JP5363663B2 - 分子または粒子を検出するアッセイにおけるダイナミックレンジを拡張するための方法またはシステム - Google Patents

分子または粒子を検出するアッセイにおけるダイナミックレンジを拡張するための方法またはシステム Download PDF

Info

Publication number
JP5363663B2
JP5363663B2 JP2012556169A JP2012556169A JP5363663B2 JP 5363663 B2 JP5363663 B2 JP 5363663B2 JP 2012556169 A JP2012556169 A JP 2012556169A JP 2012556169 A JP2012556169 A JP 2012556169A JP 5363663 B2 JP5363663 B2 JP 5363663B2
Authority
JP
Japan
Prior art keywords
analyte
concentration
beads
molecules
particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2012556169A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013521500A5 (https=
JP2013521500A (ja
Inventor
リシン，デービット，エム．
フルニエ，デービット
ダフィー，デービット，シー．
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Quanterix Corp
Original Assignee
Quanterix Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US12/731,136 external-priority patent/US8415171B2/en
Application filed by Quanterix Corp filed Critical Quanterix Corp
Publication of JP2013521500A publication Critical patent/JP2013521500A/ja
Publication of JP2013521500A5 publication Critical patent/JP2013521500A5/ja
Application granted granted Critical
Publication of JP5363663B2 publication Critical patent/JP5363663B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/062—LED's
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/924—Hydrolases (3) acting on glycosyl compounds (3.2)

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
JP2012556169A 2010-03-01 2011-03-01 分子または粒子を検出するアッセイにおけるダイナミックレンジを拡張するための方法またはシステム Active JP5363663B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US30916510P 2010-03-01 2010-03-01
US61/309,165 2010-03-01
US12/731,136 US8415171B2 (en) 2010-03-01 2010-03-24 Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US12/731,136 2010-03-24
US201161441894P 2011-02-11 2011-02-11
US61/441,894 2011-02-11
PCT/US2011/026665 WO2011109379A1 (en) 2010-03-01 2011-03-01 Methods and systems for extending dynamic range in assays for the detection of molecules or particles

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013184218A Division JP5816237B2 (ja) 2010-03-01 2013-09-05 分子または粒子を検出するアッセイにおけるダイナミックレンジを拡張するための方法またはシステム

Publications (3)

Publication Number Publication Date
JP2013521500A JP2013521500A (ja) 2013-06-10
JP2013521500A5 JP2013521500A5 (https=) 2013-07-25
JP5363663B2 true JP5363663B2 (ja) 2013-12-11

Family

ID=44088987

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2012556169A Active JP5363663B2 (ja) 2010-03-01 2011-03-01 分子または粒子を検出するアッセイにおけるダイナミックレンジを拡張するための方法またはシステム
JP2013184218A Active JP5816237B2 (ja) 2010-03-01 2013-09-05 分子または粒子を検出するアッセイにおけるダイナミックレンジを拡張するための方法またはシステム

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2013184218A Active JP5816237B2 (ja) 2010-03-01 2013-09-05 分子または粒子を検出するアッセイにおけるダイナミックレンジを拡張するための方法またはシステム

Country Status (7)

Country Link
US (5) US9110025B2 (https=)
EP (1) EP2542890B1 (https=)
JP (2) JP5363663B2 (https=)
CN (1) CN103026232B (https=)
CA (1) CA2791655C (https=)
ES (1) ES2544635T3 (https=)
WO (1) WO2011109379A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10780706B2 (en) 2018-03-16 2020-09-22 Ricoh Company, Ltd. Discharging device and discharging method
WO2022202218A1 (ja) 2021-03-26 2022-09-29 国立研究開発法人産業技術総合研究所 ウエルアレイと粒子とを用いた生体物質検出方法、ウエルアレイ及び検出装置
WO2022202217A1 (ja) 2021-03-26 2022-09-29 国立研究開発法人産業技術総合研究所 ウエルアレイを用いたウイルス検出方法、ウエルアレイ及び検出装置

