JP5539723B2 - ニコチン性アセチルコリン受容体サブタイプ選択的なジアザビシクロアルカンのアミド - Google Patents

ニコチン性アセチルコリン受容体サブタイプ選択的なジアザビシクロアルカンのアミド Download PDF

Info

Publication number
JP5539723B2
JP5539723B2 JP2009535465A JP2009535465A JP5539723B2 JP 5539723 B2 JP5539723 B2 JP 5539723B2 JP 2009535465 A JP2009535465 A JP 2009535465A JP 2009535465 A JP2009535465 A JP 2009535465A JP 5539723 B2 JP5539723 B2 JP 5539723B2
Authority
JP
Japan
Prior art keywords
diazabicyclo
ylcarbonyl
octane
compounds
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2009535465A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010509230A5 (enExample
JP2010509230A (ja
Inventor
マズロフ，アナトリー
ミャオ，ラン
シャオ，ユン−デ
ハモンド，フィリップ，エス．
ミラー，クレイグ，エイチ．
アキレディー，シュリニビサ，ラオ
マーシィ，ヴィー，シュリニヴァサ
ウィテカー，レジナ，シー
アール． ブレイニング，スコツト
メルヴィン，マット，エス．
Original Assignee
ターガセプト，インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ターガセプト，インコーポレイテッド filed Critical ターガセプト，インコーポレイテッド
Publication of JP2010509230A publication Critical patent/JP2010509230A/ja
Publication of JP2010509230A5 publication Critical patent/JP2010509230A5/ja
Application granted granted Critical
Publication of JP5539723B2 publication Critical patent/JP5539723B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2009535465A 2006-11-02 2007-11-01 ニコチン性アセチルコリン受容体サブタイプ選択的なジアザビシクロアルカンのアミド Active JP5539723B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US85607906P 2006-11-02 2006-11-02
US60/856,079 2006-11-02
PCT/US2007/083330 WO2008057938A1 (en) 2006-11-02 2007-11-01 Nicotinic acetylcholine receptorsub-type selective amides of diazabicycloalkanes

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012253103A Division JP5739398B2 (ja) 2006-11-02 2012-11-19 ニコチン性アセチルコリン受容体サブタイプ選択的なジアザビシクロアルカンのアミド

Publications (3)

Publication Number Publication Date
JP2010509230A JP2010509230A (ja) 2010-03-25
JP2010509230A5 JP2010509230A5 (enExample) 2013-01-17
JP5539723B2 true JP5539723B2 (ja) 2014-07-02

Family

ID=39233054

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2009535465A Active JP5539723B2 (ja) 2006-11-02 2007-11-01 ニコチン性アセチルコリン受容体サブタイプ選択的なジアザビシクロアルカンのアミド
JP2012253103A Active JP5739398B2 (ja) 2006-11-02 2012-11-19 ニコチン性アセチルコリン受容体サブタイプ選択的なジアザビシクロアルカンのアミド

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2012253103A Active JP5739398B2 (ja) 2006-11-02 2012-11-19 ニコチン性アセチルコリン受容体サブタイプ選択的なジアザビシクロアルカンのアミド

Country Status (32)

