JP2009524422A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009524422A5 JP2009524422A5 JP2008551872A JP2008551872A JP2009524422A5 JP 2009524422 A5 JP2009524422 A5 JP 2009524422A5 JP 2008551872 A JP2008551872 A JP 2008551872A JP 2008551872 A JP2008551872 A JP 2008551872A JP 2009524422 A5 JP2009524422 A5 JP 2009524422A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- binding
- terminal
- domain
- binding complex
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 34
- 229920001184 polypeptide Polymers 0.000 claims 33
- 102000004196 processed proteins & peptides Human genes 0.000 claims 33
- 238000006471 dimerization reaction Methods 0.000 claims 9
- 108091033319 polynucleotide Proteins 0.000 claims 7
- 102000040430 polynucleotide Human genes 0.000 claims 7
- 239000002157 polynucleotide Substances 0.000 claims 7
- 239000013598 vector Substances 0.000 claims 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
- 239000013604 expression vector Substances 0.000 claims 4
- 239000012636 effector Substances 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 108060003951 Immunoglobulin Proteins 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 102000018358 immunoglobulin Human genes 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 102000009027 Albumins Human genes 0.000 claims 1
- 108010088751 Albumins Proteins 0.000 claims 1
- 102000004506 Blood Proteins Human genes 0.000 claims 1
- 108010017384 Blood Proteins Proteins 0.000 claims 1
- 108091026890 Coding region Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000000032 diagnostic agent Substances 0.000 claims 1
- 229940039227 diagnostic agent Drugs 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 239000000833 heterodimer Substances 0.000 claims 1
- 239000000710 homodimer Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- 230000003285 pharmacodynamic effect Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000000018 receptor agonist Substances 0.000 claims 1
- 229940044601 receptor agonist Drugs 0.000 claims 1
- 239000002464 receptor antagonist Substances 0.000 claims 1
- 229940044551 receptor antagonist Drugs 0.000 claims 1
- 230000001131 transforming effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0601513.5A GB0601513D0 (en) | 2006-01-25 | 2006-01-25 | Binding molecules 3 |
| PCT/GB2007/000258 WO2007085837A1 (en) | 2006-01-25 | 2007-01-25 | Binding molecules |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009524422A JP2009524422A (ja) | 2009-07-02 |
| JP2009524422A5 true JP2009524422A5 (https=) | 2010-03-11 |
Family
ID=36060850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008551872A Pending JP2009524422A (ja) | 2006-01-25 | 2007-01-25 | 結合分子３ |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20090169548A1 (https=) |
| EP (1) | EP1989229A1 (https=) |
| JP (1) | JP2009524422A (https=) |
| KR (1) | KR20080106201A (https=) |
| CN (1) | CN101472946A (https=) |
| AU (1) | AU2007209130A1 (https=) |
| BR (1) | BRPI0706737A2 (https=) |
| CA (1) | CA2637945A1 (https=) |
| GB (1) | GB0601513D0 (https=) |
| RU (1) | RU2008134519A (https=) |
| TW (1) | TW200808824A (https=) |
| WO (1) | WO2007085837A1 (https=) |
| ZA (1) | ZA200806492B (https=) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2535349A1 (en) | 2007-09-26 | 2012-12-19 | UCB Pharma S.A. | Dual specificity antibody fusions |
| CA2737241C (en) | 2008-09-26 | 2017-08-29 | Ucb Pharma S.A. | Multivalent antibody fusion proteins |
