JP5603770B2 - Ｃｃｒ２受容体拮抗薬およびその使用 - Google Patents
Ｃｃｒ２受容体拮抗薬およびその使用 Download PDFInfo
- Publication number
- JP5603770B2 JP5603770B2 JP2010509818A JP2010509818A JP5603770B2 JP 5603770 B2 JP5603770 B2 JP 5603770B2 JP 2010509818 A JP2010509818 A JP 2010509818A JP 2010509818 A JP2010509818 A JP 2010509818A JP 5603770 B2 JP5603770 B2 JP 5603770B2
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- amino
- chloro
- methyl
- quinazoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- SPOQOVBTEXXRSU-UHFFFAOYSA-N CC(C(c(cc1)cc(Cl)c1Cl)=NN1)=CC1=O Chemical compound CC(C(c(cc1)cc(Cl)c1Cl)=NN1)=CC1=O SPOQOVBTEXXRSU-UHFFFAOYSA-N 0.000 description 1
- NRUHHOVQAIAJLM-UHFFFAOYSA-N CC(C)(C)OC(N1CCN(CC2OCCN(Cc3ccccc3)C2)CC1)=O Chemical compound CC(C)(C)OC(N1CCN(CC2OCCN(Cc3ccccc3)C2)CC1)=O NRUHHOVQAIAJLM-UHFFFAOYSA-N 0.000 description 1
- NAVSGTUNFADZMR-UHFFFAOYSA-N CC(C)N1CC(C(N(CC2)CCN2c2n[nH]c(-c3cc(C=C)cc(Cl)c3)c2)=O)NCC1 Chemical compound CC(C)N1CC(C(N(CC2)CCN2c2n[nH]c(-c3cc(C=C)cc(Cl)c3)c2)=O)NCC1 NAVSGTUNFADZMR-UHFFFAOYSA-N 0.000 description 1
- VTHZDAFPOSMJMY-UHFFFAOYSA-N CC(C)N1CC(C(N(CC2)CCN2c2n[nH]c(-c3cc(Cl)cc(Cl)c3)c2)=O)OCC1 Chemical compound CC(C)N1CC(C(N(CC2)CCN2c2n[nH]c(-c3cc(Cl)cc(Cl)c3)c2)=O)OCC1 VTHZDAFPOSMJMY-UHFFFAOYSA-N 0.000 description 1
- NQXZAUNUYSPZCA-XRWIVYGQSA-N CC(CCC1)CN1[C@H](CC1)CC[C@]1(c(cc1)cnc1OC)O Chemical compound CC(CCC1)CN1[C@H](CC1)CC[C@]1(c(cc1)cnc1OC)O NQXZAUNUYSPZCA-XRWIVYGQSA-N 0.000 description 1
- PHNFCQMBGZQDLX-UHFFFAOYSA-N CC1CN(CC(CC2)CCC2(c(cc2)cnc2OC)O)CCC1 Chemical compound CC1CN(CC(CC2)CCC2(c(cc2)cnc2OC)O)CCC1 PHNFCQMBGZQDLX-UHFFFAOYSA-N 0.000 description 1
- ZVAZLNQNANWZDB-UHFFFAOYSA-N CC1CN(Cc2ccc(cc[nH]3)c3c2)CCC1 Chemical compound CC1CN(Cc2ccc(cc[nH]3)c3c2)CCC1 ZVAZLNQNANWZDB-UHFFFAOYSA-N 0.000 description 1
- 0 CCc1ccc(C*2CCCCC2)cc1 Chemical compound CCc1ccc(C*2CCCCC2)cc1 0.000 description 1
- TZIMSHYSZIQBMK-UHFFFAOYSA-N CN(C)CCNC(CC1)CCN1c1ccc(-c(cc2Cl)ccc2Cl)nn1 Chemical compound CN(C)CCNC(CC1)CCN1c1ccc(-c(cc2Cl)ccc2Cl)nn1 TZIMSHYSZIQBMK-UHFFFAOYSA-N 0.000 description 1
- XHDCUCTVUKCSPL-UHFFFAOYSA-N CSC(SC)=CC(c(cc1Cl)ccc1Cl)=O Chemical compound CSC(SC)=CC(c(cc1Cl)ccc1Cl)=O XHDCUCTVUKCSPL-UHFFFAOYSA-N 0.000 description 1
- UGXNHQRUQGXTQA-UHFFFAOYSA-N Clc(cc1)c(C2CC2)cc1-c1cc(N2CCN(CC(C3)OCCN3C3CCCCC3)CC2)n[nH]1 Chemical compound Clc(cc1)c(C2CC2)cc1-c1cc(N2CCN(CC(C3)OCCN3C3CCCCC3)CC2)n[nH]1 UGXNHQRUQGXTQA-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07109376 | 2007-05-31 | ||
| EP07109376.9 | 2007-05-31 | ||
| PCT/EP2008/056573 WO2008145681A2 (en) | 2007-05-31 | 2008-05-29 | Ccr2 receptor antagonists and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010528089A JP2010528089A (ja) | 2010-08-19 |
| JP2010528089A5 JP2010528089A5 (https=) | 2011-07-14 |
| JP5603770B2 true JP5603770B2 (ja) | 2014-10-08 |
Family
ID=38752546
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010509818A Active JP5603770B2 (ja) | 2007-05-31 | 2008-05-29 | Ｃｃｒ２受容体拮抗薬およびその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8653262B2 (https=) |
| EP (1) | EP2155689B1 (https=) |
| JP (1) | JP5603770B2 (https=) |
| AR (1) | AR066799A1 (https=) |
| CA (1) | CA2687931C (https=) |
| CL (1) | CL2008001593A1 (https=) |
| TW (1) | TW200904434A (https=) |
| WO (1) | WO2008145681A2 (https=) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP2455382B1 (en) | 2005-12-13 | 2016-10-26 | Incyte Holdings Corporation | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors |
