JP5315060B2 - 置換ベンゾフラン、ベンゾチオフェン、ベンゾセレノフェンおよびインドールおよびそれらのチューブリン重合阻害剤としての使用 - Google Patents
置換ベンゾフラン、ベンゾチオフェン、ベンゾセレノフェンおよびインドールおよびそれらのチューブリン重合阻害剤としての使用 Download PDFInfo
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- JP5315060B2 JP5315060B2 JP2008552645A JP2008552645A JP5315060B2 JP 5315060 B2 JP5315060 B2 JP 5315060B2 JP 2008552645 A JP2008552645 A JP 2008552645A JP 2008552645 A JP2008552645 A JP 2008552645A JP 5315060 B2 JP5315060 B2 JP 5315060B2
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- optionally substituted
- methoxy
- hydroxy
- trimethoxybenzoyl
- benzofuran
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- 0 **c1c(**)c(**)c(**)c2c1*C(*)=C2*c1c(*)c(*)c(*)c(*)c1* Chemical compound **c1c(**)c(**)c(**)c2c1*C(*)=C2*c1c(*)c(*)c(*)c(*)c1* 0.000 description 1
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- KLMZGVQPCSGQON-UHFFFAOYSA-N CN(C)CCNc1c(C(c(cc2OC)cc(OC)c2OC)=O)c(ccc(OC)c2O)c2[o]1 Chemical compound CN(C)CCNc1c(C(c(cc2OC)cc(OC)c2OC)=O)c(ccc(OC)c2O)c2[o]1 KLMZGVQPCSGQON-UHFFFAOYSA-N 0.000 description 1
- UOSNIQFPVNZJES-UHFFFAOYSA-N COc(cc1[o]2)ccc1c(C(c(cc1OC)cc(OC)c1OC)=O)c2Br Chemical compound COc(cc1[o]2)ccc1c(C(c(cc1OC)cc(OC)c1OC)=O)c2Br UOSNIQFPVNZJES-UHFFFAOYSA-N 0.000 description 1
- WHIZKSTYGYPORO-UHFFFAOYSA-N COc(ccc1c2[o]c(N)c1C(c(cc1OC)cc(OC)c1OC)=O)c2O Chemical compound COc(ccc1c2[o]c(N)c1C(c(cc1OC)cc(OC)c1OC)=O)c2O WHIZKSTYGYPORO-UHFFFAOYSA-N 0.000 description 1
- HCAGBQONKUMFFE-UHFFFAOYSA-N COc(ccc1c2[o]cc1C(c(cc1OC)cc(OC)c1OC)=O)c2[N+]([O-])=O Chemical compound COc(ccc1c2[o]cc1C(c(cc1OC)cc(OC)c1OC)=O)c2[N+]([O-])=O HCAGBQONKUMFFE-UHFFFAOYSA-N 0.000 description 1
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- QFBMIUNSDUVNRI-UHFFFAOYSA-N COc1ccc2c(C(c(cc3OC)cc(OC)c3OC)=O)c(O)[o]c2c1 Chemical compound COc1ccc2c(C(c(cc3OC)cc(OC)c3OC)=O)c(O)[o]c2c1 QFBMIUNSDUVNRI-UHFFFAOYSA-N 0.000 description 1
- WCGAGQQGJWUDSM-UHFFFAOYSA-N Cc([s]c1c2)c(C(c(cc3OC)cc(OC)c3OC)=O)c1ccc2OC Chemical compound Cc([s]c1c2)c(C(c(cc3OC)cc(OC)c3OC)=O)c1ccc2OC WCGAGQQGJWUDSM-UHFFFAOYSA-N 0.000 description 1
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- Plural Heterocyclic Compounds (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76533706P | 2006-02-03 | 2006-02-03 | |
| US60/765,337 | 2006-02-03 | ||
| PCT/AU2007/000101 WO2007087684A1 (en) | 2006-02-03 | 2007-02-02 | Substituted benzofurans, benzothiophenes, benzoselenophenes and indoles and their use as tubulin polymerisation inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009531281A JP2009531281A (ja) | 2009-09-03 |
| JP2009531281A5 JP2009531281A5 (https=) | 2011-03-10 |
| JP5315060B2 true JP5315060B2 (ja) | 2013-10-16 |
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| EP (2) | EP1984333B1 (https=) |
| JP (1) | JP5315060B2 (https=) |
| AT (1) | ATE555091T1 (https=) |
| AU (1) | AU2007211840B2 (https=) |
| CA (1) | CA2640678C (https=) |
| DK (1) | DK1984333T3 (https=) |
| ES (1) | ES2386299T3 (https=) |
| NZ (1) | NZ570014A (https=) |
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| CA2546002C (en) | 2003-11-20 | 2012-09-18 | Janssen Pharmaceutica N.V. | 7-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors |
| ATE540936T1 (de) | 2004-06-30 | 2012-01-15 | Janssen Pharmaceutica Nv | Substituierte 2-alkyl-chinazolinonderivate als parp-hemmer |
| EA011552B1 (ru) | 2004-06-30 | 2009-04-28 | Янссен Фармацевтика Н.В. | Производные хиназолиндиона в качестве ингибиторов parp |
| SG154433A1 (en) | 2004-06-30 | 2009-08-28 | Janssen Pharmaceutica Nv | Phthalazine derivatives as parp inhibitors |
| JP5315060B2 (ja) | 2006-02-03 | 2013-10-16 | バイオノミックス リミテッド | 置換ベンゾフラン、ベンゾチオフェン、ベンゾセレノフェンおよびインドールおよびそれらのチューブリン重合阻害剤としての使用 |
| US8299256B2 (en) | 2007-03-08 | 2012-10-30 | Janssen Pharmaceutica Nv | Quinolinone derivatives as PARP and TANK inhibitors |
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Also Published As
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| WO2007087684A1 (en) | 2007-08-09 |
| ATE555091T1 (de) | 2012-05-15 |
| ES2386299T3 (es) | 2012-08-16 |
| EP1984333B1 (en) | 2012-04-25 |
| US20130053351A1 (en) | 2013-02-28 |
| CA2640678A1 (en) | 2007-08-09 |
| PT1984333E (pt) | 2012-07-16 |
| NZ570014A (en) | 2011-04-29 |
| US20140171642A1 (en) | 2014-06-19 |
| EP1984333A4 (en) | 2010-05-19 |
| DK1984333T3 (da) | 2012-07-23 |
| JP2009531281A (ja) | 2009-09-03 |
| EP2460793A1 (en) | 2012-06-06 |
| US10213409B2 (en) | 2019-02-26 |
| US20100004208A1 (en) | 2010-01-07 |
| EP1984333A1 (en) | 2008-10-29 |
| AU2007211840A1 (en) | 2007-08-09 |
| US9346842B2 (en) | 2016-05-24 |
| US8716335B2 (en) | 2014-05-06 |
| AU2007211840B2 (en) | 2012-03-01 |
| HK1124329A1 (en) | 2009-07-10 |
| CA2640678C (en) | 2015-03-31 |
| US20170020840A1 (en) | 2017-01-26 |
| US8680135B2 (en) | 2014-03-25 |
| US8198466B2 (en) | 2012-06-12 |
| US20120214770A1 (en) | 2012-08-23 |
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