JP5405746B2 - 脂肪族生物分解性リンカーに基づく放出可能なポリマー複合体 - Google Patents
脂肪族生物分解性リンカーに基づく放出可能なポリマー複合体 Download PDFInfo
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- JP5405746B2 JP5405746B2 JP2007546901A JP2007546901A JP5405746B2 JP 5405746 B2 JP5405746 B2 JP 5405746B2 JP 2007546901 A JP2007546901 A JP 2007546901A JP 2007546901 A JP2007546901 A JP 2007546901A JP 5405746 B2 JP5405746 B2 JP 5405746B2
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- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polyamides (AREA)
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Applications Claiming Priority (3)
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|---|---|---|---|
| US11/011,818 US7413738B2 (en) | 2002-08-13 | 2004-12-14 | Releasable polymeric conjugates based on biodegradable linkers |
| US11/011,818 | 2004-12-14 | ||
| PCT/US2005/045467 WO2006066020A2 (en) | 2004-12-14 | 2005-12-13 | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
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| JP2008523239A JP2008523239A (ja) | 2008-07-03 |
| JP2008523239A5 JP2008523239A5 (enExample) | 2013-10-24 |
| JP5405746B2 true JP5405746B2 (ja) | 2014-02-05 |
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| US (2) | US7413738B2 (enExample) |
| EP (1) | EP1827497A4 (enExample) |
| JP (1) | JP5405746B2 (enExample) |
| KR (1) | KR20070089739A (enExample) |
| CN (1) | CN101076353B (enExample) |
| AU (1) | AU2005316520B2 (enExample) |
| CA (1) | CA2589975C (enExample) |
| IL (1) | IL183582A0 (enExample) |
| MX (1) | MX2007007034A (enExample) |
| RU (1) | RU2007126802A (enExample) |
| TW (1) | TWI375556B (enExample) |
| WO (1) | WO2006066020A2 (enExample) |
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| US7087229B2 (en) * | 2003-05-30 | 2006-08-08 | Enzon Pharmaceuticals, Inc. | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
| US7122189B2 (en) * | 2002-08-13 | 2006-10-17 | Enzon, Inc. | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
| US7413738B2 (en) * | 2002-08-13 | 2008-08-19 | Enzon Pharmaceuticals, Inc. | Releasable polymeric conjugates based on biodegradable linkers |
| US7365127B2 (en) * | 2005-02-04 | 2008-04-29 | Enzon Pharmaceuticals, Inc. | Process for the preparation of polymer conjugates |
| CA2600303A1 (en) * | 2005-05-04 | 2006-11-09 | Lonza Ag | Solid phase bound thymosin alpha-1 and its synthesis |
| GB2427360A (en) | 2005-06-22 | 2006-12-27 | Complex Biosystems Gmbh | Aliphatic prodrug linker |
| US8133707B2 (en) * | 2006-01-17 | 2012-03-13 | Enzon Pharmaceuticals, Inc. | Methods of preparing activated polymers having alpha nitrogen groups |
| EP2035016A2 (en) * | 2006-06-09 | 2009-03-18 | Enzon Pharmaceuticals, Inc. | Indenoisoquinoline-releasable polymer conjugates |
| US8110559B2 (en) * | 2006-09-15 | 2012-02-07 | Enzon Pharmaceuticals, Inc. | Hindered ester-based biodegradable linkers for oligonucleotide delivery |
| CA2662973A1 (en) * | 2006-09-15 | 2008-03-20 | Enzon Pharmaceuticals, Inc. | Lysine-based polymeric linkers |
| JP2010503705A (ja) * | 2006-09-15 | 2010-02-04 | エンゾン ファーマスーティカルズ インコーポレイテッド | ヒンダードエステル系の生分解性リンカーを有するポリアルキレンオキサイド |
| MX2009002856A (es) * | 2006-09-15 | 2009-03-30 | Enzon Pharmaceuticals Inc | Conjugados polimericos que contienen porciones cargadas positivamente. |