| DE102006039003A1 (de) | 2006-08-19 | 2008-02-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Verbindungen |
| CA2687931C (en) | 2007-05-31 | 2016-05-24 | Boehringer Ingelheim International Gmbh | Ccr2 receptor antagonists and uses thereof |
| EP3070090B1 (en) | 2007-06-13 | 2018-12-12 | Incyte Holdings Corporation | Use of salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h- pyrazol-1-yl)-3- cyclopentylpropanenitrile |
| CN101821245B (zh) | 2007-08-14 | 2012-10-10 | 贝林格尔·英格海姆国际有限公司 | 化合物 |
| EP2025675A1 (de) | 2007-08-14 | 2009-02-18 | Boehringer Ingelheim International GmbH | Arylsulfonamide mit analgetischer Wirkung |
| US20100331298A1 (en) * | 2007-12-10 | 2010-12-30 | Cytopathfinder, Inc. | Carboxamide Compounds and Their Use |
| US20110301350A1 (en) * | 2008-08-12 | 2011-12-08 | Boehringer Ingelheim International Gmbh | Process for preparing cycloalkyl-substituted piperazine compounds |
| EP2352501B1 (en) * | 2008-11-03 | 2014-01-01 | ChemoCentryx, Inc. | Compounds for use in the treatment of osteoporosis |
| HUE025547T2 (en) | 2008-12-19 | 2016-02-29 | Boehringer Ingelheim Int | Cyclic pyrimidine-4-carboxamides as CCR2 receptor antagonists for the treatment of inflammation, asthma and COPD |
| SG176111A1 (en) | 2009-05-22 | 2011-12-29 | Incyte Corp | 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors |
| JP5775070B2 (ja) | 2009-05-22 | 2015-09-09 | インサイト・コーポレイションＩｎｃｙｔｅ Ｃｏｒｐｏｒａｔｉｏｎ | ヤヌスキナーゼ阻害剤としてのピラゾール−４−イル−ピロロ［２，３−ｄ］ピリミジンおよびピロール−３−イル−ピロロ［２，３−ｄ］ピリミジンのＮ−（ヘテロ）アリール−ピロリジン誘導体 |
| AR078012A1 (es) | 2009-09-01 | 2011-10-05 | Incyte Corp | Derivados heterociclicos de las pirazol-4-il- pirrolo (2,3-d) pirimidinas como inhibidores de la quinasa janus |
| ES2674275T3 (es) | 2009-12-17 | 2018-06-28 | Centrexion Therapeutics Corporation | Antagonistas del receptor CCR2 y usos de los mismos |
| PT3354652T (pt) | 2010-03-10 | 2020-07-20 | Incyte Holdings Corp | Derivados de piperidin-4-ilazetidina como inibidores de jak1 |
| EP2569298B1 (en) * | 2010-05-12 | 2015-11-25 | Boehringer Ingelheim International GmbH | Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments |
| WO2011141477A1 (en) | 2010-05-12 | 2011-11-17 | Boehringer Ingelheim International Gmbh | New ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments |
| WO2011144501A1 (en) | 2010-05-17 | 2011-11-24 | Boehringer Ingelheim International Gmbh | Ccr2 antagonists and uses thereof |
| RS54824B1 (sr) | 2010-05-21 | 2016-10-31 | Incyte Holdings Corp | Topikalna formulacija za inhibiciju jak-a |
| EP2576542B1 (en) * | 2010-05-25 | 2015-04-22 | Boehringer Ingelheim International GmbH | Cyclic amide derivatives of pyridazine-3-carboxylic acids and their use in the treatment of pulmonary, pain, immune related and cardiovascular diseases |
| EP2576538B1 (en) | 2010-06-01 | 2015-10-28 | Boehringer Ingelheim International GmbH | New CCR2 antagonists |
| AU2011261375B2 (en) | 2010-06-04 | 2016-09-22 | Albany Molecular Research, Inc. | Glycine transporter-1 inhibitors, methods of making them, and uses thereof |
| CA2818542A1 (en) | 2010-11-19 | 2012-05-24 | Incyte Corporation | Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors |
| WO2012068440A1 (en) | 2010-11-19 | 2012-05-24 | Incyte Corporation | Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors |
| EP2707367B1 (en) * | 2011-05-12 | 2019-10-09 | Bionomics Limited | Methods for preparing naphthyridines |
| MY165963A (en) | 2011-06-20 | 2018-05-18 | Incyte Holdings Corp | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors |
| EP2731941B1 (en) | 2011-07-15 | 2019-05-08 | Boehringer Ingelheim International GmbH | Novel and selective ccr2 antagonists |
| TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | 作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物 |
| UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
| CA2852160A1 (en) | 2011-10-28 | 2013-05-02 | Galderma Research & Development | New leukocyte infiltrate markers for rosacea and uses thereof |
| TW201406761A (zh) | 2012-05-18 | 2014-02-16 | Incyte Corp | 做爲ｊａｋ抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物 |
| CN113384546A (zh) | 2012-11-15 | 2021-09-14 | 因赛特公司 | 鲁索利替尼的缓释剂型 |
| WO2014138168A1 (en) | 2013-03-06 | 2014-09-12 | Incyte Corporation | Processes and intermediates for making a jak inhibitor |
| WO2014169087A2 (en) * | 2013-04-10 | 2014-10-16 | The Trustees Of Columbia University In The City Of New York | Treatment of proximal spinal muscular atrophy |
| GB201309508D0 (en) | 2013-05-28 | 2013-07-10 | Redx Pharma Ltd | Compounds |
| GB201311953D0 (en) * | 2013-07-03 | 2013-08-14 | Redx Pharma Ltd | Compounds |
| SG10201801069QA (en) | 2013-08-07 | 2018-03-28 | Incyte Corp | Sustained release dosage forms for a jak1 inhibitor |
| US9498467B2 (en) | 2014-05-30 | 2016-11-22 | Incyte Corporation | Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1 |
| EP3256126B1 (en) * | 2015-02-09 | 2024-03-27 | F. Hoffmann-La Roche AG | Compounds for the treatment of cancer |
| EP3053577A1 (en) * | 2015-02-09 | 2016-08-10 | F. Hoffmann-La Roche AG | Compounds for the treatment of cancer |
| MX383744B (es) | 2015-07-02 | 2025-03-14 | Centrexion Therapeutics Corp | Citrato de (4-((3r,4r)-3-metoxitetrahidro-piran-4-ilamino)piperidin-1-il) (5-metil-6-(((2r, 6s)-6-(p-tolil)tetrahidro-2h-piran-2-il) metilamino) pirimidin-4-il) metanona. |
| CN112480005B (zh) * | 2017-11-08 | 2022-08-19 | 北京嘉林药业股份有限公司 | 化合物及其治疗癌症的用途 |
| AR113922A1 (es) | 2017-12-08 | 2020-07-01 | Incyte Corp | Terapia de combinación de dosis baja para el tratamiento de neoplasias mieloproliferativas |
| EA202091830A1 (ru) | 2018-01-30 | 2020-12-29 | Инсайт Корпорейшн | Способы и промежуточные соединения для получения ингибитора jak |
| MD3773593T2 (ro) | 2018-03-30 | 2024-10-31 | Incyte Corp | Tratament hidradenitei supurative utilizând inhibitori ai JAK |
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- 2008-05-29 CA CA2687931A patent/CA2687931C/en active Active
- 2008-05-29 JP JP2010509818A patent/JP5603770B2/ja active Active
- 2008-05-29 US US12/602,274 patent/US8653262B2/en active Active
- 2008-05-29 WO PCT/EP2008/056573 patent/WO2008145681A2/en not_active Ceased
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|---|---|
| CL2008001593A1 (es) | 2009-09-11 |
| US8653262B2 (en) | 2014-02-18 |
| EP2155689B1 (en) | 2015-07-08 |
| CA2687931A1 (en) | 2008-12-04 |
| TW200904434A (en) | 2009-02-01 |
| JP2010528089A (ja) | 2010-08-19 |
| EP2155689A2 (en) | 2010-02-24 |
| WO2008145681A2 (en) | 2008-12-04 |
| CA2687931C (en) | 2016-05-24 |
| US20100204209A1 (en) | 2010-08-12 |
| WO2008145681A3 (en) | 2009-03-05 |
| AR066799A1 (es) | 2009-09-16 |
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