Country Link
US (6) US8114889B2 (enExample)
EP (2) EP2094703B1 (enExample)
JP (2) JP5539723B2 (enExample)
KR (2) KR20100124356A (enExample)
CN (4) CN102942569B (enExample)
AR (2) AR063451A1 (enExample)
AT (2) ATE509022T1 (enExample)
AU (2) AU2007317433B2 (enExample)
BR (2) BRPI0717930A2 (enExample)
CA (1) CA2663925C (enExample)
CL (1) CL2007003155A1 (enExample)
CO (1) CO6180435A2 (enExample)
CY (1) CY1112374T1 (enExample)
DK (1) DK2094703T3 (enExample)
ES (2) ES2395157T3 (enExample)
HR (1) HRP20110570T1 (enExample)
IL (2) IL197618A (enExample)
MX (1) MX2009004801A (enExample)
MY (2) MY156730A (enExample)
NO (1) NO20091251L (enExample)
NZ (2) NZ587847A (enExample)
PE (2) PE20081441A1 (enExample)
PL (1) PL2094703T3 (enExample)
PT (1) PT2094703E (enExample)
RS (1) RS51834B (enExample)
RU (2) RU2517693C2 (enExample)
SA (1) SA07280584B1 (enExample)
SI (1) SI2094703T1 (enExample)
TW (3) TWI405763B (enExample)
UA (2) UA106718C2 (enExample)
UY (1) UY30686A1 (enExample)
WO (1) WO2008057938A1 (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI405763B (zh) * 2006-11-02 2013-08-21 Targacept Inc 菸鹼乙醯膽鹼受體亞型選擇性之二氮雜雙環烷類醯胺
US20110071180A1 (en) * 2008-03-05 2011-03-24 Targacept, Inc. Sub-type selective amides of diazabicycloalkanes
WO2009113950A1 (en) * 2008-03-10 2009-09-17 Astrazeneca Ab Therapeutic combinations of (a) an antipsychotic and (b) an alpha-4/beta-2 (a4b2)-neuronal nicotinic receptor agonist
WO2009147190A1 (en) 2008-06-05 2009-12-10 Glaxo Group Limited Novel compounds
JP5502076B2 (ja) 2008-06-05 2014-05-28 グラクソ グループ リミテッド 新規化合物
WO2009147188A1 (en) 2008-06-05 2009-12-10 Glaxo Group Limited Benzpyrazol derivatives as inhibitors of pi3 kinases
JP2012502039A (ja) * 2008-09-05 2012-01-26 ターガセプト，インコーポレイテッド ジアザビシクロオクタンのアミド及びその用途
WO2010028011A1 (en) * 2008-09-05 2010-03-11 Targacept, Inc. Amides of diazabicyclononanes and uses thereof
WO2010080757A2 (en) 2009-01-07 2010-07-15 Astrazeneca Ab Combinations with an alpha-4beta-2 nicotinic agonist
US8524751B2 (en) 2009-03-09 2013-09-03 GlaxoSmithKline Intellecutual Property Development 4-oxadiazol-2-YL-indazoles as inhibitors of P13 kinases
RS53830B1 (sr) 2009-04-30 2015-06-30 Glaxo Group Limited Indazoli supstituisani oksazolom kao inhibitori pi3-kinaze
