JP5461405B2 - 嚢胞性線維症膜コンダクタンス制御因子の調節因子 - Google Patents

嚢胞性線維症膜コンダクタンス制御因子の調節因子 Download PDF

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JP5461405B2
JP5461405B2 JP2010525061A JP2010525061A JP5461405B2 JP 5461405 B2 JP5461405 B2 JP 5461405B2 JP 2010525061 A JP2010525061 A JP 2010525061A JP 2010525061 A JP2010525061 A JP 2010525061A JP 5461405 B2 JP5461405 B2 JP 5461405B2
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compound
optionally substituted
ring
aliphatic
formula
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JP2010539185A5 (enExample
JP2010539185A (ja
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ヘイリー ビンチ，
ピーター ディー．ジェイ． グルーテニュイス，
ルアー， サラ エス． ハディーダ
チンラン チョウ，
アナ ヘーゼルウッド，
レブ ティー．ディー． ファニング，
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Vertex Pharmaceuticals Inc
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones

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  • Endocrinology (AREA)
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  • Hospice & Palliative Care (AREA)
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  • Rheumatology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2010525061A 2007-09-14 2008-09-15 嚢胞性線維症膜コンダクタンス制御因子の調節因子 Expired - Fee Related JP5461405B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97259907P 2007-09-14 2007-09-14
US60/972,599 2007-09-14
PCT/US2008/076376 WO2009036412A1 (en) 2007-09-14 2008-09-15 Modulators of cystic fibrosis transmembrane conductance regulator

Publications (3)

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JP2010539185A JP2010539185A (ja) 2010-12-16
JP2010539185A5 JP2010539185A5 (enExample) 2012-10-25
JP5461405B2 true JP5461405B2 (ja) 2014-04-02

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JP2010525061A Expired - Fee Related JP5461405B2 (ja) 2007-09-14 2008-09-15 嚢胞性線維症膜コンダクタンス制御因子の調節因子

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US (3) US8188283B2 (enExample)
EP (1) EP2201010B1 (enExample)
JP (1) JP5461405B2 (enExample)
CN (1) CN101821266B (enExample)
AU (1) AU2008298545B2 (enExample)
CA (1) CA2699382C (enExample)
ES (1) ES2445442T3 (enExample)
NZ (1) NZ583878A (enExample)
WO (1) WO2009036412A1 (enExample)

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US10022352B2 (en) 2006-04-07 2018-07-17 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
USRE50453E1 (en) 2006-04-07 2025-06-10 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
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US9012496B2 (en) 2012-07-16 2015-04-21 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of (R)-1-(2,2-difluorobenzo[D][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide and administration thereof
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CA2699382A1 (en) 2009-03-19
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US20130178496A1 (en) 2013-07-11
US8748612B2 (en) 2014-06-10
NZ583878A (en) 2012-10-26
US20100261750A1 (en) 2010-10-14
EP2201010A1 (en) 2010-06-30
US20130018070A1 (en) 2013-01-17
WO2009036412A1 (en) 2009-03-19
CN101821266B (zh) 2014-03-12
WO2009036412A8 (en) 2013-08-01
US8188283B2 (en) 2012-05-29
CN101821266A (zh) 2010-09-01
ES2445442T3 (es) 2014-03-03
US8410132B2 (en) 2013-04-02
CA2699382C (en) 2016-05-10

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