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US8492098B2 (en) 2006-02-21 2013-07-23 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of reaction components that affect a reaction
JP5503540B2 (ja) * 2007-08-30 2014-05-28 トラスティーズ・オブ・タフツ・カレッジ 溶液中の分析物濃度を決定する方法
US8222047B2 (en) * 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
US9678068B2 (en) * 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
US8236574B2 (en) * 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
CN103026232B (zh) * 2010-03-01 2015-02-04 匡特里克斯公司 扩大用于检测分子或颗粒的测定法中的动态范围的方法和系统
US8415171B2 (en) 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
US10018627B2 (en) 2011-03-08 2018-07-10 Japan Science And Technology Agency Method for sealing substances, method for detecting target molecule, array, kit, and target molecule detection device
EP2685266A1 (en) 2011-03-08 2014-01-15 Japan Science And Technology Agency Bead sealing method, method for detecting target molecule, array, kit, and target molecule detection device
WO2012142301A2 (en) 2011-04-12 2012-10-18 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patients recovery from a brain injury
JP5822534B2 (ja) * 2011-05-13 2015-11-24 株式会社日立ハイテクノロジーズ 自動分析装置
CA2804843C (en) 2012-02-06 2021-02-02 Ortho-Clinical Diagnostics, Inc. Multiple time windows for extending the range of an assay
US9568431B2 (en) 2012-04-16 2017-02-14 Access Medical Systems, Ltd. Luminescent immunoassays for quantitating analytes having a wide concentration range
JP6200948B2 (ja) 2012-05-25 2017-09-20 ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル マイクロ流体デバイス
WO2014014911A1 (en) * 2012-07-16 2014-01-23 Siloam Biosciences, Inc. Point of care testing assay system using novel microfluidics
EP2877483B1 (en) * 2012-07-25 2019-05-15 Bio-rad Laboratories, Inc. Targeted delivery of reagents through patterned transfer sheets
US9932626B2 (en) 2013-01-15 2018-04-03 Quanterix Corporation Detection of DNA or RNA using single molecule arrays and other techniques
US9618520B2 (en) 2013-04-25 2017-04-11 Vladislav B. Bergo Microarray compositions and methods of their use
EP3121590B1 (en) * 2014-03-20 2023-08-02 Universal Bio Research Co., Ltd. Lightguide aggregate inspection device and inspection method
RU2691694C2 (ru) 2014-07-08 2019-06-17 Японское Агентство По Науке И Технике Способ герметизации вещества
WO2016115256A1 (en) * 2015-01-13 2016-07-21 Quanterix Corporation Methods relating to improving accuracy of capture object-based assays
WO2016130923A1 (en) 2015-02-13 2016-08-18 Quanterix Corporation Immunoassays for diffrential detection of clostridium difficile
EP3313573A2 (en) 2015-07-22 2018-05-02 The University of North Carolina at Chapel Hill Fluidic devices with bead well geometries with spatially separated bead retention and signal detection segments and related methods
US11016084B2 (en) 2015-10-05 2021-05-25 The University Of North Carolina At Chapel Hill Decoding methods for multiplexing assays and associated fluidic devices, kits, and solid supports
US12130290B2 (en) 2016-11-29 2024-10-29 Trustees Of Tufts College Compositions and methods for diagnosing breast cancer
US10324041B2 (en) * 2016-12-21 2019-06-18 Abbott Japan Co., Ltd. Optical imaging system using lateral illumination for digital assays
CN120685901A (zh) * 2017-02-08 2025-09-23 上海宜晟生物科技有限公司 数字测定
CA3053132A1 (en) 2017-02-09 2018-08-16 Essenlix Corp. Assay with amplification
AU2018327347A1 (en) 2017-09-07 2020-03-19 Adeptrix Corp. Multiplexed bead arrays for proteomics
WO2019060607A1 (en) 2017-09-20 2019-03-28 Quanterix Corporation METHODS AND SYSTEMS FOR DETECTING MOLECULES OF ANALYTES
US20200386751A1 (en) * 2017-11-28 2020-12-10 Inanobio, Inc. Field effect transistor sensor detection assays and systems and methods of making and using same
WO2019186277A1 (en) 2018-03-28 2019-10-03 Institut Pasteur Ultrasensitive hiv-1 p24 detection assay
WO2019199869A1 (en) * 2018-04-10 2019-10-17 Quanterix Corporation Quantification of biomarkers present in physiological samples
WO2020068174A2 (en) 2018-05-18 2020-04-02 The University Of North Carolina At Chapel Hill Compositions, devices, and methods for improving a surface property of a substrate
EP3837543A4 (en) * 2018-08-16 2022-11-16 Essenlix Corporation CELL ANALYSIS IN BODY FLUID, ESPECIALLY BLOOD
CN112189139B (zh) 2018-09-26 2024-10-29 北卡罗来纳-查佩尔山大学 用于改进测定的化合物、组合物和方法
CN113826011A (zh) * 2019-02-27 2021-12-21 纳米马赛克公司 纳米传感器及其用途
US11976269B2 (en) * 2019-03-18 2024-05-07 Cellular Research, Inc. Precise delivery of components into fluids
CN112147090B (zh) * 2019-06-28 2024-10-01 深圳迈瑞生物医疗电子股份有限公司 一种生化分析仪和生化反应中发生底物耗尽的判断方法
CN111060683B (zh) * 2019-12-09 2023-11-21 彩科(苏州)生物科技有限公司 一种多重免疫分子检测方法及试剂盒
US20210187503A1 (en) * 2019-12-19 2021-06-24 Personal Genomics Taiwan, Inc. Apparatus and system for single-molecule nucleic acids detection
CN111366563B (zh) * 2020-03-13 2022-04-19 量准（上海）医疗器械有限公司 数字化等离子免疫吸附试剂盒及其制造和测试方法
EP4135897A2 (en) 2020-04-15 2023-02-22 Quanterix Corporation Methods and systems related to highly sensitive, digital assays by improved delivery of capture objects
US11686730B2 (en) 2020-04-30 2023-06-27 Quanterix Corporation Quantitative antibody test
EP4157992A4 (en) 2020-05-26 2024-07-31 Bio-Rad Laboratories, Inc. APPARATUS AND METHOD FOR RAPID DIGITAL DETECTION
US20230236179A1 (en) * 2020-06-23 2023-07-27 The Brigham And Women`S Hospital, Inc. Single Molecule Assays for Ultrasensitive Detection of Biomolecules
JPWO2024204729A1 (https=) * 2023-03-30 2024-10-03
CN117388227B (zh) * 2023-10-18 2024-05-31 博瑞生物医药（苏州）股份有限公司 使用检测微球测定样品中目标分子浓度的方法、计算机可读介质和分析设备
CN119880859B (zh) * 2023-10-24 2026-01-27 博瑞生物医药（苏州）股份有限公司 使用检测微球测定样品中目标分子浓度的方法、计算机可读介质和分析设备
WO2025126815A1 (ja) * 2023-12-12 2025-06-19 東ソー株式会社 目的物質の測定値を補正する方法

