JP5487440B2 - 鏡像異性的に純粋なアミンの調製方法 - Google Patents
鏡像異性的に純粋なアミンの調製方法 Download PDFInfo
- Publication number
- JP5487440B2 JP5487440B2 JP2011512213A JP2011512213A JP5487440B2 JP 5487440 B2 JP5487440 B2 JP 5487440B2 JP 2011512213 A JP2011512213 A JP 2011512213A JP 2011512213 A JP2011512213 A JP 2011512213A JP 5487440 B2 JP5487440 B2 JP 5487440B2
- Authority
- JP
- Japan
- Prior art keywords
- acid
- rasagiline
- salt
- organic solvent
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 69
- XJEVHMGJSYVQBQ-SECBINFHSA-N (1r)-2,3-dihydro-1h-inden-1-amine Chemical compound C1=CC=C2[C@H](N)CCC2=C1 XJEVHMGJSYVQBQ-SECBINFHSA-N 0.000 claims description 60
- 150000003839 salts Chemical class 0.000 claims description 60
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- 239000000203 mixture Substances 0.000 claims description 25
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/82—Purification; Separation; Stabilisation; Use of additives
- C07C209/86—Separation
- C07C209/88—Separation of optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
- C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
- C07C211/42—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems with six-membered aromatic rings being part of the condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
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- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurosurgery (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN973/KOL/2008 | 2008-06-02 | ||
| IN973KO2008 | 2008-06-02 | ||
| PCT/GB2009/050608 WO2009147430A1 (en) | 2008-06-02 | 2009-06-02 | A process for the preparation of enantiomerically pure amines |
Publications (3)
| Publication Number | Publication Date |
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| JP2011522023A JP2011522023A (ja) | 2011-07-28 |
| JP2011522023A5 JP2011522023A5 (enExample) | 2012-07-19 |
| JP5487440B2 true JP5487440B2 (ja) | 2014-05-07 |
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| US (2) | US8569545B2 (enExample) |
| EP (1) | EP2285769B1 (enExample) |
| JP (1) | JP5487440B2 (enExample) |
| CN (2) | CN103896779B (enExample) |
| AU (1) | AU2009254927B2 (enExample) |
| CA (2) | CA2723869C (enExample) |
| CY (1) | CY1115577T1 (enExample) |
| NZ (1) | NZ589486A (enExample) |
| PL (1) | PL2285769T3 (enExample) |
| WO (1) | WO2009147430A1 (enExample) |
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| AU2009254927B2 (en) * | 2008-06-02 | 2014-03-13 | Generics [Uk] Limited | A process for the preparation of enantiomerically pure amines |
| EP2681186B1 (en) | 2011-03-03 | 2016-05-11 | Synthon BV | Process of resolution of 1-aminoindan |
| WO2015033261A1 (en) | 2013-09-03 | 2015-03-12 | Universidade De Évora | Process for preparing cyclic chiral amines and alcohols by intramolecular catalytic arylation of boronic acid or ester aldehydes and imine substrates |
| CN104326920B (zh) * | 2014-10-13 | 2016-03-16 | 江苏清泉化学股份有限公司 | 一种去除间苯二甲胺中杂质的方法 |
| CN105018560B (zh) * | 2015-08-13 | 2018-09-14 | 陈永军 | 动态动力学拆分制备(s)-6-甲氧基-1-氨基茚满 |
| CN105063161B (zh) * | 2015-08-18 | 2018-11-09 | 陈永军 | 一种r-1-氨基茚满的制备方法 |
| CN105087742B (zh) * | 2015-08-18 | 2018-09-14 | 陈永军 | 动态动力学拆分制备r-6-羟基-1-氨基茚满 |
| CN105177103B (zh) * | 2015-08-19 | 2019-03-12 | 陈永军 | 一种r-6-羟基-1-氨基茚满的制备方法 |
| AR110150A1 (es) * | 2016-11-09 | 2019-02-27 | Roivant Sciences Gmbh | Procesos para la preparación de inhibidores de tph1 |
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| US3198834A (en) | 1964-07-27 | 1965-08-03 | Snc Science Union Et Compagnie | Optical isomers of trifluoromethylated phenethylamines |
| US3728388A (en) | 1970-08-10 | 1973-04-17 | Sterling Drug Inc | 1-amino-2,3-disubstituted cyclopropenylium salts |
| US3855227A (en) * | 1972-05-08 | 1974-12-17 | C Hollander | ({31 )-di-o-isopropylidene-2-keto-l-gulonates |
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2009
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Also Published As
| Publication number | Publication date |
|---|---|
| US20110251288A1 (en) | 2011-10-13 |
| EP2285769A1 (en) | 2011-02-23 |
| EP2285769B1 (en) | 2014-08-13 |
| PL2285769T3 (pl) | 2015-01-30 |
| US20130303741A1 (en) | 2013-11-14 |
| CA2723869A1 (en) | 2009-12-10 |
| CN102123980B (zh) | 2014-05-07 |
| NZ589486A (en) | 2012-08-31 |
| CA2812006A1 (en) | 2009-12-10 |
| AU2009254927A1 (en) | 2009-12-10 |
| WO2009147430A1 (en) | 2009-12-10 |
| US8809589B2 (en) | 2014-08-19 |
| CA2723869C (en) | 2013-07-16 |
| CN103896779B (zh) | 2015-12-30 |
| AU2009254927B2 (en) | 2014-03-13 |
| CA2812006C (en) | 2016-07-26 |
| CN102123980A (zh) | 2011-07-13 |
| CN103896779A (zh) | 2014-07-02 |
| CY1115577T1 (el) | 2017-01-04 |
| JP2011522023A (ja) | 2011-07-28 |
| US8569545B2 (en) | 2013-10-29 |
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