JP5568298B2 - 検体センサ内で電気化学反応を実行する方法 - Google Patents
検体センサ内で電気化学反応を実行する方法 Download PDFInfo
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| PCT/US2007/008491 WO2007114943A2 (en) | 2006-04-04 | 2007-04-04 | Methods and materials for controlling the electrochemistry of analyte sensors |
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| US8527026B2 (en) | 1997-03-04 | 2013-09-03 | Dexcom, Inc. | Device and method for determining analyte levels |
| US6391005B1 (en) | 1998-03-30 | 2002-05-21 | Agilent Technologies, Inc. | Apparatus and method for penetration with shaft having a sensor for sensing penetration depth |
| US8641644B2 (en) | 2000-11-21 | 2014-02-04 | Sanofi-Aventis Deutschland Gmbh | Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means |
| US7041068B2 (en) | 2001-06-12 | 2006-05-09 | Pelikan Technologies, Inc. | Sampling module device and method |
| US9427532B2 (en) | 2001-06-12 | 2016-08-30 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
| US9795747B2 (en) | 2010-06-02 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for lancet actuation |
| AU2002348683A1 (en) | 2001-06-12 | 2002-12-23 | Pelikan Technologies, Inc. | Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge |
| ES2336081T3 (es) | 2001-06-12 | 2010-04-08 | Pelikan Technologies Inc. | Dispositivo de puncion de auto-optimizacion con medios de adaptacion a variaciones temporales en las propiedades cutaneas. |
| ATE485766T1 (de) | 2001-06-12 | 2010-11-15 | Pelikan Technologies Inc | Elektrisches betätigungselement für eine lanzette |
| US9226699B2 (en) | 2002-04-19 | 2016-01-05 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling module with a continuous compression tissue interface surface |
| US8337419B2 (en) | 2002-04-19 | 2012-12-25 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
| US7981056B2 (en) | 2002-04-19 | 2011-07-19 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
| US20030032874A1 (en) | 2001-07-27 | 2003-02-13 | Dexcom, Inc. | Sensor head for use with implantable devices |
| US9282925B2 (en) | 2002-02-12 | 2016-03-15 | Dexcom, Inc. | Systems and methods for replacing signal artifacts in a glucose sensor data stream |
| US8260393B2 (en) | 2003-07-25 | 2012-09-04 | Dexcom, Inc. | Systems and methods for replacing signal data artifacts in a glucose sensor data stream |
| US7613491B2 (en) | 2002-05-22 | 2009-11-03 | Dexcom, Inc. | Silicone based membranes for use in implantable glucose sensors |
| US7828728B2 (en) | 2003-07-25 | 2010-11-09 | Dexcom, Inc. | Analyte sensor |
| US8364229B2 (en) | 2003-07-25 | 2013-01-29 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
| US8010174B2 (en) | 2003-08-22 | 2011-08-30 | Dexcom, Inc. | Systems and methods for replacing signal artifacts in a glucose sensor data stream |
| US7976476B2 (en) | 2002-04-19 | 2011-07-12 | Pelikan Technologies, Inc. | Device and method for variable speed lancet |
| US8360992B2 (en) | 2002-04-19 | 2013-01-29 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
| US7229458B2 (en) | 2002-04-19 | 2007-06-12 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US7491178B2 (en) | 2002-04-19 | 2009-02-17 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US7892183B2 (en) | 2002-04-19 | 2011-02-22 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
| US8579831B2 (en) | 2002-04-19 | 2013-11-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
| US8702624B2 (en) | 2006-09-29 | 2014-04-22 | Sanofi-Aventis Deutschland Gmbh | Analyte measurement device with a single shot actuator |
| US8221334B2 (en) | 2002-04-19 | 2012-07-17 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
| US8372016B2 (en) | 2002-04-19 | 2013-02-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling and analyte sensing |
| US8267870B2 (en) | 2002-04-19 | 2012-09-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling with hybrid actuation |
| US7297122B2 (en) | 2002-04-19 | 2007-11-20 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US7674232B2 (en) | 2002-04-19 | 2010-03-09 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US7901362B2 (en) | 2002-04-19 | 2011-03-08 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US7909778B2 (en) | 2002-04-19 | 2011-03-22 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US7226461B2 (en) | 2002-04-19 | 2007-06-05 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device with sterility barrier release |
| US9314194B2 (en) | 2002-04-19 | 2016-04-19 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
| US7232451B2 (en) | 2002-04-19 | 2007-06-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US7175642B2 (en) | 2002-04-19 | 2007-02-13 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
| US7547287B2 (en) | 2002-04-19 | 2009-06-16 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US9248267B2 (en) | 2002-04-19 | 2016-02-02 | Sanofi-Aventis Deustchland Gmbh | Tissue penetration device |
| US7331931B2 (en) | 2002-04-19 | 2008-02-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US9795334B2 (en) | 2002-04-19 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
| US8784335B2 (en) | 2002-04-19 | 2014-07-22 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling device with a capacitive sensor |
| US9492111B2 (en) * | 2002-04-22 | 2016-11-15 | Medtronic Minimed, Inc. | Methods and materials for stabilizing analyte sensors |
