JP5401457B2 - 抗菌ペプチド、組成物及びその使用方法 - Google Patents
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CA2672886C (en) * | 2006-12-29 | 2015-02-10 | Revance Therapeutics, Inc. | Transport molecules using reverse sequence hiv-tat polypeptides |
| US8080518B2 (en) * | 2007-12-05 | 2011-12-20 | Arbor Vita Corporation | Co-administration of an agent linked to an internalization peptide with an anti-inflammatory |
| EP3031825B1 (en) | 2008-03-14 | 2019-07-24 | Allergan, Inc. | Immuno-based botulinum toxin serotype a activity assays |
| DK2379104T3 (en) * | 2008-12-31 | 2018-04-30 | Revance Therapeutics Inc | Injectable botulinum toxin formulations |
| JP6140445B2 (ja) * | 2009-04-01 | 2017-05-31 | ルバンス セラピュティックス インク．Ｒｅｖａｎｃｅ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 血管の過敏反応と関連した皮膚状態を治療する方法および組成物 |
| EP3682895A1 (en) | 2009-06-10 | 2020-07-22 | NoNO Inc. | Co-administration of an agent linked to a tat-internalization peptide with a mast cell degranulation inhibitor |
| CA2766521C (en) * | 2009-06-25 | 2020-07-21 | Revance Therapeutics, Inc. | Albumin-free botulinum toxin formulations |
| US10022083B2 (en) | 2011-06-02 | 2018-07-17 | Abdulmohsen E. A. H. Al-Terki | Multiple oral and nasal surgical procedures method and kit |
| US8387798B1 (en) | 2012-04-27 | 2013-03-05 | Abdulmohsen E. A. H. Al-Terki | Mutiple oral and nasal surgical procedures method and kit |
| FR2997304B1 (fr) | 2012-10-26 | 2017-07-07 | Isp Investments Inc | Utilisation d’un extrait de lin, en tant qu’agent actif activateur de la synthese de peptides antimicrobiens |
| WO2014066916A2 (en) | 2012-10-28 | 2014-05-01 | Revance Therapeutics, Inc. | Compositions and methods for safe treatment of rhinitis |
| US20140242110A1 (en) * | 2013-02-28 | 2014-08-28 | Dt Scimed, Llc | Dose, localization, and formulation of botulinum toxins in skin and muscle |
| US11484580B2 (en) | 2014-07-18 | 2022-11-01 | Revance Therapeutics, Inc. | Topical ocular preparation of botulinum toxin for use in ocular surface disease |
| US11793783B2 (en) | 2015-08-05 | 2023-10-24 | Cmpd Licensing, Llc | Compositions and methods for treating an infection |
| US11684567B2 (en) | 2015-08-05 | 2023-06-27 | Cmpd Licensing, Llc | Compositions and methods for treating an infection |
| US11446236B2 (en) | 2015-08-05 | 2022-09-20 | Cmpd Licensing, Llc | Topical antimicrobial compositions and methods of formulating the same |
| EP3349781A2 (en) | 2015-09-17 | 2018-07-25 | Contrafect Corporation | Use of lysin to restore/augment antibacterial activity in the presence of pulmonary surfactant of antibiotics inhibited thereby |
| US10105381B2 (en) * | 2016-05-23 | 2018-10-23 | Cmpd Licensing, Llc | Compositions and methods for treating an infection |
| US10144767B2 (en) * | 2016-08-18 | 2018-12-04 | Board Of Regents Of The University Of Nebraska | Anti-microbial peptides and coatings |
| CN117731591A (zh) * | 2016-11-21 | 2024-03-22 | 艾里奥治疗公司 | 大试剂的透皮递送 |
| US12161703B2 (en) | 2017-08-28 | 2024-12-10 | Revance Therapeutics, Inc. | Transmucosal botulinum toxin compositions, kits, and methods for treating bladder disorders |
