JP2010531144A5 - - Google Patents
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- JP2010531144A5 JP2010531144A5 JP2010513575A JP2010513575A JP2010531144A5 JP 2010531144 A5 JP2010531144 A5 JP 2010531144A5 JP 2010513575 A JP2010513575 A JP 2010513575A JP 2010513575 A JP2010513575 A JP 2010513575A JP 2010531144 A5 JP2010531144 A5 JP 2010531144A5
- Authority
- JP
- Japan
- Prior art keywords
- library
- target
- binds
- modular antibody
- affinity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims 10
- 239000003446 ligand Substances 0.000 claims 8
- 239000012636 effector Substances 0.000 claims 4
- 230000035772 mutation Effects 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- 108010087819 Fc receptors Proteins 0.000 claims 2
- 102000009109 Fc receptors Human genes 0.000 claims 2
- 102100026122 High affinity immunoglobulin gamma Fc receptor I Human genes 0.000 claims 2
- 101000913074 Homo sapiens High affinity immunoglobulin gamma Fc receptor I Proteins 0.000 claims 2
- 101000917826 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor II-a Proteins 0.000 claims 2
- 101000917824 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor II-b Proteins 0.000 claims 2
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 2
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 claims 2
- 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 claims 2
- 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 claims 2
- 102100029204 Low affinity immunoglobulin gamma Fc region receptor II-a Human genes 0.000 claims 2
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 230000002068 genetic effect Effects 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 101710117290 Aldo-keto reductase family 1 member C4 Proteins 0.000 claims 1
- 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 claims 1
- 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 102000007562 Serum Albumin Human genes 0.000 claims 1
- 108010071390 Serum Albumin Proteins 0.000 claims 1
- 101710120037 Toxin CcdB Proteins 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 108010026228 mRNA guanylyltransferase Proteins 0.000 claims 1
- 238000002823 phage display Methods 0.000 claims 1
- 238000002818 protein evolution Methods 0.000 claims 1
- 238000002708 random mutagenesis Methods 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 238000002741 site-directed mutagenesis Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94628707P | 2007-06-26 | 2007-06-26 | |
| US60/946,287 | 2007-06-26 | ||
| US4982608P | 2008-05-02 | 2008-05-02 | |
| US61/049,826 | 2008-05-02 | ||
| PCT/AT2008/000232 WO2009000006A1 (en) | 2007-06-26 | 2008-06-26 | Display of binding agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010531144A JP2010531144A (ja) | 2010-09-24 |
| JP2010531144A5 true JP2010531144A5 (https=) | 2011-05-19 |
| JP5602625B2 JP5602625B2 (ja) | 2014-10-08 |
Family
ID=39791174
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010513575A Active JP5602625B2 (ja) | 2007-06-26 | 2008-06-26 | 結合物質のディスプレイ |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US8921279B2 (https=) |
| EP (2) | EP3241842B1 (https=) |
| JP (1) | JP5602625B2 (https=) |
| CN (1) | CN101802006B (https=) |
| DK (1) | DK2158220T3 (https=) |
| ES (2) | ES2975748T3 (https=) |
| HU (1) | HUE066143T2 (https=) |
| PL (1) | PL3241842T3 (https=) |
| WO (1) | WO2009000006A1 (https=) |
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-
2008
- 2008-06-26 EP EP17159886.5A patent/EP3241842B1/en active Active
- 2008-06-26 WO PCT/AT2008/000232 patent/WO2009000006A1/en not_active Ceased
- 2008-06-26 PL PL17159886.5T patent/PL3241842T3/pl unknown
- 2008-06-26 HU HUE17159886A patent/HUE066143T2/hu unknown
- 2008-06-26 DK DK08756842.4T patent/DK2158220T3/en active
- 2008-06-26 US US12/666,618 patent/US8921279B2/en active Active
- 2008-06-26 CN CN2008801048918A patent/CN101802006B/zh active Active
- 2008-06-26 ES ES17159886T patent/ES2975748T3/es active Active
- 2008-06-26 ES ES08756842.4T patent/ES2627223T3/es active Active
- 2008-06-26 EP EP08756842.4A patent/EP2158220B1/en active Active
- 2008-06-26 JP JP2010513575A patent/JP5602625B2/ja active Active
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2014
- 2014-12-01 US US14/556,662 patent/US9651559B2/en active Active
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2017
- 2017-05-16 US US15/596,596 patent/US20170247432A1/en not_active Abandoned
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