| US7226978B2 (en) | 2002-05-22 | 2007-06-05 | Dexcom, Inc. | Techniques to improve polyurethane membranes for implantable glucose sensors |
| US8574895B2 (en) | 2002-12-30 | 2013-11-05 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus using optical techniques to measure analyte levels |
| EP1628567B1 (en) | 2003-05-30 | 2010-08-04 | Pelikan Technologies Inc. | Method and apparatus for fluid injection |
| EP1633235B1 (en) | 2003-06-06 | 2014-05-21 | Sanofi-Aventis Deutschland GmbH | Apparatus for body fluid sampling and analyte sensing |
| WO2006001797A1 (en) | 2004-06-14 | 2006-01-05 | Pelikan Technologies, Inc. | Low pain penetrating |
| US7761130B2 (en) | 2003-07-25 | 2010-07-20 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| US8282549B2 (en) | 2003-12-09 | 2012-10-09 | Dexcom, Inc. | Signal processing for continuous analyte sensor |
| EP1649260A4 (en) | 2003-07-25 | 2010-07-07 | Dexcom Inc | ELECTRODE SYSTEMS FOR ELECTROCHEMICAL DETECTORS |
| EP1648298A4 (en) | 2003-07-25 | 2010-01-13 | Dexcom Inc | OXYGEN-IMPROVED MEMBRANE SYSTEMS FOR IMPLANTABLE DEVICES |
| US9763609B2 (en) | 2003-07-25 | 2017-09-19 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
| US7774145B2 (en) | 2003-08-01 | 2010-08-10 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US7591801B2 (en) | 2004-02-26 | 2009-09-22 | Dexcom, Inc. | Integrated delivery device for continuous glucose sensor |
| US7519408B2 (en) | 2003-11-19 | 2009-04-14 | Dexcom, Inc. | Integrated receiver for continuous analyte sensor |
| US8761856B2 (en) | 2003-08-01 | 2014-06-24 | Dexcom, Inc. | System and methods for processing analyte sensor data |
| US20190357827A1 (en) | 2003-08-01 | 2019-11-28 | Dexcom, Inc. | Analyte sensor |
| US7920906B2 (en) | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
| US20140121989A1 (en) | 2003-08-22 | 2014-05-01 | Dexcom, Inc. | Systems and methods for processing analyte sensor data |
| EP1671096A4 (en) | 2003-09-29 | 2009-09-16 | Pelikan Technologies Inc | METHOD AND APPARATUS FOR PROVIDING IMPROVED SAMPLE CAPTURING DEVICE |
| US9351680B2 (en) | 2003-10-14 | 2016-05-31 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a variable user interface |
| US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
| US8364231B2 (en) | 2006-10-04 | 2013-01-29 | Dexcom, Inc. | Analyte sensor |
| US8423114B2 (en) | 2006-10-04 | 2013-04-16 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| US8532730B2 (en) | 2006-10-04 | 2013-09-10 | Dexcom, Inc. | Analyte sensor |
| US11633133B2 (en) | 2003-12-05 | 2023-04-25 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| WO2005057168A2 (en) | 2003-12-05 | 2005-06-23 | Dexcom, Inc. | Calibration techniques for a continuous analyte sensor |
| EP1706026B1 (en) | 2003-12-31 | 2017-03-01 | Sanofi-Aventis Deutschland GmbH | Method and apparatus for improving fluidic flow and sample capture |
| US7822454B1 (en) | 2005-01-03 | 2010-10-26 | Pelikan Technologies, Inc. | Fluid sampling device with improved analyte detecting member configuration |
| WO2009048462A1 (en) | 2007-10-09 | 2009-04-16 | Dexcom, Inc. | Integrated insulin delivery system with continuous glucose sensor |
| US8808228B2 (en) | 2004-02-26 | 2014-08-19 | Dexcom, Inc. | Integrated medicament delivery device for use with continuous analyte sensor |
| US8277713B2 (en) | 2004-05-03 | 2012-10-02 | Dexcom, Inc. | Implantable analyte sensor |
| WO2006011062A2 (en) | 2004-05-20 | 2006-02-02 | Albatros Technologies Gmbh & Co. Kg | Printable hydrogel for biosensors |
| WO2005120365A1 (en) | 2004-06-03 | 2005-12-22 | Pelikan Technologies, Inc. | Method and apparatus for a fluid sampling device |
| US9775553B2 (en) | 2004-06-03 | 2017-10-03 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a fluid sampling device |
| US8989833B2 (en) | 2004-07-13 | 2015-03-24 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US20070045902A1 (en) | 2004-07-13 | 2007-03-01 | Brauker James H | Analyte sensor |
| US8452368B2 (en) | 2004-07-13 | 2013-05-28 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US8652831B2 (en) | 2004-12-30 | 2014-02-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for analyte measurement test time |
| US8744546B2 (en) | 2005-05-05 | 2014-06-03 | Dexcom, Inc. | Cellulosic-based resistance domain for an analyte sensor |
| US7725148B2 (en) | 2005-09-23 | 2010-05-25 | Medtronic Minimed, Inc. | Sensor with layered electrodes |
| US8052618B2 (en) * | 2006-10-15 | 2011-11-08 | Roche Diagnostics Operations, Inc. | Diagnostic test element and process for its production |
| US20200037875A1 (en) | 2007-05-18 | 2020-02-06 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
| DK2540225T3 (en) * | 2007-05-30 | 2015-10-12 | Bayer Healthcare Llc | A process for producing a multilayer coating |
| US20080306444A1 (en) | 2007-06-08 | 2008-12-11 | Dexcom, Inc. | Integrated medicament delivery device for use with continuous analyte sensor |
| US8512731B2 (en) * | 2007-11-13 | 2013-08-20 | Medtronic Minimed, Inc. | Antimicrobial coatings for medical devices and methods for making and using them |
| WO2009097357A1 (en) * | 2008-01-29 | 2009-08-06 | Medtronic Minimed, Inc. | Analyte sensors having nanostructured electrodes and methods for making and using them |
