JP5345273B2 - 口中清涼化組成物 - Google Patents
口中清涼化組成物 Download PDFInfo
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- JP5345273B2 JP5345273B2 JP2006037214A JP2006037214A JP5345273B2 JP 5345273 B2 JP5345273 B2 JP 5345273B2 JP 2006037214 A JP2006037214 A JP 2006037214A JP 2006037214 A JP2006037214 A JP 2006037214A JP 5345273 B2 JP5345273 B2 JP 5345273B2
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- 235000013399 edible fruits Nutrition 0.000 description 1
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- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
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- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
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- 229940087305 limonene Drugs 0.000 description 1
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- 229930007744 linalool Natural products 0.000 description 1
- UWKAYLJWKGQEPM-UHFFFAOYSA-N linalool acetate Natural products CC(C)=CCCC(C)(C=C)OC(C)=O UWKAYLJWKGQEPM-UHFFFAOYSA-N 0.000 description 1
- SXQCTESRRZBPHJ-UHFFFAOYSA-M lissamine rhodamine Chemical compound [Na+].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=C(S([O-])(=O)=O)C=C1S([O-])(=O)=O SXQCTESRRZBPHJ-UHFFFAOYSA-M 0.000 description 1
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- 239000008267 milk Substances 0.000 description 1
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- 239000013588 oral product Substances 0.000 description 1
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- 239000002244 precipitate Substances 0.000 description 1
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- 230000001105 regulatory effect Effects 0.000 description 1
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- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
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- 235000010356 sorbitol Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 238000000194 supercritical-fluid extraction Methods 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Description
中鎖脂肪酸トリグリセライド(A)として、炭素数8と炭素数10の飽和脂肪酸からなるトリグリセライドの混合物(C8/C10酸トリグリセライド)を、ジペプチド甘味剤(B)としてアスパルテームを、および清涼化剤(C)としてメントールを、香料としてソーダフレーバーをそれぞれ用い、これらを表1に示す割合(ジペプチド甘味剤(B):0.5〜5重量%、清涼化剤(C):10〜35重量%)で配合して口中清涼化組成物を得た。具体的には、C8/C10酸トリグリセライドとアスパルテームを混合して液状混合物を調製し、75℃で1時間撹拌した。その後、室温まで冷却した液状混合物にメントールとソーダフレーバーを添加し、30分間撹拌して、口中清涼化組成物を得た。
表1に示すように、比較例1〜4では清涼化剤(C)を10〜35重量%の範囲以外の割合で配合し、比較例5〜7ではジペプチド甘味剤(B)を0.5〜5重量%の範囲以外の割合で配合し、比較例8では脂質としてヒマワリ油(中鎖脂肪酸トリグリセライドではない)を用いた以外、実施例と同様にして、口中清涼化組成物を得た。
実施例および比較例で得られた口中清涼化組成物について、下記の項目の評価を行った。得られた評価結果を表1にまとめて示す。
○:口中清涼化組成物の製造後1ヶ月経っても沈殿、分離などが起こらない
×:口中清涼化組成物の製造後1時間以内に沈殿、分離などが起こる
パネラー10名が口中清涼化組成物を120mg充填したカプセルを食べ、以下の基準に従って清涼感を評価した。
2:清涼感が強すぎる
1:どちらかといえば清涼感が強い
0:清涼感がちょうどよい
−1:清涼感がどちかといえば弱い
−2:清涼感が弱すぎる
パネラー10名が口中清涼化組成物を120mg充填したカプセルを食べ、以下の基準に従って甘味を評価した。
1:どちらかといえば甘い
0:甘味がちょうどよい
−1:どちらかといえば甘くない
−2:甘くない
パネラー10名が口中清涼化組成物を120mg充填したカプセルを食べ、以下の基準に従って食感を評価した。
×:油によるベタツキあり
パネラー10名が口中清涼化組成物を120mg充填したカプセルを食べ、以下の基準に従って清涼感の持続性を評価した。
Claims (7)
- (A)C8酸および/またはC10酸トリグリセライド、
(B)ジペプチド甘味剤、および
(C)メントールおよびその誘導体、ミント精油並びにユーカリ精油からなる群から選択される少なくとも1種の清涼化剤、
を含む口中清涼化組成物であって、
組成物中のC8酸および/またはC10酸トリグリセライド(A)の割合が59〜87.4重量%であり、
組成物中のジペプチド甘味剤(B)の割合が0.5〜5重量%であり、
組成物中の清涼化剤(C)の割合が10〜35重量%である、
口中清涼化組成物。 - 組成物中のジペプチド甘味剤(B)の割合が0.5〜2重量%であり、組成物中の清涼化剤(C)の割合が12〜20重量%である請求項1記載の口中清涼化組成物。
- ジペプチド甘味剤(B)1重量部に対して、清涼化剤(C)が8〜30重量部である請求項1または2に記載の口中清涼化組成物。
- ジペプチド甘味剤(B)1重量部に対して、清涼化剤(C)が10〜16重量部である請求項3記載の口中清涼化組成物。
- ジペプチド甘味剤(B)がアスパルテームである請求項1〜4のいずれかに記載の口中清涼化組成物。
- 清涼化剤(C)がメントールおよび/またはその誘導体である請求項1〜5のいずれかに記載の口中清涼化組成物。
- 軟質膜剤によって被包されている請求項1〜6のいずれかに記載の口中清涼化組成物。
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JP2006037214A JP5345273B2 (ja) | 2006-02-14 | 2006-02-14 | 口中清涼化組成物 |
PCT/JP2007/052513 WO2007094316A1 (ja) | 2006-02-14 | 2007-02-13 | 口中清涼化組成物 |
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JP6602578B2 (ja) * | 2015-07-10 | 2019-11-06 | 小林製薬株式会社 | 経口組成物 |
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JP2961587B2 (ja) * | 1992-06-27 | 1999-10-12 | 花王株式会社 | 界面活性剤含有継ぎ目無しカプセル粒子 |
JP3667045B2 (ja) * | 1997-09-10 | 2005-07-06 | 森下仁丹株式会社 | 口臭除去用多重ソフトカプセルおよびその製造法 |
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JP2000026257A (ja) * | 1998-07-08 | 2000-01-25 | Kao Corp | 口腔用組成物 |
JP2000273050A (ja) * | 1999-03-19 | 2000-10-03 | Kobayashi Pharmaceut Co Ltd | 苦みがマスキングされた液状製剤 |
JP2000273051A (ja) * | 1999-03-19 | 2000-10-03 | Kobayashi Pharmaceut Co Ltd | 苦みがマスキングされた液状製剤 |
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JP2003125706A (ja) * | 2001-10-23 | 2003-05-07 | Lion Corp | 口中清涼製剤 |
KR100490279B1 (ko) * | 2002-07-18 | 2005-05-17 | 주식회사 서흥캅셀 | 구취제거 및 구강 청량 효과를 지닌 젤라틴 연질캅셀제 |
JP2005029513A (ja) * | 2003-07-07 | 2005-02-03 | Kobayashi Pharmaceut Co Ltd | 口息清涼剤およびその製造方法 |
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JP2007217310A (ja) | 2007-08-30 |
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