JP5517384B2 - 注射可能な医薬調製剤の製法 - Google Patents

注射可能な医薬調製剤の製法 Download PDF

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Publication number
JP5517384B2
JP5517384B2 JP2001502882A JP2001502882A JP5517384B2 JP 5517384 B2 JP5517384 B2 JP 5517384B2 JP 2001502882 A JP2001502882 A JP 2001502882A JP 2001502882 A JP2001502882 A JP 2001502882A JP 5517384 B2 JP5517384 B2 JP 5517384B2
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group
agent
protein
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therapeutically
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Japanese (ja)
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JP2003501486A5 (https=
JP2003501486A (ja
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クラッツ フェリックス
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KTB Tumorforschungs GmbH
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KTB Tumorforschungs GmbH
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545Heterocyclic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2001502882A 1999-06-09 2000-06-07 注射可能な医薬調製剤の製法 Expired - Lifetime JP5517384B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19926154A DE19926154A1 (de) 1999-06-09 1999-06-09 Verfahren zur Herstellung einer injizierbaren Arzneimittelzubereitung
DE19926154.7 1999-06-09
PCT/EP2000/005272 WO2000076551A2 (de) 1999-06-09 2000-06-07 Verfahren zur herstellung einer injizierbaren arzneimittelzubereitung

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011102053A Division JP5871483B2 (ja) 1999-06-09 2011-04-28 注射可能な医薬調製剤の製法

Publications (3)

Publication Number Publication Date
JP2003501486A JP2003501486A (ja) 2003-01-14
JP2003501486A5 JP2003501486A5 (https=) 2012-11-01
JP5517384B2 true JP5517384B2 (ja) 2014-06-11

Family

ID=7910588

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2001502882A Expired - Lifetime JP5517384B2 (ja) 1999-06-09 2000-06-07 注射可能な医薬調製剤の製法
JP2011102053A Expired - Lifetime JP5871483B2 (ja) 1999-06-09 2011-04-28 注射可能な医薬調製剤の製法
JP2013268998A Withdrawn JP2014055192A (ja) 1999-06-09 2013-12-26 注射可能な医薬調製剤の製法
JP2015252087A Expired - Lifetime JP6290166B2 (ja) 1999-06-09 2015-12-24 注射可能な医薬調製剤の製法
JP2017214959A Expired - Lifetime JP6573947B2 (ja) 1999-06-09 2017-11-07 注射可能な医薬調製剤の製法

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2011102053A Expired - Lifetime JP5871483B2 (ja) 1999-06-09 2011-04-28 注射可能な医薬調製剤の製法
JP2013268998A Withdrawn JP2014055192A (ja) 1999-06-09 2013-12-26 注射可能な医薬調製剤の製法
JP2015252087A Expired - Lifetime JP6290166B2 (ja) 1999-06-09 2015-12-24 注射可能な医薬調製剤の製法
JP2017214959A Expired - Lifetime JP6573947B2 (ja) 1999-06-09 2017-11-07 注射可能な医薬調製剤の製法

Country Status (13)

Country Link
US (5) US7387771B1 (https=)
EP (3) EP2347770B2 (https=)
JP (5) JP5517384B2 (https=)
AT (1) ATE339225T1 (https=)
AU (1) AU779697B2 (https=)
CA (1) CA2374964C (https=)
CY (2) CY1105701T1 (https=)
DE (2) DE19926154A1 (https=)
DK (3) DK1704864T3 (https=)
ES (3) ES2269160T3 (https=)
PT (3) PT1704864E (https=)
SI (1) SI1704864T1 (https=)
WO (1) WO2000076551A2 (https=)

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EP2347770A3 (de) 2011-11-09
CY1105701T1 (el) 2010-12-22
PT1704864E (pt) 2012-07-02
EP1704864A2 (de) 2006-09-27
SI1704864T1 (sl) 2012-09-28
ES2269160T3 (es) 2007-04-01
CA2374964C (en) 2012-05-22
ES2385230T3 (es) 2012-07-19
AU779697B2 (en) 2005-02-10
EP1183050A2 (de) 2002-03-06
JP2016047847A (ja) 2016-04-07
US20150196573A1 (en) 2015-07-16
ES2623017T5 (es) 2020-04-07
EP1183050B1 (de) 2006-09-13
US8153581B2 (en) 2012-04-10
JP2014055192A (ja) 2014-03-27
CA2374964A1 (en) 2000-12-21
EP2347770B2 (de) 2019-10-23
JP5871483B2 (ja) 2016-03-01
EP1704864A3 (de) 2007-01-10
WO2000076551A2 (de) 2000-12-21
EP1704864B1 (de) 2012-05-23
ES2623017T3 (es) 2017-07-10
JP2011173913A (ja) 2011-09-08
DE19926154A1 (de) 2000-12-14
PT2347770T (pt) 2017-06-20
ATE339225T1 (de) 2006-10-15
DK1183050T3 (da) 2007-01-02
US7387771B1 (en) 2008-06-17
AU5970900A (en) 2001-01-02
DK2347770T3 (en) 2017-07-03
EP2347770A2 (de) 2011-07-27
EP2347770B1 (de) 2017-03-08
US20120195832A1 (en) 2012-08-02
US8846602B2 (en) 2014-09-30
US20060233707A1 (en) 2006-10-19
WO2000076551A3 (de) 2001-08-16
EP1704864B9 (de) 2012-09-19
DK2347770T4 (da) 2020-02-03
JP2003501486A (ja) 2003-01-14
JP6290166B2 (ja) 2018-03-07
CY1113370T1 (el) 2016-06-22
PT1183050E (pt) 2007-01-31
US20100215574A1 (en) 2010-08-26
JP6573947B2 (ja) 2019-09-11
DK1704864T3 (da) 2012-09-03
JP2018035191A (ja) 2018-03-08
DE50013468D1 (de) 2006-10-26

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