JP5592348B2 - Ａｍｐにより活性化されたプロテインキナーゼ（ａｍｐｋ）アクチベーターとしてのチエノピリドン誘導体 - Google Patents
Ａｍｐにより活性化されたプロテインキナーゼ（ａｍｐｋ）アクチベーターとしてのチエノピリドン誘導体 Download PDFInfo
- Publication number
- JP5592348B2 JP5592348B2 JP2011503353A JP2011503353A JP5592348B2 JP 5592348 B2 JP5592348 B2 JP 5592348B2 JP 2011503353 A JP2011503353 A JP 2011503353A JP 2011503353 A JP2011503353 A JP 2011503353A JP 5592348 B2 JP5592348 B2 JP 5592348B2
- Authority
- JP
- Japan
- Prior art keywords
- hydroxy
- pyridin
- dihydro
- thieno
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08290364 | 2008-04-11 | ||
| EP08290364.2 | 2008-04-11 | ||
| PCT/EP2009/001937 WO2009124636A1 (en) | 2008-04-11 | 2009-03-17 | Thienopyridone derivatives as amp-activated protein kinase (ampk) activators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011516510A JP2011516510A (ja) | 2011-05-26 |
| JP2011516510A5 JP2011516510A5 (cg-RX-API-DMAC7.html) | 2012-05-17 |
| JP5592348B2 true JP5592348B2 (ja) | 2014-09-17 |
Family
ID=40671017
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011503353A Expired - Fee Related JP5592348B2 (ja) | 2008-04-11 | 2009-03-17 | Ａｍｐにより活性化されたプロテインキナーゼ（ａｍｐｋ）アクチベーターとしてのチエノピリドン誘導体 |
Country Status (25)
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20120549T1 (hr) * | 2008-05-05 | 2012-07-31 | Merck@Patent@GmbH | Derivati tienopiridona kao amp aktivirani aktivatori protein kinaze ampk |
| DK2519527T3 (da) * | 2009-12-29 | 2014-01-27 | Poxel | Thieno[2,3-b]pyridindion-aktivatorer af ampk og terapeutiske anvendelser deraf |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2552435A1 (en) | 2010-04-02 | 2013-02-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions comprising ampk activator (metformin/troglitazone) for the treatment of myotonic dystrophy type 1 (dm1) |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| JP5990170B2 (ja) * | 2010-09-01 | 2016-09-07 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | 除草活性を有するケトスルタム類及びジケトピリジン類 |
| EP2683690A1 (en) * | 2011-03-07 | 2014-01-15 | GlaxoSmithKline LLC | Quinolinone derivatives |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
| EP2679591A1 (en) | 2012-06-29 | 2014-01-01 | Poxel | Thienopyridone derivatives useful as activators of AMPK |
| EP2970177A1 (en) | 2013-03-15 | 2016-01-20 | Pfizer Inc. | Indole compounds that activate ampk |
| US9827222B2 (en) * | 2013-07-01 | 2017-11-28 | Emory University | Treating or preventing nephrogenic diabetes insipidus |
| WO2015103480A1 (en) | 2014-01-02 | 2015-07-09 | Massachusetts Eye & Ear Infirmary | Treating ocular neovascularization |
| CN104945369A (zh) * | 2015-06-23 | 2015-09-30 | 佛山市赛维斯医药科技有限公司 | 一种含六甲基苯环和硝基苯结构的黄原酸酯类化合物、其制备方法及用途 |
| CN104892569A (zh) * | 2015-06-23 | 2015-09-09 | 佛山市赛维斯医药科技有限公司 | 末端取代的硝苯六甲苯黄原酸酯类的化合物、制备方法及用途 |
