JP5389326B2 - アレルゲンペプチド断片およびその利用 - Google Patents

アレルゲンペプチド断片およびその利用 Download PDF

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Publication number
JP5389326B2
JP5389326B2 JP2006506543A JP2006506543A JP5389326B2 JP 5389326 B2 JP5389326 B2 JP 5389326B2 JP 2006506543 A JP2006506543 A JP 2006506543A JP 2006506543 A JP2006506543 A JP 2006506543A JP 5389326 B2 JP5389326 B2 JP 5389326B2
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allergen
peptide fragments
amino acid
seq
peptide
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JP2006520380A (ja
JP2006520380A5 (enExample
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フランソワ スペルティーニ,
ブレイズ コルテジー,
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アネルギ エスアー
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/168Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/35Allergens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43531Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from mites
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C07K14/43572Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from bees

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Insects & Arthropods (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Botany (AREA)
  • Pulmonology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Transplantation (AREA)
  • Otolaryngology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
JP2006506543A 2003-03-14 2004-03-15 アレルゲンペプチド断片およびその利用 Expired - Fee Related JP5389326B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US45500403P 2003-03-14 2003-03-14
US60/455,004 2003-03-14
US10/799,514 2004-03-12
US10/799,514 US7923209B2 (en) 2003-03-14 2004-03-12 Allergen peptide fragments and use thereof
PCT/IB2004/001300 WO2004081028A2 (en) 2003-03-14 2004-03-15 Allergen peptide fragments and use thereof

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2006165170A Division JP5390742B2 (ja) 2003-03-14 2006-06-14 アレルゲンペプチド断片を含む組成物
JP2013170083A Division JP2013256520A (ja) 2003-03-14 2013-08-20 アレルゲンペプチド断片およびその利用

Publications (3)

Publication Number Publication Date
JP2006520380A JP2006520380A (ja) 2006-09-07
JP2006520380A5 JP2006520380A5 (enExample) 2009-05-07
JP5389326B2 true JP5389326B2 (ja) 2014-01-15

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Family Applications (4)

Application Number Title Priority Date Filing Date
JP2006506543A Expired - Fee Related JP5389326B2 (ja) 2003-03-14 2004-03-15 アレルゲンペプチド断片およびその利用
JP2006165170A Expired - Fee Related JP5390742B2 (ja) 2003-03-14 2006-06-14 アレルゲンペプチド断片を含む組成物
JP2011094277A Pending JP2011201886A (ja) 2003-03-14 2011-04-20 アレルゲンペプチド断片を含む組成物
JP2013170083A Pending JP2013256520A (ja) 2003-03-14 2013-08-20 アレルゲンペプチド断片およびその利用

Family Applications After (3)

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JP2006165170A Expired - Fee Related JP5390742B2 (ja) 2003-03-14 2006-06-14 アレルゲンペプチド断片を含む組成物
JP2011094277A Pending JP2011201886A (ja) 2003-03-14 2011-04-20 アレルゲンペプチド断片を含む組成物
JP2013170083A Pending JP2013256520A (ja) 2003-03-14 2013-08-20 アレルゲンペプチド断片およびその利用

Country Status (6)