Family Cites Families (293)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3521244A (en) 1968-10-23 1970-07-21 Rca Corp Electrical circuit for processing periodic signal pulses
US3712986A (en) 1969-04-03 1973-01-23 Westinghouse Electric Corp Electron imaging device utilizing a fiber optic input window
US4016550A (en) 1975-11-24 1977-04-05 Rca Corporation Charge transfer readout of charge injection device arrays
SE427505B (sv) 1977-03-04 1983-04-11 Pharmacia Diagnostics Ab Reagens till anvendning vid immunkemiska bestemningsmetoder
US4200110A (en) 1977-11-28 1980-04-29 United States Of America Fiber optic pH probe
JPS58219456A (ja) 1982-06-16 1983-12-20 Aloka Co Ltd 生化学分析装置
FR2565350B1 (fr) 1984-06-05 1986-10-10 Paris Nord Universite Moyens propres a permettre le support, le traitement, le stockage et l'analyse automatiques en continu d'echantillons biologiques
US4631211A (en) 1985-03-25 1986-12-23 Scripps Clinic & Research Foundation Means for sequential solid phase organic synthesis and methods using the same
US4780421A (en) * 1986-04-03 1988-10-25 Sclavo Inc. Cleavable labels for use in binding assays
US5252494A (en) 1986-06-25 1993-10-12 Trustees Of Tufts College Fiber optic sensors, apparatus, and detection methods using controlled release polymers and reagent formulations held within a polymeric reaction matrix
WO1988005533A1 (en) 1987-01-16 1988-07-28 Kelsius, Inc. Amplification of signals from optical fibers
FR2613074B1 (fr) 1987-03-27 1990-06-08 Commissariat Energie Atomique Capteur chimique actif, a fibres optiques
US4962037A (en) 1987-10-07 1990-10-09 United States Of America Method for rapid base sequencing in DNA and RNA
US5700637A (en) 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US5028535A (en) 1989-01-10 1991-07-02 Biosite Diagnostics, Inc. Threshold ligand-receptor assay
US4924870A (en) 1989-01-13 1990-05-15 Fiberoptic Sensor Technologies, Inc. Fiber optic sensors
US5196306A (en) 1989-03-29 1993-03-23 E. I. Du Pont De Nemours And Company Method for the detection or quantitation of an analyte using an analyte dependent enzyme activation system
US5026159A (en) 1989-05-19 1991-06-25 Acrogen, Inc. Area-modulated luminescence (AML)
US5190857A (en) 1989-05-19 1993-03-02 Acrogen, Inc. Optical method for measuring an analyte using area-modulated luminescence
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5091300A (en) 1989-08-03 1992-02-25 Merck & Co., Inc. Radio-immuno assay for hepatitis b virus pres2 antibodies
US5152816A (en) 1989-10-16 1992-10-06 Corning Incorporated Method of enlarging end of capillary tube bore
US5108961A (en) 1989-12-29 1992-04-28 Circon Corporation Etchable core glass compositions and method for manufacturing a high performance microchannel plate
US5770029A (en) 1996-07-30 1998-06-23 Soane Biosciences Integrated electrophoretic microdevices
US5532138A (en) 1990-04-26 1996-07-02 Behringwerke Ag Method and kits for determining peroxidatively active catalysts
US5683867A (en) 1990-06-11 1997-11-04 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: blended SELEX
US5270163A (en) 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
US5567588A (en) 1990-06-11 1996-10-22 University Research Corporation Systematic evolution of ligands by exponential enrichment: Solution SELEX
ES2259800T3 (es) 1990-06-11 2006-10-16 Gilead Sciences, Inc. Procedimientos de uso de ligandos de acido nucleico.
US5496938A (en) 1990-06-11 1996-03-05 Nexstar Pharmaceuticals, Inc. Nucleic acid ligands to HIV-RT and HIV-1 rev
US5637459A (en) 1990-06-11 1997-06-10 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chimeric selex
US5705337A (en) 1990-06-11 1998-01-06 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chemi-SELEX
US6582908B2 (en) * 1990-12-06 2003-06-24 Affymetrix, Inc. Oligonucleotides
US5320814A (en) 1991-01-25 1994-06-14 Trustees Of Tufts College Fiber optic array sensors, apparatus, and methods for concurrently visualizing and chemically detecting multiple analytes of interest in a fluid sample
US5250264A (en) 1991-01-25 1993-10-05 Trustees Of Tufts College Method of making imaging fiber optic sensors to concurrently detect multiple analytes of interest in a fluid sample
US5244813A (en) 1991-01-25 1993-09-14 Trustees Of Tufts College Fiber optic sensor, apparatus, and methods for detecting an organic analyte in a fluid or vapor sample
US5244636A (en) 1991-01-25 1993-09-14 Trustees Of Tufts College Imaging fiber optic array sensors, apparatus, and methods for concurrently detecting multiple analytes of interest in a fluid sample
US5770358A (en) 1991-09-18 1998-06-23 Affymax Technologies N.V. Tagged synthetic oligomer libraries
US6943034B1 (en) 1991-11-22 2005-09-13 Affymetrix, Inc. Combinatorial strategies for polymer synthesis
US5315375A (en) 1992-02-11 1994-05-24 Acrogen, Inc. Sensitive light detection system
HU9201687D0 (en) 1992-05-21 1992-08-28 Arpad Furka Preparation of sets from peptid mixtures with polycomponents and their use for the identification of biologically active peptides
US6156270A (en) 1992-05-21 2000-12-05 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US5329461A (en) 1992-07-23 1994-07-12 Acrogen, Inc. Digital analyte detection system
US5298741A (en) 1993-01-13 1994-03-29 Trustees Of Tufts College Thin film fiber optic sensor array and apparatus for concurrent viewing and chemical sensing of a sample
US7241569B2 (en) 1993-01-18 2007-07-10 Olympus Corporation Method and a device for the evaluation of biopolymer fitness
JP3441763B2 (ja) 1993-06-30 2003-09-02 キリン−アムジエン・インコーポレーテツド モノクローナル抗体及び該モノクローナル抗体を用いたヒトｇ−ｃｓｆの測定法
US6087186A (en) 1993-07-16 2000-07-11 Irori Methods and apparatus for synthesizing labeled combinatorial chemistry libraries
US5374395A (en) 1993-10-14 1994-12-20 Amoco Corporation Diagnostics instrument
US6015880A (en) 1994-03-16 2000-01-18 California Institute Of Technology Method and substrate for performing multiple sequential reactions on a matrix
US6589736B1 (en) 1994-11-22 2003-07-08 The Trustees Of Boston University Photocleavable agents and conjugates for the detection and isolation of biomolecules
WO1995032425A1 (en) 1994-05-23 1995-11-30 Smithkline Beecham Corporation Encoded combinatorial libraries
WO1995035506A2 (en) 1994-06-17 1995-12-28 Kensington Laboratories, Inc. Scribe mark reader
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5512490A (en) 1994-08-11 1996-04-30 Trustees Of Tufts College Optical sensor, optical sensing apparatus, and methods for detecting an analyte of interest using spectral recognition patterns
US6001564A (en) * 1994-09-12 1999-12-14 Infectio Diagnostic, Inc. Species specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories
US5620850A (en) 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US6013445A (en) 1996-06-06 2000-01-11 Lynx Therapeutics, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US20030104361A1 (en) 1997-09-29 2003-06-05 Susan Weininger Method of detection of nucleic acids with a specific sequence composition
US6884357B2 (en) 1995-02-21 2005-04-26 Iqbal Waheed Siddiqi Apparatus and method for processing magnetic particles
US6329139B1 (en) 1995-04-25 2001-12-11 Discovery Partners International Automated sorting system for matrices with memory
US5532379A (en) 1995-05-05 1996-07-02 Pierce Chemical Company Biotin containing heterobifunctional cleavable compounds
US5690894A (en) 1995-05-23 1997-11-25 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
IL115465A0 (en) 1995-09-29 1995-12-31 Yeda Res & Dev Assay for the diagnosis of dementia
US5981180A (en) 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
DE19540098C2 (de) 1995-10-27 2001-05-17 Inst Chemo Biosensorik Verfahren und Mehrkanalbiosensor zur Mehrkomponentenanalyse von Mischungen und/oder Gemischen
DK0862656T3 (da) 1995-11-21 2001-04-09 Univ Yale Unimolekylær segmentamplifikation og -detektering
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US5633972A (en) 1995-11-29 1997-05-27 Trustees Of Tufts College Superresolution imaging fiber for subwavelength light energy generation and near-field optical microscopy
US5641634A (en) 1995-11-30 1997-06-24 Mandecki; Wlodek Electronically-indexed solid-phase assay for biomolecules
US5814524A (en) 1995-12-14 1998-09-29 Trustees Of Tufts College Optical sensor apparatus for far-field viewing and making optical analytical measurements at remote locations
US5846839A (en) 1995-12-22 1998-12-08 Glaxo Group Limited Methods for hard-tagging an encoded synthetic library
AU1689897A (en) 1995-12-29 1997-07-28 Intel Corporation Cmos imaging device with integrated flash memory image correction circuitry
US5837196A (en) 1996-01-26 1998-11-17 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
US6387707B1 (en) 1996-04-25 2002-05-14 Bioarray Solutions Array Cytometry
US6586193B2 (en) 1996-04-25 2003-07-01 Genicon Sciences Corporation Analyte assay using particulate labels
US5824478A (en) 1996-04-30 1998-10-20 Vysis, Inc. Diagnostic methods and probes
US5885529A (en) * 1996-06-28 1999-03-23 Dpc Cirrus, Inc. Automated immunoassay analyzer
DK0925494T3 (da) * 1996-09-04 2002-07-01 Scandinavian Micro Biodevices Mikrostrømningssystem til partikelseparation og analyse
KR100343218B1 (ko) * 1996-10-31 2002-08-22 삼성전자 주식회사 자기공명영상장치용고주파코일
US6133436A (en) 1996-11-06 2000-10-17 Sequenom, Inc. Beads bound to a solid support and to nucleic acids
US5900481A (en) 1996-11-06 1999-05-04 Sequenom, Inc. Bead linkers for immobilizing nucleic acids to solid supports
EP0963443B1 (en) 1996-12-10 2006-03-08 Sequenom, Inc. Releasable nonvolatile mass-label molecules
SE9700384D0 (sv) 1997-02-04 1997-02-04 Biacore Ab Analytical method and apparatus
US6327410B1 (en) 1997-03-14 2001-12-04 The Trustees Of Tufts College Target analyte sensors utilizing Microspheres
US6023540A (en) 1997-03-14 2000-02-08 Trustees Of Tufts College Fiber optic sensor with encoded microspheres
US7622294B2 (en) 1997-03-14 2009-11-24 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
US20030027126A1 (en) 1997-03-14 2003-02-06 Walt David R. Methods for detecting target analytes and enzymatic reactions
US6143496A (en) 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
US6406845B1 (en) 1997-05-05 2002-06-18 Trustees Of Tuft College Fiber optic biosensor for selectively detecting oligonucleotide species in a mixed fluid sample
US6203983B1 (en) 1997-06-16 2001-03-20 Affymetrix, Inc. Method for detecting chemical interactions between naturally occurring bio-polymers which are non-identical binding partners
FR2764989B1 (fr) 1997-06-20 1999-08-27 Pasteur Sanofi Diagnostics Procede de dosage du c-peptide
US6174695B1 (en) 1997-08-12 2001-01-16 The Regents Of The University Of California Epoxide hydrolase inhibitor methods
US7070921B2 (en) 2000-04-28 2006-07-04 Molecular Devices Corporation Molecular modification assays
US7632651B2 (en) 1997-09-15 2009-12-15 Mds Analytical Technologies (Us) Inc. Molecular modification assays
US6838051B2 (en) 1999-05-03 2005-01-04 Ljl Biosystems, Inc. Integrated sample-processing system
US7348181B2 (en) 1997-10-06 2008-03-25 Trustees Of Tufts College Self-encoding sensor with microspheres
US7115884B1 (en) 1997-10-06 2006-10-03 Trustees Of Tufts College Self-encoding fiber optic sensor
CA2306501C (en) 1997-10-14 2011-03-29 Luminex Corporation Precision fluorescently dyed particles and methods of making and using same
US6878345B1 (en) 1997-12-08 2005-04-12 Thomas W. Astle Ultra high throughput bioassay screening system
SE9800360D0 (sv) 1998-02-06 1998-02-06 Goeteborg University Science I Method, apparatus and flow cell for high sensitivity detection of fluorescent molecules
US6210910B1 (en) 1998-03-02 2001-04-03 Trustees Of Tufts College Optical fiber biosensor array comprising cell populations confined to microcavities
AU3601599A (en) 1998-03-25 1999-10-18 Ulf Landegren Rolling circle replication of padlock probes
IL139631A0 (en) 1998-05-13 2002-02-10 Ddx Inc Enumeration method of analyte detection
EP1090293B2 (en) 1998-06-24 2019-01-23 Illumina, Inc. Decoding of array sensors with microspheres
US6908770B1 (en) 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
EP1115424A1 (de) 1998-08-28 2001-07-18 Febit Ferrarius Biotechnology GmbH Verfahren und messeinrichtung zur bestimmung einer vielzahl von analyten in einer probe
US7079241B2 (en) 2000-04-06 2006-07-18 Invitrogen Corp. Spatial positioning of spectrally labeled beads
US6285807B1 (en) 1998-11-16 2001-09-04 Trustees Of Tufts College Fiber optic sensor for long-term analyte measurements in fluids
DE19854003A1 (de) 1998-11-18 2000-05-25 Jenoptik Jena Gmbh Simultanes Magnetpartikelhandling in zweidimensionaler Anordnung
US6429027B1 (en) 1998-12-28 2002-08-06 Illumina, Inc. Composite arrays utilizing microspheres
CA2359352C (en) 1999-02-09 2004-09-21 Illumina, Inc. Arrays comprising a fiducial and automated information processing in randomly ordered arrays
WO2000049382A2 (en) 1999-02-16 2000-08-24 The Perkin-Elmer Corporation Bead dispensing system
AU779835B2 (en) 1999-05-20 2005-02-10 Illumina, Inc. Method and apparatus for retaining and presenting at least one microsphere array to solutions and/or to optical imaging systems
EP1190100B1 (en) 1999-05-20 2012-07-25 Illumina, Inc. Combinatorial decoding of random nucleic acid arrays
US8080380B2 (en) 1999-05-21 2011-12-20 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US6706519B1 (en) 1999-06-22 2004-03-16 Tecan Trading Ag Devices and methods for the performance of miniaturized in vitro amplification assays
AU1325201A (en) * 1999-07-16 2001-02-05 Board Of Regents, The University Of Texas System Detection system based on an analyte reactive particle