| DE102008009817A1 (de) * | 2008-02-19 | 2009-08-27 | Epcos Ag | Verbundwerkstoff zur Temperaturmessung, Temperatursensor aufweisend den Verbundwerkstoff und Verfahren zur Herstellung des Verbundwerkstoffs und des Temperatursensors |
| WO2009105709A1 (en) | 2008-02-21 | 2009-08-27 | Dexcom, Inc. | Systems and methods for processing, transmitting and displaying sensor data |
| US20090275815A1 (en) * | 2008-03-21 | 2009-11-05 | Nova Biomedical Corporation | Temperature-compensated in-vivo sensor |
| US8682408B2 (en) | 2008-03-28 | 2014-03-25 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
| US8583204B2 (en) | 2008-03-28 | 2013-11-12 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
| US11730407B2 (en) | 2008-03-28 | 2023-08-22 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
| US8093532B2 (en) | 2008-03-31 | 2012-01-10 | Electro Scientific Industries, Inc. | Laser machining of fired ceramic and other hard and/or thick materials |
| WO2009126900A1 (en) | 2008-04-11 | 2009-10-15 | Pelikan Technologies, Inc. | Method and apparatus for analyte detecting device |
| KR100956616B1 (ko) * | 2008-04-18 | 2010-05-11 | 한국표준과학연구원 | 다이아프램을 이용한 압력 측정 장치 및 압력 측정 방법 |
| US20090325221A1 (en) * | 2008-06-30 | 2009-12-31 | Kimberly-Clark Worldwide, Inc. | Temporary Tattoo Decals for Detecting the Presence of an Analyte |
| KR20100013577A (ko) * | 2008-07-31 | 2010-02-10 | 서울대학교산학협력단 | 나노패터닝에 있어서 벌지효과의 제거 |
| US20100025238A1 (en) * | 2008-07-31 | 2010-02-04 | Medtronic Minimed, Inc. | Analyte sensor apparatuses having improved electrode configurations and methods for making and using them |
| US8700114B2 (en) | 2008-07-31 | 2014-04-15 | Medtronic Minmed, Inc. | Analyte sensor apparatuses comprising multiple implantable sensor elements and methods for making and using them |
| WO2010017119A1 (en) * | 2008-08-06 | 2010-02-11 | Reusense, Llc | Reusable analyte sensing system and methods |
| WO2010027771A1 (en) * | 2008-08-27 | 2010-03-11 | Edwards Lifesciences Corporation | Analyte sensor |
| EP2163190A1 (de) * | 2008-09-11 | 2010-03-17 | Roche Diagnostics GmbH | Elektrodensystem für Messung einer Analytkonzentration in-vivo |
| CA2737461A1 (en) | 2008-09-19 | 2010-03-25 | Tandem Diabetes Care, Inc. | Solute concentration measurement device and related methods |
| EP4549933A3 (en) | 2008-09-19 | 2025-05-21 | DexCom, Inc. | Particle-containing membrane and particulate electrode for analyte sensors |
| EP2344021B1 (en) * | 2008-09-23 | 2013-01-23 | GILUPI GmbH | Diagnostic analyte collection device based on flexible polymers with biological surface modification and microfluidic functionality |
| US8148160B2 (en) * | 2008-12-04 | 2012-04-03 | Waseda University | Electrode for molecular sensing and method for molecular sensing |
| EP2206462A1 (en) * | 2009-01-13 | 2010-07-14 | Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO | A non-invasive chemical sensor, a skin patch, a packaging material and a monitoring system using the same |
| US9375169B2 (en) | 2009-01-30 | 2016-06-28 | Sanofi-Aventis Deutschland Gmbh | Cam drive for managing disposable penetrating member actions with a single motor and motor and control system |
| US8696917B2 (en) * | 2009-02-09 | 2014-04-15 | Edwards Lifesciences Corporation | Analyte sensor and fabrication methods |
| WO2010099507A1 (en) * | 2009-02-26 | 2010-09-02 | Abbott Diabetes Care Inc. | Improved analyte sensors and methods of making and using the same |
| US8573027B2 (en) | 2009-02-27 | 2013-11-05 | Tandem Diabetes Care, Inc. | Methods and devices for determination of flow reservoir volume |
| US9250106B2 (en) | 2009-02-27 | 2016-02-02 | Tandem Diabetes Care, Inc. | Methods and devices for determination of flow reservoir volume |
| US20110004085A1 (en) | 2009-04-30 | 2011-01-06 | Dexcom, Inc. | Performance reports associated with continuous sensor data from multiple analysis time periods |
| US9351677B2 (en) | 2009-07-02 | 2016-05-31 | Dexcom, Inc. | Analyte sensor with increased reference capacity |
| US9237864B2 (en) | 2009-07-02 | 2016-01-19 | Dexcom, Inc. | Analyte sensors and methods of manufacturing same |
| US8926561B2 (en) | 2009-07-30 | 2015-01-06 | Tandem Diabetes Care, Inc. | Infusion pump system with disposable cartridge having pressure venting and pressure feedback |
| EP2482724A2 (en) | 2009-09-30 | 2012-08-08 | Dexcom, Inc. | Transcutaneous analyte sensor |
| EP2545853B1 (en) | 2010-03-09 | 2017-10-25 | ARKRAY, Inc. | Electrochemical sensor |
| CN102892894A (zh) * | 2010-03-16 | 2013-01-23 | 爱德华兹生命科学公司 | 高能辐射不灵敏分析物传感器 |
| US8965476B2 (en) | 2010-04-16 | 2015-02-24 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
| US8940141B2 (en) | 2010-05-19 | 2015-01-27 | Lifescan Scotland Limited | Analytical test strip with an electrode having electrochemically active and inert areas of a predetermined size and distribution |
| US8608921B2 (en) * | 2011-01-20 | 2013-12-17 | Medtronic Minimed, Inc. | Layered enzyme compositions for use with analyte sensors |
| EP3575796B1 (en) | 2011-04-15 | 2020-11-11 | DexCom, Inc. | Advanced analyte sensor calibration and error detection |
| US9989522B2 (en) | 2011-11-01 | 2018-06-05 | Medtronic Minimed, Inc. | Methods and materials for modulating start-up time and air removal in dry sensors |