RU2417082C2 (ru) * 2009-07-14 2011-04-27 Учреждение Российской Академии Наук Институт Физиологически Активных Веществ Ран (Ифав Ран) Средство для восстановления утраченной памяти в норме и патологии у пациентов всех возрастных групп на основе n, n'-замещенных 3, 7-диазабицикло[3.3.1]нонанов, фармацевтическая композиция на его основе и способ ее применения
JP5536227B2 (ja) 2009-11-18 2014-07-02 スヴェン・ライフ・サイエンシズ・リミテッド α４β２ニコチン性アセチルコリン受容体リガンドとしての二環式化合物
ES2552932T3 (es) 2009-12-29 2015-12-03 Suven Life Sciences Limited Ligandos del receptor nicotínico neuronal de la acetilcolina alfa4beta2
GB201018124D0 (en) 2010-10-27 2010-12-08 Glaxo Group Ltd Polymorphs and salts
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
AU2014356583B2 (en) 2013-11-26 2019-02-28 F. Hoffmann-La Roche Ag New octahydro-cyclobuta (1,2-c;3,4-c')dipyrrol-2-yl
MA50635A (fr) 2014-03-26 2020-08-12 Hoffmann La Roche Nouveaux composés bicycliques comme inhibiteurs de la production d'autotaxin (atx) et de l'acide lysophosphatidique
CN107106542B (zh) 2014-10-20 2020-05-08 奥伊斯特普安生物制药公司 治疗眼部病状的方法
EP3344619B1 (en) 2015-09-04 2020-10-28 H. Hoffnabb-La Roche Ag Phenoxymethyl derivatives
BR112018006080A2 (pt) 2015-09-24 2018-10-09 F. Hoffmann-La Roche Ag novos compostos bicíclicos como inibidores de dupla ação de atx/ca
WO2017050747A1 (en) 2015-09-24 2017-03-30 F. Hoffmann-La Roche Ag New bicyclic compounds as dual atx/ca inhibitors
MA42918A (fr) 2015-09-24 2018-08-01 Hoffmann La Roche Composés bicycliques utilisés en tant qu'inhibiteurs d'atx
AU2016328437A1 (en) 2015-09-24 2018-01-25 F. Hoffmann-La Roche Ag Bicyclic compounds as ATX inhibitors
NZ746468A (en) 2016-04-07 2023-06-30 Oyster Point Pharma Inc Methods of treating ocular conditions
RU2019132254A (ru) 2017-03-16 2021-04-16 Ф. Хоффманн-Ля Рош Аг Гетероциклические соединения, пригодные в качестве дуальных ингибиторов atx/ca
EP3596060B1 (en) 2017-03-16 2023-09-20 F. Hoffmann-La Roche AG New bicyclic compounds as atx inhibitors
AR111295A1 (es) * 2017-03-20 2019-06-26 Forma Therapeutics Inc Composiciones de pirrolopirrol como activadores de piruvato quinasa (pkr)
WO2020061255A1 (en) 2018-09-19 2020-03-26 Forma Therapeutics, Inc. Activating pyruvate kinase r
US20200129485A1 (en) 2018-09-19 2020-04-30 Forma Therapeutics, Inc. Treating sickle cell disease with a pyruvate kinase r activating compound
MX2022003025A (es) 2019-09-19 2022-04-07 Forma Therapeutics Inc Activacion de la piruvato cinasa r.
US12128035B2 (en) 2021-03-19 2024-10-29 Novo Nordisk Health Care Ag Activating pyruvate kinase R