Country Link
US (5) US7923209B2 (enExample)
EP (4) EP2368574A1 (enExample)
JP (4) JP5389326B2 (enExample)
AU (2) AU2004220274B2 (enExample)
CA (2) CA2519083C (enExample)
WO (1) WO2004081028A2 (enExample)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7923209B2 (en) 2003-03-14 2011-04-12 Anergis, S.A. Allergen peptide fragments and use thereof
US7608693B2 (en) 2006-10-02 2009-10-27 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human IL-4 receptor
US9017697B2 (en) 2006-10-12 2015-04-28 The University Of Queensland Compositions and methods for modulating immune responses
GB0710529D0 (en) 2007-06-01 2007-07-11 Circassia Ltd Vaccine
ITMI20072421A1 (it) * 2007-12-21 2009-06-22 Lofarma Spa Allergeni ed allergoidi da veleno d'api
SI2393511T1 (sl) * 2009-02-09 2016-10-28 Anergis Sa Sosednje prekrivajoči se peptidi za zdravljenje alergije na cvetni prah breze
JP5728678B2 (ja) * 2009-03-26 2015-06-03 国立大学法人名古屋大学 アレルギー疾患を診断するための方法
GB201002559D0 (en) * 2010-02-15 2010-03-31 Circassia Ltd Birch peptides for vaccine
CN107184971A (zh) * 2010-04-30 2017-09-22 艾洛维特有限责任公司 经由口腔粘膜变应性脱敏的方法、制品和试剂盒
WO2011137422A2 (en) 2010-04-30 2011-11-03 Apellis Pharmaceuticals, Inc. Methods and articles for preventing or reducing risk of developing a hyperallergenic immune system
CA2816529A1 (en) 2010-11-01 2012-05-10 University Of Technology, Sydney Immune-modulating agents and uses therefor
EP2460824A1 (en) * 2010-12-01 2012-06-06 Biomay Ag Hypoallergenic polypeptides for the treatment of house dust mite allergy
US9005627B2 (en) 2011-06-27 2015-04-14 Anergis S.A. Contiguous overlapping peptides for treatment of ragweed pollen allergy
TWI656880B (zh) 2012-08-21 2019-04-21 法商賽諾菲生物技術公司 投與il-4r拮抗劑以治療或預防氣喘之方法
HUE039387T2 (hu) 2012-09-07 2018-12-28 Regeneron Pharma Atópiás dermatitisz kezelési módszerei egy IL-4R antagonista adagolásával
CN105120894B (zh) 2012-10-30 2019-02-15 阿拉沃克斯有限公司 新颖的免疫治疗分子和其用途
TWI755763B (zh) 2013-06-04 2022-02-21 美商再生元醫藥公司 藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法
WO2014195803A2 (en) * 2013-06-06 2014-12-11 Anergis S.A. Contiguous overlapping peptides for treatment of house dust mites allergy
TWI634900B (zh) 2013-07-11 2018-09-11 再生元醫藥公司 藉由投與il-4r抑制劑治療嗜酸性食道炎的方法
CA2924714C (en) 2013-09-19 2024-04-09 Allovate, Llc Toothpaste for delivering allergens to oral mucosa
BR112016006813A2 (pt) * 2013-09-25 2017-09-19 Aravax Pty Ltd Composição imunoterapêutica nova e seus usos
AU2015222951B2 (en) 2014-02-28 2020-06-11 Regeneron Pharmaceuticals, Inc. Methods for treating skin infection by administering an IL-4R antagonist
WO2016077675A1 (en) 2014-11-14 2016-05-19 Sanofi Biotechnology Methods for treating chronic sinusitis with nasal polyps by administering an il-4r antagonist
US10232048B1 (en) 2014-11-18 2019-03-19 Divine Api-Logics, LLC Apitherapy method and composition
WO2017179025A1 (en) * 2016-04-15 2017-10-19 Alk-Abelló A/S Epitope polypeptides of ragweed pollen allergens
CN109789196B (zh) 2016-09-01 2024-03-19 瑞泽恩制药公司 用于通过施用il-4r拮抗剂来预防或治疗变态反应的方法
TWI784988B (zh) 2016-12-01 2022-12-01 美商再生元醫藥公司 治療發炎症狀的方法
WO2019028367A1 (en) 2017-08-04 2019-02-07 Regeneron Pharmaceuticals, Inc. METHODS OF TREATING ESOPHAGITIS WITH ACTIVE EOSINOPHILES
PT3515465T (pt) 2017-08-18 2024-03-04 Regeneron Pharma Métodos para o tratamento de uma dermatite atópica grave mediante a administração de um inibidor de il-4r
ES2969049T3 (es) 2017-10-30 2024-05-16 Sanofi Biotechnology Antagonista de IL-4R para uso en un método para tratar o prevenir el asma
SG11202009371WA (en) 2018-05-13 2020-10-29 Regeneron Pharma Methods for treating atopic dermatitis by administering an il-4r inhibitor
US20200188511A1 (en) 2018-12-12 2020-06-18 Anergis S.A. Methods of improving efficacy of allergy vaccines
CN121102493A (zh) 2019-03-21 2025-12-12 瑞泽恩制药公司 用于治疗过敏症的il-4/il-13途径抑制剂和浆细胞消融的组合
CN115175700A (zh) 2019-07-16 2022-10-11 赛诺菲生物技术公司 用于通过施用il-4r拮抗剂治疗或预防哮喘的方法
SG11202113312VA (en) 2019-08-05 2021-12-30 Regeneron Pharma Methods for treating allergy and enhancing allergen-specific immunotherapy by administering an il-4r antagonist
EP4010373A1 (en) 2019-08-05 2022-06-15 Regeneron Pharmaceuticals, Inc. Methods for treating atopic dermatitis by administering an il-4r antagonist

