MX2009010967A - Un metodo para la preparacion de mirtazapina. - Google Patents
Un metodo para la preparacion de mirtazapina.Info
- Publication number
- MX2009010967A MX2009010967A MX2009010967A MX2009010967A MX2009010967A MX 2009010967 A MX2009010967 A MX 2009010967A MX 2009010967 A MX2009010967 A MX 2009010967A MX 2009010967 A MX2009010967 A MX 2009010967A MX 2009010967 A MX2009010967 A MX 2009010967A
- Authority
- MX
- Mexico
- Prior art keywords
- compound
- mirtazapine
- formula
- preparation
- enantiomeric excess
- Prior art date
Links
- RONZAEMNMFQXRA-UHFFFAOYSA-N mirtazapine Chemical compound C1C2=CC=CN=C2N2CCN(C)CC2C2=CC=CC=C21 RONZAEMNMFQXRA-UHFFFAOYSA-N 0.000 title abstract 4
- 229960001785 mirtazapine Drugs 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 2
- -1 carboxylic acid compound Chemical class 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000002440 hydroxy compounds Chemical class 0.000 abstract 2
- 150000002576 ketones Chemical class 0.000 abstract 2
- 125000002843 carboxylic acid group Chemical group 0.000 abstract 1
- 125000000468 ketone group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07105985 | 2007-04-11 | ||
| PCT/EP2008/054316 WO2008125578A2 (en) | 2007-04-11 | 2008-04-10 | A method for the preparation of mirtazapine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2009010967A true MX2009010967A (es) | 2009-12-15 |
Family
ID=38474342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2009010967A MX2009010967A (es) | 2007-04-11 | 2008-04-10 | Un metodo para la preparacion de mirtazapina. |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP2146993B1 (enExample) |
| JP (1) | JP5635905B2 (enExample) |
| CN (1) | CN101679431B (enExample) |
| AR (1) | AR066005A1 (enExample) |
| CA (1) | CA2684021A1 (enExample) |
| MX (1) | MX2009010967A (enExample) |
| WO (1) | WO2008125578A2 (enExample) |
| ZA (1) | ZA200907537B (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG191831A1 (en) | 2011-03-31 | 2013-08-30 | Kaneka Corp | Process for preparing cyclic amine compounds |
| SI3261645T1 (sl) | 2015-02-27 | 2021-08-31 | Dechra Limited | Stimulacija apetita, uravnavanje izgube mase in zdravljenje anoreksije pri psih in mačkah |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL189199C (nl) * | 1975-04-05 | 1993-02-01 | Akzo Nv | Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten. |
| CA2309744A1 (en) | 1997-11-14 | 1999-05-27 | Akzo Nobel N.V. | Use of mirtazapine for treating sleep apneas |
| PL366289A1 (en) | 1999-04-19 | 2005-01-24 | Teva Pharmaceutical Industries Ltd. | Novel synthesis and crystallization of piperazine ring-containing compounds |
| AU6476300A (en) | 1999-09-30 | 2001-05-10 | Sumika Fine Chemicals Co., Ltd. | Process for the preparation of a piperazine derivative |
| WO2001042239A1 (en) | 1999-12-13 | 2001-06-14 | Sumika Fine Chemicals Co., Ltd. | Process for the preparation of a pyridinemethanol compound |
| KR20020069371A (ko) | 2000-02-11 | 2002-08-30 | 악조 노벨 엔.브이. | 수면 장애의 치료를 위한 미르타자핀의 용도 |
| DE60133674D1 (de) | 2001-09-14 | 2008-05-29 | Medichem Sa | Zwischenprodukte für die herstellung von mirtazapin und verfahren zu deren herstellung |
| US6806283B2 (en) * | 2002-05-06 | 2004-10-19 | Virginia Commonwealth University | Selective serotonin receptor antagonists and therapeutic applications thereof |
| UA83666C2 (ru) * | 2003-07-10 | 2008-08-11 | Н.В. Органон | Способ получения энантиомерно чистого миртазапина |
| LT2896397T (lt) * | 2003-08-01 | 2017-11-27 | Mitsubishi Tanabe Pharma Corporation | Nauji junginiai, turintys inhibitorinį aktyvumą prieš nuo natrio priklausomą gliukozės transporterį |
| JP2007284358A (ja) | 2006-04-13 | 2007-11-01 | Sumitomo Chemical Co Ltd | 光学活性なピペラジン化合物の製造方法 |
| TW200815370A (en) * | 2006-06-16 | 2008-04-01 | Organon Nv | Stereoselective synthesis of (S)-1-methyl-3-phenylpiperazine |
-
2008
- 2008-04-10 WO PCT/EP2008/054316 patent/WO2008125578A2/en not_active Ceased
- 2008-04-10 EP EP08736038.4A patent/EP2146993B1/en active Active
- 2008-04-10 CA CA002684021A patent/CA2684021A1/en not_active Abandoned
- 2008-04-10 MX MX2009010967A patent/MX2009010967A/es not_active Application Discontinuation
- 2008-04-10 AR ARP080101475 patent/AR066005A1/es unknown
- 2008-04-10 JP JP2010502504A patent/JP5635905B2/ja active Active
- 2008-04-10 CN CN200880016144.9A patent/CN101679431B/zh active Active
-
2009
- 2009-10-27 ZA ZA200907537A patent/ZA200907537B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101679431A (zh) | 2010-03-24 |
| EP2146993B1 (en) | 2015-08-05 |
| CA2684021A1 (en) | 2008-10-23 |
| ZA200907537B (en) | 2010-07-28 |
| CN101679431B (zh) | 2013-08-14 |
| WO2008125578A2 (en) | 2008-10-23 |
| WO2008125578A3 (en) | 2008-12-24 |
| AR066005A1 (es) | 2009-07-15 |
| JP5635905B2 (ja) | 2014-12-03 |
| JP2010523620A (ja) | 2010-07-15 |
| EP2146993A2 (en) | 2010-01-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB | Transfer or rights |
Owner name: MERCK SHARP & DOHME B.V. |
|
| GB | Transfer or rights |
Owner name: MERCK SHARP & DOHME B.V. |
|
| FA | Abandonment or withdrawal |