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4922901A (en) 1988-09-08 1990-05-08 R. J. Reynolds Tobacco Company Drug delivery articles utilizing electrical energy
IL107184A (en) 1992-10-09 1997-08-14 Abbott Lab Heterocyclic ether compounds that enhance cognitive function
US5852041A (en) 1993-04-07 1998-12-22 Sibia Neurosciences, Inc. Substituted pyridines useful as modulators of acethylcholine receptors
US5493026A (en) 1993-10-25 1996-02-20 Organix, Inc. Substituted 2-carboxyalkyl-3-(fluorophenyl)-8-(3-halopropen-2-yl) nortropanes and their use as imaging for agents for neurodegenerative disorders
US5468858A (en) * 1993-10-28 1995-11-21 The Board Of Regents Of Oklahoma State University Physical Sciences N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents
ATE177099T1 (de) * 1993-12-29 1999-03-15 Pfizer Diazabicyclische neurokinin antagonisten
US5457121A (en) 1994-09-02 1995-10-10 Eli Lilly And Company Cis-hexahydro-5-(1,2,3,4-tetrahydro-2-naphthalenyl)pyrrolo<3,4-c>pyrroles as inhibitors of serotonin reuptake
US5597919A (en) 1995-01-06 1997-01-28 Dull; Gary M. Pyrimidinyl or Pyridinyl alkenyl amine compounds
US5604231A (en) 1995-01-06 1997-02-18 Smith; Carr J. Pharmaceutical compositions for prevention and treatment of ulcerative colitis
US5585388A (en) 1995-04-07 1996-12-17 Sibia Neurosciences, Inc. Substituted pyridines useful as modulators of acetylcholine receptors
US5583140A (en) 1995-05-17 1996-12-10 Bencherif; Merouane Pharmaceutical compositions for the treatment of central nervous system disorders
IL118279A (en) 1995-06-07 2006-10-05 Abbott Lab Compounds 3 - Pyridyloxy (or Thio) Alkyl Heterocyclic Pharmaceutical Compositions Containing Them and Their Uses for Preparing Drugs to Control Synaptic Chemical Transmission
US5616716A (en) 1996-01-06 1997-04-01 Dull; Gary M. (3-(5-ethoxypyridin)yl)-alkenyl 1 amine compounds
SE9600683D0 (sv) * 1996-02-23 1996-02-23 Astra Ab Azabicyclic esters of carbamic acids useful in therapy
US5663356A (en) * 1996-04-23 1997-09-02 Ruecroft; Graham Method for preparation of aryl substituted alefinic secondary amino compounds
US5726189A (en) 1996-05-03 1998-03-10 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Method for imaging nicotinic acetylcholinergic receptors in the brain using radiolabeled pyridyl-7-azabicyclo 2.2.1!heptanes
US5952339A (en) 1998-04-02 1999-09-14 Bencherif; Merouane Pharmaceutical compositions and methods of using nicotinic antagonists for treating a condition or disorder characterized by alteration in normal neurotransmitter release
MXPA02005884A (es) * 1999-12-14 2002-10-23 Neurosearch As Heteroaril-diazabicicloalcanos novedosos.
US6809105B2 (en) * 2000-04-27 2004-10-26 Abbott Laboratories Diazabicyclic central nervous system active agents
WO2002070523A1 (en) 2001-03-07 2002-09-12 Pfizer Products Inc. Modulators of chemokine receptor activity
EP1406900B1 (en) 2001-07-06 2006-10-04 Neurosearch A/S Novel compounds, their preparation and use
SE0202430D0 (sv) * 2002-08-14 2002-08-14 Astrazeneca Ab New Compounds
SE0202465D0 (sv) * 2002-08-14 2002-08-14 Astrazeneca Ab New compounds
CN1317280C (zh) * 2003-02-27 2007-05-23 神经研究公司 新的二氮杂双环芳基衍生物
JP2006519208A (ja) * 2003-02-27 2006-08-24 ニューロサーチ、アクティーゼルスカブ 新規ジアザビシクロアリール誘導体
US7399765B2 (en) 2003-09-19 2008-07-15 Abbott Laboratories Substituted diazabicycloalkane derivatives
US7365193B2 (en) * 2004-02-04 2008-04-29 Abbott Laboratories Amino-substituted tricyclic derivatives and methods of use
ATE382623T1 (de) * 2004-06-09 2008-01-15 Hoffmann La Roche Octahydropyrrolo(3,4-c)pyrrolderivate und deren verwendung als antivirale mitteln
CA2574307A1 (en) * 2004-07-22 2006-02-02 Cumbre Pharmaceuticals Inc. Rifamycin derivatives for treating microbial infections
CN101193635A (zh) 2005-05-13 2008-06-04 莱西肯医药有限公司 多环化合物及其使用方法
TWI405763B (zh) * 2006-11-02 2013-08-21 Targacept Inc 菸鹼乙醯膽鹼受體亞型選擇性之二氮雜雙環烷類醯胺

