CA2684021A1 - A method for the preparation of an enantiomer of a tetracyclic benzazepine - Google Patents

A method for the preparation of an enantiomer of a tetracyclic benzazepine Download PDF

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Publication number
CA2684021A1
CA2684021A1 CA002684021A CA2684021A CA2684021A1 CA 2684021 A1 CA2684021 A1 CA 2684021A1 CA 002684021 A CA002684021 A CA 002684021A CA 2684021 A CA2684021 A CA 2684021A CA 2684021 A1 CA2684021 A1 CA 2684021A1
Authority
CA
Canada
Prior art keywords
compound
mirtazapine
formula
enantiomeric excess
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002684021A
Other languages
English (en)
French (fr)
Inventor
Gerardus Johannes Kemperman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme BV
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2684021A1 publication Critical patent/CA2684021A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002684021A 2007-04-11 2008-04-10 A method for the preparation of an enantiomer of a tetracyclic benzazepine Abandoned CA2684021A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07105985 2007-04-11
EP07105985.1 2007-04-11
PCT/EP2008/054316 WO2008125578A2 (en) 2007-04-11 2008-04-10 A method for the preparation of mirtazapine

Publications (1)

Publication Number Publication Date
CA2684021A1 true CA2684021A1 (en) 2008-10-23

Family

ID=38474342

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002684021A Abandoned CA2684021A1 (en) 2007-04-11 2008-04-10 A method for the preparation of an enantiomer of a tetracyclic benzazepine

Country Status (8)

Country Link
EP (1) EP2146993B1 (enExample)
JP (1) JP5635905B2 (enExample)
CN (1) CN101679431B (enExample)
AR (1) AR066005A1 (enExample)
CA (1) CA2684021A1 (enExample)
MX (1) MX2009010967A (enExample)
WO (1) WO2008125578A2 (enExample)
ZA (1) ZA200907537B (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG191831A1 (en) 2011-03-31 2013-08-30 Kaneka Corp Process for preparing cyclic amine compounds
SI3261645T1 (sl) 2015-02-27 2021-08-31 Dechra Limited Stimulacija apetita, uravnavanje izgube mase in zdravljenje anoreksije pri psih in mačkah

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL189199C (nl) * 1975-04-05 1993-02-01 Akzo Nv Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten.
CA2309744A1 (en) 1997-11-14 1999-05-27 Akzo Nobel N.V. Use of mirtazapine for treating sleep apneas
PL366289A1 (en) 1999-04-19 2005-01-24 Teva Pharmaceutical Industries Ltd. Novel synthesis and crystallization of piperazine ring-containing compounds
AU6476300A (en) 1999-09-30 2001-05-10 Sumika Fine Chemicals Co., Ltd. Process for the preparation of a piperazine derivative
WO2001042239A1 (en) 1999-12-13 2001-06-14 Sumika Fine Chemicals Co., Ltd. Process for the preparation of a pyridinemethanol compound
KR20020069371A (ko) 2000-02-11 2002-08-30 악조 노벨 엔.브이. 수면 장애의 치료를 위한 미르타자핀의 용도
DE60133674D1 (de) 2001-09-14 2008-05-29 Medichem Sa Zwischenprodukte für die herstellung von mirtazapin und verfahren zu deren herstellung
US6806283B2 (en) * 2002-05-06 2004-10-19 Virginia Commonwealth University Selective serotonin receptor antagonists and therapeutic applications thereof
UA83666C2 (ru) * 2003-07-10 2008-08-11 Н.В. Органон Способ получения энантиомерно чистого миртазапина
LT2896397T (lt) * 2003-08-01 2017-11-27 Mitsubishi Tanabe Pharma Corporation Nauji junginiai, turintys inhibitorinį aktyvumą prieš nuo natrio priklausomą gliukozės transporterį
JP2007284358A (ja) 2006-04-13 2007-11-01 Sumitomo Chemical Co Ltd 光学活性なピペラジン化合物の製造方法
TW200815370A (en) * 2006-06-16 2008-04-01 Organon Nv Stereoselective synthesis of (S)-1-methyl-3-phenylpiperazine

Also Published As

Publication number Publication date
CN101679431A (zh) 2010-03-24
EP2146993B1 (en) 2015-08-05
MX2009010967A (es) 2009-12-15
ZA200907537B (en) 2010-07-28
CN101679431B (zh) 2013-08-14
WO2008125578A2 (en) 2008-10-23
WO2008125578A3 (en) 2008-12-24
AR066005A1 (es) 2009-07-15
JP5635905B2 (ja) 2014-12-03
JP2010523620A (ja) 2010-07-15
EP2146993A2 (en) 2010-01-27

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20150202