MX2007007034A - Conjugados polimericos liberables en base a enlazadores biodegradables alifaticos. - Google Patents
Conjugados polimericos liberables en base a enlazadores biodegradables alifaticos.Info
- Publication number
- MX2007007034A MX2007007034A MX2007007034A MX2007007034A MX2007007034A MX 2007007034 A MX2007007034 A MX 2007007034A MX 2007007034 A MX2007007034 A MX 2007007034A MX 2007007034 A MX2007007034 A MX 2007007034A MX 2007007034 A MX2007007034 A MX 2007007034A
- Authority
- MX
- Mexico
- Prior art keywords
- group
- substituted
- compound
- alkyls
- independently
- Prior art date
Links
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- 239000003826 tablet Substances 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
- WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- NZVYCXVTEHPMHE-ZSUJOUNUSA-N thymalfasin Chemical compound CC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O NZVYCXVTEHPMHE-ZSUJOUNUSA-N 0.000 description 1
- 229960004231 thymalfasin Drugs 0.000 description 1
- 125000005425 toluyl group Chemical group 0.000 description 1
- 238000003325 tomography Methods 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 102000003390 tumor necrosis factor Human genes 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 241000701447 unidentified baculovirus Species 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/16—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Polyethers (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polyamides (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/011,818 US7413738B2 (en) | 2002-08-13 | 2004-12-14 | Releasable polymeric conjugates based on biodegradable linkers |
| PCT/US2005/045467 WO2006066020A2 (en) | 2004-12-14 | 2005-12-13 | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2007007034A true MX2007007034A (es) | 2007-08-03 |
Family
ID=36588567
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2007007034A MX2007007034A (es) | 2004-12-14 | 2005-12-13 | Conjugados polimericos liberables en base a enlazadores biodegradables alifaticos. |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7413738B2 (enExample) |
| EP (1) | EP1827497A4 (enExample) |
| JP (1) | JP5405746B2 (enExample) |
| KR (1) | KR20070089739A (enExample) |
| CN (1) | CN101076353B (enExample) |
| AU (1) | AU2005316520B2 (enExample) |
| CA (1) | CA2589975C (enExample) |
| IL (1) | IL183582A0 (enExample) |
| MX (1) | MX2007007034A (enExample) |
| RU (1) | RU2007126802A (enExample) |
| TW (1) | TWI375556B (enExample) |
| WO (1) | WO2006066020A2 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7087229B2 (en) * | 2003-05-30 | 2006-08-08 | Enzon Pharmaceuticals, Inc. | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
| US7122189B2 (en) * | 2002-08-13 | 2006-10-17 | Enzon, Inc. | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
| US7413738B2 (en) * | 2002-08-13 | 2008-08-19 | Enzon Pharmaceuticals, Inc. | Releasable polymeric conjugates based on biodegradable linkers |
| US7365127B2 (en) * | 2005-02-04 | 2008-04-29 | Enzon Pharmaceuticals, Inc. | Process for the preparation of polymer conjugates |
| DK1891104T3 (da) * | 2005-05-04 | 2009-11-30 | Lonza Ag | Fastfasebundet thmosin-alfa1 og syntese deraf |
| GB2427360A (en) * | 2005-06-22 | 2006-12-27 | Complex Biosystems Gmbh | Aliphatic prodrug linker |
| US8133707B2 (en) * | 2006-01-17 | 2012-03-13 | Enzon Pharmaceuticals, Inc. | Methods of preparing activated polymers having alpha nitrogen groups |
| US20090156629A1 (en) * | 2006-06-09 | 2009-06-18 | Enzon Pharmaceuticals, Inc. | Indenoisoquinoline-releasable polymer conjugates |
| MX2009002857A (es) * | 2006-09-15 | 2009-03-30 | Enzon Pharmaceuticals Inc | Enlazadores polimericos basados en lisina. |
| AU2007296055A1 (en) * | 2006-09-15 | 2008-03-20 | Enzon Pharmaceuticals, Inc. | Polymeric conjugates containing positively-charged moieties |
| US8110559B2 (en) * | 2006-09-15 | 2012-02-07 | Enzon Pharmaceuticals, Inc. | Hindered ester-based biodegradable linkers for oligonucleotide delivery |
| CN101534861B (zh) * | 2006-09-15 | 2013-10-02 | 安佐制药股份有限公司 | 具有基于位阻酯的生物可降解连接基的聚环氧烷 |
| JP2010510810A (ja) * | 2006-11-27 | 2010-04-08 | エンゾン ファーマスーティカルズ インコーポレイテッド | ポリマー低分子干渉ｒｎａ複合体 |