US6713309B1 (en) 1999-07-30 2004-03-30 Large Scale Proteomics Corporation Microarrays and their manufacture
WO2001018524A2 (en) 1999-08-30 2001-03-15 Illumina, Inc. Methods for improving signal detection from an array
US7244559B2 (en) 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7211390B2 (en) 1999-09-16 2007-05-01 454 Life Sciences Corporation Method of sequencing a nucleic acid
JP2001249079A (ja) 1999-12-28 2001-09-14 Fujirebio Inc 発光量調節剤を用いた化学発光測定方法及び酵素免疫測定方法
ATE403145T1 (de) 2000-01-31 2008-08-15 Univ Texas Tragbare vorrichtung mit einer sensor-array- anordnung
DE10005301A1 (de) 2000-02-07 2001-08-09 Trutnau Hans Heinrich Multi-Schritt-Kinetik molekularer Interaktionen als analytisches Mess- und Auswerte-Verfahren
AU2001247417A1 (en) 2000-03-14 2001-09-24 Trustees Of Tufts College Cross-reactive sensors
JP2001269196A (ja) 2000-03-24 2001-10-02 Hamamatsu Photonics Kk 被検体核酸の定量方法、および被検体核酸の分子数の計数方法
US20020090650A1 (en) 2000-04-06 2002-07-11 Quantum Dot Corporation Two-dimensional spectral imaging system
EP1287167A2 (en) 2000-04-11 2003-03-05 Mats Bo Johan Nilsson Nucleic acid detection medium
US7682837B2 (en) 2000-05-05 2010-03-23 Board Of Trustees Of Leland Stanford Junior University Devices and methods to form a randomly ordered array of magnetic beads and uses thereof
US20040009614A1 (en) 2000-05-12 2004-01-15 Ahn Chong H Magnetic bead-based arrays
US7601497B2 (en) 2000-06-15 2009-10-13 Qiagen Gaithersburg, Inc. Detection of nucleic acids by target-specific hybrid capture method
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
DK1180679T3 (da) 2000-08-14 2013-02-04 Evotec Ag Fremgangsmåde til detektion af fluorescerende prøver ved hjælp af momentanalyse
US20060068409A1 (en) 2000-11-27 2006-03-30 Phan Brigitte C Use of restriction enzymes and other chemical methods to decrease non-specific binding in dual bead assays and related bio-discs, methods, and system apparatus for detecting medical targets
ATE282829T1 (de) 2001-02-15 2004-12-15 Unibio S R L Diagnostisches verfahren zur erkennung von bakterieller vaginose auf basis der bestimmung von anti-gardnerella-vaginalis-gvh-toxin antikörpern
US6573051B2 (en) 2001-03-09 2003-06-03 Molecular Staging, Inc. Open circle probes with intramolecular stem structures
US20030162236A1 (en) 2001-03-26 2003-08-28 Response Biomedical Corporation Compensation for variability in specific binding in quantitative assays
JP2004532404A (ja) 2001-03-28 2004-10-21 ジェネテック・バイオテクノロジー・（シャンハイ）・カンパニー・リミテッド 多数のアナライトを検出するための装置および方法
US7060441B2 (en) 2001-05-04 2006-06-13 Biomerieux Method for fragmenting and labeling DNA involving abasic sites and phosphate labeling
US20030008313A1 (en) 2001-06-19 2003-01-09 Wiltshire Richard S. Process for enhanced molecular target detection using layered rolling circle amplification
WO2003008943A1 (en) 2001-07-19 2003-01-30 Tufts University Optical array device and methods of use thereof for screening, analysis and manipulation of particles
US20040241688A1 (en) * 2001-07-19 2004-12-02 Cuneyt Bukusoglu Human tissue specific drug screening procedure
GB2378245A (en) 2001-08-03 2003-02-05 Mats Nilsson Nucleic acid amplification method
US20030040129A1 (en) 2001-08-20 2003-02-27 Shah Haresh P. Binding assays using magnetically immobilized arrays
DK2184346T3 (en) 2001-09-06 2017-06-26 Rapid Micro Biosystems Inc Rapid detection of replicating cells
US20030091475A1 (en) 2001-09-26 2003-05-15 Micralyne Inc. Bead trapping device
US7195913B2 (en) 2001-10-05 2007-03-27 Surmodics, Inc. Randomly ordered arrays and methods of making and using
GB0124812D0 (en) 2001-10-16 2001-12-05 Polymer Lab Ltd Material
US6902921B2 (en) 2001-10-30 2005-06-07 454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
GB2382137A (en) 2001-11-20 2003-05-21 Mats Gullberg Nucleic acid enrichment
US7632671B2 (en) 2001-11-29 2009-12-15 Sun-Wing Tong Molecular detection and assay by electrobiochip micro-array
AU2002353049A1 (en) 2001-12-14 2003-06-30 Corning Incorporated Two step etching process for an optical fiber preform
US20030119203A1 (en) 2001-12-24 2003-06-26 Kimberly-Clark Worldwide, Inc. Lateral flow assay devices and methods for conducting assays
WO2003065019A1 (en) 2002-01-25 2003-08-07 Illumina, Inc. Sensor arrays for detecting analytes in fluids
US7553619B2 (en) 2002-02-08 2009-06-30 Qiagen Gmbh Detection method using dissociated rolling circle amplification
US7480433B2 (en) 2002-02-19 2009-01-20 Tufts University Electro-optical stimulation/measurement
US7232547B2 (en) 2002-03-22 2007-06-19 Marshfield Clinic Apparatus and method for testing and continuously reading low-volume samples
US7312085B2 (en) 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
WO2003089901A2 (en) 2002-04-19 2003-10-30 Palsson Bernhard O Methods for preparing libraries of unique tags and related screening methods
CA2485437A1 (en) 2002-05-10 2003-11-20 Pharmacia Corporation Peptide compounds and their use as protease substrates
AU2003229544A1 (en) 2002-05-24 2003-12-12 F. Sperling Aps A method for testing the interaction between at least one liquid sample and a respective solid sample.
US7387889B2 (en) 2002-08-22 2008-06-17 Massachusetts Institute Of Technology Measurement of concentrations and binding energetics
US7285424B2 (en) 2002-08-27 2007-10-23 Kimberly-Clark Worldwide, Inc. Membrane-based assay devices
US7597936B2 (en) 2002-11-26 2009-10-06 University Of Utah Research Foundation Method of producing a pigmented composite microporous material
EP1576351A4 (en) 2002-11-26 2010-06-23 Univ Utah Res Found MICROPOROUS MATERIALS; METHODS AND ARTICLES FOR LOCALIZING AND QUANTIFYING ANALYTES
JP4395133B2 (ja) 2002-12-20 2010-01-06 カリパー・ライフ・サイエンシズ・インク． Ｄｎａの単一分子増幅および検出
WO2004065000A1 (en) 2003-01-21 2004-08-05 Illumina Inc. Chemical reaction monitor
CA2513899C (en) 2003-01-29 2013-03-26 454 Corporation Methods of amplifying and sequencing nucleic acids
US7575865B2 (en) 2003-01-29 2009-08-18 454 Life Sciences Corporation Methods of amplifying and sequencing nucleic acids
US7041481B2 (en) 2003-03-14 2006-05-09 The Regents Of The University Of California Chemical amplification based on fluid partitioning
US8043834B2 (en) 2003-03-31 2011-10-25 Qiagen Gmbh Universal reagents for rolling circle amplification and methods of use
WO2004107321A2 (en) 2003-05-28 2004-12-09 Tufts University High density optical data storage
JP2004354164A (ja) * 2003-05-28 2004-12-16 Olympus Corp 微粒子を用いた検体の検査方法及びその検査システム
US20040248103A1 (en) 2003-06-04 2004-12-09 Feaver William John Proximity-mediated rolling circle amplification
US7572581B2 (en) 2003-06-30 2009-08-11 Roche Molecular Systems, Inc. 2′-terminator nucleotide-related methods and systems
