JP5523824B2 - 抗−5t4抗体およびその使用 - Google Patents
抗−5t4抗体およびその使用 Download PDFInfo
- Publication number
- JP5523824B2 JP5523824B2 JP2009500565A JP2009500565A JP5523824B2 JP 5523824 B2 JP5523824 B2 JP 5523824B2 JP 2009500565 A JP2009500565 A JP 2009500565A JP 2009500565 A JP2009500565 A JP 2009500565A JP 5523824 B2 JP5523824 B2 JP 5523824B2
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- antibody
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- variable region
- chain variable
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78134606P | 2006-03-10 | 2006-03-10 | |
US60/781,346 | 2006-03-10 | ||
US89124807P | 2007-02-23 | 2007-02-23 | |
US60/891,248 | 2007-02-23 | ||
PCT/US2007/063685 WO2007106744A2 (fr) | 2006-03-10 | 2007-03-09 | Anticorps anti-5t4 et leurs utilisations |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2009529578A JP2009529578A (ja) | 2009-08-20 |
JP2009529578A5 JP2009529578A5 (fr) | 2010-04-22 |
JP5523824B2 true JP5523824B2 (ja) | 2014-06-18 |
Family
ID=38445207
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009500565A Expired - Fee Related JP5523824B2 (ja) | 2006-03-10 | 2007-03-09 | 抗−5t4抗体およびその使用 |
Country Status (30)
Country | Link |
---|---|
US (5) | US8044178B2 (fr) |
EP (3) | EP2368914B1 (fr) |
JP (1) | JP5523824B2 (fr) |
KR (2) | KR101443752B1 (fr) |
CN (1) | CN101437850B (fr) |
AR (1) | AR059809A1 (fr) |
AU (1) | AU2007226696C1 (fr) |
BR (1) | BRPI0708771B8 (fr) |
CA (1) | CA2645097C (fr) |
CR (1) | CR10273A (fr) |
DK (2) | DK1994055T3 (fr) |
EC (1) | ECSP088733A (fr) |
ES (2) | ES2712942T3 (fr) |
GT (1) | GT200800181A (fr) |
HK (1) | HK1121473A1 (fr) |
IL (2) | IL193986A (fr) |
MX (1) | MX2008011492A (fr) |
MY (1) | MY148763A (fr) |
NO (1) | NO20083891L (fr) |
NZ (2) | NZ596295A (fr) |
PA (1) | PA8718601A1 (fr) |
PE (1) | PE20080119A1 (fr) |
PL (1) | PL1994055T3 (fr) |
PT (1) | PT1994055E (fr) |
SA (1) | SA07280101B1 (fr) |
SG (1) | SG170091A1 (fr) |
SI (1) | SI1994055T1 (fr) |
TW (2) | TWI421257B (fr) |
WO (1) | WO2007106744A2 (fr) |
ZA (1) | ZA200808075B (fr) |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
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CA2634783A1 (fr) * | 2005-12-23 | 2008-05-08 | Board Of Regents Of The University Of Texas System | Therapies anti-hyperproliferatives ciblant des hdgf |
TWI421257B (zh) * | 2006-03-10 | 2014-01-01 | Wyeth Corp | 抗5t4抗體及其用途 |
CN102719444B (zh) | 2006-09-01 | 2016-12-14 | 人类多细胞株治疗学公司 | 人或人源化免疫球蛋白在非人转基因动物中增强的表达 |
ES2405605T3 (es) | 2009-03-27 | 2013-05-31 | Wyeth Llc | Células iniciadoras de tumores y procedimientos de uso de las mismas |
GB0918383D0 (en) * | 2009-10-20 | 2009-12-02 | Cancer Rec Tech Ltd | Prognostic,screening and treatment methods and agents for treatment of metastasis and inflammation |
UA107490C2 (uk) | 2010-04-07 | 2015-01-12 | Еббві Інк. | TNF-α-ЗВ'ЯЗУВАЛЬНИЙ БІЛОК |
ES2683953T3 (es) * | 2011-02-07 | 2018-09-28 | Aggamin Llc | Procedimientos y sistemas para tratar o prevenir trastornos hipertensivos gestacionales |
PL2694111T3 (pl) * | 2011-04-01 | 2017-01-31 | Wyeth Llc | Koniugaty przeciwciało-lek |
