JP5602625B2 - 結合物質のディスプレイ - Google Patents

結合物質のディスプレイ Download PDF

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Publication number
JP5602625B2
JP5602625B2 JP2010513575A JP2010513575A JP5602625B2 JP 5602625 B2 JP5602625 B2 JP 5602625B2 JP 2010513575 A JP2010513575 A JP 2010513575A JP 2010513575 A JP2010513575 A JP 2010513575A JP 5602625 B2 JP5602625 B2 JP 5602625B2
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binding
antibody
library
cells
modular
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Japanese (ja)
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JP2010531144A5 (https=
JP2010531144A (ja
Inventor
ヒムラー ゴットフリード
リューカー フローリアン
ウォズニアク−クノップ ゴルダナ
ムッデ ヘールト
レードル ゲルダ
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F Star Biotechnologische Forschungs und Entwicklungsges mbH
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F Star Biotechnologische Forschungs und Entwicklungsges mbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/6857—Antibody fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/10—Immunoglobulin or domain(s) thereof as scaffolds for inserted non-Ig peptide sequences, e.g. for vaccination purposes
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2010513575A 2007-06-26 2008-06-26 結合物質のディスプレイ Active JP5602625B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US94628707P 2007-06-26 2007-06-26
US60/946,287 2007-06-26
US4982608P 2008-05-02 2008-05-02
US61/049,826 2008-05-02
PCT/AT2008/000232 WO2009000006A1 (en) 2007-06-26 2008-06-26 Display of binding agents

Publications (3)

Publication Number Publication Date
JP2010531144A JP2010531144A (ja) 2010-09-24
JP2010531144A5 JP2010531144A5 (https=) 2011-05-19
JP5602625B2 true JP5602625B2 (ja) 2014-10-08

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010513575A Active JP5602625B2 (ja) 2007-06-26 2008-06-26 結合物質のディスプレイ

Country Status (9)

Country Link
US (3) US8921279B2 (https=)
EP (2) EP3241842B1 (https=)
JP (1) JP5602625B2 (https=)
CN (1) CN101802006B (https=)
DK (1) DK2158220T3 (https=)
ES (2) ES2975748T3 (https=)
HU (1) HUE066143T2 (https=)
PL (1) PL3241842T3 (https=)
WO (1) WO2009000006A1 (https=)

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US8921279B2 (en) 2014-12-30
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US20170247432A1 (en) 2017-08-31
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EP3241842C0 (en) 2024-01-31
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