JP5403868B2 - 鼻用医薬製剤およびその使用方法 - Google Patents
鼻用医薬製剤およびその使用方法 Download PDFInfo
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- JP5403868B2 JP5403868B2 JP2006504901A JP2006504901A JP5403868B2 JP 5403868 B2 JP5403868 B2 JP 5403868B2 JP 2006504901 A JP2006504901 A JP 2006504901A JP 2006504901 A JP2006504901 A JP 2006504901A JP 5403868 B2 JP5403868 B2 JP 5403868B2
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- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
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| US10/414,756 US7811606B2 (en) | 2003-04-16 | 2003-04-16 | Nasal pharmaceutical formulations and methods of using the same |
| PCT/EP2004/003314 WO2004091574A1 (en) | 2003-04-16 | 2004-03-29 | Nasal pharmaceutical formulations and methods of using the same |
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| US7544192B2 (en) * | 2003-03-14 | 2009-06-09 | Sinexus, Inc. | Sinus delivery of sustained release therapeutics |
| US7811606B2 (en) * | 2003-04-16 | 2010-10-12 | Dey, L.P. | Nasal pharmaceutical formulations and methods of using the same |
| US9808471B2 (en) * | 2003-04-16 | 2017-11-07 | Mylan Specialty Lp | Nasal pharmaceutical formulations and methods of using the same |
| US8912174B2 (en) | 2003-04-16 | 2014-12-16 | Mylan Pharmaceuticals Inc. | Formulations and methods for treating rhinosinusitis |
| KR100675379B1 (ko) * | 2005-01-25 | 2007-01-29 | 삼성전자주식회사 | 프린팅 시스템 및 프린팅 방법 |
| CA2603081C (en) * | 2005-04-04 | 2013-09-03 | Sinexus, Inc. | Device and methods for treating paranasal sinus conditions |
| US8535707B2 (en) * | 2006-07-10 | 2013-09-17 | Intersect Ent, Inc. | Devices and methods for delivering active agents to the osteomeatal complex |
| DK2231065T3 (da) | 2007-12-18 | 2021-02-01 | Intersect Ent Inc | Selvekspanderende anordninger |
| CA2732355A1 (en) | 2008-08-01 | 2010-02-04 | Intersect Ent, Inc. | Methods and devices for crimping self-expanding devices |
| US7863074B2 (en) * | 2008-09-30 | 2011-01-04 | Stion Corporation | Patterning electrode materials free from berm structures for thin film photovoltaic cells |
| EP3103502A1 (en) * | 2009-05-15 | 2016-12-14 | Intersect ENT, Inc. | Expandable devices and methods therefor |
| ES2612257T3 (es) * | 2011-05-03 | 2017-05-16 | Chiesi Farmaceutici S.P.A. | Formulación de suspensión mejorada de dipropionato de beclometasona para administración mediante inhalación |
| BR112013027390A2 (pt) * | 2011-05-04 | 2017-01-17 | Chiesi Farma Spa | formulação farmacêutica |
| EP3636227B1 (en) | 2013-03-14 | 2024-08-28 | Intersect ENT, Inc. | Systems and devices for treating a sinus condition |
| US11554229B2 (en) | 2013-03-26 | 2023-01-17 | OptiNose Inc. | Nasal administration |
| US10758550B2 (en) | 2013-10-04 | 2020-09-01 | Glenmark Specialty S.A. | Treatment of allergic rhinitis using a combination of mometasone and olopatadine |
| CN113679931A (zh) | 2015-01-22 | 2021-11-23 | 因特尔赛克特耳鼻喉公司 | 药物涂覆的气囊 |
| CN104940994B (zh) * | 2015-07-14 | 2017-09-19 | 江苏威克斯医疗科技有限公司 | 一种人造鼻粘膜及其用途 |
| CN107320449B (zh) * | 2017-08-07 | 2020-09-15 | 武汉武药科技有限公司 | 丙酸氟替卡松鼻喷雾剂及其制备方法 |
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| GB8432063D0 (en) * | 1984-12-19 | 1985-01-30 | Riker Laboratories Inc | Physically modified steroids |
| DE3887591T2 (de) | 1987-07-07 | 1994-05-19 | Beecham Group Plc | Pinacidil zur Behandlung von pulmonaler Hypertonie oder Rechtsversagen. |
| AU610175B2 (en) | 1988-05-25 | 1991-05-16 | Biogal Gyogyszergyar | Pharmaceutical composition comprising a compound containing sulfhydryl group(s) for the treatment of otitis |
| JPH03165833A (ja) * | 1989-02-28 | 1991-07-17 | Isamu Horikoshi | 新規懸濁化方法及びこの方法によって得られる組成物 |
| CA2010894A1 (en) | 1989-02-28 | 1990-08-31 | Isamu Horikoshi | Method of forming a suspension and composition formed by said method |
| SE9000207L (sv) | 1990-01-22 | 1991-07-23 | Nobel Chemicals Ab | Laekemedel samt anvaendningen av detsamma |
