RU2007126802A - Расщепляемые полимерные конъюгаты на основе алифатических биодеградируемых линкеров - Google Patents
Расщепляемые полимерные конъюгаты на основе алифатических биодеградируемых линкеров Download PDFInfo
- Publication number
- RU2007126802A RU2007126802A RU2007126802/04A RU2007126802A RU2007126802A RU 2007126802 A RU2007126802 A RU 2007126802A RU 2007126802/04 A RU2007126802/04 A RU 2007126802/04A RU 2007126802 A RU2007126802 A RU 2007126802A RU 2007126802 A RU2007126802 A RU 2007126802A
- Authority
- RU
- Russia
- Prior art keywords
- group
- substituted
- alkyl
- compound according
- independently
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 claims 32
- 150000001875 compounds Chemical class 0.000 claims 25
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 17
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 15
- 125000006716 (C1-C6) heteroalkyl group Chemical group 0.000 claims 13
- 239000012634 fragment Substances 0.000 claims 13
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 12
- 125000003710 aryl alkyl group Chemical group 0.000 claims 11
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 125000003118 aryl group Chemical group 0.000 claims 9
- 230000001588 bifunctional effect Effects 0.000 claims 9
- 229920000642 polymer Polymers 0.000 claims 8
- 239000001257 hydrogen Substances 0.000 claims 7
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 125000004405 heteroalkoxy group Chemical group 0.000 claims 6
- 150000002431 hydrogen Chemical class 0.000 claims 6
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 125000003107 substituted aryl group Chemical group 0.000 claims 5
- 229910052717 sulfur Inorganic materials 0.000 claims 5
- 230000000890 antigenic effect Effects 0.000 claims 4
- 230000003993 interaction Effects 0.000 claims 4
- 239000013067 intermediate product Substances 0.000 claims 4
- 230000008685 targeting Effects 0.000 claims 4
- 230000003213 activating effect Effects 0.000 claims 3
- 239000013543 active substance Substances 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 229940039227 diagnostic agent Drugs 0.000 claims 3
- 239000000032 diagnostic agent Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 238000006116 polymerization reaction Methods 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 230000000903 blocking effect Effects 0.000 claims 2
- 125000000524 functional group Chemical group 0.000 claims 2
- 125000004404 heteroalkyl group Chemical group 0.000 claims 2
- 230000002209 hydrophobic effect Effects 0.000 claims 2
- -1 leaving groups Chemical group 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 238000010511 deprotection reaction Methods 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 229920000233 poly(alkylene oxides) Polymers 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- ZTQUZAZOVJMJDT-UHFFFAOYSA-N CCC(CCOC(N)=C)OC(CC)=C Chemical compound CCC(CCOC(N)=C)OC(CC)=C ZTQUZAZOVJMJDT-UHFFFAOYSA-N 0.000 description 1
- 0 CCCOCCOCC*[N+]([O-])OCC Chemical compound CCCOCCOCC*[N+]([O-])OCC 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/16—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Polyethers (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polyamides (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/011,818 US7413738B2 (en) | 2002-08-13 | 2004-12-14 | Releasable polymeric conjugates based on biodegradable linkers |
| US11/011,818 | 2004-12-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2007126802A true RU2007126802A (ru) | 2009-01-27 |
Family
ID=36588567
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2007126802/04A RU2007126802A (ru) | 2004-12-14 | 2005-12-13 | Расщепляемые полимерные конъюгаты на основе алифатических биодеградируемых линкеров |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7413738B2 (enExample) |
| EP (1) | EP1827497A4 (enExample) |
| JP (1) | JP5405746B2 (enExample) |
| KR (1) | KR20070089739A (enExample) |
| CN (1) | CN101076353B (enExample) |
| AU (1) | AU2005316520B2 (enExample) |