| US8999720B2 (en) | 2011-11-17 | 2015-04-07 | Medtronic Minimed, Inc. | Aqueous radiation protecting formulations and methods for making and using them |
| US9103727B2 (en) | 2012-01-03 | 2015-08-11 | The Regents Of The University Of Michigan | Composite Fabry-Pérot sensor |
| US9180242B2 (en) | 2012-05-17 | 2015-11-10 | Tandem Diabetes Care, Inc. | Methods and devices for multiple fluid transfer |
| US9493807B2 (en) | 2012-05-25 | 2016-11-15 | Medtronic Minimed, Inc. | Foldover sensors and methods for making and using them |
| GB201211309D0 (en) * | 2012-06-26 | 2012-08-08 | Fujifilm Mfg Europe Bv | Process for preparing membranes |
| US20140012115A1 (en) | 2012-07-03 | 2014-01-09 | Medtronic Minimed, Inc. | Plasma deposited adhesion promoter layers for use with analyte sensors |
| WO2014022641A1 (en) * | 2012-08-01 | 2014-02-06 | Massachusetts Institute Of Technology | Actuation and control of stamp deformation in microcontact printing |
| US10194840B2 (en) | 2012-12-06 | 2019-02-05 | Medtronic Minimed, Inc. | Microarray electrodes useful with analyte sensors and methods for making and using them |
| US10426383B2 (en) | 2013-01-22 | 2019-10-01 | Medtronic Minimed, Inc. | Muting glucose sensor oxygen response and reducing electrode edge growth with pulsed current plating |
| WO2014158351A1 (en) * | 2013-03-13 | 2014-10-02 | Applied Materials, Inc. | Post treatment for constant reduction with pore generation on low-k dielectric films |
| US9173998B2 (en) | 2013-03-14 | 2015-11-03 | Tandem Diabetes Care, Inc. | System and method for detecting occlusions in an infusion pump |
| US9828620B2 (en) | 2013-06-28 | 2017-11-28 | Verily Life Sciences Llc | Porous polymeric formulation prepared using monomer |
| US9750445B2 (en) | 2013-06-28 | 2017-09-05 | Verily Life Sciences Llc | Porous polymeric formulation prepared using porogens |
| US20150122647A1 (en) | 2013-11-07 | 2015-05-07 | Medtronic Minimed, Inc. | Enzyme matrices for use with ethylene oxide sterilization |
| US20150160151A1 (en) * | 2013-12-06 | 2015-06-11 | Google Inc. | Formulation and Storage Method to Enhance the Enzyme and Sensor Stabilities |
| US9476853B2 (en) * | 2013-12-10 | 2016-10-25 | Life Technologies Corporation | System and method for forming microwells |
| TWI583947B (zh) * | 2013-12-16 | 2017-05-21 | 聖高拜塑膠製品公司 | 電極及製造電極的方法 |
| US9739746B1 (en) | 2013-12-23 | 2017-08-22 | Google Inc. | Analyte sensor incorporating negatively charged moieties |
| US9834805B2 (en) | 2013-12-23 | 2017-12-05 | Verily Life Sciences Llc | Two-layer analyte sensor |
| US9855359B2 (en) | 2013-12-23 | 2018-01-02 | Verily Life Sciences Llc | Analyte sensors with ethylene oxide immunity |
| US9681828B2 (en) * | 2014-05-01 | 2017-06-20 | Medtronic Minimed, Inc. | Physiological characteristic sensors and methods for forming such sensors |
| US10335302B2 (en) | 2015-02-24 | 2019-07-02 | Elira, Inc. | Systems and methods for using transcutaneous electrical stimulation to enable dietary interventions |
| US20220062621A1 (en) | 2015-02-24 | 2022-03-03 | Elira, Inc. | Electrical Stimulation-Based Weight Management System |
| US10864367B2 (en) | 2015-02-24 | 2020-12-15 | Elira, Inc. | Methods for using an electrical dermal patch in a manner that reduces adverse patient reactions |
| US9956393B2 (en) | 2015-02-24 | 2018-05-01 | Elira, Inc. | Systems for increasing a delay in the gastric emptying time for a patient using a transcutaneous electro-dermal patch |
| US10765863B2 (en) | 2015-02-24 | 2020-09-08 | Elira, Inc. | Systems and methods for using a transcutaneous electrical stimulation device to deliver titrated therapy |
| US10376145B2 (en) | 2015-02-24 | 2019-08-13 | Elira, Inc. | Systems and methods for enabling a patient to achieve a weight loss objective using an electrical dermal patch |
| CA2977584C (en) | 2015-02-24 | 2024-03-05 | Elira Therapeutics, Inc. | Systems and methods for enabling appetite modulation and/or improving dietary compliance using an electro-dermal patch |
| JP6534959B2 (ja) * | 2016-04-21 | 2019-06-26 | 信越化学工業株式会社 | 有機膜の形成方法及び半導体装置用基板の製造方法 |
| US11298059B2 (en) | 2016-05-13 | 2022-04-12 | PercuSense, Inc. | Analyte sensor |
| EP3263712B1 (en) | 2016-06-29 | 2025-03-26 | Roche Diabetes Care GmbH | Galvanically functionalized sensors |
| CN118533932A (zh) | 2016-11-30 | 2024-08-23 | 美国圣戈班性能塑料公司 | 电极及电极制造方法 |
| US11134868B2 (en) | 2017-03-17 | 2021-10-05 | Medtronic Minimed, Inc. | Metal pillar device structures and methods for making and using them in electrochemical and/or electrocatalytic applications |
| US10856784B2 (en) | 2017-06-30 | 2020-12-08 | Medtronic Minimed, Inc. | Sensor initialization methods for faster body sensor response |
| US10522398B2 (en) * | 2017-08-31 | 2019-12-31 | International Business Machines Corporation | Modulating metal interconnect surface topography |
| US11331022B2 (en) | 2017-10-24 | 2022-05-17 | Dexcom, Inc. | Pre-connected analyte sensors |
| US11382540B2 (en) | 2017-10-24 | 2022-07-12 | Dexcom, Inc. | Pre-connected analyte sensors |
| US12042284B2 (en) | 2018-01-23 | 2024-07-23 | Medtronic Minimed, Inc. | Implantable polymer surfaces exhibiting reduced in vivo inflammatory responses |