| TW200836762A (en) * | 2006-11-27 | 2008-09-16 | Enzon Pharmaceuticals Inc | Polymeric short interfering RNA conjugates |
| TW200835514A (en) * | 2006-12-29 | 2008-09-01 | Enzon Pharmaceuticals Inc | Use of adenosine deaminase for treating pulmonary disease |
| CA2684750C (en) * | 2007-04-20 | 2014-08-05 | Enzon Pharmaceuticals, Inc. | Stable recombinant adenosine deaminase |
| CA2684749C (en) * | 2007-04-20 | 2016-06-21 | Enzon Pharmaceuticals, Inc. | Use of adenosine deaminase for cancer therapy |
| US20100203066A1 (en) * | 2007-08-20 | 2010-08-12 | Enzon Pharmaceuticals, Inc. | Polymeric linkers containing pyridyl disulfide moieties |
| CA3187392A1 (en) | 2013-10-15 | 2015-04-23 | Seagen Inc. | Pegylated drug-linkers for improved ligand-drug conjugate pharmacokinetics |
| US11844839B2 (en) | 2016-03-25 | 2023-12-19 | Seagen Inc. | Process for the preparation of pegylated drug-linkers and intermediates thereof |
| JP7527787B2 (ja) | 2017-03-24 | 2024-08-05 | シージェン インコーポレイテッド | グルクロニド薬物－リンカーの調製のためのプロセスおよびその中間体 |
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| US3888797A (en) | 1970-08-04 | 1975-06-10 | Carapus Company Limited | Detergent composition |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| DE4135115A1 (de) | 1991-10-24 | 1993-04-29 | Trigon Chemie Gmbh | Kationaktive tenside |
| US5679711A (en) | 1993-10-08 | 1997-10-21 | Fhj Scientific, Inc. | Hydroxyl ions as novel therapeutic agents and compounds that modulate these ions, compositions employing these agents, therapeutic methods for using such agents |
| US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US5919455A (en) | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| CA2473100A1 (en) | 2002-02-25 | 2003-08-28 | Kudos Pharmaceuticals Limited | Pyranones useful as atm inhibitors |
| US7087229B2 (en) * | 2003-05-30 | 2006-08-08 | Enzon Pharmaceuticals, Inc. | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
| US7413738B2 (en) * | 2002-08-13 | 2008-08-19 | Enzon Pharmaceuticals, Inc. | Releasable polymeric conjugates based on biodegradable linkers |
| US7122189B2 (en) * | 2002-08-13 | 2006-10-17 | Enzon, Inc. | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
| WO2004044222A2 (en) | 2002-11-12 | 2004-05-27 | Enzon Pharmaceuticals, Inc. | Polymeric prodrugs of vancomycin |
| US7332164B2 (en) | 2003-03-21 | 2008-02-19 | Enzon Pharmaceuticals, Inc. | Heterobifunctional polymeric bioconjugates |
| RU2394041C2 (ru) | 2003-04-13 | 2010-07-10 | Энзон Фармасьютикалз, Инк. | Полимерные олигонуклеотидные пролекарства |
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| US7413738B2 (en) | 2008-08-19 |
| IL183582A0 (en) | 2007-09-20 |
| CA2589975A1 (en) | 2006-06-22 |
| MX2007007034A (es) | 2007-08-03 |
| EP1827497A4 (en) | 2010-09-29 |
| JP2008523239A (ja) | 2008-07-03 |
| US20080305070A1 (en) | 2008-12-11 |
| WO2006066020A2 (en) | 2006-06-22 |
| TW200635576A (en) | 2006-10-16 |
| TWI375556B (en) | 2012-11-01 |
| WO2006066020A3 (en) | 2006-08-10 |
| RU2007126802A (ru) | 2009-01-27 |
| EP1827497A2 (en) | 2007-09-05 |
| AU2005316520A1 (en) | 2006-06-22 |
| US20050197290A1 (en) | 2005-09-08 |
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