CN101679431B - 制备四环苯并氮杂卓的对映异构体的方法 - Google Patents

制备四环苯并氮杂卓的对映异构体的方法 Download PDF

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Publication number
CN101679431B
CN101679431B CN200880016144.9A CN200880016144A CN101679431B CN 101679431 B CN101679431 B CN 101679431B CN 200880016144 A CN200880016144 A CN 200880016144A CN 101679431 B CN101679431 B CN 101679431B
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China
Prior art keywords
compound
formula
mirtazapine
enantiomeric excess
preparation
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CN200880016144.9A
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English (en)
Chinese (zh)
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CN101679431A (zh
Inventor
G·J·肯佩曼
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Merck Sharp and Dohme BV
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MSD Oss BV
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN200880016144.9A 2007-04-11 2008-04-10 制备四环苯并氮杂卓的对映异构体的方法 Active CN101679431B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07105985 2007-04-11
EP07105985.1 2007-04-11
PCT/EP2008/054316 WO2008125578A2 (en) 2007-04-11 2008-04-10 A method for the preparation of mirtazapine

Publications (2)

Publication Number Publication Date
CN101679431A CN101679431A (zh) 2010-03-24
CN101679431B true CN101679431B (zh) 2013-08-14

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ID=38474342

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CN200880016144.9A Active CN101679431B (zh) 2007-04-11 2008-04-10 制备四环苯并氮杂卓的对映异构体的方法

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Country Link
EP (1) EP2146993B1 (enExample)
JP (1) JP5635905B2 (enExample)
CN (1) CN101679431B (enExample)
AR (1) AR066005A1 (enExample)
CA (1) CA2684021A1 (enExample)
MX (1) MX2009010967A (enExample)
WO (1) WO2008125578A2 (enExample)
ZA (1) ZA200907537B (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012133486A1 (ja) * 2011-03-31 2012-10-04 株式会社カネカ 環状アミン化合物の製造法
PT3261645T (pt) 2015-02-27 2021-06-17 Dechra Ltd Estimulação do apetite, gestão da perda de peso, e tratamento da anorexia em cães e gatos

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4062848A (en) * 1975-04-05 1977-12-13 Akzona Incorporated Tetracyclic compounds
CN1820000A (zh) * 2003-07-10 2006-08-16 阿克佐诺贝尔公司 制备对映体纯的米氮平的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ296282B6 (cs) 1997-11-14 2006-02-15 Akzo Nobel N. V. Farmaceutický prostredek
TR200103028T2 (tr) 1999-04-19 2002-01-21 Teva Pharmaceutical Industries Ltd. Piperazin halka içeren bileşiklerin yeni sentezi ve kristalleştirilmesi
AU6476300A (en) 1999-09-30 2001-05-10 Sumika Fine Chemicals Co., Ltd. Process for the preparation of a piperazine derivative
WO2001042239A1 (en) 1999-12-13 2001-06-14 Sumika Fine Chemicals Co., Ltd. Process for the preparation of a pyridinemethanol compound
IL150290A0 (en) 2000-02-11 2002-12-01 Akzo Nobel Nv The use of mirtazapine for the treatment of sleep disorders
ATE392410T1 (de) 2001-09-14 2008-05-15 Medichem Sa Zwischenprodukte für die herstellung von mirtazapin und verfahren zu deren herstellung
US6806283B2 (en) * 2002-05-06 2004-10-19 Virginia Commonwealth University Selective serotonin receptor antagonists and therapeutic applications thereof
RS53365B (sr) * 2003-08-01 2014-10-31 Mitsubishi Tanabe Pharma Corporation Nova jedinjenja koja imaju inhibitorno dejstvo na transporter glukoze zavisan od natrijuma
JP2007284358A (ja) 2006-04-13 2007-11-01 Sumitomo Chemical Co Ltd 光学活性なピペラジン化合物の製造方法
TW200815370A (en) * 2006-06-16 2008-04-01 Organon Nv Stereoselective synthesis of (S)-1-methyl-3-phenylpiperazine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4062848A (en) * 1975-04-05 1977-12-13 Akzona Incorporated Tetracyclic compounds
CN1820000A (zh) * 2003-07-10 2006-08-16 阿克佐诺贝尔公司 制备对映体纯的米氮平的方法

Also Published As

Publication number Publication date
MX2009010967A (es) 2009-12-15
WO2008125578A3 (en) 2008-12-24
EP2146993B1 (en) 2015-08-05
CN101679431A (zh) 2010-03-24
CA2684021A1 (en) 2008-10-23
ZA200907537B (en) 2010-07-28
EP2146993A2 (en) 2010-01-27
AR066005A1 (es) 2009-07-15
JP2010523620A (ja) 2010-07-15
WO2008125578A2 (en) 2008-10-23
JP5635905B2 (ja) 2014-12-03

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