| US11186859B2 (en) | 2018-02-07 | 2021-11-30 | Medtronic Minimed, Inc. | Multilayer electrochemical analyte sensors and methods for making and using them |
| US11220735B2 (en) * | 2018-02-08 | 2022-01-11 | Medtronic Minimed, Inc. | Methods for controlling physical vapor deposition metal film adhesion to substrates and surfaces |
| US11583213B2 (en) | 2018-02-08 | 2023-02-21 | Medtronic Minimed, Inc. | Glucose sensor electrode design |
| KR102050952B1 (ko) * | 2018-02-20 | 2019-12-02 | 고려대학교 산학협력단 | 부착형 신축성 땀센서 |
| US11109784B2 (en) * | 2018-04-09 | 2021-09-07 | California Institute Of Technology | Metal-enzyme sandwich layers |
| TWI668444B (zh) * | 2018-07-17 | 2019-08-11 | 淡江大學 | 檢測裝置及檢測系統 |
| US11464908B2 (en) | 2019-02-18 | 2022-10-11 | Tandem Diabetes Care, Inc. | Methods and apparatus for monitoring infusion sites for ambulatory infusion pumps |
| TWI699189B (zh) | 2019-05-29 | 2020-07-21 | 華廣生技股份有限公司 | 生物感測裝置及生物感測裝置啟動方法 |
| US11718865B2 (en) | 2019-07-26 | 2023-08-08 | Medtronic Minimed, Inc. | Methods to improve oxygen delivery to implantable sensors |
| US11523757B2 (en) | 2019-08-01 | 2022-12-13 | Medtronic Minimed, Inc. | Micro-pillar working electrodes design to reduce backflow of hydrogen peroxide in glucose sensor |
| US12082924B2 (en) | 2020-07-31 | 2024-09-10 | Medtronic Minimed, Inc. | Sensor identification and integrity check design |
| US20220133190A1 (en) | 2020-10-29 | 2022-05-05 | Medtronic Minimed, Inc. | Glucose biosensors comprising direct electron transfer enzymes and methods of making and using them |
| US11717787B2 (en) * | 2021-01-04 | 2023-08-08 | Saudi Arabian Oil Company | High free volume membrane for gas separation |
| US20220338768A1 (en) | 2021-04-09 | 2022-10-27 | Medtronic Minimed, Inc. | Hexamethyldisiloxane membranes for analyte sensors |
| AU2022261713B2 (en) | 2021-04-19 | 2025-11-27 | W. L. Gore & Associates, Inc. | Electrochemical analyte biosensors, associated compositions of matter, and methods for making and using same |
| US12433515B2 (en) | 2021-08-13 | 2025-10-07 | Medtronic Minimed, Inc. | Dry electrochemical impedance spectroscopy metrology for conductive chemical layers |
| US12442786B2 (en) | 2021-10-14 | 2025-10-14 | Medtronic Minimed, Inc. | Sensors for 3-hydroxybutyrate detection |
| US12527500B2 (en) | 2021-12-02 | 2026-01-20 | Medtronic Minimed, Inc. | Ketone limiting membrane and dual layer membrane approach for ketone sensing |
| CN114224334B (zh) * | 2021-12-28 | 2024-11-29 | 苏州原理科技有限公司 | 植入式生物传感器及制备方法 |
| KR102699866B1 (ko) * | 2021-12-29 | 2024-08-29 | 재단법인대구경북과학기술원 | 기계적 및 화학적 내구성이 향상된 생체전극 및 이의 제조방법 |
| EP4382611A1 (en) | 2022-08-31 | 2024-06-12 | Medtronic MiniMed, Inc. | Sensors for 3-hydroxybutyrate detection |
| CN115736909B (zh) * | 2022-12-08 | 2025-08-05 | 深圳清华大学研究院 | 血糖检测装置及血糖检测系统 |
| CN115856052B (zh) * | 2022-12-27 | 2023-09-15 | 北京大学 | 一种糖尿病生物传感器 |
| WO2025048947A1 (en) * | 2023-08-31 | 2025-03-06 | Virginia Tech Intellectual Properties, Inc. | Assembly of flexible interconnects using sedimentation |
Family Cites Families (133)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2899658A (en) * | 1959-08-11 | Leaf-type electrical resistance strain gage | ||
| US2402950A (en) * | 1943-04-13 | 1946-07-02 | Merlyn M Culver | Molded part and method of forming same |
| US2519541A (en) * | 1947-11-08 | 1950-08-22 | Fluid Control Engineering Co | Valve construction |
| US4034959A (en) * | 1975-12-24 | 1977-07-12 | Acf Industries, Incorporated | Valve seal retaining means |
| US4104099A (en) * | 1977-01-27 | 1978-08-01 | International Telephone And Telegraph Corporation | Method and apparatus for lapping or polishing materials |
| US4163544A (en) * | 1977-11-10 | 1979-08-07 | Acf Industries, Incorporated | Two piece composite valve seal ring construction |
| US4373527B1 (en) * | 1979-04-27 | 1995-06-27 | Univ Johns Hopkins | Implantable programmable medication infusion system |
| US4573994A (en) * | 1979-04-27 | 1986-03-04 | The Johns Hopkins University | Refillable medication infusion apparatus |
| US4783441A (en) * | 1979-04-30 | 1988-11-08 | Hoechst Aktiengesellschaft | Aqueous protein solutions stable to denaturation |
| US4356074A (en) * | 1980-08-25 | 1982-10-26 | The Yellow Springs Instrument Company, Inc. | Substrate specific galactose oxidase enzyme electrodes |
| US4373009A (en) * | 1981-05-18 | 1983-02-08 | International Silicone Corporation | Method of forming a hydrophilic coating on a substrate |
| US4569641A (en) * | 1982-09-07 | 1986-02-11 | Greatbatch Enterprises, Inc. | Low power electromagnetic pump |
| US4714234A (en) * | 1982-09-07 | 1987-12-22 | Greatbatch Enterprises, Inc. | Low power electromagnetic valve |
| US4568250A (en) * | 1982-09-07 | 1986-02-04 | Greatbatch Enterprises, Inc. | Low power electromagnetic pump |
| US4769013A (en) * | 1982-09-13 | 1988-09-06 | Hydromer, Inc. | Bio-effecting medical material and device |
| US4636150A (en) * | 1983-05-23 | 1987-01-13 | Greatbatch Enterprises, Inc. | Low power electromagnetic pump |
| US4560375A (en) * | 1983-06-30 | 1985-12-24 | Pudenz-Schulte Medical Research Corp. | Flow control valve |
| JPS60173452U (ja) | 1984-04-27 | 1985-11-16 | クラリオン株式会社 | 車両用盗難防止装置 |
| IL73536A (en) * | 1984-09-13 | 1987-12-20 | Eltech Systems Corp | Composite catalytic material particularly for electrolysis electrodes,its manufacture and its use in electrolysis |