| CA2091360C (en) | 1990-09-10 | 1997-04-08 | Pui-Ho Yuen | Mometasone furoate monohydrate, process for making same and pharmaceutical compositions |
| US5177447A (en) * | 1990-11-06 | 1993-01-05 | Bear Automotive Service Equipment Company | Automated breakout box for automotive testing |
| US5174475A (en) | 1991-03-26 | 1992-12-29 | Glaxo Inc. | Sequential dosing of antifungal and antiinflammatory compositions |
| US5593688A (en) | 1993-06-25 | 1997-01-14 | Nexstar Pharmaceuticals, Inc. | Liposomal targeting of ischemic tissue |
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| AU7106996A (en) | 1995-09-07 | 1997-03-27 | Fuisz Technologies Ltd. | System for rendering substantially non-dissoluble bio-affecting agents bio-available |
| US6576636B2 (en) | 1996-05-22 | 2003-06-10 | Protarga, Inc. | Method of treating a liver disorder with fatty acid-antiviral agent conjugates |
| US5795909A (en) | 1996-05-22 | 1998-08-18 | Neuromedica, Inc. | DHA-pharmaceutical agent conjugates of taxanes |
| US5976573A (en) | 1996-07-03 | 1999-11-02 | Rorer Pharmaceutical Products Inc. | Aqueous-based pharmaceutical composition |
| TW416953B (en) | 1996-09-25 | 2001-01-01 | Takeda Chemical Industries Ltd | Tricyclic compounds for eliciting a prostaglandin I2 receptor agonistic effect, their production and use |
| FR2756739B1 (fr) | 1996-12-05 | 2000-04-28 | Astra Ab | Nouvelle formulation de budesonide |
| TW503113B (en) | 1997-01-16 | 2002-09-21 | Senju Pharma Co | Aqueous suspension for nasal administration |
| DE69804998T2 (de) | 1997-10-09 | 2002-12-12 | Schering Corp., Kenilworth | Mometasonfuroat-suspensionen zum zerstäuben |
| EE200000253A (et) | 1997-10-22 | 2001-06-15 | Ponikau Jens | Seentevastase toimeaine kasutamine ravimite valmistamiseks, mis on ette nähtud mitteinvasiivsetest seenorganismidest tingitud haiguste raviks või vältimiseks |
| JP3386349B2 (ja) | 1997-10-30 | 2003-03-17 | 帝人株式会社 | 水性懸濁医薬品組成物 |
| SE9704186D0 (sv) * | 1997-11-14 | 1997-11-14 | Astra Ab | New composition of matter |
| US6423423B2 (en) | 1998-05-06 | 2002-07-23 | Calsonic Kansei Corporation | Formed strip and roll forming |
| US6241969B1 (en) | 1998-06-26 | 2001-06-05 | Elan Corporation Plc | Aqueous compositions containing corticosteroids for nasal and pulmonary delivery |
| CA2341732C (en) | 1998-08-26 | 2008-08-19 | Teijin Limited | Powder composition for nasal administration |
| IT1303692B1 (it) | 1998-11-03 | 2001-02-23 | Chiesi Farma Spa | Procedimento per la preparazione di sospensioni di particelle difarmaci da somministrare per inalazione. |
| US20040141925A1 (en) | 1998-11-12 | 2004-07-22 | Elan Pharma International Ltd. | Novel triamcinolone compositions |
| US7521068B2 (en) | 1998-11-12 | 2009-04-21 | Elan Pharma International Ltd. | Dry powder aerosols of nanoparticulate drugs |
| US6521212B1 (en) | 1999-03-18 | 2003-02-18 | United Therapeutics Corporation | Method for treating peripheral vascular disease by administering benzindene prostaglandins by inhalation |
| WO2000074699A1 (en) | 1999-06-03 | 2000-12-14 | Johnson & Johnson Consumer France Sas | Extracts of feverfew (tanacetum parthenium) against inflammatory disorders |
| JP2001002589A (ja) * | 1999-06-18 | 2001-01-09 | Teijin Ltd | 穏やかな薬物血中濃度の上昇を可能とする経鼻投与用組成物 |
| US20020061281A1 (en) | 1999-07-06 | 2002-05-23 | Osbakken Robert S. | Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis |
| AU6076200A (en) | 1999-07-08 | 2001-01-30 | Johnson & Johnson Consumer Companies, Inc. | Exothermic bandage |
| GB9918559D0 (en) * | 1999-08-07 | 1999-10-06 | Glaxo Wellcome Kk | Novel pharmaceutical formulation |
| AU6852900A (en) | 1999-08-20 | 2001-03-19 | Norton Healthcare Ltd | Method to produce powders for pulmonary or nasal administration |
| GB9925934D0 (en) * | 1999-11-03 | 1999-12-29 | Glaxo Group Ltd | Novel apparatus and process |
| FI20002217A (fi) | 1999-12-30 | 2001-07-01 | Orion Yhtymae Oyj | Inhalaatiopartikkelit |
| GB0009605D0 (en) * | 2000-04-18 | 2000-06-07 | Glaxo Group Ltd | Medicaments |