| EP2117528A4 (en) * | 2006-12-29 | 2013-01-02 | Sigma Tau Rare Diseases S A | USE OF ADENOSINE DEAMINASE FOR THE TREATMENT OF LUNG DISEASES |
| AU2008242748B2 (en) * | 2007-04-20 | 2013-12-05 | Unikeris Limited | Stable recombinant adenosine deaminase |
| DK2147122T3 (da) * | 2007-04-20 | 2014-10-13 | Sigma Tau Rare Diseases S A | Enzymatisk kræftbehandling |
| CA2695532A1 (en) * | 2007-08-20 | 2009-02-26 | Enzon Pharmaceuticals, Inc. | Polymeric linkers containing pyridyl disulfide moieties |
| KR102538993B1 (ko) | 2013-10-15 | 2023-06-02 | 씨젠 인크. | 개선된 리간드-약물 컨쥬게이트 약물동력학을 위한 peg화된 약물-링커 |
| EP3433278A4 (en) | 2016-03-25 | 2019-11-06 | Seattle Genetics, Inc. | METHOD FOR THE PRODUCTION OF PEGYLATED ACTIVE LINKERS AND INTERMEDIATE PRODUCTS THEREOF |
| JP7527787B2 (ja) | 2017-03-24 | 2024-08-05 | シージェン インコーポレイテッド | グルクロニド薬物－リンカーの調製のためのプロセスおよびその中間体 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3888797A (en) * | 1970-08-04 | 1975-06-10 | Carapus Company Limited | Detergent composition |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| DE4135115A1 (de) | 1991-10-24 | 1993-04-29 | Trigon Chemie Gmbh | Kationaktive tenside |
| US5679711A (en) * | 1993-10-08 | 1997-10-21 | Fhj Scientific, Inc. | Hydroxyl ions as novel therapeutic agents and compounds that modulate these ions, compositions employing these agents, therapeutic methods for using such agents |
| US5919455A (en) | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| CN100358891C (zh) | 2002-02-25 | 2008-01-02 | 库多斯药物有限公司 | 可用作atm抑制剂的吡喃酮 |
| US7087229B2 (en) | 2003-05-30 | 2006-08-08 | Enzon Pharmaceuticals, Inc. | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
| US7413738B2 (en) | 2002-08-13 | 2008-08-19 | Enzon Pharmaceuticals, Inc. | Releasable polymeric conjugates based on biodegradable linkers |
| US7122189B2 (en) * | 2002-08-13 | 2006-10-17 | Enzon, Inc. | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
| AU2003287605A1 (en) | 2002-11-12 | 2004-06-03 | Enzon Pharmaceuticals, Inc. | Polymeric prodrugs of vancomycin |
| US7332164B2 (en) | 2003-03-21 | 2008-02-19 | Enzon Pharmaceuticals, Inc. | Heterobifunctional polymeric bioconjugates |
| MXPA05011022A (es) | 2003-04-13 | 2006-04-27 | Enzon Pharmaceuticals Inc | Profarmacos oligonucleotidos polimericos. |
-
2004
- 2004-12-14 US US11/011,818 patent/US7413738B2/en not_active Expired - Fee Related
-
2005
- 2005-11-29 TW TW094141400A patent/TWI375556B/zh not_active IP Right Cessation
- 2005-12-13 CA CA2589975A patent/CA2589975C/en not_active Expired - Fee Related
- 2005-12-13 RU RU2007126802/04A patent/RU2007126802A/ru not_active Application Discontinuation
- 2005-12-13 CN CN200580042661XA patent/CN101076353B/zh not_active Expired - Fee Related
- 2005-12-13 WO PCT/US2005/045467 patent/WO2006066020A2/en not_active Ceased
- 2005-12-13 JP JP2007546901A patent/JP5405746B2/ja not_active Expired - Fee Related
- 2005-12-13 AU AU2005316520A patent/AU2005316520B2/en not_active Ceased
- 2005-12-13 MX MX2007007034A patent/MX2007007034A/es active IP Right Grant
- 2005-12-13 EP EP05854230A patent/EP1827497A4/en not_active Withdrawn
- 2005-12-13 KR KR1020077015937A patent/KR20070089739A/ko not_active Withdrawn
-
2007
- 2007-05-31 IL IL183582A patent/IL183582A0/en unknown
-
2008
- 2008-07-25 US US12/180,187 patent/US8192743B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IL183582A0 (en) | 2007-09-20 |
| EP1827497A2 (en) | 2007-09-05 |
| AU2005316520B2 (en) | 2011-09-29 |
| US7413738B2 (en) | 2008-08-19 |
| WO2006066020A2 (en) | 2006-06-22 |
| JP2008523239A (ja) | 2008-07-03 |
| US20080305070A1 (en) | 2008-12-11 |
| CN101076353B (zh) | 2010-12-08 |
| CN101076353A (zh) | 2007-11-21 |
| KR20070089739A (ko) | 2007-08-31 |
| WO2006066020A3 (en) | 2006-08-10 |
| TWI375556B (en) | 2012-11-01 |
| JP5405746B2 (ja) | 2014-02-05 |
| US8192743B2 (en) | 2012-06-05 |
| CA2589975A1 (en) | 2006-06-22 |
| EP1827497A4 (en) | 2010-09-29 |
| US20050197290A1 (en) | 2005-09-08 |
| TW200635576A (en) | 2006-10-16 |
| AU2005316520A1 (en) | 2006-06-22 |
| CA2589975C (en) | 2013-12-10 |
| RU2007126802A (ru) | 2009-01-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |