JP5512655B2 - Ｃ型肝炎ウイルス阻害剤 - Google Patents

Ｃ型肝炎ウイルス阻害剤 Download PDF

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Publication number
JP5512655B2
JP5512655B2 JP2011505096A JP2011505096A JP5512655B2 JP 5512655 B2 JP5512655 B2 JP 5512655B2 JP 2011505096 A JP2011505096 A JP 2011505096A JP 2011505096 A JP2011505096 A JP 2011505096A JP 5512655 B2 JP5512655 B2 JP 5512655B2
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JP
Japan
Prior art keywords
compound
hcv
alkyl
nmr
mmol
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Expired - Fee Related
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JP2011505096A
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English (en)
Japanese (ja)
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JP2011518163A (ja
JP2011518163A5 (enExample
Inventor
ニ・シン
ブライアン・リー・ベナブルズ
ポール・マイケル・スコーラ
アラン・シャンドン・ワン
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Publication of JP2011518163A5 publication Critical patent/JP2011518163A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrrole Compounds (AREA)
JP2011505096A 2008-04-16 2009-04-09 Ｃ型肝炎ウイルス阻害剤 Expired - Fee Related JP5512655B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US4543408P 2008-04-16 2008-04-16
US61/045,434 2008-04-16
US12/418,677 2009-04-06
US12/418,677 US8163921B2 (en) 2008-04-16 2009-04-06 Hepatitis C virus inhibitors
PCT/US2009/039993 WO2009129109A1 (en) 2008-04-16 2009-04-09 Hepatitis c virus inhibitors

Publications (3)

Publication Number Publication Date
JP2011518163A JP2011518163A (ja) 2011-06-23
JP2011518163A5 JP2011518163A5 (enExample) 2012-05-17
JP5512655B2 true JP5512655B2 (ja) 2014-06-04

Family

ID=40666703

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011505096A Expired - Fee Related JP5512655B2 (ja) 2008-04-16 2009-04-09 Ｃ型肝炎ウイルス阻害剤

Country Status (11)

Country Link
US (1) US8163921B2 (enExample)
EP (2) EP2265606B1 (enExample)
JP (1) JP5512655B2 (enExample)
KR (1) KR101610418B1 (enExample)
CN (2) CN102083821B (enExample)
AR (1) AR071370A1 (enExample)
CL (1) CL2009000923A1 (enExample)
MX (1) MX2010010974A (enExample)
PE (1) PE20091841A1 (enExample)
TW (1) TW200946523A (enExample)
WO (1) WO2009129109A1 (enExample)

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Also Published As

Publication number Publication date
CN102083821B (zh) 2014-09-17
AR071370A1 (es) 2010-06-16
PE20091841A1 (es) 2009-12-04
US8163921B2 (en) 2012-04-24
KR101610418B1 (ko) 2016-04-07
EP2813500B1 (en) 2016-08-17
JP2011518163A (ja) 2011-06-23
EP2265606B1 (en) 2015-10-21
WO2009129109A1 (en) 2009-10-22
KR20100132078A (ko) 2010-12-16
CN103936819B (zh) 2016-11-16
AU2009236467A1 (en) 2009-10-22
EP2265606A1 (en) 2010-12-29
TW200946523A (en) 2009-11-16
US20090274652A1 (en) 2009-11-05
EP2813500A1 (en) 2014-12-17
CL2009000923A1 (es) 2009-09-11
CN102083821A (zh) 2011-06-01
CN103936819A (zh) 2014-07-23
MX2010010974A (es) 2010-11-01

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