TW200815370A (en) * 2006-06-16 2008-04-01 Organon Nv Stereoselective synthesis of (S)-1-methyl-3-phenylpiperazine

Also Published As

Publication number Publication date
CN101679431A (zh) 2010-03-24
EP2146993B1 (en) 2015-08-05
CA2684021A1 (en) 2008-10-23
MX2009010967A (es) 2009-12-15
ZA200907537B (en) 2010-07-28
CN101679431B (zh) 2013-08-14
WO2008125578A2 (en) 2008-10-23
WO2008125578A3 (en) 2008-12-24
AR066005A1 (es) 2009-07-15
JP2010523620A (ja) 2010-07-15
EP2146993A2 (en) 2010-01-27

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