CN101679431B - 制备四环苯并氮杂卓的对映异构体的方法 - Google Patents

制备四环苯并氮杂卓的对映异构体的方法 Download PDF

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Publication number
CN101679431B
CN101679431B CN200880016144.9A CN200880016144A CN101679431B CN 101679431 B CN101679431 B CN 101679431B CN 200880016144 A CN200880016144 A CN 200880016144A CN 101679431 B CN101679431 B CN 101679431B
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China
Prior art keywords
compound
formula
mirtazapine
enantiomeric excess
preparation
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CN200880016144.9A
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English (en)
Chinese (zh)
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CN101679431A (zh
Inventor
G·J·肯佩曼
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Merck Sharp and Dohme BV
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MSD Oss BV
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN200880016144.9A 2007-04-11 2008-04-10 制备四环苯并氮杂卓的对映异构体的方法 Active CN101679431B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07105985 2007-04-11
EP07105985.1 2007-04-11
PCT/EP2008/054316 WO2008125578A2 (en) 2007-04-11 2008-04-10 A method for the preparation of mirtazapine

Publications (2)

Publication Number Publication Date
CN101679431A CN101679431A (zh) 2010-03-24
CN101679431B true CN101679431B (zh) 2013-08-14

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CN200880016144.9A Active CN101679431B (zh) 2007-04-11 2008-04-10 制备四环苯并氮杂卓的对映异构体的方法

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EP (1) EP2146993B1 (enExample)
JP (1) JP5635905B2 (enExample)
CN (1) CN101679431B (enExample)
AR (1) AR066005A1 (enExample)
CA (1) CA2684021A1 (enExample)
MX (1) MX2009010967A (enExample)
WO (1) WO2008125578A2 (enExample)
ZA (1) ZA200907537B (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG191831A1 (en) * 2011-03-31 2013-08-30 Kaneka Corp Process for preparing cyclic amine compounds
SI3261645T1 (sl) 2015-02-27 2021-08-31 Dechra Limited Stimulacija apetita, uravnavanje izgube mase in zdravljenje anoreksije pri psih in mačkah
CN121204204A (zh) * 2025-11-27 2025-12-26 山东静远药业有限公司 一种苯磺酸米洛巴林关键中间体的对映体杂质的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4062848A (en) * 1975-04-05 1977-12-13 Akzona Incorporated Tetracyclic compounds
CN1820000A (zh) * 2003-07-10 2006-08-16 阿克佐诺贝尔公司 制备对映体纯的米氮平的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1030667E (pt) 1997-11-14 2005-06-30 Akzo Nobel Nv Utilizacao de mirtazapina para o fabrico de um medicamento para o tratamento de apenas do sono
CN1679586A (zh) 1999-04-19 2005-10-12 特瓦制药工业有限公司 含哌嗪环化合物的新型合成和结晶方法
WO2001025185A1 (en) 1999-09-30 2001-04-12 Sumika Fine Chemicals Co., Ltd. Process for the preparation of a piperazine derivative
AU6474200A (en) 1999-12-13 2001-06-18 Sumika Fine Chemicals Co., Ltd. Process for the preparation of a pyridinemethanol compound
ES2258071T3 (es) 2000-02-11 2006-08-16 Akzo Nobel N.V. Utilizacion de mirtazepina para trastornos del sueño.
US7265223B2 (en) 2001-09-14 2007-09-04 Medichem, S.A. Intermediate compounds for the preparation of mirtazapine and production methods thereof
US6806283B2 (en) * 2002-05-06 2004-10-19 Virginia Commonwealth University Selective serotonin receptor antagonists and therapeutic applications thereof
WO2005012326A1 (en) * 2003-08-01 2005-02-10 Tanabe Seiyaku Co., Ltd. Novel compounds having inhibitory activity against sodium-dependant transporter
JP2007284358A (ja) 2006-04-13 2007-11-01 Sumitomo Chemical Co Ltd 光学活性なピペラジン化合物の製造方法
TW200815370A (en) * 2006-06-16 2008-04-01 Organon Nv Stereoselective synthesis of (S)-1-methyl-3-phenylpiperazine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4062848A (en) * 1975-04-05 1977-12-13 Akzona Incorporated Tetracyclic compounds
CN1820000A (zh) * 2003-07-10 2006-08-16 阿克佐诺贝尔公司 制备对映体纯的米氮平的方法

Also Published As

Publication number Publication date
ZA200907537B (en) 2010-07-28
JP5635905B2 (ja) 2014-12-03
JP2010523620A (ja) 2010-07-15
AR066005A1 (es) 2009-07-15
CA2684021A1 (en) 2008-10-23
WO2008125578A2 (en) 2008-10-23
CN101679431A (zh) 2010-03-24
MX2009010967A (es) 2009-12-15
EP2146993A2 (en) 2010-01-27
EP2146993B1 (en) 2015-08-05
WO2008125578A3 (en) 2008-12-24

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