US8048627B2 (en) 2003-07-05 2011-11-01 The Johns Hopkins University Method and compositions for detection and enumeration of genetic variations
WO2005019419A2 (en) 2003-07-31 2005-03-03 Singulex, Inc. Co-detection of single polypeptide and polynucleotide molecules
US8022013B2 (en) 2003-08-29 2011-09-20 Illumina, Inc. Method of forming and using solid-phase support
US20050226780A1 (en) 2003-09-19 2005-10-13 Donald Sandell Manual seal applicator
SE0302525D0 (sv) 2003-09-24 2003-09-24 Biacore Ab Method and system for interaction analysis
WO2005033283A2 (en) 2003-09-30 2005-04-14 Singulex, Inc. Methods for enhancing the analysis of particle detection
AU2004286253A1 (en) 2003-10-28 2005-05-12 Bioarray Solutions Ltd. Gel-shell beads with adsorbed or bound biomolecules
US20050255491A1 (en) 2003-11-13 2005-11-17 Lee Frank D Small molecule and peptide arrays and uses thereof
WO2005054431A2 (en) 2003-12-01 2005-06-16 454 Corporation Method for isolation of independent, parallel chemical micro-reactions using a porous filter
US20050266433A1 (en) 2004-03-03 2005-12-01 Ravi Kapur Magnetic device for isolation of cells and biomolecules in a microfluidic environment
US8634072B2 (en) * 2004-03-06 2014-01-21 Michael Trainer Methods and apparatus for determining characteristics of particles
WO2005095262A1 (en) 2004-04-01 2005-10-13 Nanyang Technological University Microchip and method for detecting molecules and molecular interactions
US8961900B2 (en) 2004-04-28 2015-02-24 Yokogawa Electric Corporation Chemical reaction cartridge, method of producing chemical reaction cartridge, and mechanism for driving chemical reaction cartridge
DE102004021780B4 (de) 2004-04-30 2008-10-02 Siemens Ag Verfahren und Anordnung zur DNA-Isolierung mit Trockenreagenzien
ATE541054T1 (de) 2004-05-12 2012-01-15 Nanosphere Inc Bio-barcode erkennung für zielmoleküle
US7776583B2 (en) 2004-06-03 2010-08-17 Meso Scale Technologies, Llc Methods and apparatuses for conducting assays
CN103884698B (zh) 2004-06-07 2017-04-12 先锋生物科技股份有限公司 用于微流体器件的光学透镜系统和方法
CA2475240A1 (en) 2004-07-20 2006-01-20 Biophys, Inc. Method and device to measure dynamic internal calibration true dose response curves
KR100806568B1 (ko) 2004-08-21 2008-02-28 주식회사 엘지생명과학 미세 유체 소자 및 이를 구비한 진단 및 분석 장치
CN1286987C (zh) * 2004-09-23 2006-11-29 湖南大学 一维生物芯片及其在基因、蛋白表达分析中的应用
WO2006047038A1 (en) 2004-09-28 2006-05-04 Trustees Of Tufts College Apparatus and method for cell migration assays
US8685711B2 (en) * 2004-09-28 2014-04-01 Singulex, Inc. Methods and compositions for highly sensitive detection of molecules
JP2008514955A (ja) 2004-09-28 2008-05-08 シンギュレックス・インコーポレイテッド サンプル分析システムおよび方法
US7572640B2 (en) 2004-09-28 2009-08-11 Singulex, Inc. Method for highly sensitive detection of single protein molecules labeled with fluorescent moieties
WO2006055735A2 (en) 2004-11-16 2006-05-26 Illumina, Inc Scanner having spatial light modulator
WO2006055739A2 (en) * 2004-11-17 2006-05-26 Robert Sack Stationary phase antibody arrays for trace protein analysis
AU2006208907A1 (en) 2005-01-26 2006-08-03 Enigma Diagnostics Ltd Method for carrying out a multi-step reaction, breakable container for storing reagents and method for transferring solid reagent using an electrostatically charged wand
WO2006102297A1 (en) 2005-03-22 2006-09-28 Applera Corporation Automated seal applicator
US7682816B2 (en) 2005-04-07 2010-03-23 454 Life Sciences Corporation Thin film coated microwell arrays and methods of using same
EP1871897B1 (en) 2005-04-12 2010-09-29 Olink AB Methods for production of oligonucleotides
US7989166B2 (en) 2005-04-12 2011-08-02 In Situ Rcp A/S Circle probes and their use in the identification of biomolecules
EP1721657A1 (en) 2005-05-13 2006-11-15 SONY DEUTSCHLAND GmbH A method of fabricating a polymeric membrane having at least one pore
WO2007044091A2 (en) 2005-06-02 2007-04-19 Fluidigm Corporation Analysis using microfluidic partitioning devices
CA2614180A1 (en) 2005-07-06 2007-01-11 The Regents Of The University Of California Apparatuses, systems, and methods for isolating and separating biological materials
US7595473B2 (en) 2005-08-22 2009-09-29 Tufts University Method and system of array imaging
EP1938101A2 (en) 2005-09-13 2008-07-02 Fluidigm Corporation Microfluidic assay devices and methods
CN101044251A (zh) 2005-09-15 2007-09-26 株式会社Lg生命科学 用于固定生物分子的粘合剂珠以及使用该粘合剂珠制造生物芯片的方法
CN101523156A (zh) 2005-09-16 2009-09-02 加利福尼亚大学董事会 用于分析物检测的比色生物条形码扩增测定
WO2007035633A2 (en) 2005-09-16 2007-03-29 President & Fellows Of Harvard College Screening assays and methods
WO2007044974A2 (en) 2005-10-12 2007-04-19 The Research Foundation Of State University Of New York Absolute pcr quantification
US20070116607A1 (en) 2005-11-23 2007-05-24 Pharmacom Microlelectronics, Inc. Microsystems that integrate three-dimensional microarray and multi-layer microfluidics for combinatorial detection of bioagent at single molecule level
WO2007072290A2 (en) 2005-12-21 2007-06-28 Koninklijke Philips Electronics N.V. Method of performing a microarray assay
WO2007072922A1 (ja) 2005-12-22 2007-06-28 Rohm Co., Ltd. 免疫測定装置及び方法
WO2007081385A2 (en) 2006-01-11 2007-07-19 Raindance Technologies, Inc. Microfluidic devices and methods of use in the formation and control of nanoreactors
GB0600927D0 (en) 2006-01-17 2006-02-22 Glaxosmithkline Biolog Sa Assay and materials therefor
US8492098B2 (en) 2006-02-21 2013-07-23 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of reaction components that affect a reaction
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US8975216B2 (en) 2006-03-30 2015-03-10 Pacific Biosciences Of California Articles having localized molecules disposed thereon and methods of producing same
US7838250B1 (en) 2006-04-04 2010-11-23 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
JP5308328B2 (ja) 2006-04-04 2013-10-09 シングレックス，インコーポレイテッド トロポニンの分析のための高感度のシステムおよび方法
US8470606B2 (en) 2006-04-18 2013-06-25 Duke University Manipulation of beads in droplets and methods for splitting droplets
US7759062B2 (en) 2006-06-09 2010-07-20 Third Wave Technologies, Inc. T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection
JP4866462B2 (ja) 2006-08-03 2012-02-01 ナショナル ユニバーシティ オブ シンガポール マイクロアレイシステム、およびマイクロアレイの製造方法
CN1928561A (zh) 2006-09-15 2007-03-14 东南大学 基于光子晶体微球的多元免疫检测方法
JP2010510528A (ja) 2006-11-22 2010-04-02 ライフ テクノロジーズ コーポレーション 自己免疫疾患のバイオマーカー
PL2111303T3 (pl) 2007-01-26 2015-04-30 Haas Mondomix B V Urządzenie i sposób dozowania spienionych mas
WO2008116093A2 (en) 2007-03-20 2008-09-25 Becton, Dickinson And Company Assays using surface-enhanced raman spectroscopy (sers)-active particles
US8592221B2 (en) 2007-04-19 2013-11-26 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
EP2167633A4 (en) 2007-07-16 2014-12-24 California Inst Of Techn MICROFLUIDIC DEVICES, METHODS AND SYSTEMS FOR DETECTING TARGET MOLECULES