WO2013028810A1 (fr) | 2011-08-22 | 2013-02-28 | Cangene Corporation | Anticorps du clostridium difficile |
CA2846432A1 (fr) | 2011-09-23 | 2013-03-28 | Amgen Research (Munich) Gmbh | Molecules de liaison bispecifiques pour 5t4 et cd3 |
WO2013068874A1 (fr) | 2011-11-11 | 2013-05-16 | Pfizer Inc. | Conjugués anticorps-médicament |
US10254286B2 (en) | 2012-01-24 | 2019-04-09 | Pfizer Inc. | Methods for detecting 5T4-positive circulating tumor cells and methods of diagnosis of 5T4-positive cancer in a mammalian subject |
US9221908B2 (en) | 2012-12-12 | 2015-12-29 | Vasculox, Inc. | Therapeutic CD47 antibodies |
WO2014093678A2 (fr) | 2012-12-12 | 2014-06-19 | Frazier William A | Anticorps anti-cd47 thérapeutiques |
WO2014137931A1 (fr) * | 2013-03-06 | 2014-09-12 | Imaginab, Inc. | Constructions de liaison à un antigène se liant à 5t4 |
CA2905418C (fr) * | 2013-03-13 | 2023-03-28 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Procedes de modulation de la cytotoxicite chimiotherapeutique |
CA2915960A1 (fr) * | 2013-06-17 | 2014-12-24 | Asana Biosciences, Llc | Molecule d'immunofusion ciblant 5t4 et procedes correspondants |
EP3054992B1 (fr) | 2013-10-11 | 2019-08-14 | Asana BioSciences, LLC | Conjugués médicament-polymère-protéine |
JP6420331B2 (ja) | 2013-10-11 | 2018-11-07 | メルサナ セラピューティクス,インコーポレイティド | タンパク質−高分子−薬剤コンジュゲート |
PE20161413A1 (es) | 2013-11-04 | 2017-01-10 | Stemcentrx Inc | Conjugados de anticuerpo anti-efna4-farmaco |
WO2015155345A1 (fr) * | 2014-04-11 | 2015-10-15 | Medimmune Limited | Anticorps et conjugués anticorps-médicament |
US10407743B2 (en) | 2014-05-22 | 2019-09-10 | Synthon Biopharmaceuticals B.V. | Site-specific conjugation of linker drugs to antibodies and resulting ADCs |
EA035419B9 (ru) * | 2014-05-29 | 2020-08-07 | Мэкроудженикс, Инк. | Триспецифичные связывающие молекулы и способы их применения |
DK3453406T3 (da) | 2014-07-29 | 2021-07-12 | Cellectis | ROR1(NTRKR1)-specifikke kimære antigenreceptorer til cancerimmunterapi |
JP2017522893A (ja) | 2014-07-31 | 2017-08-17 | セレクティスCellectis | Ror1特異的多重鎖キメラ抗原受容体 |
JP6810685B2 (ja) * | 2014-09-04 | 2021-01-06 | セレクティスCellectis | 癌免疫療法のための栄養膜糖タンパク質(5t4、tpbg)特異的キメラ抗原受容体 |
JP2018508193A (ja) * | 2015-01-22 | 2018-03-29 | プロセナ バイオサイエンシーズ リミテッド | メディンを認識する抗体 |
TW201706300A (zh) | 2015-05-20 | 2017-02-16 | 瑟勒提斯公司 | 用於癌症免疫療法之抗-gd3專一性嵌合抗原受體 |
NZ740686A (en) | 2015-09-18 | 2021-12-24 | Arch Oncology Inc | Therapeutic cd47 antibodies |
EP3184547A1 (fr) * | 2015-10-29 | 2017-06-28 | F. Hoffmann-La Roche AG | Anticorps anti-tpbg et procédés d'utilisation |
ES2889398T3 (es) * | 2015-11-24 | 2022-01-12 | Byondis Bv | Anticuerpos anti-5T4 y conjugados de anticuerpo-fármaco |
CN110606890B (zh) * | 2015-12-24 | 2021-11-26 | 凯惠科技发展(上海)有限公司 | 一种tpbg抗体及其制备方法、其偶联物和应用 |
EP3487518A4 (fr) * | 2016-07-20 | 2020-08-12 | Aerpio Therapeutics LLC | Anticorps monoclonaux humanisés ciblant ve-ptp (hptp-ss) |
EP3529276A4 (fr) | 2016-10-21 | 2020-06-17 | Arch Oncology, Inc. | Anticorps cd47 thérapeutiques |
US11135307B2 (en) | 2016-11-23 | 2021-10-05 | Mersana Therapeutics, Inc. | Peptide-containing linkers for antibody-drug conjugates |