| US20020013331A1 (en) | 2000-06-26 | 2002-01-31 | Williams Robert O. | Methods and compositions for treating pain of the mucous membrane |
| GB0016040D0 (en) | 2000-06-29 | 2000-08-23 | Glaxo Group Ltd | Novel process for preparing crystalline particles |
| DK2153819T3 (da) | 2000-07-14 | 2012-12-03 | Allergan Inc | Anvendelse af en opløselighedsforbedrende bestanddel i en vandig sammensætning omfattende brimonidintartrat |
| US6608054B2 (en) | 2001-03-20 | 2003-08-19 | Boehringer Ingelheim Pharma Kg | Pharmaceutical compositions based on anticholinergics and endothelin antagonists |
| US20020090388A1 (en) | 2000-12-01 | 2002-07-11 | Humes H. David | Intravascular drug delivery device and use therefor |
| DE10060890C2 (de) | 2000-12-07 | 2003-04-03 | Meta Motoren Energietech | Vorrichtung zum Umschalten des Betriebs eines Ladungswechselventils einer Brennkraftmaschine |
| MXPA03006958A (es) * | 2001-02-05 | 2003-11-18 | Upjohn Co | Composicion para administracion rectal de farmaco antibacterial de oxazolidinona. |
| GB0105560D0 (en) | 2001-03-07 | 2001-04-25 | Glaxo Group Ltd | Pharmaceutical formulations |
| US8552054B2 (en) | 2001-03-23 | 2013-10-08 | Luitpold Pharmaceuticals, Inc. | Fatty amine drug conjugates |
| EP1423107B1 (en) | 2001-03-23 | 2012-05-09 | Luitpold Pharmaceuticals, Inc. | Fatty alcohol drug conjugates |
| US20020198209A1 (en) | 2001-05-03 | 2002-12-26 | Allergan Sales Inc. | Compositions having enhanced pharmacokinetic characteristics |
| AU2002355419A1 (en) | 2001-08-06 | 2003-02-24 | Genomed, Llc | Methods and compositions for treating diseases associated with excesses in ace |
| FR2831446B1 (fr) | 2001-10-26 | 2004-03-05 | Sanofi Synthelabo | Utilisation de l'irbesartan pour la preparation de medicaments utiles pour la prevention ou le traitement de l'hypertension pulmonaire |
| ITMI20022674A1 (it) | 2002-12-18 | 2004-06-19 | Chiesi Farma Spa | Procedimento per la preparazione di formulazioni sterili a base di principi attivi farmaceutici cristallini micronizzati da somministrare come sospensioni acquose per inalazione. |
| US9808471B2 (en) * | 2003-04-16 | 2017-11-07 | Mylan Specialty Lp | Nasal pharmaceutical formulations and methods of using the same |
| US7811606B2 (en) * | 2003-04-16 | 2010-10-12 | Dey, L.P. | Nasal pharmaceutical formulations and methods of using the same |
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2003
- 2003-04-16 US US10/414,756 patent/US7811606B2/en active Active
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- 2004-03-29 WO PCT/EP2004/003315 patent/WO2004091575A1/en active Application Filing
- 2004-03-29 BR BRPI0409434-4A patent/BRPI0409434A/pt not_active Application Discontinuation
- 2004-03-29 RU RU2005135332/15A patent/RU2373925C2/ru active
- 2004-03-29 MX MXPA05011105A patent/MXPA05011105A/es active IP Right Grant
- 2004-03-29 EP EP04724015.5A patent/EP1613281B1/en not_active Expired - Lifetime
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Also Published As
| Publication number | Publication date |
|---|---|
| CA2522291A1 (en) | 2004-10-28 |
| AU2004229148B8 (en) | 2010-12-02 |
| RU2373925C2 (ru) | 2009-11-27 |
| BRPI0409434A (pt) | 2006-04-18 |
| JP2006523629A (ja) | 2006-10-19 |
| CN1805729B (zh) | 2010-09-22 |
| WO2004091575A1 (en) | 2004-10-28 |
| CA2522291C (en) | 2011-12-06 |
| ZA200509238B (en) | 2007-04-25 |
| EP1613281B1 (en) | 2016-10-05 |
| KR20060003009A (ko) | 2006-01-09 |
| RU2005135332A (ru) | 2006-08-10 |
| US8158154B2 (en) | 2012-04-17 |
| EP1613281A1 (en) | 2006-01-11 |
| US20080058295A1 (en) | 2008-03-06 |
| US7811606B2 (en) | 2010-10-12 |
| ES2609910T3 (es) | 2017-04-25 |
| MXPA05011105A (es) | 2006-05-19 |
| KR101312331B1 (ko) | 2013-09-27 |
| AU2004229148B2 (en) | 2010-11-25 |
| CN1805729A (zh) | 2006-07-19 |
| US20060039871A1 (en) | 2006-02-23 |
| HK1091727A1 (en) | 2007-01-26 |
| US20040208831A1 (en) | 2004-10-21 |
| AU2004229148A1 (en) | 2004-10-28 |
| US7972627B2 (en) | 2011-07-05 |
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