| US4626244A (en) * | 1985-02-01 | 1986-12-02 | Consolidated Controls Corporation | Implantable medication infusion device |
| DE3610316A1 (de) * | 1985-03-29 | 1986-10-30 | Four Brain K.K., Hiroshima | Gebissbasis mit einer gummiartigen elastischen unterfutter- bzw. einlageschicht und verfahren zu seiner herstellung |
| WO1986007632A1 (en) * | 1985-06-21 | 1986-12-31 | Matsushita Electric Industrial Co., Ltd. | Biosensor and method of manufacturing same |
| US4890620A (en) * | 1985-09-20 | 1990-01-02 | The Regents Of The University Of California | Two-dimensional diffusion glucose substrate sensing electrode |
| US5019260A (en) * | 1986-12-23 | 1991-05-28 | Pall Corporation | Filtration media with low protein adsorbability |
| JPS63182559A (ja) * | 1987-01-24 | 1988-07-27 | Kanzaki Paper Mfg Co Ltd | 酵素電極の製造方法 |
| US4759828A (en) * | 1987-04-09 | 1988-07-26 | Nova Biomedical Corporation | Glucose electrode and method of determining glucose |
| US5352348A (en) * | 1987-04-09 | 1994-10-04 | Nova Biomedical Corporation | Method of using enzyme electrode |
| US5001009A (en) * | 1987-09-02 | 1991-03-19 | Sterilization Technical Services, Inc. | Lubricious hydrophilic composite coated on substrates |
| US4950256A (en) * | 1988-04-07 | 1990-08-21 | Luther Medical Products, Inc. | Non-thrombogenic intravascular time release catheter |
| US5196088A (en) * | 1988-08-05 | 1993-03-23 | Tru Vue, Inc. | Process and apparatus for producing non-glare glass by etching |
| US5212050A (en) * | 1988-11-14 | 1993-05-18 | Mier Randall M | Method of forming a permselective layer |
| US5200051A (en) * | 1988-11-14 | 1993-04-06 | I-Stat Corporation | Wholly microfabricated biosensors and process for the manufacture and use thereof |
| US5063081A (en) * | 1988-11-14 | 1991-11-05 | I-Stat Corporation | Method of manufacturing a plurality of uniform microfabricated sensing devices having an immobilized ligand receptor |
| US5077210A (en) * | 1989-01-13 | 1991-12-31 | Eigler Frances S | Immobilization of active agents on substrates with a silane and heterobifunctional crosslinking agent |
| EP0397130B1 (en) * | 1989-05-11 | 1995-04-19 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Medical device having highly biocompatible surface and method for manufacturing the same |
| US4958661A (en) * | 1989-08-08 | 1990-09-25 | The Lee Company | Check valve |
| US5330911A (en) * | 1989-09-28 | 1994-07-19 | Board Of Regents, The University Of Texas System | Surfaces having desirable cell adhesive effects |
| US5288636A (en) * | 1989-12-15 | 1994-02-22 | Boehringer Mannheim Corporation | Enzyme electrode system |
| DE58904449D1 (de) * | 1989-12-21 | 1993-06-24 | Siemens Ag | Anordnung zum transkutanen ein- oder nachfuellen von fluessigen medikamenten in ein implantierbares medikamentendosiergeraet. |
| US5108819A (en) * | 1990-02-14 | 1992-04-28 | Eli Lilly And Company | Thin film electrical component |
| US5165407A (en) * | 1990-04-19 | 1992-11-24 | The University Of Kansas | Implantable glucose sensor |
| DE4018597A1 (de) * | 1990-06-09 | 1991-12-12 | Draegerwerk Ag | Messelektrode fuer eine elektrochemische gasmesszelle |
| AU648316B2 (en) * | 1990-06-29 | 1994-04-21 | Electroplating Engineers Of Japan, Limited | Platinum electoforming and platinum electroplating |
| JP3017816B2 (ja) * | 1991-02-20 | 2000-03-13 | 清原 まさ子 | 流体制御器 |
| US5593852A (en) * | 1993-12-02 | 1997-01-14 | Heller; Adam | Subcutaneous glucose electrode |
| US5773270A (en) * | 1991-03-12 | 1998-06-30 | Chiron Diagnostics Corporation | Three-layered membrane for use in an electrochemical sensor system |
| WO1993001221A1 (en) * | 1991-07-05 | 1993-01-21 | Biocompatibles Limited | Polymeric surface coatings |
| US5322063A (en) * | 1991-10-04 | 1994-06-21 | Eli Lilly And Company | Hydrophilic polyurethane membranes for electrochemical glucose sensors |
| ZA938555B (en) * | 1992-11-23 | 1994-08-02 | Lilly Co Eli | Technique to improve the performance of electrochemical sensors |
| US5308641A (en) * | 1993-01-19 | 1994-05-03 | Medtronic, Inc. | Biocompatibility of solid surfaces |
| US5229172A (en) * | 1993-01-19 | 1993-07-20 | Medtronic, Inc. | Modification of polymeric surface by graft polymerization |
| US5299571A (en) * | 1993-01-22 | 1994-04-05 | Eli Lilly And Company | Apparatus and method for implantation of sensors |
| US5433710A (en) * | 1993-03-16 | 1995-07-18 | Minimed, Inc. | Medication infusion pump with fluoropolymer valve seat |
| US5328954A (en) * | 1993-04-16 | 1994-07-12 | Icet, Inc. | Encrusting and bacterial resistant coatings for medical applications |
| CA2174246C (en) * | 1993-10-29 | 2004-05-11 | Gary R. Schildgen | Method of manufacturing a medical electrical lead |
| US5390691A (en) * | 1994-01-27 | 1995-02-21 | Sproule; Ronald | Bleed valve for water supply for camping vehicle |
| US5437999A (en) * | 1994-02-22 | 1995-08-01 | Boehringer Mannheim Corporation | Electrochemical sensor |
| US5391250A (en) * | 1994-03-15 | 1995-02-21 | Minimed Inc. | Method of fabricating thin film sensors |
| US5390671A (en) * | 1994-03-15 | 1995-02-21 | Minimed Inc. | Transcutaneous sensor insertion set |
| ATE202942T1 (de) * | 1994-04-15 | 2001-07-15 | Cobe Cardiovascular Inc | Blutverträglicher beschichteter artikel |
