JP5508260B2 - ｍＴＯＲキナーゼおよび／またはＰ１３Ｋに関連する病気に用いられるモルホリノピリミジン誘導体 - Google Patents

ｍＴＯＲキナーゼおよび／またはＰ１３Ｋに関連する病気に用いられるモルホリノピリミジン誘導体 Download PDF

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JP5508260B2
JP5508260B2 JP2010515602A JP2010515602A JP5508260B2 JP 5508260 B2 JP5508260 B2 JP 5508260B2 JP 2010515602 A JP2010515602 A JP 2010515602A JP 2010515602 A JP2010515602 A JP 2010515602A JP 5508260 B2 JP5508260 B2 JP 5508260B2
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alkyl
amino
alkoxy
halo
bis
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パイク，カート・ゴードン
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AstraZeneca AB
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2010515602A 2007-07-09 2008-07-08 ｍＴＯＲキナーゼおよび／またはＰ１３Ｋに関連する病気に用いられるモルホリノピリミジン誘導体 Expired - Fee Related JP5508260B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94853907P 2007-07-09 2007-07-09
US60/948,539 2007-07-09
PCT/GB2008/050548 WO2009007750A1 (en) 2007-07-09 2008-07-08 Morpholino pyrimidine derivatives used in diseases linked to mtor kinase and/or pi3k

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JP2010533160A JP2010533160A (ja) 2010-10-21
JP2010533160A5 JP2010533160A5 (https=) 2012-08-16
JP5508260B2 true JP5508260B2 (ja) 2014-05-28

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US (1) US8138183B2 (https=)
EP (1) EP2176238B1 (https=)
JP (1) JP5508260B2 (https=)
KR (1) KR20100042280A (https=)
CN (1) CN101809002B (https=)
AR (1) AR070079A1 (https=)
AT (1) ATE554075T1 (https=)
AU (1) AU2008273891B2 (https=)
BR (1) BRPI0814688A2 (https=)
CA (1) CA2692720A1 (https=)
CL (1) CL2008003940A1 (https=)
CO (1) CO6251364A2 (https=)
CR (1) CR11200A (https=)
DO (1) DOP2010000012A (https=)
EA (1) EA018708B1 (https=)
EC (1) ECSP109935A (https=)
ES (1) ES2385692T3 (https=)
NI (1) NI201000002A (https=)
PE (1) PE20100138A1 (https=)
WO (1) WO2009007750A1 (https=)
ZA (1) ZA200909224B (https=)

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DOP2010000012A (es) 2010-01-31
AU2008273891A1 (en) 2009-01-15
KR20100042280A (ko) 2010-04-23
WO2009007750A1 (en) 2009-01-15
CR11200A (es) 2010-06-17
BRPI0814688A2 (pt) 2017-06-06
ATE554075T1 (de) 2012-05-15
EP2176238B1 (en) 2012-04-18
PE20100138A1 (es) 2010-03-20
NI201000002A (es) 2010-10-12
CN101809002A (zh) 2010-08-18
ZA200909224B (en) 2011-05-25
CO6251364A2 (es) 2011-02-21
ES2385692T3 (es) 2012-07-30
JP2010533160A (ja) 2010-10-21
AU2008273891B2 (en) 2012-01-12
US20100249131A1 (en) 2010-09-30
US8138183B2 (en) 2012-03-20
CL2008003940A1 (es) 2010-09-24
EA018708B1 (ru) 2013-10-30
CN101809002B (zh) 2013-03-27
CA2692720A1 (en) 2009-01-15
EP2176238A1 (en) 2010-04-21
EA201000091A1 (ru) 2010-06-30
AR070079A1 (es) 2010-03-10
HK1142906A1 (en) 2010-12-17

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