CA2519083C - Allergen peptide fragments and use thereof - Google Patents
Allergen peptide fragments and use thereof Download PDFInfo
- Publication number
- CA2519083C CA2519083C CA2519083A CA2519083A CA2519083C CA 2519083 C CA2519083 C CA 2519083C CA 2519083 A CA2519083 A CA 2519083A CA 2519083 A CA2519083 A CA 2519083A CA 2519083 C CA2519083 C CA 2519083C
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- Prior art keywords
- allergen
- seq
- peptide
- peptide fragments
- amino acid
- Prior art date
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Classifications
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/168—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
- C07K14/43531—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from mites
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
- C07K14/43572—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from bees
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
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- Immunology (AREA)
- Zoology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Pulmonology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Transplantation (AREA)
- Otolaryngology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Priority Applications (1)
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| US10/799,514 US7923209B2 (en) | 2003-03-14 | 2004-03-12 | Allergen peptide fragments and use thereof |
| PCT/IB2004/001300 WO2004081028A2 (en) | 2003-03-14 | 2004-03-15 | Allergen peptide fragments and use thereof |
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| CA2519083A1 CA2519083A1 (en) | 2004-09-23 |
| CA2519083C true CA2519083C (en) | 2017-06-13 |
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| EP (4) | EP2368574A1 (enExample) |
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| US7608693B2 (en) | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
| US9017697B2 (en) | 2006-10-12 | 2015-04-28 | The University Of Queensland | Compositions and methods for modulating immune responses |
| GB0710529D0 (en) | 2007-06-01 | 2007-07-11 | Circassia Ltd | Vaccine |
| ITMI20072421A1 (it) * | 2007-12-21 | 2009-06-22 | Lofarma Spa | Allergeni ed allergoidi da veleno d'api |
| SI2393511T1 (sl) * | 2009-02-09 | 2016-10-28 | Anergis Sa | Sosednje prekrivajoči se peptidi za zdravljenje alergije na cvetni prah breze |
| JP5728678B2 (ja) * | 2009-03-26 | 2015-06-03 | 国立大学法人名古屋大学 | アレルギー疾患を診断するための方法 |
| GB201002559D0 (en) * | 2010-02-15 | 2010-03-31 | Circassia Ltd | Birch peptides for vaccine |
| CN107184971A (zh) * | 2010-04-30 | 2017-09-22 | 艾洛维特有限责任公司 | 经由口腔粘膜变应性脱敏的方法、制品和试剂盒 |
| WO2011137422A2 (en) | 2010-04-30 | 2011-11-03 | Apellis Pharmaceuticals, Inc. | Methods and articles for preventing or reducing risk of developing a hyperallergenic immune system |
| CA2816529A1 (en) | 2010-11-01 | 2012-05-10 | University Of Technology, Sydney | Immune-modulating agents and uses therefor |
| EP2460824A1 (en) * | 2010-12-01 | 2012-06-06 | Biomay Ag | Hypoallergenic polypeptides for the treatment of house dust mite allergy |
| US9005627B2 (en) | 2011-06-27 | 2015-04-14 | Anergis S.A. | Contiguous overlapping peptides for treatment of ragweed pollen allergy |
| TWI656880B (zh) | 2012-08-21 | 2019-04-21 | 法商賽諾菲生物技術公司 | 投與ｉｌ－４ｒ拮抗劑以治療或預防氣喘之方法 |
| HUE039387T2 (hu) | 2012-09-07 | 2018-12-28 | Regeneron Pharma | Atópiás dermatitisz kezelési módszerei egy IL-4R antagonista adagolásával |
| CN105120894B (zh) | 2012-10-30 | 2019-02-15 | 阿拉沃克斯有限公司 | 新颖的免疫治疗分子和其用途 |
| TWI755763B (zh) | 2013-06-04 | 2022-02-21 | 美商再生元醫藥公司 | 藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法 |
| WO2014195803A2 (en) * | 2013-06-06 | 2014-12-11 | Anergis S.A. | Contiguous overlapping peptides for treatment of house dust mites allergy |
| TWI634900B (zh) | 2013-07-11 | 2018-09-11 | 再生元醫藥公司 | 藉由投與ｉｌ－４ｒ抑制劑治療嗜酸性食道炎的方法 |
