JP5416124B2 - 抗−Ｂｃｌ−２活性剤とタイプＩＩ抗−ＣＤ２０抗体のとの組み合わせ療法 - Google Patents

抗−Ｂｃｌ−２活性剤とタイプＩＩ抗−ＣＤ２０抗体のとの組み合わせ療法 Download PDF

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JP5416124B2
JP5416124B2 JP2010528326A JP2010528326A JP5416124B2 JP 5416124 B2 JP5416124 B2 JP 5416124B2 JP 2010528326 A JP2010528326 A JP 2010528326A JP 2010528326 A JP2010528326 A JP 2010528326A JP 5416124 B2 JP5416124 B2 JP 5416124B2
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antibody
bcl
type
cell
cancer
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JP2011500521A (ja
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フリース，トマス
クライン，クリスティアン
ブレマー，パメラ
ウマナ，パブロ
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ロシュ グリクアート アクチェンゲゼルシャフト
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2010528326A 2007-10-15 2008-10-13 抗−Ｂｃｌ−２活性剤とタイプＩＩ抗−ＣＤ２０抗体のとの組み合わせ療法 Expired - Fee Related JP5416124B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07020120.7 2007-10-15
EP07020120 2007-10-15
PCT/EP2008/008635 WO2009049841A1 (en) 2007-10-15 2008-10-13 Combination therapy of a type ii anti-cd20 antibody with an anti-bcl-2 active agent

Publications (2)

Publication Number Publication Date
JP2011500521A JP2011500521A (ja) 2011-01-06
JP5416124B2 true JP5416124B2 (ja) 2014-02-12

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JP2010528326A Expired - Fee Related JP5416124B2 (ja) 2007-10-15 2008-10-13 抗−Ｂｃｌ−２活性剤とタイプＩＩ抗−ＣＤ２０抗体のとの組み合わせ療法

Country Status (16)

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US (6) US20090098118A1 (zh)
EP (2) EP2203185A1 (zh)
JP (1) JP5416124B2 (zh)
KR (1) KR101278395B1 (zh)
CN (1) CN101827611B (zh)
AR (1) AR068862A1 (zh)
AU (1) AU2008314068B2 (zh)
BR (1) BRPI0818673A2 (zh)
CA (1) CA2702300A1 (zh)
CL (1) CL2008003035A1 (zh)
IL (1) IL204744A0 (zh)
MX (1) MX2010003815A (zh)
PE (1) PE20090966A1 (zh)
RU (1) RU2541805C2 (zh)
TW (1) TWI430809B (zh)
WO (1) WO2009049841A1 (zh)

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US8546399B2 (en) 2009-05-26 2013-10-01 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
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Publication number Publication date
US20140004104A1 (en) 2014-01-02
MX2010003815A (es) 2010-08-04
US20090098118A1 (en) 2009-04-16
JP2011500521A (ja) 2011-01-06
AR068862A1 (es) 2009-12-09
US20110287006A1 (en) 2011-11-24
CA2702300A1 (en) 2009-04-23
IL204744A0 (en) 2010-11-30
EP2604277A1 (en) 2013-06-19
CN101827611B (zh) 2014-01-15
AU2008314068B2 (en) 2014-01-16
RU2541805C2 (ru) 2015-02-20
PE20090966A1 (es) 2009-07-13
RU2010118448A (ru) 2012-05-20
BRPI0818673A2 (pt) 2015-09-08
KR101278395B1 (ko) 2013-06-24
US20150056186A1 (en) 2015-02-26
AU2008314068A1 (en) 2009-04-23
WO2009049841A1 (en) 2009-04-23
TW200920401A (en) 2009-05-16
US20110086025A1 (en) 2011-04-14
US20120276085A1 (en) 2012-11-01
EP2203185A1 (en) 2010-07-07
TWI430809B (zh) 2014-03-21
CL2008003035A1 (es) 2010-01-11
CN101827611A (zh) 2010-09-08
KR20100056559A (ko) 2010-05-27

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