Also Published As

Publication number Publication date
MY145602A (en) 2012-03-15
MY156730A (en) 2016-03-15
AR079840A2 (es) 2012-02-22
UA106718C2 (uk) 2014-10-10
PE20110671A1 (es) 2011-10-20
EP2284171A1 (en) 2011-02-16
RS51834B (sr) 2012-02-29
US20100081683A1 (en) 2010-04-01
AU2010219323B2 (en) 2012-05-03
CN101528745A (zh) 2009-09-09
CA2663925A1 (en) 2008-05-15
CN102020646B (zh) 2013-11-13
CN102942569A (zh) 2013-02-27
CN102942569B (zh) 2015-10-28
JP5739398B2 (ja) 2015-06-24
US20130005789A1 (en) 2013-01-03
BRPI0717930A2 (pt) 2011-05-10
EP2094703B1 (en) 2011-05-11
CL2007003155A1 (es) 2008-05-16
US20100173932A1 (en) 2010-07-08
CN101528745B (zh) 2011-09-14
RU2009120674A (ru) 2010-12-10
AR063451A1 (es) 2009-01-28
PE20081441A1 (es) 2008-10-30
IL209026A (en) 2014-03-31
TWI405763B (zh) 2013-08-21
JP2013056919A (ja) 2013-03-28
EP2094703A1 (en) 2009-09-02
RU2517693C2 (ru) 2014-05-27
HK1149751A1 (en) 2011-10-14
IL209026A0 (en) 2011-01-31
IL197618A (en) 2013-09-30
PT2094703E (pt) 2011-07-22
US8859609B2 (en) 2014-10-14
AU2007317433B2 (en) 2012-05-10
ES2395212T3 (es) 2013-02-11
DK2094703T3 (da) 2011-08-29
PL2094703T3 (pl) 2011-10-31
CA2663925C (en) 2015-04-21
NO20091251L (no) 2009-05-28
US8114889B2 (en) 2012-02-14
UA98944C2 (ru) 2012-07-10
CN102020646A (zh) 2011-04-20
WO2008057938A1 (en) 2008-05-15
RU2009138600A (ru) 2011-04-27
AU2010219323A1 (en) 2010-09-30
KR20090074051A (ko) 2009-07-03
MX2009004801A (es) 2009-07-31
RU2448969C2 (ru) 2012-04-27
KR101415705B1 (ko) 2014-07-04
ATE509022T1 (de) 2011-05-15
TW201305176A (zh) 2013-02-01
BRPI0722387A2 (pt) 2023-02-23
CY1112374T1 (el) 2015-12-09
TWI454262B (zh) 2014-10-01
EP2284171B1 (en) 2012-02-15
US9580434B2 (en) 2017-02-28
ES2395157T3 (es) 2013-02-08
SA07280584B1 (ar) 2010-11-02
AU2007317433A1 (en) 2008-05-15
US20160039833A1 (en) 2016-02-11
TW200826935A (en) 2008-07-01
US8268860B2 (en) 2012-09-18
TWI404532B (zh) 2013-08-11
US8921410B2 (en) 2014-12-30
CN102838605B (zh) 2017-04-26
US20120289572A1 (en) 2012-11-15
HK1133260A1 (en) 2010-03-19
CO6180435A2 (es) 2010-07-19
IL197618A0 (en) 2009-12-24
SI2094703T1 (sl) 2011-07-29
HRP20110570T1 (hr) 2011-09-30
ATE545646T1 (de) 2012-03-15
CN102838605A (zh) 2012-12-26
UY30686A1 (es) 2009-08-03
KR20100124356A (ko) 2010-11-26
NZ587847A (en) 2011-09-30
US20150080576A1 (en) 2015-03-19
TW201114424A (en) 2011-05-01
JP2010509230A (ja) 2010-03-25
NZ575557A (en) 2011-01-28

Similar Documents

Publication Publication Date Title
JP5739398B2 (ja) ニコチン性アセチルコリン受容体サブタイプ選択的なジアザビシクロアルカンのアミド
CN102648202A (zh) 作为神经元烟碱乙酰胆碱受体配体的3,6-二氮杂双环[3.1.1]庚烷
AU2012205208A1 (en) Nicotinic acetylcholine receptor sub-type selective amides of diazabicycloalkanes
HK1133260B (en) Nicotinic acetylcholine receptorsub-type selective amides of diazabicycloalkanes
HK1149751B (en) Amides of diazabicycloalkanes selective for nicotinic acetylcholine receptor sub-types

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20100928

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20121119

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130108

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130903

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20131127

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20131204

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20140408

R150 Certificate of patent or registration of utility model

Ref document number: 5539723

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20140501

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313113

S531 Written request for registration of change of domicile

Free format text: JAPANESE INTERMEDIATE CODE: R313531

S533 Written request for registration of change of name

Free format text: JAPANESE INTERMEDIATE CODE: R313533

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250