| US5482473A (en) * | 1994-05-09 | 1996-01-09 | Minimed Inc. | Flex circuit connector |
| US5662960A (en) * | 1995-02-01 | 1997-09-02 | Schneider (Usa) Inc. | Process for producing slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with a poly (n-vinylpyrrolidone) polymer hydrogel |
| US5568806A (en) * | 1995-02-16 | 1996-10-29 | Minimed Inc. | Transcutaneous sensor insertion set |
| US5702754A (en) * | 1995-02-22 | 1997-12-30 | Meadox Medicals, Inc. | Method of providing a substrate with a hydrophilic coating and substrates, particularly medical devices, provided with such coatings |
| JPH08247988A (ja) * | 1995-03-07 | 1996-09-27 | Nippon Telegr & Teleph Corp <Ntt> | 電気化学検出器及びその製造方法 |
| AU5363596A (en) * | 1995-03-17 | 1996-10-08 | Regents Of The University Of Minnesota | Biocompatible materials |
| US5882494A (en) * | 1995-03-27 | 1999-03-16 | Minimed, Inc. | Polyurethane/polyurea compositions containing silicone for biosensor membranes |
| US5786439A (en) * | 1996-10-24 | 1998-07-28 | Minimed Inc. | Hydrophilic, swellable coatings for biosensors |
| US5609629A (en) * | 1995-06-07 | 1997-03-11 | Med Institute, Inc. | Coated implantable medical device |
| US5620738A (en) * | 1995-06-07 | 1997-04-15 | Union Carbide Chemicals & Plastics Technology Corporation | Non-reactive lubicious coating process |
| US5672638A (en) * | 1995-08-22 | 1997-09-30 | Medtronic, Inc. | Biocompatability for solid surfaces |
| US5607475A (en) * | 1995-08-22 | 1997-03-04 | Medtronic, Inc. | Biocompatible medical article and method |
| US5913040A (en) * | 1995-08-22 | 1999-06-15 | Backweb Ltd. | Method and apparatus for transmitting and displaying information between a remote network and a local computer |
| US5716506A (en) * | 1995-10-06 | 1998-02-10 | Board Of Trustees Of The University Of Illinois | Electrochemical sensors for gas detection |
| US5972199A (en) * | 1995-10-11 | 1999-10-26 | E. Heller & Company | Electrochemical analyte sensors using thermostable peroxidase |
| US5711861A (en) * | 1995-11-22 | 1998-01-27 | Ward; W. Kenneth | Device for monitoring changes in analyte concentration |
| US5809242A (en) * | 1996-04-19 | 1998-09-15 | Juno Online Services, L.P. | Electronic mail system for displaying advertisement at local computer received from remote system while the local computer is off-line the remote system |
| US5728420A (en) | 1996-08-09 | 1998-03-17 | Medtronic, Inc. | Oxidative method for attachment of glycoproteins to surfaces of medical devices |
| US5696314A (en) * | 1996-07-12 | 1997-12-09 | Chiron Diagnostics Corporation | Multilayer enzyme electrode membranes and methods of making same |
| US6013855A (en) * | 1996-08-06 | 2000-01-11 | United States Surgical | Grafting of biocompatible hydrophilic polymers onto inorganic and metal surfaces |
| US5804048A (en) * | 1996-08-15 | 1998-09-08 | Via Medical Corporation | Electrode assembly for assaying glucose |
| KR0176334B1 (ko) | 1996-08-19 | 1999-04-01 | 박원훈 | 내인체 감염성 삽입금속표면의 코팅방법 및 그 치료기술 |
| WO1998008553A1 (en) | 1996-08-29 | 1998-03-05 | Medtronic, Inc. | Biocompatibility for solid surfaces |
| US5855618A (en) | 1996-09-13 | 1999-01-05 | Meadox Medicals, Inc. | Polyurethanes grafted with polyethylene oxide chains containing covalently bonded heparin |
| DE69733307T2 (de) | 1996-11-01 | 2006-01-19 | Medtronic MiniMed, Inc., Northridge | Pumpe zur medikamentösen infusion mit einer durch ein protein stabilisierten beschichtung |
| JP2943739B2 (ja) * | 1996-12-13 | 1999-08-30 | 日本電気株式会社 | 尿糖計および尿糖測定方法 |
| US5964993A (en) * | 1996-12-19 | 1999-10-12 | Implanted Biosystems Inc. | Glucose sensor |
| US5858186A (en) * | 1996-12-20 | 1999-01-12 | The Regents Of The University Of California | Urea biosensor for hemodialysis monitoring |
| CA2278709A1 (en) * | 1997-01-27 | 1998-08-13 | Benjamin Slotznick | System for delivering and displaying primary and secondary information |
| US6558351B1 (en) * | 1999-06-03 | 2003-05-06 | Medtronic Minimed, Inc. | Closed loop system for controlling insulin infusion |
| US5954643A (en) | 1997-06-09 | 1999-09-21 | Minimid Inc. | Insertion set for a transcutaneous sensor |
| US6411998B1 (en) * | 1997-09-08 | 2002-06-25 | International Business Machines Corporation | World wide web internet delay monitor |
| US6119028A (en) * | 1997-10-20 | 2000-09-12 | Alfred E. Mann Foundation | Implantable enzyme-based monitoring systems having improved longevity due to improved exterior surfaces |
| US5965244A (en) | 1997-10-24 | 1999-10-12 | Rexam Graphics Inc. | Printing medium comprised of porous medium |
| US5880364A (en) | 1997-10-31 | 1999-03-09 | Cosense, Inc. | Non-contact ultrasonic micromeasurement system |
| US5939208A (en) * | 1997-11-07 | 1999-08-17 | Biomimetics, Inc. | Method for creation of biomimetic surfaces |
| US6579690B1 (en) * | 1997-12-05 | 2003-06-17 | Therasense, Inc. | Blood analyte monitoring through subcutaneous measurement |
| US6103033A (en) | 1998-03-04 | 2000-08-15 | Therasense, Inc. | Process for producing an electrochemical biosensor |
| US6134461A (en) | 1998-03-04 | 2000-10-17 | E. Heller & Company | Electrochemical analyte |
| US6175752B1 (en) | 1998-04-30 | 2001-01-16 | Therasense, Inc. | Analyte monitoring device and methods of use |