| CN105037321A (zh) * | 2015-06-23 | 2015-11-11 | 佛山市赛维斯医药科技有限公司 | 含六甲基苯环的黄原酸酯类的ampk激活剂、制备方法及用途 |
| CN105037322A (zh) * | 2015-06-23 | 2015-11-11 | 佛山市赛维斯医药科技有限公司 | 含六甲基苯环和烷氧苯结构的黄原酸酯类化合物、其制备方法及用途 |
| CN104945370A (zh) * | 2015-06-23 | 2015-09-30 | 佛山市赛维斯医药科技有限公司 | 含卤代噻吩和硝苯六甲苯结构的黄原酸酯类化合物、制备方法及用途 |
| CN104892568A (zh) * | 2015-06-23 | 2015-09-09 | 佛山市赛维斯医药科技有限公司 | 一种含六甲基苯环和腈基苯结构的黄原酸酯类化合物、其制备方法及用途 |
| CN105037296A (zh) * | 2015-06-24 | 2015-11-11 | 佛山市赛维斯医药科技有限公司 | 一类卤代苯双酰基苄胺类的ampk激活剂、其制备方法及用途 |
| CN104926757A (zh) * | 2015-06-24 | 2015-09-23 | 佛山市赛维斯医药科技有限公司 | 含烷氧苯基的双酰基苄胺类ampk激活剂、其制备方法及用途 |
| CN104926755A (zh) * | 2015-06-24 | 2015-09-23 | 佛山市赛维斯医药科技有限公司 | 硝苯双酰基苄胺类ampk激活剂、其制备方法及用途 |
| CN104926756A (zh) * | 2015-06-24 | 2015-09-23 | 佛山市赛维斯医药科技有限公司 | 一类含腈基苯的双酰基苄胺类化合物、其制备方法及用途 |
| CN105001181A (zh) * | 2015-06-24 | 2015-10-28 | 佛山市赛维斯医药科技有限公司 | 一类双酰基苄胺类的ampk激活剂、其制备方法及用途 |
| CN104945372A (zh) * | 2015-06-24 | 2015-09-30 | 佛山市赛维斯医药科技有限公司 | 一种含二硝基以及六甲苯结构的黄原酸酯类化合物、制备方法及用途 |
| CN105001194A (zh) * | 2015-06-24 | 2015-10-28 | 佛山市赛维斯医药科技有限公司 | 一种含氨基噻吩以及六甲苯结构的黄原酸酯类化合物、制备方法及用途 |
| CN104945371A (zh) * | 2015-06-24 | 2015-09-30 | 佛山市赛维斯医药科技有限公司 | 一种含腈基噻吩以及六甲苯结构的黄原酸酯类化合物、制备方法及用途 |
| MA42456B1 (fr) * | 2015-06-25 | 2021-06-30 | Univ Health Network | Inhibiteurs de hpk1 et leurs procédés d'utilisation |
| US20190054096A1 (en) | 2015-09-30 | 2019-02-21 | Instituto De Medicina Molecular | Methods for attenuating parasite virulence |
| WO2018002215A1 (en) | 2016-06-30 | 2018-01-04 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of cardiomyopathies |
| MX2021005772A (es) * | 2018-11-16 | 2021-10-13 | Poxel | Sal de monohidrato potasico de un derivado de tienopiridona y su proceso de preparacion. |
| WO2020201263A1 (en) | 2019-04-01 | 2020-10-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment and prevention of cardiac remodeling |
| AU2021244824A1 (en) | 2020-03-26 | 2022-10-27 | Poxel | Use of a thienopyridone derivative in the treatment of adrenoleukodystrophy or adrenomyeloneuropathy |
| BR112022019403A2 (pt) * | 2020-04-02 | 2022-12-06 | Poxel | Uso de um derivado de tienopiridona no tratamento de doença renal policística autossômica dominante (drpad) |
| WO2021236617A1 (en) | 2020-05-19 | 2021-11-25 | Kallyope, Inc. | Ampk activators |
| CN116390925A (zh) | 2020-06-26 | 2023-07-04 | 卡尔优普公司 | Ampk活化剂 |
| EP4221700A1 (en) | 2020-09-30 | 2023-08-09 | Bioverativ Therapeutics Inc. | Ampk activators and methods of use thereof |
| WO2022106892A1 (en) | 2020-11-17 | 2022-05-27 | Instituto De Medicina Molecular | Anti-malarial compounds |
| JP2024540522A (ja) | 2021-11-19 | 2024-10-31 | ザ・ブロード・インスティテュート・インコーポレイテッド | キナーゼを標的結合部分で標識するための二官能性キメラ分子及びその使用方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ233641A (en) | 1989-05-16 | 1992-07-28 | Merrell Dow Pharma | Quinoline and thienopyridine derivatives and excitatory amino acid antagonistic pharmaceutical compositions |
