JP5431949B2 - 減損した創傷治癒の組成物としての抗コネキシンポリヌクレオチド - Google Patents

減損した創傷治癒の組成物としての抗コネキシンポリヌクレオチド Download PDF

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JP5431949B2
JP5431949B2 JP2009541370A JP2009541370A JP5431949B2 JP 5431949 B2 JP5431949 B2 JP 5431949B2 JP 2009541370 A JP2009541370 A JP 2009541370A JP 2009541370 A JP2009541370 A JP 2009541370A JP 5431949 B2 JP5431949 B2 JP 5431949B2
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connexin
composition
wound
polynucleotide
healing
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JP2010512404A5 (enExample
JP2010512404A (ja
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デイビッド エル. ベッカー,
コリン アール. グリーン,
ブラッドフォード ジェイ. ダフト,
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コーダ セラピューティクス, インコーポレイテッド
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/7105Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/11Antisense
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering nucleic acids [NA]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00Applications; Uses
    • C12N2320/30Special therapeutic applications
    • C12N2320/35Special therapeutic applications based on a specific dosage / administration regimen

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2009541370A 2006-12-11 2007-12-11 減損した創傷治癒の組成物としての抗コネキシンポリヌクレオチド Expired - Fee Related JP5431949B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87440406P 2006-12-11 2006-12-11
US60/874,404 2006-12-11
PCT/US2007/025446 WO2008073479A2 (en) 2006-12-11 2007-12-11 Anticonnexin polynucleotides as impaired wound healing compositions

Related Child Applications (1)

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JP2013117401A Division JP5911454B2 (ja) 2006-12-11 2013-06-03 減損した創傷治癒の組成物としての抗コネキシンポリヌクレオチド

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JP2010512404A JP2010512404A (ja) 2010-04-22
JP2010512404A5 JP2010512404A5 (enExample) 2012-01-19
JP5431949B2 true JP5431949B2 (ja) 2014-03-05

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JP2009541370A Expired - Fee Related JP5431949B2 (ja) 2006-12-11 2007-12-11 減損した創傷治癒の組成物としての抗コネキシンポリヌクレオチド
JP2013117401A Expired - Fee Related JP5911454B2 (ja) 2006-12-11 2013-06-03 減損した創傷治癒の組成物としての抗コネキシンポリヌクレオチド
JP2015000248A Pending JP2015063565A (ja) 2006-12-11 2015-01-05 減損した創傷治癒の組成物としての抗コネキシンポリヌクレオチド

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JP2015000248A Pending JP2015063565A (ja) 2006-12-11 2015-01-05 減損した創傷治癒の組成物としての抗コネキシンポリヌクレオチド

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US (5) US8063023B2 (enExample)
EP (3) EP2543378A1 (enExample)
JP (3) JP5431949B2 (enExample)
KR (1) KR101521306B1 (enExample)
CN (2) CN103520197B (enExample)
AU (1) AU2007333535B2 (enExample)
BR (1) BRPI0721094A2 (enExample)
CA (1) CA2672220A1 (enExample)
DK (1) DK2101791T3 (enExample)
ES (1) ES2527131T3 (enExample)
PL (1) PL2101791T3 (enExample)
PT (1) PT2101791E (enExample)
RU (1) RU2521329C2 (enExample)
SI (1) SI2101791T1 (enExample)
WO (1) WO2008073479A2 (enExample)