| CN107353334B (zh) * | 2017-08-30 | 2020-02-07 | 四川大学 | 基于唾液富酪蛋白的仿生防龋多肽、其衍生物和盐及应用 |
| CN107556374B (zh) * | 2017-08-30 | 2020-02-07 | 四川大学 | 唾液富脯蛋白仿生防龋功能多肽、其衍生物和盐及其应用 |
| JP7266202B2 (ja) * | 2018-02-19 | 2023-04-28 | 株式会社ファンケル | 化粧料及び抗炎症剤 |
| BR112022020450A2 (pt) * | 2020-04-08 | 2022-12-20 | Amicrobe Inc | Composições e usos de polímeros de aminoácidos sintéticos aplicados localmente para prevenção e tratamento de infecções virais |
| WO2025059665A1 (en) | 2023-09-15 | 2025-03-20 | Revance Therapeutics, Inc. | Serial treatment with botulinum toxin for cervical dystonia |
| WO2025064729A1 (en) | 2023-09-19 | 2025-03-27 | Revance Therapeutics, Inc. | Treatment with botulinum toxin in patients in need of a rapid onset cosmetic effect and smoother skin appearance |
| WO2025072381A1 (en) | 2023-09-25 | 2025-04-03 | Revance Therapeutics, Inc. | Methods for determining influence of carrier peptide on the binding of a therapeutic protein to a cell membrane |
Family Cites Families (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5744166A (en) | 1989-02-25 | 1998-04-28 | Danbiosyst Uk Limited | Drug delivery compositions |
| WO1994004686A1 (en) | 1992-08-21 | 1994-03-03 | Biogen, Inc. | Tat-derived transport polypeptides |
| US5674980A (en) | 1989-12-21 | 1997-10-07 | Biogen Inc | Fusion protein comprising tat-derived transport moiety |
| US5804604A (en) | 1989-12-21 | 1998-09-08 | Biogen, Inc. | Tat-derived transport polypeptides and fusion proteins |
| CA2134119A1 (en) | 1992-04-23 | 1993-11-11 | Michael Twist | Treatment of herpesvirus infection |
| WO1995011038A1 (en) * | 1993-10-22 | 1995-04-27 | Allelix Biopharmaceuticals Inc. | Treatment of cytomegalovirus infection |
| EP1591129B1 (en) | 1993-12-28 | 2010-02-24 | Allergan, Inc. | Use of the neurotoxic component of botulinum toxin for treating pain associated with cervical dystonia |
| US6232295B1 (en) | 1994-10-12 | 2001-05-15 | Jon Faiz Kayyem | Cell-specific contrast agent and gene delivery vehicles |
| GB9508204D0 (en) | 1995-04-21 | 1995-06-07 | Speywood Lab Ltd | A novel agent able to modify peripheral afferent function |
| WO1997008199A2 (en) | 1995-08-23 | 1997-03-06 | University Of British Columbia | Antimicrobial cationic peptides and methods of screening for the same |
| US6043218A (en) | 1996-10-22 | 2000-03-28 | Medical University Of South Carolina | Positively charged non-natural amino acids, methods of making thereof, and use thereof in peptides |
| GB9623051D0 (en) | 1996-11-06 | 1997-01-08 | Schacht Etienne H | Delivery of DNA to target cells in biological systems |
| CA2314267A1 (en) | 1997-12-10 | 1999-06-17 | Washington University | Anti-pathogen system and methods of use thereof |
| CN1281512A (zh) | 1997-12-12 | 2001-01-24 | 昂尼克斯药物公司 | p53+肿瘤细胞的选择性杀伤和诊断 |
| DE69929361T2 (de) | 1998-10-27 | 2006-09-14 | Mayo Foundation For Medical Education And Research, Rochester | Botulinumtoxine zur verstärkung der wundheilung |
| JP2002531113A (ja) | 1998-12-10 | 2002-09-24 | ワシントン大学 | 蛋白質の形質導入システムおよびその使用法 |
| CN1320880C (zh) | 1998-12-23 | 2007-06-13 | 伊迪亚股份公司 | 改进的体内局部无创伤用制剂 |