| SG175077A1 (en) | 2009-04-07 | 2011-11-28 | Roche Glycart Ag | Trivalent, bispecific antibodies |
| US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
| DK3622815T3 (da) | 2009-07-08 | 2023-06-26 | Kymab Ltd | Gnavermodeller og terapeutiske molekyler |
| US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
| EP2478013B1 (en) | 2009-09-16 | 2018-10-24 | F.Hoffmann-La Roche Ag | Coiled coil and/or tether containing protein complexes and uses thereof |
| CN103068846B9 (zh) | 2010-08-24 | 2016-09-28 | 弗·哈夫曼-拉罗切有限公司 | 包含二硫键稳定性Fv片段的双特异性抗体 |
| MX342034B (es) | 2011-02-28 | 2016-09-12 | Hoffmann La Roche | Proteinas monovalentes que se unen a antigenos. |
| AR085404A1 (es) | 2011-02-28 | 2013-09-25 | Hoffmann La Roche | Proteinas de union a antigeno |
| BR112014006394A2 (pt) | 2011-09-19 | 2017-03-28 | Kymab Ltd | manipulação de diversidade genética de imunoglobulina e terapêuticos multi-anticorpos |
| WO2013045916A1 (en) | 2011-09-26 | 2013-04-04 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
| WO2013048243A1 (en) | 2011-09-29 | 2013-04-04 | Apo-T B.V. | Multi-specific binding molecules targeting aberrant cells |
| SG11201401422VA (en) * | 2011-10-27 | 2014-09-26 | Genmab As | Production of heterodimeric proteins |
| US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
| CA2860914A1 (en) | 2012-01-13 | 2013-07-18 | Apo-T B.V. | Aberrant cell-restricted immunoglobulins provided with a toxic moiety |
| US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
| GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| CN102851338A (zh) * | 2012-07-25 | 2013-01-02 | 苏州康宁杰瑞生物科技有限公司 | 利用电荷排斥作用制备同二聚体蛋白混合物的方法 |
| US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
| US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| GB2518221A (en) * | 2013-09-16 | 2015-03-18 | Sergej Michailovic Kiprijanov | Tetravalent antigen-binding protein molecule |
| AU2014330922A1 (en) | 2013-10-01 | 2016-03-03 | Kymab Limited | Animal models and therapeutic molecules |
| BR112016006929A2 (pt) | 2013-10-11 | 2017-09-19 | Hoffmann La Roche | Anticorpo, ácido nucleico, vetor de expressão, célula hospedeira, métodos de preparação de anticorpo, de tratamento de pacientes e de geração de um anticorpo, composição farmacêutica e uso do anticorpo |
| GB201409558D0 (en) | 2014-05-29 | 2014-07-16 | Ucb Biopharma Sprl | Method |
| GB201412659D0 (en) | 2014-07-16 | 2014-08-27 | Ucb Biopharma Sprl | Molecules |
| GB201412658D0 (en) | 2014-07-16 | 2014-08-27 | Ucb Biopharma Sprl | Molecules |
| EP3227332B1 (en) | 2014-12-03 | 2019-11-06 | F.Hoffmann-La Roche Ag | Multispecific antibodies |
| GB201601073D0 (en) | 2016-01-20 | 2016-03-02 | Ucb Biopharma Sprl | Antibodies |
| GB201601077D0 (en) | 2016-01-20 | 2016-03-02 | Ucb Biopharma Sprl | Antibody molecule |
| GB201601075D0 (en) | 2016-01-20 | 2016-03-02 | Ucb Biopharma Sprl | Antibodies molecules |
| EP3356415B1 (en) | 2015-09-29 | 2024-05-01 | Amgen Inc. | Asgr inhibitors for reduzing cholesterol levels |
| GB201521389D0 (en) | 2015-12-03 | 2016-01-20 | Ucb Biopharma Sprl | Method |
| GB201521382D0 (en) | 2015-12-03 | 2016-01-20 | Ucb Biopharma Sprl | Antibodies |
| GB201521393D0 (en) | 2015-12-03 | 2016-01-20 | Ucb Biopharma Sprl | Antibodies |
| GB201521383D0 (en) | 2015-12-03 | 2016-01-20 | Ucb Biopharma Sprl And Ucb Celltech | Method |
| GB201521391D0 (en) | 2015-12-03 | 2016-01-20 | Ucb Biopharma Sprl | Antibodies |