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KR20150004906A (ko) 2005-02-03 2015-01-13 코다 테라퓨틱스 (엔지) 리미티드 항-코넥신 화합물 및 그의 용도
KR20150072458A (ko) 2006-11-15 2015-06-29 코다 테라퓨틱스, 인크. 상처 치유를 위한 개선 방법 및 조성물
RU2521329C2 (ru) 2006-12-11 2014-06-27 Коуда Терапьютикс, Инк. Композиции и способы лечения плохо заживающих ран
US20080249044A1 (en) * 2007-04-03 2008-10-09 Masaya Tanaka Nucleic acid external skin formulation
JP2011506447A (ja) * 2007-12-11 2011-03-03 コーダ セラピューティクス, インコーポレイテッド 損傷した創傷治癒組成物および治療
AU2008335717A1 (en) * 2007-12-11 2009-06-18 Coda Therapeutics, Inc. Impaired wound healing compositions and treatments
US8975237B2 (en) 2007-12-21 2015-03-10 Coda Therapeutics, Inc. Treatment of fibrotic conditions
AU2008343756A1 (en) * 2007-12-21 2009-07-09 Coda Therapeutics, Inc. Use of anti-connexin polypeptide agent in combination with anti-connexin polynucleotide agent for the treatment of fibrotic conditions
WO2012076985A2 (en) * 2010-12-06 2012-06-14 The University Of British Columbia Granzyme b inhibitor compositions, methods and uses for promoting wound healing
GB201117538D0 (en) * 2011-10-11 2011-11-23 Royal Veterinary College The Methods
KR102038948B1 (ko) 2012-03-01 2019-11-26 퍼스트스트링 리서치 인코포레이티드 알파 코넥신 c-말단 (act) 펩타이드를 포함하는 국소 겔
CN104736709A (zh) * 2012-03-27 2015-06-24 科达治疗公司 基于钙粘蛋白调节的组合物和治疗
US9156896B2 (en) 2013-03-15 2015-10-13 Coda Therapeutics, Inc. Wound healing compositions and treatments
CA2941140A1 (en) * 2014-03-14 2015-09-17 Coda Therapeutics Treatment of resistant lesions
EP4491184A3 (en) 2014-08-22 2025-03-26 Auckland Uniservices Limited Channel modulators
CN113694077A (zh) * 2015-08-13 2021-11-26 索马根尼科斯公司 用于伤口愈合的短小发夹rna与微rna的组合物以及方法
EP3518847B1 (en) * 2016-09-27 2023-03-01 Smith & Nephew plc Wound closure devices with dissolvable portions
CA3061738A1 (en) 2017-04-28 2018-11-01 Auckland Uniservices Limited Methods of treatment and novel constructs
CN108588075A (zh) * 2018-05-03 2018-09-28 天德悦(北京)生物科技有限责任公司 人Cx43基因干扰序列、shRNA-Cx43病毒及低表达Cx43蛋白的细胞系
MX2023004631A (es) 2020-10-22 2023-07-20 Xequel Bio Inc Formulaciones peptidicas y usos oftalmicos de las mismas.
RU2754383C1 (ru) * 2020-12-07 2021-09-01 Федеральное Государственное Бюджетное Учреждение "Национальный Медицинский Исследовательский Центр Эндокринологии" Министерства Здравоохранения Российской Федерации (Фгбу "Нмиц Эндокринологии" Минздрава России) Способ лечения неинфицированного послеоперационного раневого дефекта стопы при отсутствии признаков критической ишемии конечности у больных с нейропатической и нейроишемической формой синдрома диабетической стопы

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KR20150072458A (ko) 2006-11-15 2015-06-29 코다 테라퓨틱스, 인크. 상처 치유를 위한 개선 방법 및 조성물
RU2521329C2 (ru) 2006-12-11 2014-06-27 Коуда Терапьютикс, Инк. Композиции и способы лечения плохо заживающих ран
KR20150028856A (ko) 2007-05-31 2015-03-16 안테리오스, 인코퍼레이티드 핵산 나노입자 및 이의 용도
JP2011506447A (ja) 2007-12-11 2011-03-03 コーダ セラピューティクス, インコーポレイテッド 損傷した創傷治癒組成物および治療
AU2008335717A1 (en) 2007-12-11 2009-06-18 Coda Therapeutics, Inc. Impaired wound healing compositions and treatments

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Publication number Publication date
KR101521306B1 (ko) 2015-05-18
US20130143952A1 (en) 2013-06-06
ES2527131T3 (es) 2015-01-20
US9637745B2 (en) 2017-05-02
US20080242631A1 (en) 2008-10-02
WO2008073479A2 (en) 2008-06-19
AU2007333535B2 (en) 2014-04-17
RU2521329C2 (ru) 2014-06-27
RU2009126594A (ru) 2011-01-20
US20170240905A1 (en) 2017-08-24
PT2101791E (pt) 2014-12-18
BRPI0721094A2 (pt) 2014-02-11
CN103520197B (zh) 2017-11-21
JP2013173796A (ja) 2013-09-05
AU2007333535A1 (en) 2008-06-19
EP2101791B1 (en) 2014-09-10
US9029339B2 (en) 2015-05-12
CN103520197A (zh) 2014-01-22
SI2101791T1 (sl) 2015-02-27
US8063023B2 (en) 2011-11-22
CA2672220A1 (en) 2008-06-19
KR20090118910A (ko) 2009-11-18
JP2015063565A (ja) 2015-04-09
JP2010512404A (ja) 2010-04-22
CN101835476A (zh) 2010-09-15
US20150315598A1 (en) 2015-11-05
HK1136213A1 (en) 2010-06-25
US20120289579A1 (en) 2012-11-15
EP2543377A1 (en) 2013-01-09
EP2101791A2 (en) 2009-09-23
WO2008073479A3 (en) 2008-08-07
DK2101791T3 (en) 2015-01-05
US8685940B2 (en) 2014-04-01
JP5911454B2 (ja) 2016-04-27
CN101835476B (zh) 2016-08-17
PL2101791T3 (pl) 2015-04-30
EP2543378A1 (en) 2013-01-09

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