JP2009531281A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009531281A5 JP2009531281A5 JP2008552645A JP2008552645A JP2009531281A5 JP 2009531281 A5 JP2009531281 A5 JP 2009531281A5 JP 2008552645 A JP2008552645 A JP 2008552645A JP 2008552645 A JP2008552645 A JP 2008552645A JP 2009531281 A5 JP2009531281 A5 JP 2009531281A5
- Authority
- JP
- Japan
- Prior art keywords
- inhibitor
- tubulin polymerization
- kit
- compound
- inhibition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003112 inhibitor Substances 0.000 claims 9
- MQLACMBJVPINKE-UHFFFAOYSA-N 10-[(3-hydroxy-4-methoxyphenyl)methylidene]anthracen-9-one Chemical compound C1=C(O)C(OC)=CC=C1C=C1C2=CC=CC=C2C(=O)C2=CC=CC=C21 MQLACMBJVPINKE-UHFFFAOYSA-N 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 8
- 230000005764 inhibitory process Effects 0.000 claims 5
- 229940122530 Tubulin polymerization inhibitor Drugs 0.000 claims 4
- 229940124572 antihypotensive agent Drugs 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 231100000433 cytotoxic Toxicity 0.000 claims 4
- 230000001472 cytotoxic effect Effects 0.000 claims 4
- 239000005555 hypertensive agent Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76533706P | 2006-02-03 | 2006-02-03 | |
| US60/765,337 | 2006-02-03 | ||
| PCT/AU2007/000101 WO2007087684A1 (en) | 2006-02-03 | 2007-02-02 | Substituted benzofurans, benzothiophenes, benzoselenophenes and indoles and their use as tubulin polymerisation inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009531281A JP2009531281A (ja) | 2009-09-03 |
| JP2009531281A5 true JP2009531281A5 (https=) | 2011-03-10 |
| JP5315060B2 JP5315060B2 (ja) | 2013-10-16 |
Family
ID=38327089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008552645A Expired - Fee Related JP5315060B2 (ja) | 2006-02-03 | 2007-02-02 | 置換ベンゾフラン、ベンゾチオフェン、ベンゾセレノフェンおよびインドールおよびそれらのチューブリン重合阻害剤としての使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US8198466B2 (https=) |
| EP (2) | EP1984333B1 (https=) |
| JP (1) | JP5315060B2 (https=) |
| AT (1) | ATE555091T1 (https=) |
| AU (1) | AU2007211840B2 (https=) |
| CA (1) | CA2640678C (https=) |
| DK (1) | DK1984333T3 (https=) |
| ES (1) | ES2386299T3 (https=) |
| NZ (1) | NZ570014A (https=) |
| PT (1) | PT1984333E (https=) |
| WO (1) | WO2007087684A1 (https=) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0416206A (pt) | 2003-11-20 | 2006-12-26 | Janssen Pharmaceutica Nv | 2-quinolinonas e 2-quinoxalinonas substituìdas por 6-alquenila e 6-fenilalquila como inibidores de polimerase de poli(adp-ribose) |
| CA2546002C (en) | 2003-11-20 | 2012-09-18 | Janssen Pharmaceutica N.V. | 7-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors |
| ATE540936T1 (de) | 2004-06-30 | 2012-01-15 | Janssen Pharmaceutica Nv | Substituierte 2-alkyl-chinazolinonderivate als parp-hemmer |
| EA011552B1 (ru) | 2004-06-30 | 2009-04-28 | Янссен Фармацевтика Н.В. | Производные хиназолиндиона в качестве ингибиторов parp |
| SG154433A1 (en) | 2004-06-30 | 2009-08-28 | Janssen Pharmaceutica Nv | Phthalazine derivatives as parp inhibitors |
| JP5315060B2 (ja) | 2006-02-03 | 2013-10-16 | バイオノミックス リミテッド | 置換ベンゾフラン、ベンゾチオフェン、ベンゾセレノフェンおよびインドールおよびそれらのチューブリン重合阻害剤としての使用 |