| EP3692061A1 (en) | 2017-10-04 | 2020-08-12 | Amgen Inc. | Transthyretin immunoglobulin fusions |
| GB2576914A (en) | 2018-09-06 | 2020-03-11 | Kymab Ltd | Antigen-binding molecules comprising unpaired variable domains produced in mammals |
| MA56110A (fr) | 2019-06-07 | 2022-04-13 | Amgen Inc | Constructions de liaison bispécifiques à lieurs clivables de manière sélective |
| CN113461824A (zh) * | 2020-03-31 | 2021-10-01 | 普米斯生物技术(珠海)有限公司 | 一种构建多特异性抗体的平台 |
| EP4161969A1 (en) | 2020-06-04 | 2023-04-12 | Amgen Inc. | Bispecific binding constructs |
| US20250277024A1 (en) | 2020-12-03 | 2025-09-04 | Amgen Inc. | Molecules with multiple binding domains |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ121599A3 (cs) * | 1998-04-09 | 1999-10-13 | Aventis Pharma Deutschland Gmbh | Jednořetězcová molekula vázající několik antigenů, způsob její přípravy a léčivo obsahující tuto molekulu |
| CA2410551A1 (en) * | 2000-06-30 | 2002-01-10 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw (Vib) | Heterodimeric fusion proteins |
| EP1558645B1 (en) * | 2002-11-08 | 2011-07-27 | Ablynx N.V. | Stabilized single domain antibodies in pharmaceutical composition adapted for inhalation |
| KR101151957B1 (ko) * | 2004-07-22 | 2012-06-01 | 로저 킹돈 크레이그 | 결합 분자 |
| US7612181B2 (en) * | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
-
2006
- 2006-01-25 GB GBGB0601513.5A patent/GB0601513D0/en not_active Ceased
-
2007
- 2007-01-25 CA CA002637945A patent/CA2637945A1/en not_active Abandoned
- 2007-01-25 RU RU2008134519/13A patent/RU2008134519A/ru not_active Application Discontinuation
- 2007-01-25 KR KR1020087020710A patent/KR20080106201A/ko not_active Withdrawn
- 2007-01-25 JP JP2008551872A patent/JP2009524422A/ja active Pending
- 2007-01-25 ZA ZA200806492A patent/ZA200806492B/xx unknown
- 2007-01-25 US US12/161,986 patent/US20090169548A1/en not_active Abandoned
- 2007-01-25 AU AU2007209130A patent/AU2007209130A1/en not_active Abandoned
- 2007-01-25 TW TW096102902A patent/TW200808824A/zh unknown
- 2007-01-25 WO PCT/GB2007/000258 patent/WO2007085837A1/en not_active Ceased
- 2007-01-25 BR BRPI0706737-2A patent/BRPI0706737A2/pt not_active IP Right Cessation
- 2007-01-25 CN CNA200780010769XA patent/CN101472946A/zh active Pending
- 2007-01-25 EP EP07705029A patent/EP1989229A1/en not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009524422A5 (https=) | ||
| JP7703486B2 (ja) | Ｔｃｒライブラリ | |
| JP2020517294A5 (https=) | ||
| Lu et al. | Di-diabody: a novel tetravalent bispecific antibody molecule by design | |
| JP5150488B2 (ja) | Ｆｃ領域含有タンパク質を精製する方法 | |
| IL275743A (en) | New bispecific format suitable for use in high-through-put screening | |
| JP2019068822A5 (https=) | ||
| JP2021042257A5 (https=) | ||
| JP2011526794A5 (https=) | ||
| JP2010511397A5 (https=) | ||
| JP2020515518A5 (https=) | ||
| CA2468583A1 (en) | Self-assembling multimeric binding complexes derived from ab5 toxin family members | |
| JP2020506898A5 (https=) | ||
| JP2016527314A5 (https=) | ||
| JP2018537421A5 (https=) | ||
| JP2019500862A5 (https=) | ||
| HRP20140760T1 (hr) | Citotoksiäśni imunoglobulin | |
| JP2010531144A5 (https=) | ||
| JP2014525735A5 (https=) | ||
| JP2011526792A5 (https=) | ||
| RU2015152077A (ru) | Тримерные антигенсвязывающие молекулы | |
| JP2005506064A5 (https=) | ||
| WO2009010539A2 (en) | Receptor for interleukin-6 (il-6) from macaca fascicularis | |
| JP2013163673A5 (https=) | ||
| JP2022523710A5 (https=) |