| DE19932749B4 (de) * | 1998-07-23 | 2006-05-04 | Robert Bosch Gmbh | Schichtsystem und Verfahren zu dessen Herstellung sowie dessen Verwendung |
| US6554798B1 (en) * | 1998-08-18 | 2003-04-29 | Medtronic Minimed, Inc. | External infusion device with remote programming, bolus estimator and/or vibration alarm capabilities |
| ATE269114T1 (de) * | 1998-11-20 | 2004-07-15 | Univ Connecticut | Verfahren und vorrichtung zur steuerung der gewebeimplantat-interaktionen |
| US6368274B1 (en) * | 1999-07-01 | 2002-04-09 | Medtronic Minimed, Inc. | Reusable analyte sensor site and method of using the same |
| US6413393B1 (en) * | 1999-07-07 | 2002-07-02 | Minimed, Inc. | Sensor including UV-absorbing polymer and method of manufacture |
| US6645359B1 (en) * | 2000-10-06 | 2003-11-11 | Roche Diagnostics Corporation | Biosensor |
| US7073246B2 (en) * | 1999-10-04 | 2006-07-11 | Roche Diagnostics Operations, Inc. | Method of making a biosensor |
| US20020139668A1 (en) * | 1999-11-03 | 2002-10-03 | Raghbir Singh Bhullar | Embedded metallic deposits |
| EP1253852B1 (en) | 2000-02-10 | 2007-09-19 | Medtronic MiniMed, Inc. | Analyte sensor |
| US6484045B1 (en) * | 2000-02-10 | 2002-11-19 | Medtronic Minimed, Inc. | Analyte sensor and method of making the same |
| US6340421B1 (en) * | 2000-05-16 | 2002-01-22 | Minimed Inc. | Microelectrogravimetric method for plating a biosensor |
| US6642015B2 (en) | 2000-12-29 | 2003-11-04 | Minimed Inc. | Hydrophilic polymeric material for coating biosensors |
| US6721587B2 (en) * | 2001-02-15 | 2004-04-13 | Regents Of The University Of California | Membrane and electrode structure for implantable sensor |
| US20030032874A1 (en) | 2001-07-27 | 2003-02-13 | Dexcom, Inc. | Sensor head for use with implantable devices |
| WO2003048736A2 (en) * | 2001-12-05 | 2003-06-12 | University Of Washington | Microfluidic device and surface decoration process for solid phase affinity binding assays |
| EP1345057A3 (de) * | 2002-03-16 | 2004-08-04 | Nexans | Verfahren zur Herstellung eines optischen Kabels |
| US7813780B2 (en) * | 2005-12-13 | 2010-10-12 | Medtronic Minimed, Inc. | Biosensors and methods for making and using them |
| DE10221435B4 (de) * | 2002-05-14 | 2004-10-28 | Isabella Dr. Moser | Enzymelektrodenanordnung, ein Verfahren zu deren Herstellung sowie eine diese Enzymelektrodenanordnung umfassende Biosensoranordnung |
| EP1418428A1 (en) * | 2002-11-07 | 2004-05-12 | GenOdyssee | Method to provide natural therapeutic agents with high therapeutic index |
| US7162289B2 (en) * | 2002-09-27 | 2007-01-09 | Medtronic Minimed, Inc. | Method and apparatus for enhancing the integrity of an implantable sensor device |
| US20040074785A1 (en) * | 2002-10-18 | 2004-04-22 | Holker James D. | Analyte sensors and methods for making them |
| US20050272989A1 (en) * | 2004-06-04 | 2005-12-08 | Medtronic Minimed, Inc. | Analyte sensors and methods for making and using them |
| US20070088208A1 (en) * | 2003-02-17 | 2007-04-19 | Mikito Yasuzawa | Linear device |
| WO2004088309A2 (en) * | 2003-03-28 | 2004-10-14 | Cantata Laboratories, Inc. | Methods for diagnosing urinary tract and prostatic disorders |
| US7718439B2 (en) * | 2003-06-20 | 2010-05-18 | Roche Diagnostics Operations, Inc. | System and method for coding information on a biosensor test strip |
| JP2005060166A (ja) * | 2003-08-12 | 2005-03-10 | Canon Inc | カーボン被覆構造体およびその製造方法、及びカーボンチューブの製造方法、及びカーボン被覆電極、及び機能性素子 |
| US20050090607A1 (en) * | 2003-10-28 | 2005-04-28 | Dexcom, Inc. | Silicone composition for biocompatible membrane |
| US7387714B2 (en) * | 2003-11-06 | 2008-06-17 | 3M Innovative Properties Company | Electrochemical sensor strip |
| US8277713B2 (en) * | 2004-05-03 | 2012-10-02 | Dexcom, Inc. | Implantable analyte sensor |
| US20050245799A1 (en) * | 2004-05-03 | 2005-11-03 | Dexcom, Inc. | Implantable analyte sensor |
| US20070045902A1 (en) | 2004-07-13 | 2007-03-01 | Brauker James H | Analyte sensor |
| WO2006026748A1 (en) * | 2004-08-31 | 2006-03-09 | Lifescan Scotland Limited | Method of manufacturing an auto-calibrating sensor |
| US7468033B2 (en) * | 2004-09-08 | 2008-12-23 | Medtronic Minimed, Inc. | Blood contacting sensor |
-
2006
- 2006-04-04 US US11/397,543 patent/US20070227907A1/en not_active Abandoned
-
2007
- 2007-04-04 EP EP07754927A patent/EP2005157A2/en not_active Withdrawn
- 2007-04-04 JP JP2009504298A patent/JP5568298B2/ja not_active Expired - Fee Related
- 2007-04-04 CA CA2648151A patent/CA2648151C/en active Active
- 2007-04-04 WO PCT/US2007/008491 patent/WO2007114943A2/en not_active Ceased
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2009
- 2009-12-22 US US12/644,949 patent/US20100096278A1/en not_active Abandoned
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2010
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Also Published As
| Publication number | Publication date |
|---|---|
| CA2648151A1 (en) | 2007-10-11 |
| JP2009532700A (ja) | 2009-09-10 |
| US20100096278A1 (en) | 2010-04-22 |
| CA2648151C (en) | 2022-08-23 |
| WO2007114943A3 (en) | 2008-03-06 |
| WO2007114943A2 (en) | 2007-10-11 |
| US20100175992A1 (en) | 2010-07-15 |
| US9541519B2 (en) | 2017-01-10 |
| EP2005157A2 (en) | 2008-12-24 |
| US20070227907A1 (en) | 2007-10-04 |
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