| CA2924714C (en) | 2013-09-19 | 2024-04-09 | Allovate, Llc | Toothpaste for delivering allergens to oral mucosa |
| BR112016006813A2 (pt) * | 2013-09-25 | 2017-09-19 | Aravax Pty Ltd | Composição imunoterapêutica nova e seus usos |
| AU2015222951B2 (en) | 2014-02-28 | 2020-06-11 | Regeneron Pharmaceuticals, Inc. | Methods for treating skin infection by administering an IL-4R antagonist |
| WO2016077675A1 (en) | 2014-11-14 | 2016-05-19 | Sanofi Biotechnology | Methods for treating chronic sinusitis with nasal polyps by administering an il-4r antagonist |
| US10232048B1 (en) | 2014-11-18 | 2019-03-19 | Divine Api-Logics, LLC | Apitherapy method and composition |
| WO2017179025A1 (en) * | 2016-04-15 | 2017-10-19 | Alk-Abelló A/S | Epitope polypeptides of ragweed pollen allergens |
| CN109789196B (zh) | 2016-09-01 | 2024-03-19 | 瑞泽恩制药公司 | 用于通过施用il-4r拮抗剂来预防或治疗变态反应的方法 |
| TWI784988B (zh) | 2016-12-01 | 2022-12-01 | 美商再生元醫藥公司 | 治療發炎症狀的方法 |
| WO2019028367A1 (en) | 2017-08-04 | 2019-02-07 | Regeneron Pharmaceuticals, Inc. | METHODS OF TREATING ESOPHAGITIS WITH ACTIVE EOSINOPHILES |
| PT3515465T (pt) | 2017-08-18 | 2024-03-04 | Regeneron Pharma | Métodos para o tratamento de uma dermatite atópica grave mediante a administração de um inibidor de il-4r |
| ES2969049T3 (es) | 2017-10-30 | 2024-05-16 | Sanofi Biotechnology | Antagonista de IL-4R para uso en un método para tratar o prevenir el asma |
| SG11202009371WA (en) | 2018-05-13 | 2020-10-29 | Regeneron Pharma | Methods for treating atopic dermatitis by administering an il-4r inhibitor |
| US20200188511A1 (en) | 2018-12-12 | 2020-06-18 | Anergis S.A. | Methods of improving efficacy of allergy vaccines |
| CN121102493A (zh) | 2019-03-21 | 2025-12-12 | 瑞泽恩制药公司 | 用于治疗过敏症的il-4/il-13途径抑制剂和浆细胞消融的组合 |
| CN115175700A (zh) | 2019-07-16 | 2022-10-11 | 赛诺菲生物技术公司 | 用于通过施用il-4r拮抗剂治疗或预防哮喘的方法 |
| SG11202113312VA (en) | 2019-08-05 | 2021-12-30 | Regeneron Pharma | Methods for treating allergy and enhancing allergen-specific immunotherapy by administering an il-4r antagonist |
| EP4010373A1 (en) | 2019-08-05 | 2022-06-15 | Regeneron Pharmaceuticals, Inc. | Methods for treating atopic dermatitis by administering an il-4r antagonist |
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| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4473495A (en) | 1983-07-28 | 1984-09-25 | Northwestern University | Albumin-solubilized hymenoptera venoms for vaccine use |
| WO1988010297A1 (en) | 1987-06-17 | 1988-12-29 | Princess Margaret Children's Medical Research Foun | Cloning of mite allergens |
| JP2594123B2 (ja) | 1987-09-12 | 1997-03-26 | 株式会社林原生物化学研究所 | 減感作剤 |
| US5152980A (en) | 1988-05-19 | 1992-10-06 | The Beth Israel Hospital Association | Induction of tolerance to a foreign antigen IL-2 receptor-binding substances |
| US5124249A (en) | 1989-11-28 | 1992-06-23 | Khan Rashid H | Method for evaluating protection to bee venom |
| US5565338A (en) | 1990-06-04 | 1996-10-15 | La Jolla Institute For Allergy And Immunology | Suppressor T-cell hybridoma and production of allergen specific glycosylation inhibiting factor |
| US5965709A (en) | 1991-08-14 | 1999-10-12 | Genentech, Inc. | IgE antagonists |
| IL105153A (en) | 1992-03-25 | 1999-12-22 | Immulogic Pharma Corp | Therapeutic compositions comprising peptides derived from human t cell reactive feline protein |
| IT1254360B (it) | 1992-05-11 | 1995-09-14 | San Romanello Centro Fond | Epitopi immunologicamente omologhi di hla e proteine del virus hiv. |
| US5582995A (en) | 1993-06-11 | 1996-12-10 | The General Hospital Corporation | Methods of screening for compounds which inhibit the direct binding of Ras to Raf |
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| AU9531698A (en) | 1997-10-15 | 1999-05-03 | Alk A/S | Composition and method for treating an encephalomyelopathic, demyelinating or autoimmune disease |
