TWI375556B - Releasable polymeric conjugates based on aliphatic biodegradable linkers - Google Patents
Releasable polymeric conjugates based on aliphatic biodegradable linkers Download PDFInfo
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- TWI375556B TWI375556B TW094141400A TW94141400A TWI375556B TW I375556 B TWI375556 B TW I375556B TW 094141400 A TW094141400 A TW 094141400A TW 94141400 A TW94141400 A TW 94141400A TW I375556 B TWI375556 B TW I375556B
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- 125000001931 aliphatic group Chemical group 0.000 title 1
- 229920000642 polymer Polymers 0.000 claims description 70
- 150000001875 compounds Chemical class 0.000 claims description 68
- 125000000217 alkyl group Chemical group 0.000 claims description 58
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 51
- 229920001223 polyethylene glycol Polymers 0.000 claims description 50
- 239000002202 Polyethylene glycol Substances 0.000 claims description 45
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims description 34
- -1 phenoxy (phenoxy) Chemical class 0.000 claims description 33
- 125000003118 aryl group Chemical group 0.000 claims description 30
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 29
- 239000004471 Glycine Substances 0.000 claims description 26
- 125000005647 linker group Chemical group 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 23
- 239000002253 acid Substances 0.000 claims description 22
- 230000001588 bifunctional effect Effects 0.000 claims description 22
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- 229910052757 nitrogen Inorganic materials 0.000 claims description 21
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- 125000000547 substituted alkyl group Chemical group 0.000 claims description 13
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- 125000000304 alkynyl group Chemical group 0.000 claims description 11
- 125000000524 functional group Chemical group 0.000 claims description 11
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- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
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Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polyamides (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Peptides Or Proteins (AREA)
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| EP2035016A2 (en) * | 2006-06-09 | 2009-03-18 | Enzon Pharmaceuticals, Inc. | Indenoisoquinoline-releasable polymer conjugates |
| US8110559B2 (en) * | 2006-09-15 | 2012-02-07 | Enzon Pharmaceuticals, Inc. | Hindered ester-based biodegradable linkers for oligonucleotide delivery |
| CN101534861B (zh) * | 2006-09-15 | 2013-10-02 | 安佐制药股份有限公司 | 具有基于位阻酯的生物可降解连接基的聚环氧烷 |
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| WO2008083302A2 (en) * | 2006-12-29 | 2008-07-10 | Enzon Pharmaceuticals, Inc. | Use of adenosine deaminase for treating pulmonary disease |
| EP2147116B1 (en) * | 2007-04-20 | 2016-03-02 | Sigma-Tau Rare Disease Ltd | Stable recombinant adenosine deaminase |
| BRPI0810384B8 (pt) * | 2007-04-20 | 2021-05-25 | Defiante Farm S A | terapia enzimática anticâncer |
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| US3888797A (en) | 1970-08-04 | 1975-06-10 | Carapus Company Limited | Detergent composition |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| DE4135115A1 (de) | 1991-10-24 | 1993-04-29 | Trigon Chemie Gmbh | Kationaktive tenside |
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| US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US5919455A (en) | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| PT1485377E (pt) | 2002-02-25 | 2010-03-12 | Kudos Pharm Ltd | Piranonas úteis como inibidores da atm |
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| US7122189B2 (en) * | 2002-08-13 | 2006-10-17 | Enzon, Inc. | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
| US7413738B2 (en) * | 2002-08-13 | 2008-08-19 | Enzon Pharmaceuticals, Inc. | Releasable polymeric conjugates based on biodegradable linkers |
| AU2003287605A1 (en) * | 2002-11-12 | 2004-06-03 | Enzon Pharmaceuticals, Inc. | Polymeric prodrugs of vancomycin |
| US7332164B2 (en) | 2003-03-21 | 2008-02-19 | Enzon Pharmaceuticals, Inc. | Heterobifunctional polymeric bioconjugates |
| KR20060015505A (ko) | 2003-04-13 | 2006-02-17 | 엔존 파마슈티컬즈, 인코포레이티드 | 올리고뉴클레오타이드 전구약물 |
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- 2005-12-13 EP EP05854230A patent/EP1827497A4/en not_active Withdrawn
- 2005-12-13 RU RU2007126802/04A patent/RU2007126802A/ru not_active Application Discontinuation
- 2005-12-13 AU AU2005316520A patent/AU2005316520B2/en not_active Ceased
- 2005-12-13 CA CA2589975A patent/CA2589975C/en not_active Expired - Fee Related
- 2005-12-13 KR KR1020077015937A patent/KR20070089739A/ko not_active Withdrawn
- 2005-12-13 MX MX2007007034A patent/MX2007007034A/es active IP Right Grant
- 2005-12-13 JP JP2007546901A patent/JP5405746B2/ja not_active Expired - Fee Related
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Also Published As
| Publication number | Publication date |
|---|---|
| US20080305070A1 (en) | 2008-12-11 |
| JP5405746B2 (ja) | 2014-02-05 |
| WO2006066020A3 (en) | 2006-08-10 |
| WO2006066020A2 (en) | 2006-06-22 |
| US7413738B2 (en) | 2008-08-19 |
| TW200635576A (en) | 2006-10-16 |
| CA2589975C (en) | 2013-12-10 |
| RU2007126802A (ru) | 2009-01-27 |
| AU2005316520A1 (en) | 2006-06-22 |
| CN101076353A (zh) | 2007-11-21 |
| IL183582A0 (en) | 2007-09-20 |
| EP1827497A4 (en) | 2010-09-29 |
| US20050197290A1 (en) | 2005-09-08 |
| CA2589975A1 (en) | 2006-06-22 |
| AU2005316520B2 (en) | 2011-09-29 |
| US8192743B2 (en) | 2012-06-05 |
| KR20070089739A (ko) | 2007-08-31 |
| MX2007007034A (es) | 2007-08-03 |
| EP1827497A2 (en) | 2007-09-05 |
| JP2008523239A (ja) | 2008-07-03 |
| CN101076353B (zh) | 2010-12-08 |
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