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4473495A (en) 1983-07-28 1984-09-25 Northwestern University Albumin-solubilized hymenoptera venoms for vaccine use
WO1988010297A1 (en) 1987-06-17 1988-12-29 Princess Margaret Children's Medical Research Foun Cloning of mite allergens
JP2594123B2 (ja) 1987-09-12 1997-03-26 株式会社林原生物化学研究所 減感作剤
US5152980A (en) 1988-05-19 1992-10-06 The Beth Israel Hospital Association Induction of tolerance to a foreign antigen IL-2 receptor-binding substances
US5124249A (en) 1989-11-28 1992-06-23 Khan Rashid H Method for evaluating protection to bee venom
US5565338A (en) 1990-06-04 1996-10-15 La Jolla Institute For Allergy And Immunology Suppressor T-cell hybridoma and production of allergen specific glycosylation inhibiting factor
US5965709A (en) 1991-08-14 1999-10-12 Genentech, Inc. IgE antagonists
IL105153A (en) 1992-03-25 1999-12-22 Immulogic Pharma Corp Therapeutic compositions comprising peptides derived from human t cell reactive feline protein
IT1254360B (it) 1992-05-11 1995-09-14 San Romanello Centro Fond Epitopi immunologicamente omologhi di hla e proteine del virus hiv.
US5582995A (en) 1993-06-11 1996-12-10 The General Hospital Corporation Methods of screening for compounds which inhibit the direct binding of Ras to Raf
US6074673A (en) 1996-04-22 2000-06-13 Guillen; Manuel Slow-release, self-absorbing, drug delivery system
AU9531698A (en) 1997-10-15 1999-05-03 Alk A/S Composition and method for treating an encephalomyelopathic, demyelinating or autoimmune disease
WO1999034826A1 (en) 1998-01-09 1999-07-15 Circassia Limited Methods and compositions for desensitisation
GB2341389B (en) 1998-09-14 2000-07-12 Pan Pacific Pharmaceuticals In Useful properties of a bee venom protein and gene encoding same
FR2788698B1 (fr) 1999-01-27 2001-03-30 Commissariat Energie Atomique Peptides et proteines aptes a desensibiliser les sujets allergiques au venin d'abeille et compositions les contenant
US20030211510A1 (en) 1999-06-30 2003-11-13 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
US6780416B1 (en) 2000-02-18 2004-08-24 Ecole Polytechnique Federale De Lausanne Bee venom polypeptides and methods of use thereof
US20020193295A1 (en) 2001-05-04 2002-12-19 Emanuel Calenoff Immunogenic peptides and uses thereof
WO2004002415A2 (en) * 2002-06-27 2004-01-08 Dana-Farber Cancer Institute, Inc. Compositions and methods for modulating a cytotoxic t lymphocyte immune response
US7923209B2 (en) 2003-03-14 2011-04-12 Anergis, S.A. Allergen peptide fragments and use thereof

Also Published As

Publication number Publication date
AU2004220274A1 (en) 2004-09-23
EP2368574A1 (en) 2011-09-28
US20120100167A1 (en) 2012-04-26
JP2011201886A (ja) 2011-10-13
JP2013256520A (ja) 2013-12-26
US20070110673A1 (en) 2007-05-17
US9808503B2 (en) 2017-11-07
EP2687230A1 (en) 2014-01-22
AU2010212310A1 (en) 2010-09-02
AU2004220274B2 (en) 2010-05-13
JP2006520380A (ja) 2006-09-07
JP2007001975A (ja) 2007-01-11
US9193773B2 (en) 2015-11-24
US20140193444A1 (en) 2014-07-10
CA2759072A1 (en) 2004-09-23
US8703144B2 (en) 2014-04-22
AU2010212310B2 (en) 2012-01-19
US20160095899A1 (en) 2016-04-07
JP5390742B2 (ja) 2014-01-15
US20040241178A1 (en) 2004-12-02
WO2004081028A2 (en) 2004-09-23
EP2204189A2 (en) 2010-07-07
US8075897B2 (en) 2011-12-13
EP1603591A2 (en) 2005-12-14
EP2204189A3 (en) 2010-09-29
CA2519083C (en) 2017-06-13
CA2519083A1 (en) 2004-09-23
US7923209B2 (en) 2011-04-12
WO2004081028A3 (en) 2005-02-17

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