| CA (1) | CA2589975C (enExample) |
| IL (1) | IL183582A0 (enExample) |
| MX (1) | MX2007007034A (enExample) |
| RU (1) | RU2007126802A (enExample) |
| TW (1) | TWI375556B (enExample) |
| WO (1) | WO2006066020A2 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7087229B2 (en) * | 2003-05-30 | 2006-08-08 | Enzon Pharmaceuticals, Inc. | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
| US7122189B2 (en) * | 2002-08-13 | 2006-10-17 | Enzon, Inc. | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
| US7413738B2 (en) * | 2002-08-13 | 2008-08-19 | Enzon Pharmaceuticals, Inc. | Releasable polymeric conjugates based on biodegradable linkers |
| US7365127B2 (en) * | 2005-02-04 | 2008-04-29 | Enzon Pharmaceuticals, Inc. | Process for the preparation of polymer conjugates |
| CA2600303A1 (en) * | 2005-05-04 | 2006-11-09 | Lonza Ag | Solid phase bound thymosin alpha-1 and its synthesis |
| GB2427360A (en) | 2005-06-22 | 2006-12-27 | Complex Biosystems Gmbh | Aliphatic prodrug linker |
| US8133707B2 (en) * | 2006-01-17 | 2012-03-13 | Enzon Pharmaceuticals, Inc. | Methods of preparing activated polymers having alpha nitrogen groups |
| EP2035016A2 (en) * | 2006-06-09 | 2009-03-18 | Enzon Pharmaceuticals, Inc. | Indenoisoquinoline-releasable polymer conjugates |
| US8110559B2 (en) * | 2006-09-15 | 2012-02-07 | Enzon Pharmaceuticals, Inc. | Hindered ester-based biodegradable linkers for oligonucleotide delivery |
| CA2662973A1 (en) * | 2006-09-15 | 2008-03-20 | Enzon Pharmaceuticals, Inc. | Lysine-based polymeric linkers |
| JP2010503705A (ja) * | 2006-09-15 | 2010-02-04 | エンゾン ファーマスーティカルズ インコーポレイテッド | ヒンダードエステル系の生分解性リンカーを有するポリアルキレンオキサイド |
| MX2009002856A (es) * | 2006-09-15 | 2009-03-30 | Enzon Pharmaceuticals Inc | Conjugados polimericos que contienen porciones cargadas positivamente. |
| TW200836762A (en) * | 2006-11-27 | 2008-09-16 | Enzon Pharmaceuticals Inc | Polymeric short interfering RNA conjugates |
| TW200835514A (en) * | 2006-12-29 | 2008-09-01 | Enzon Pharmaceuticals Inc | Use of adenosine deaminase for treating pulmonary disease |
| CA2684750C (en) * | 2007-04-20 | 2014-08-05 | Enzon Pharmaceuticals, Inc. | Stable recombinant adenosine deaminase |
| CA2684749C (en) * | 2007-04-20 | 2016-06-21 | Enzon Pharmaceuticals, Inc. | Use of adenosine deaminase for cancer therapy |
| US20100203066A1 (en) * | 2007-08-20 | 2010-08-12 | Enzon Pharmaceuticals, Inc. | Polymeric linkers containing pyridyl disulfide moieties |
| CA3187392A1 (en) | 2013-10-15 | 2015-04-23 | Seagen Inc. | Pegylated drug-linkers for improved ligand-drug conjugate pharmacokinetics |
| US11844839B2 (en) | 2016-03-25 | 2023-12-19 | Seagen Inc. | Process for the preparation of pegylated drug-linkers and intermediates thereof |
| JP7527787B2 (ja) | 2017-03-24 | 2024-08-05 | シージェン インコーポレイテッド | グルクロニド薬物－リンカーの調製のためのプロセスおよびその中間体 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3888797A (en) | 1970-08-04 | 1975-06-10 | Carapus Company Limited | Detergent composition |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| DE4135115A1 (de) | 1991-10-24 | 1993-04-29 | Trigon Chemie Gmbh | Kationaktive tenside |
| US5679711A (en) | 1993-10-08 | 1997-10-21 | Fhj Scientific, Inc. | Hydroxyl ions as novel therapeutic agents and compounds that modulate these ions, compositions employing these agents, therapeutic methods for using such agents |
| US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US5919455A (en) | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| CA2473100A1 (en) | 2002-02-25 | 2003-08-28 | Kudos Pharmaceuticals Limited | Pyranones useful as atm inhibitors |
| US7087229B2 (en) * | 2003-05-30 | 2006-08-08 | Enzon Pharmaceuticals, Inc. | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
| US7413738B2 (en) * | 2002-08-13 | 2008-08-19 | Enzon Pharmaceuticals, Inc. | Releasable polymeric conjugates based on biodegradable linkers |
| US7122189B2 (en) * | 2002-08-13 | 2006-10-17 | Enzon, Inc. | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
| WO2004044222A2 (en) | 2002-11-12 | 2004-05-27 | Enzon Pharmaceuticals, Inc. | Polymeric prodrugs of vancomycin |
| US7332164B2 (en) | 2003-03-21 | 2008-02-19 | Enzon Pharmaceuticals, Inc. | Heterobifunctional polymeric bioconjugates |
| RU2394041C2 (ru) | 2003-04-13 | 2010-07-10 | Энзон Фармасьютикалз, Инк. | Полимерные олигонуклеотидные пролекарства |
-
2004
- 2004-12-14 US US11/011,818 patent/US7413738B2/en not_active Expired - Fee Related
-
2005
- 2005-11-29 TW TW094141400A patent/TWI375556B/zh not_active IP Right Cessation
- 2005-12-13 CN CN200580042661XA patent/CN101076353B/zh not_active Expired - Fee Related
- 2005-12-13 EP EP05854230A patent/EP1827497A4/en not_active Withdrawn
- 2005-12-13 WO PCT/US2005/045467 patent/WO2006066020A2/en not_active Ceased
- 2005-12-13 JP JP2007546901A patent/JP5405746B2/ja not_active Expired - Fee Related
- 2005-12-13 CA CA2589975A patent/CA2589975C/en not_active Expired - Fee Related
- 2005-12-13 AU AU2005316520A patent/AU2005316520B2/en not_active Ceased
- 2005-12-13 MX MX2007007034A patent/MX2007007034A/es active IP Right Grant
- 2005-12-13 KR KR1020077015937A patent/KR20070089739A/ko not_active Withdrawn
- 2005-12-13 RU RU2007126802/04A patent/RU2007126802A/ru not_active Application Discontinuation
-
2007
- 2007-05-31 IL IL183582A patent/IL183582A0/en unknown
-
2008
- 2008-07-25 US US12/180,187 patent/US8192743B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN101076353B (zh) | 2010-12-08 |
| CN101076353A (zh) | 2007-11-21 |
| US8192743B2 (en) | 2012-06-05 |
| AU2005316520B2 (en) | 2011-09-29 |
| KR20070089739A (ko) | 2007-08-31 |
| CA2589975C (en) | 2013-12-10 |
| US7413738B2 (en) | 2008-08-19 |
| IL183582A0 (en) | 2007-09-20 |
| CA2589975A1 (en) | 2006-06-22 |
| MX2007007034A (es) | 2007-08-03 |
| EP1827497A4 (en) | 2010-09-29 |
| JP2008523239A (ja) | 2008-07-03 |
| US20080305070A1 (en) | 2008-12-11 |
| WO2006066020A2 (en) | 2006-06-22 |
| TW200635576A (en) | 2006-10-16 |
| TWI375556B (en) | 2012-11-01 |
| WO2006066020A3 (en) | 2006-08-10 |
| EP1827497A2 (en) | 2007-09-05 |
| JP5405746B2 (ja) | 2014-02-05 |
| AU2005316520A1 (en) | 2006-06-22 |
| US20050197290A1 (en) | 2005-09-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2007126802A (ru) | Расщепляемые полимерные конъюгаты на основе алифатических биодеградируемых линкеров | |
| RU2005141550A (ru) | Высвобождаемые полимерные конъюгаты на основе алифатических биоразлагаемых сшивающих агентов | |
| US6251382B1 (en) | Biodegradable high molecular weight polymeric linkers and their conjugates | |
| EP0973819B1 (en) | Non-antigenic branched polymer conjugates | |
| US6461603B2 (en) | Water-soluble polymer conjugates of artelinic acid | |
| ES2222689T3 (es) | Derivados del polietilenglicol con grupos reactivos proximales. | |
| ES2260859T3 (es) | Profarmacos polimericos con bloqueo trialquilo facilitado de agentes bioactivos que contienen amino. | |
| EP1055685B1 (en) | Non-antigenic branched polymer conjugates | |
| CA2493329A1 (en) | Releasable polymeric conjugates based on aliphatic biodegradable linkers | |
| JP2006505634A5 (enExample) | ||
| US6824766B2 (en) | Biodegradable high molecular weight polymeric linkers and their conjugates | |
| KR101777437B1 (ko) | 분지형 헤테로―폴리에틸렌 글리콜 및 중간체 | |
| JP2005538035A5 (enExample) | ||
| JP2002508400A5 (enExample) | ||
| WO1999030727A1 (en) | Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents | |
| JP2008523239A5 (enExample) | ||
| JP2005504006A5 (enExample) | ||
| US20180312466A1 (en) | Branched hetero polyethylene glycol and intermediate | |
| JP2005528380A5 (enExample) | ||
| RU2009122976A (ru) | Конъюгат полиэтиленгликоля-г-ксф | |
| KR20220069994A (ko) | 비대칭 분기형 분해성 폴리에틸렌글리콜 유도체 | |
| EP4035678B1 (en) | Degradable multi-arm polyethylene glycol derivative | |
| KR102836637B1 (ko) | 분기형 분해성 폴리에틸렌 글리콜 유도체 | |
| RU2009114169A (ru) | Полимерные линкеры на основе лизина | |
| RU2009114153A (ru) | Полимерные конъюгаты, содержащие положительно заряженные фрагменты |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20100827 |