US20100179069A1 (en) 2007-07-30 2010-07-15 Gn Biosystems Incorporated Method and apparatus for conducting high-throughput micro-volume experiments
US20090053719A1 (en) 2007-08-03 2009-02-26 The Chinese University Of Hong Kong Analysis of nucleic acids by digital pcr
JP2009042104A (ja) 2007-08-09 2009-02-26 Canon Inc 物質固定装置、物質検出装置および物質固定方法
JP5503540B2 (ja) * 2007-08-30 2014-05-28 トラスティーズ・オブ・タフツ・カレッジ 溶液中の分析物濃度を決定する方法
US8093063B2 (en) 2007-11-29 2012-01-10 Quest Diagnostics Investments Incorporated Assay for detecting genetic abnormalities in genomic nucleic acids
US20090254180A1 (en) 2008-01-14 2009-10-08 Walt Pazanowski Customizable vertebral replacement assembly system
US9487822B2 (en) 2008-03-19 2016-11-08 Fluidigm Corporation Method and apparatus for determining copy number variation using digital PCR
US20100189338A1 (en) 2008-04-09 2010-07-29 Nexcelom Bioscience Systems and methods for counting cells and biomolecules
ITTO20080314A1 (it) * 2008-04-23 2009-10-24 Milano Politecnico Biosensori spintronici con area attiva localizzata su una parete di dominio magnetico.
US8093064B2 (en) 2008-05-15 2012-01-10 The Regents Of The University Of California Method for using magnetic particles in droplet microfluidics
US20090307772A1 (en) 2008-05-21 2009-12-10 Honeywell International Inc. framework for scalable state estimation using multi network observations
US20090289834A1 (en) 2008-05-23 2009-11-26 Honeywell International Inc. High integrity radio altimeter
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
EP4047367A1 (en) 2008-07-18 2022-08-24 Bio-Rad Laboratories, Inc. Method for detecting target analytes with droplet libraries
US8297355B2 (en) 2008-08-22 2012-10-30 Texaco Inc. Using heat from produced fluids of oil and gas operations to produce energy
US8222047B2 (en) 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
US20100075439A1 (en) * 2008-09-23 2010-03-25 Quanterix Corporation Ultra-sensitive detection of molecules by capture-and-release using reducing agents followed by quantification
US20100075862A1 (en) 2008-09-23 2010-03-25 Quanterix Corporation High sensitivity determination of the concentration of analyte molecules or particles in a fluid sample
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
US20100075355A1 (en) * 2008-09-23 2010-03-25 Quanterix Corporation Ultra-sensitive detection of enzymes by capture-and-release followed by quantification
US9333163B2 (en) 2008-10-06 2016-05-10 Massachusetts Institute Of Technology Particles with multiple functionalized surface domains
WO2010056337A2 (en) 2008-11-12 2010-05-20 Caris Mpi, Inc. Methods and systems of using exosomes for determining phenotypes
US20100204335A1 (en) 2008-12-01 2010-08-12 Allergan, Inc. Kit and composition for eyelash growth
EP2230515B1 (en) 2009-03-16 2014-12-17 Agilent Technologies, Inc. Passivation of surfaces after ligand coupling
GB0904934D0 (en) 2009-03-23 2009-05-06 Geneseqe As Method and apparatus for detecting molecules
ES2781572T3 (es) 2009-04-14 2020-09-03 Univ California Procedimiento de creación de materiales coloreados fijando estructuras ordenadas de nanopartículas de magnetita dentro de un medio sólido
US20100330703A1 (en) 2009-06-24 2010-12-30 Seventh Sense Biosystems, Inc. Assays involving colorimetric and other signaling
GB0912909D0 (en) 2009-07-23 2009-08-26 Olink Genomics Ab Probes for specific analysis of nucleic acids
WO2011034996A1 (en) 2009-09-17 2011-03-24 Clark University Double mutant mouse and cell lines
US20110097723A1 (en) 2009-09-19 2011-04-28 Qun Liu Methods and reagents for analyte detection
WO2011038241A1 (en) 2009-09-25 2011-03-31 President And Fellows Of Harvard College Nucleic acid amplification and sequencing by synthesis with fluorogenic nucleotides
GB0921264D0 (en) 2009-12-03 2010-01-20 Olink Genomics Ab Method for amplification of target nucleic acid
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
US9678068B2 (en) 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
CN103026232B (zh) * 2010-03-01 2015-02-04 匡特里克斯公司 扩大用于检测分子或颗粒的测定法中的动态范围的方法和系统
US8415171B2 (en) 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
GB201004292D0 (en) 2010-03-15 2010-04-28 Olink Ab Assay for localised detection of analytes
GB201011971D0 (en) 2010-07-15 2010-09-01 Olink Ab Methods and product
US10669569B2 (en) 2010-10-15 2020-06-02 Navinci Diagnostics Ab Dynamic range methods
WO2012057689A1 (en) 2010-10-29 2012-05-03 Ge Healthcare Bio-Sciences Ab Proximity ligation technology for western blot applications
EP2663654A1 (en) 2011-01-14 2013-11-20 Life Technologies Corporation Methods, compositions, and kits for detecting rare cells
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
GB201101621D0 (en) 2011-01-31 2011-03-16 Olink Ab Method and product
CN103649331A (zh) 2011-02-15 2014-03-19 莱卡生物系统纽卡斯尔有限责任公司 用于mrna的定位的原位检测的方法
WO2012142301A2 (en) 2011-04-12 2012-10-18 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patients recovery from a brain injury
WO2012142300A2 (en) 2011-04-12 2012-10-18 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury resulting from a hypoxic event
EP3216872B1 (en) 2011-06-02 2020-04-01 Bio-Rad Laboratories, Inc. Enzyme quantification
WO2012170776A2 (en) 2011-06-09 2012-12-13 Quanterix Corporation Methods of determining a patient's prognosis for recurrence of prostate cancer and/or determining a course of treatment for prostate cancer following a radical prostatectomy
US9932626B2 (en) 2013-01-15 2018-04-03 Quanterix Corporation Detection of DNA or RNA using single molecule arrays and other techniques
US20160123969A1 (en) 2013-05-09 2016-05-05 Quanterix Corporation Methods, materials, and kits for covalently associating molecular species with a surface of an object
US9482622B2 (en) 2014-05-16 2016-11-01 Massachusetts Institute Of Technology Methods and apparatus for surface classification
WO2016115256A1 (en) 2015-01-13 2016-07-21 Quanterix Corporation Methods relating to improving accuracy of capture object-based assays
WO2016130923A1 (en) 2015-02-13 2016-08-18 Quanterix Corporation Immunoassays for diffrential detection of clostridium difficile
US9809163B2 (en) 2015-04-14 2017-11-07 Harman International Industries, Incorporation Techniques for transmitting an alert towards a target area
WO2018222585A2 (en) 2017-05-30 2018-12-06 Quanterix Corporation Single molecule detection and quantification of nucleic acids with single base specificity
WO2019060607A1 (en) 2017-09-20 2019-03-28 Quanterix Corporation METHODS AND SYSTEMS FOR DETECTING MOLECULES OF ANALYTES
US20200032326A1 (en) 2018-05-29 2020-01-30 Trustees Of Tufts College Ultrasensitive assays for detection of short nucleic acids
US20220205992A1 (en) 2020-12-28 2022-06-30 Quanterix Corporation Materials and kits relating to association of reporter species and targeting entities with beads