| US7056656B1 (en) | 1999-01-25 | 2006-06-06 | University Of Medicine And Dentistry Of New Jersey | Tat-derived oligourea and its method of production and use in high affinity and specific binding HIV-1 TAR RNA |
| US20030236214A1 (en) | 1999-06-09 | 2003-12-25 | Wolff Jon A. | Charge reversal of polyion complexes and treatment of peripheral occlusive disease |
| US7008924B1 (en) | 1999-07-21 | 2006-03-07 | Amgen, Inc. | VGF fusion polypeptides |
| US6669951B2 (en) | 1999-08-24 | 2003-12-30 | Cellgate, Inc. | Compositions and methods for enhancing drug delivery across and into epithelial tissues |
| US6544548B1 (en) | 1999-09-13 | 2003-04-08 | Keraplast Technologies, Ltd. | Keratin-based powders and hydrogel for pharmaceutical applications |
| US6844324B1 (en) | 1999-11-12 | 2005-01-18 | Massachusetts Institute Of Technology | Modular peptide mediated intracellular delivery system and uses therefore |
| US20030118598A1 (en) | 2000-02-08 | 2003-06-26 | Allergan, Inc. | Clostridial toxin pharmaceutical compositions |
| US6670322B2 (en) | 2000-06-01 | 2003-12-30 | Wisconsin Alumni Research Foundation | Method of targeting pharmaceuticals to motor neurons |
| US20030215412A1 (en) | 2000-07-21 | 2003-11-20 | Essentia Biosystems, Inc. | Induction of hair growth with vascular endothelial growth factor |
| US20040220100A1 (en) | 2000-07-21 | 2004-11-04 | Essentia Biosystems, Inc. | Multi-component biological transport systems |
| CA2797652C (en) | 2000-07-21 | 2016-03-08 | Revance Therapeutics, Inc. | Multi-component biological transport systems |
| US6696038B1 (en) | 2000-09-14 | 2004-02-24 | Expression Genetics, Inc. | Cationic lipopolymer as biocompatible gene delivery agent |
| US20020127247A1 (en) | 2000-11-17 | 2002-09-12 | Allergen Sales, Inc. | Modified clostridial neurotoxins with altered biological persistence |
| US7585834B2 (en) | 2001-02-16 | 2009-09-08 | The Board Of Trustees Of The Leland Stanford Junior University | Transporters comprising spaced arginine moieties |
| EP1401281A4 (en) * | 2001-05-09 | 2004-12-29 | Univ Yale | TOLL / INTERLEUKIN-1 RECEPTOR ADAPTER PROTEIN (TIRAP) |
| US7060498B1 (en) | 2001-11-28 | 2006-06-13 | Genta Salus Llc | Polycationic water soluble copolymer and method for transferring polyanionic macromolecules across biological barriers |
| US7169814B2 (en) | 2001-12-11 | 2007-01-30 | The Board Of Trustees Of The Leland Stanford Junior University | Guanidinium transport reagents and conjugates |
| WO2003072049A2 (en) | 2002-02-21 | 2003-09-04 | Essentia Biosystems, Inc. | Induction of hair growth with vascular endothelial growth factor |
| US20030215395A1 (en) | 2002-05-14 | 2003-11-20 | Lei Yu | Controllably degradable polymeric biomolecule or drug carrier and method of synthesizing said carrier |
| US20040009180A1 (en) | 2002-07-11 | 2004-01-15 | Allergan, Inc. | Transdermal botulinum toxin compositions |
| JP4154218B2 (ja) * | 2002-11-27 | 2008-09-24 | 寛紀 高麗 | 新規抗菌性ポリペプチドとその利用 |
| EP1572101A4 (en) | 2002-12-19 | 2008-04-09 | Yitzchak Hillman | TREATMENT OF DISEASES BY ANTIMICROBIAL PEPTIDES |
