CN103896779B - 用于制备对映异构纯胺的方法 - Google Patents

用于制备对映异构纯胺的方法 Download PDF

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Publication number
CN103896779B
CN103896779B CN201410143892.0A CN201410143892A CN103896779B CN 103896779 B CN103896779 B CN 103896779B CN 201410143892 A CN201410143892 A CN 201410143892A CN 103896779 B CN103896779 B CN 103896779B
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Prior art keywords
acid
rasagiline
aminoidan
organic solvent
alcohol
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Expired - Fee Related
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English (en)
Chinese (zh)
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CN103896779A (zh
Inventor
维纳亚克·戈雷
宾杜·马诺杰库马
桑迪普·索娜瓦内
达塔特雷·科卡内
辛德帕尔·汤克
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Generics UK Ltd
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Generics UK Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C07C209/86—Separation
    • C07C209/88—Separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
    • C07C211/42—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems with six-membered aromatic rings being part of the condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Vascular Medicine (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201410143892.0A 2008-06-02 2009-06-02 用于制备对映异构纯胺的方法 Expired - Fee Related CN103896779B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN973/KOL/2008 2008-06-02
IN973KO2008 2008-06-02
CN200980129438.7A CN102123980B (zh) 2008-06-02 2009-06-02 用于制备对映异构纯胺的方法

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CN200980129438.7A Division CN102123980B (zh) 2008-06-02 2009-06-02 用于制备对映异构纯胺的方法

Publications (2)

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CN103896779A CN103896779A (zh) 2014-07-02
CN103896779B true CN103896779B (zh) 2015-12-30

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CN200980129438.7A Expired - Fee Related CN102123980B (zh) 2008-06-02 2009-06-02 用于制备对映异构纯胺的方法

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US (2) US8569545B2 (enExample)
EP (1) EP2285769B1 (enExample)
JP (1) JP5487440B2 (enExample)
CN (2) CN103896779B (enExample)
AU (1) AU2009254927B2 (enExample)
CA (2) CA2723869C (enExample)
CY (1) CY1115577T1 (enExample)
NZ (1) NZ589486A (enExample)
PL (1) PL2285769T3 (enExample)
WO (1) WO2009147430A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009254927B2 (en) * 2008-06-02 2014-03-13 Generics [Uk] Limited A process for the preparation of enantiomerically pure amines
EP2681186B1 (en) 2011-03-03 2016-05-11 Synthon BV Process of resolution of 1-aminoindan
WO2015033261A1 (en) 2013-09-03 2015-03-12 Universidade De Évora Process for preparing cyclic chiral amines and alcohols by intramolecular catalytic arylation of boronic acid or ester aldehydes and imine substrates
CN104326920B (zh) * 2014-10-13 2016-03-16 江苏清泉化学股份有限公司 一种去除间苯二甲胺中杂质的方法
CN105018560B (zh) * 2015-08-13 2018-09-14 陈永军 动态动力学拆分制备(s)-6-甲氧基-1-氨基茚满
CN105063161B (zh) * 2015-08-18 2018-11-09 陈永军 一种r-1-氨基茚满的制备方法
CN105087742B (zh) * 2015-08-18 2018-09-14 陈永军 动态动力学拆分制备r-6-羟基-1-氨基茚满
CN105177103B (zh) * 2015-08-19 2019-03-12 陈永军 一种r-6-羟基-1-氨基茚满的制备方法
AR110150A1 (es) * 2016-11-09 2019-02-27 Roivant Sciences Gmbh Procesos para la preparación de inhibidores de tph1

Citations (1)

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US3928621A (en) 1974-10-10 1975-12-23 Hoffmann La Roche Antiinflammatory 2-(2-aminoalkylamino)-1,2-diphenylethanols
JPS5283938A (en) 1976-01-01 1977-07-13 Hoffmann La Roche Antiiinflammation agent and process for preparing same
HU187775B (en) 1982-07-14 1986-02-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu New process for producing propargile-amines of pharmaceutical activity
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AU607437B2 (en) 1986-09-02 1991-03-07 Du Pont Pharmaceuticals Company Resolution of dl-methyl 3-(4-(2-hydroxy-3-isopropylamino) propoxy)phenylpropionate((dl-esmolol))
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IL92952A (en) 1990-01-03 1994-06-24 Teva Pharma R-enantiomers of n-propargyl-1-aminoindan compounds, their preparation and pharmaceutical compositions containing them
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Publication number Publication date
US20110251288A1 (en) 2011-10-13
EP2285769A1 (en) 2011-02-23
EP2285769B1 (en) 2014-08-13
PL2285769T3 (pl) 2015-01-30
US20130303741A1 (en) 2013-11-14
CA2723869A1 (en) 2009-12-10
CN102123980B (zh) 2014-05-07
NZ589486A (en) 2012-08-31
CA2812006A1 (en) 2009-12-10
AU2009254927A1 (en) 2009-12-10
WO2009147430A1 (en) 2009-12-10
US8809589B2 (en) 2014-08-19
CA2723869C (en) 2013-07-16
AU2009254927B2 (en) 2014-03-13
JP5487440B2 (ja) 2014-05-07
CA2812006C (en) 2016-07-26
CN102123980A (zh) 2011-07-13
CN103896779A (zh) 2014-07-02
CY1115577T1 (el) 2017-01-04
JP2011522023A (ja) 2011-07-28
US8569545B2 (en) 2013-10-29

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