| DE4444815A1 (de) | 1994-12-15 | 1996-06-20 | Merck Patent Gmbh | Thienopyridone |
| GB0214268D0 (en) * | 2002-06-20 | 2002-07-31 | Celltech R&D Ltd | Chemical compounds |
| US7119205B2 (en) * | 2003-05-16 | 2006-10-10 | Abbott Laboratories | Thienopyridones as AMPK activators for the treatment of diabetes and obesity |
| EP1754483A1 (en) * | 2005-08-18 | 2007-02-21 | Merck Sante | Use of thienopyridone derivatives as AMPK activators and pharmaceutical compositions containing them |
| CA2714181C (en) | 2008-02-04 | 2013-12-24 | Mercury Therapeutics, Inc. | Ampk modulators |
-
2009
- 2009-03-17 UA UAA201013392A patent/UA103321C2/ru unknown
- 2009-03-17 ES ES09731265.6T patent/ES2584278T3/es active Active
- 2009-03-17 EP EP09731265.6A patent/EP2262500B1/en active Active
- 2009-03-17 HU HUE09731265A patent/HUE027857T2/en unknown
- 2009-03-17 JP JP2011503353A patent/JP5592348B2/ja not_active Expired - Fee Related
- 2009-03-17 WO PCT/EP2009/001937 patent/WO2009124636A1/en not_active Ceased
- 2009-03-17 NZ NZ589136A patent/NZ589136A/en not_active IP Right Cessation
- 2009-03-17 DK DK09731265.6T patent/DK2262500T3/en active
- 2009-03-17 PT PT97312656T patent/PT2262500T/pt unknown
- 2009-03-17 EA EA201001585A patent/EA017756B1/ru unknown
- 2009-03-17 US US12/937,147 patent/US8563729B2/en not_active Expired - Fee Related
- 2009-03-17 SI SI200931484A patent/SI2262500T1/sl unknown
- 2009-03-17 KR KR1020107025218A patent/KR101630466B1/ko not_active Expired - Fee Related
- 2009-03-17 BR BRPI0910439A patent/BRPI0910439B8/pt not_active IP Right Cessation
- 2009-03-17 MY MYPI2010004711A patent/MY155836A/en unknown
- 2009-03-17 CN CN200980112692.6A patent/CN101998853B/zh not_active Expired - Fee Related
- 2009-03-17 AU AU2009235784A patent/AU2009235784B2/en not_active Ceased
- 2009-03-17 MX MX2010011047A patent/MX2010011047A/es active IP Right Grant
- 2009-03-17 PL PL09731265.6T patent/PL2262500T3/pl unknown
- 2009-03-17 HR HRP20160907TT patent/HRP20160907T1/hr unknown
- 2009-03-17 CA CA2721025A patent/CA2721025C/en active Active
-
2010
- 2010-09-07 IL IL208067A patent/IL208067A/en active IP Right Grant
- 2010-10-07 CO CO10124423A patent/CO6300954A2/es not_active Application Discontinuation
- 2010-11-09 EC EC2010010599A patent/ECSP10010599A/es unknown
- 2010-11-10 ZA ZA2010/08050A patent/ZA201008050B/en unknown
Also Published As
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| JP5592348B2 (ja) | Ａｍｐにより活性化されたプロテインキナーゼ（ａｍｐｋ）アクチベーターとしてのチエノピリドン誘導体 | |
| JP5536757B2 (ja) | Ａｍｐにより活性化されたプロテインキナーゼ（ａｍｐｋ）アクチベーターとしてのチエノピリドン誘導体 | |
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