| IL153557A0 (en) * | 2002-12-19 | 2003-07-06 | Yitzchak Hillman | Antibodies and antagonists to antimicrobial peptides for the purpose of treating, inhibiting and preventing auto immune diseases |
| NZ567324A (en) * | 2003-02-01 | 2009-08-28 | Wyeth Corp | Active immunization to generate antibodies to soluble A-beta |
| WO2004084805A2 (en) | 2003-03-19 | 2004-10-07 | The J. David Gladstone Institutes | Acetylated tat polypeptides and methods of use thereof |
| US7125842B2 (en) * | 2003-04-07 | 2006-10-24 | Canbas Co. Ltd. | Anti-fungal compounds and methods of use |
| ZA200602754B (en) * | 2003-09-12 | 2007-06-27 | Univ British Columbia | Effectors of innate immunity determination |
| JP2005120050A (ja) * | 2003-10-20 | 2005-05-12 | Toagosei Co Ltd | 新規抗菌性ペプチドとその利用 |
| SI2985039T1 (sl) | 2004-03-03 | 2018-12-31 | Revance Therapeutics, Inc. | Topična aplikacija in transdermalna dostava toksinov botulina |
| NZ593986A (en) | 2004-03-03 | 2013-07-26 | Revance Therapeutics Inc | Compositions comprising a protein and a carrier for topical diagnostic and therapeutic transport |
| SG188092A1 (en) * | 2004-08-18 | 2013-03-28 | Novabiotics Ltd | Peptide |
| EP1656951A1 (en) * | 2004-11-12 | 2006-05-17 | Xigen S.A. | Conjugates with enhanced cell uptake activity |
| CA2629751A1 (en) | 2004-11-12 | 2006-05-18 | The University Of British Columbia | Antimicrobial peptides |
| EP1661912A1 (en) | 2004-11-29 | 2006-05-31 | Xigen S.A. | Fusion protein comprising a BH3-domain of a BH3-only protein |
| JP4730584B2 (ja) * | 2004-12-06 | 2011-07-20 | 東亞合成株式会社 | 抗菌ペプチド及びその利用 |
| JP2006238751A (ja) * | 2005-03-02 | 2006-09-14 | Toagosei Co Ltd | ベロ毒素結合性を有する抗菌ペプチド及びその利用 |
| AU2006218431B2 (en) | 2005-03-03 | 2012-12-06 | Revance Therapeutics, Inc. | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
| CA2599016A1 (en) | 2005-03-03 | 2006-09-08 | Revance Therapeutics, Inc. | Compositions and methods for topical application and transdermal delivery of an oligopeptide |
| WO2006105450A2 (en) | 2005-03-30 | 2006-10-05 | Revance Therapeutics, Inc. | Compositions and methods for treating acne |
| JP4944896B2 (ja) | 2005-11-17 | 2012-06-06 | ルバンス セラピュティックス インク． | 低減された非毒素タンパク質を含むボツリヌス毒素の局所適用及び経皮送達のための組成物及び方法 |
| BRPI0720730A2 (pt) | 2006-12-29 | 2014-04-08 | Revance Therapeutics Inc | Composições e métodos de aplicação tópica e liberação transdérmica de toxinas botulínicas estabilizadas com fragmentos de polipeptídeo derivados de hiv-tat. |
| CA2672886C (en) | 2006-12-29 | 2015-02-10 | Revance Therapeutics, Inc. | Transport molecules using reverse sequence hiv-tat polypeptides |
| ES2609914T3 (es) * | 2007-07-26 | 2017-04-25 | Revance Therapeutics, Inc. | Péptidos antimicrobianos y composiciones de los mismos |
| DK2379104T3 (en) | 2008-12-31 | 2018-04-30 | Revance Therapeutics Inc | Injectable botulinum toxin formulations |
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| JP2014076993A (ja) * | 2007-07-26 | 2014-05-01 | Revance Therapeutics Inc | 抗菌ペプチド、組成物及びその使用方法 |
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