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10780706B2 (en) 2018-03-16 2020-09-22 Ricoh Company, Ltd. Discharging device and discharging method
WO2022202218A1 (ja) 2021-03-26 2022-09-29 国立研究開発法人産業技術総合研究所 ウエルアレイと粒子とを用いた生体物質検出方法、ウエルアレイ及び検出装置
WO2022202217A1 (ja) 2021-03-26 2022-09-29 国立研究開発法人産業技術総合研究所 ウエルアレイを用いたウイルス検出方法、ウエルアレイ及び検出装置

Also Published As

Publication number Publication date
US10989713B2 (en) 2021-04-27
CN103026232A (zh) 2013-04-03
JP2014055944A (ja) 2014-03-27
US20240377397A1 (en) 2024-11-14
US20150355182A1 (en) 2015-12-10
CN103026232B (zh) 2015-02-04
US12019072B2 (en) 2024-06-25
EP2542890B1 (en) 2015-05-06
US20180224451A1 (en) 2018-08-09
CA2791655C (en) 2014-11-04
WO2011109379A1 (en) 2011-09-09
JP5816237B2 (ja) 2015-11-18
US9846155B2 (en) 2017-12-19
US20110245097A1 (en) 2011-10-06
EP2542890A1 (en) 2013-01-09
US9110025B2 (en) 2015-08-18
ES2544635T3 (es) 2015-09-02
JP2013521500A (ja) 2013-06-10
CA2791655A1 (en) 2011-09-09
US20210311058A1 (en) 2021-10-07

Similar Documents

Publication Publication Date Title
JP5363663B2 (ja) 分子または粒子を検出するアッセイにおけるダイナミックレンジを拡張するための方法またはシステム
US9551663B2 (en) Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US20250180553A1 (en) Ultra-sensitive detection of molecules or particles using beads or other capture objects
US9678068B2 (en) Ultra-sensitive detection of molecules using dual detection methods
US20230213510A1 (en) Methods relating to improving accuracy of capture object-based assays
US20100075862A1 (en) High sensitivity determination of the concentration of analyte molecules or particles in a fluid sample
JP2007155691A (ja) 物質の測定方法ならびに測定用組成物

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130610

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20130610

A871 Explanation of circumstances concerning accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A871

Effective date: 20130610

TRDD Decision of grant or rejection written
A975 Report on accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A971005

Effective date: 20130729

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20130806

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20130905

R150 Certificate of patent or registration of utility model

Ref document number: 5363663

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250