CN108084265B (zh) * | 2016-11-23 | 2021-07-02 | 复旦大学 | 特异性结合人的5t4抗原的全人源单域抗体及其应用 |
CN108285487B (zh) * | 2017-01-08 | 2021-02-19 | 浙江昭华生物医药有限公司 | 抗5t4抗体-药物偶联物及其应用 |
JP7132232B2 (ja) | 2017-02-24 | 2022-09-06 | マクロジェニクス,インコーポレーテッド | Cd137及び腫瘍抗原に結合できる二重特異性結合分子並びにその使用 |
EP3595705A1 (fr) * | 2017-03-15 | 2020-01-22 | Oxford BioMedica (UK) Limited | Procédé |
JP7305549B2 (ja) * | 2017-04-05 | 2023-07-10 | エックスディーシーエクスプローラー (シャンハイ) カンパニー リミテッド | ヒト化抗tpbg抗体およびその製造方法、その複合体および使用 |
SG11201909160WA (en) | 2017-04-11 | 2019-10-30 | Inhibrx Inc | Multispecific polypeptide constructs having constrained cd3 binding and methods of using the same |
WO2018226795A1 (fr) * | 2017-06-06 | 2018-12-13 | The Regents Of The University Of California | Anticorps anti-n-cadhérine humanisés et leurs utilisations |
KR102649757B1 (ko) | 2017-07-20 | 2024-03-21 | 압테보 리서치 앤드 디벨롭먼트 엘엘씨 | 5t4 및 4-1bb에 결합하는 항원 결합 단백질 및 관련 조성물 및 방법 |
EP3717021A1 (fr) | 2017-11-27 | 2020-10-07 | Mersana Therapeutics, Inc. | Conjugués anticorps-pyrrolobenzodiazépine |
US20220305127A1 (en) | 2017-12-21 | 2022-09-29 | Mersana Therapeutics, Inc. | Pyrrolobenzodiazepine antibody conjugates |
CN108187065B (zh) * | 2017-12-29 | 2023-04-28 | 广东众生药业股份有限公司 | 抗5t4抗体与美登素衍生物dm4偶联复合物及制备方法和用途 |
EP3735458A4 (fr) | 2018-01-03 | 2022-04-27 | Palleon Pharmaceuticals Inc. | Sialidases humaines recombinantes, protéines de fusion de sialidase et leurs méthodes d'utilisation |
MA52152A (fr) | 2018-03-12 | 2021-01-20 | Genmab As | Anticorps |
KR20210006913A (ko) | 2018-04-11 | 2021-01-19 | 인히브릭스, 인크. | 제한된 cd3 결합을 갖는 다중특이적 폴리펩티드 컨스트럭트 및 관련된 방법 및 용도 |
TW202035451A (zh) | 2018-07-24 | 2020-10-01 | 美商英伊布里克斯公司 | 含有受限cd3結合域及受體結合區之多重特異性多肽構築體及其使用方法 |
CN113166262A (zh) | 2018-10-11 | 2021-07-23 | 英伊布里克斯公司 | Pd-1单结构域抗体及其治疗组合物 |
WO2020092385A1 (fr) | 2018-10-29 | 2020-05-07 | Mersana Therapeutics, Inc. | Conjugués anticorps-médicament modifiés par une cystéine avec des lieurs contenant des peptides |
EP4028424A1 (fr) | 2019-09-12 | 2022-07-20 | Genmab A/S | Anticorps bispécifiques se liant à 5t4 et cd3 pour une utilisation dans le traitement du cancer |
EP4097129A1 (fr) | 2020-01-29 | 2022-12-07 | Inhibrx, Inc. | Anticorps cd28 à domaine unique et constructions multivalentes et multispécifiques de ceux-ci |
WO2022087416A1 (fr) * | 2020-10-22 | 2022-04-28 | Actinium Pharmaceuticals, Inc. | Combinaison de radioimmunothérapie et de blocage de cd47 dans le traitement du cancer |
CA3173557A1 (fr) * | 2021-01-06 | 2022-07-14 | Li Peng | Anticorps anti-pd-l1 et proteines de fusion de correspondantes |
WO2023155925A1 (fr) * | 2022-02-21 | 2023-08-24 | Concept To Medicine Biotech Co., Ltd. | Anticorps anti-5t4 et leurs utilisations |
EP4353220A1 (fr) * | 2022-10-12 | 2024-04-17 | Pierre Fabre Medicament | Utilisation d'une composition aqueuse liquide pour la solubilisation et la stabilisation d'un conjugué anticorps-médicament |
CN116715773B (zh) * | 2023-02-28 | 2024-03-01 | 星奕昂(上海)生物科技有限公司 | 一种靶向5t4的抗体及其应用 |
Family Cites Families (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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