| WO1999034826A1 (en) | 1998-01-09 | 1999-07-15 | Circassia Limited | Methods and compositions for desensitisation |
| GB2341389B (en) | 1998-09-14 | 2000-07-12 | Pan Pacific Pharmaceuticals In | Useful properties of a bee venom protein and gene encoding same |
| FR2788698B1 (fr) | 1999-01-27 | 2001-03-30 | Commissariat Energie Atomique | Peptides et proteines aptes a desensibiliser les sujets allergiques au venin d'abeille et compositions les contenant |
| US20030211510A1 (en) | 1999-06-30 | 2003-11-13 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| US6780416B1 (en) | 2000-02-18 | 2004-08-24 | Ecole Polytechnique Federale De Lausanne | Bee venom polypeptides and methods of use thereof |
| US20020193295A1 (en) | 2001-05-04 | 2002-12-19 | Emanuel Calenoff | Immunogenic peptides and uses thereof |
| WO2004002415A2 (en) * | 2002-06-27 | 2004-01-08 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for modulating a cytotoxic t lymphocyte immune response |
| US7923209B2 (en) | 2003-03-14 | 2011-04-12 | Anergis, S.A. | Allergen peptide fragments and use thereof |
-
2004
- 2004-03-12 US US10/799,514 patent/US7923209B2/en not_active Expired - Fee Related
- 2004-03-15 EP EP10011428A patent/EP2368574A1/en not_active Ceased
- 2004-03-15 CA CA2519083A patent/CA2519083C/en not_active Expired - Fee Related
- 2004-03-15 AU AU2004220274A patent/AU2004220274B2/en not_active Ceased
- 2004-03-15 WO PCT/IB2004/001300 patent/WO2004081028A2/en not_active Ceased
- 2004-03-15 CA CA2759072A patent/CA2759072A1/en not_active Abandoned
- 2004-03-15 EP EP04720678A patent/EP1603591A2/en not_active Withdrawn
- 2004-03-15 EP EP12006034.8A patent/EP2687230A1/en not_active Withdrawn
- 2004-03-15 JP JP2006506543A patent/JP5389326B2/ja not_active Expired - Fee Related
- 2004-03-15 EP EP09015109A patent/EP2204189A3/en not_active Ceased
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2005
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2006
- 2006-06-14 JP JP2006165170A patent/JP5390742B2/ja not_active Expired - Fee Related
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2010
- 2010-08-12 AU AU2010212310A patent/AU2010212310B2/en not_active Ceased
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2011
- 2011-04-20 JP JP2011094277A patent/JP2011201886A/ja active Pending
- 2011-10-28 US US13/284,383 patent/US8703144B2/en not_active Expired - Fee Related
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2013
- 2013-08-20 JP JP2013170083A patent/JP2013256520A/ja active Pending
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2014
- 2014-03-12 US US14/206,354 patent/US9193773B2/en not_active Expired - Fee Related
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- 2015-11-23 US US14/949,019 patent/US9808503B2/en not_active Expired - Fee Related
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|---|---|
| AU2004220274A1 (en) | 2004-09-23 |
| EP2368574A1 (en) | 2011-09-28 |
| US20120100167A1 (en) | 2012-04-26 |
| JP2011201886A (ja) | 2011-10-13 |
| JP2013256520A (ja) | 2013-12-26 |
| US20070110673A1 (en) | 2007-05-17 |
| US9808503B2 (en) | 2017-11-07 |
| EP2687230A1 (en) | 2014-01-22 |
| AU2010212310A1 (en) | 2010-09-02 |
| AU2004220274B2 (en) | 2010-05-13 |
| JP2006520380A (ja) | 2006-09-07 |
| JP2007001975A (ja) | 2007-01-11 |
| US9193773B2 (en) | 2015-11-24 |
| US20140193444A1 (en) | 2014-07-10 |
| CA2759072A1 (en) | 2004-09-23 |
| JP5389326B2 (ja) | 2014-01-15 |
| US8703144B2 (en) | 2014-04-22 |
| AU2010212310B2 (en) | 2012-01-19 |
| US20160095899A1 (en) | 2016-04-07 |
| JP5390742B2 (ja) | 2014-01-15 |
| US20040241178A1 (en) | 2004-12-02 |
| WO2004081028A2 (en) | 2004-09-23 |
| EP2204189A2 (en) | 2010-07-07 |
| US8075897B2 (en) | 2011-12-13 |
| EP1603591A2 (en) | 2005-12-14 |
| EP2204189A3 (en) | 2010-09-29 |
| CA2519083A1 (en) | 2004-09-23 |
| US7923209B2 (en) | 2011-04-12 |
| WO2004081028A3 (en) | 2005-02-17 |
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