| US8299256B2 (en) | 2007-03-08 | 2012-10-30 | Janssen Pharmaceutica Nv | Quinolinone derivatives as PARP and TANK inhibitors |
| US8404713B2 (en) | 2007-10-26 | 2013-03-26 | Janssen Pharmaceutica Nv | Quinolinone derivatives as PARP inhibitors |
| ES2367760T3 (es) | 2008-03-27 | 2011-11-08 | Janssen Pharmaceutica, N.V. | Derivados de quinazolinona como inhibidores de la polimerización de la tubulina. |
| CN101981013B (zh) | 2008-03-27 | 2013-05-29 | 詹森药业有限公司 | 作为parp和微管蛋白聚合抑制剂的四氢菲啶酮和四氢环戊二烯并喹啉酮 |
| WO2011022772A1 (en) * | 2009-08-27 | 2011-03-03 | Bionomics Limited | Combination therapy for treating proliferative diseases |
| EP2470519B1 (en) * | 2009-08-27 | 2014-12-17 | Bionomics Limited | Treatment of macular degeneration |
| AU2009240878B2 (en) * | 2009-11-27 | 2016-05-26 | Bionomics Limited | Combination Therapy for Treating Proliferative Diseases |
| WO2011063469A1 (en) * | 2009-11-27 | 2011-06-03 | Bionomics Limited | Tubulin biomarker assay |
| US20110130367A1 (en) * | 2009-11-27 | 2011-06-02 | Bionomics Limited | Combination Therapy for Treating Proliferative Diseases |
| EP2576514A1 (en) | 2010-06-04 | 2013-04-10 | Exonhit Sa | Substituted isoquinolines and their use as tubulin polymerization inhibitors |
| US8674119B2 (en) | 2010-07-16 | 2014-03-18 | Bionomics Limited | Chemical processes for the manufacture of substituted benzofurans |
| FR2962731B1 (fr) * | 2010-07-19 | 2012-08-17 | Sanofi Aventis | Procede de preparation de derives d'amino-benzoyl-benzofurane |
| US10005750B2 (en) * | 2010-10-06 | 2018-06-26 | J-Pharma Co., Ltd. | Developing potent urate transporter inhibitors: compounds designed for their uricosuric action |
| US9090633B2 (en) | 2010-11-18 | 2015-07-28 | Kasina Laila Innova Pharmaceuticals Private Limited | Substituted 4-(arylamino) selenophenopyrimidine compounds and methods of use thereof |
| KR101817221B1 (ko) | 2010-11-18 | 2018-01-10 | 카시나 라일라 이노바 파마슈티칼스 프라이빗 리미티드 | 치환된 4-(셀레노펜-2(또는 3)-일아미노)피리미딘 화합물 및 이의 사용방법 |
| CN103313599B (zh) * | 2010-12-09 | 2016-03-23 | 卡斯纳莱拉创新药物私人有限公司 | 取代的4-(芳基氨基)硒吩并嘧啶化合物及其使用方法 |
| US9039732B2 (en) | 2011-07-11 | 2015-05-26 | Covidien Lp | Surgical forceps |
| CN103906742A (zh) * | 2011-09-28 | 2014-07-02 | 世宗大学校产学协力团 | 硒吩稠合芳族化合物和其制备方法 |
| AU2013204313C1 (en) * | 2012-06-01 | 2016-04-07 | Bionomics Limited | Combination Therapy |
| CN103058988B (zh) * | 2012-12-31 | 2015-09-02 | 中国人民大学 | 苯并噻吩及其衍生物及其制备方法与应用 |
| KR101584731B1 (ko) | 2013-04-26 | 2016-01-12 | 한국생명공학연구원 | 신규 튜불린 중합 저해제 및 그 합성방법 |
| WO2014175623A1 (ko) * | 2013-04-26 | 2014-10-30 | 한국생명공학연구원 | 신규 튜불린 중합 저해제 및 그 합성방법 |
| NZ724796A (en) * | 2014-04-04 | 2019-04-26 | Bionomics Ltd | Method for treating chronic lymphocytic leukemia |
| US20170119727A1 (en) * | 2014-05-30 | 2017-05-04 | Bionomics Limited | A therapeutic protocol for treating ovarian cancer |
| US10159659B2 (en) * | 2014-07-02 | 2018-12-25 | Bionomics Limited | Predicting response to cancer therapy |
| US10564162B2 (en) * | 2014-07-02 | 2020-02-18 | Bionomics Limited | Predictive biomarkers |
| CN104860908B (zh) * | 2015-04-28 | 2017-03-22 | 广东颐正达医药科技有限公司 | 一种合成bnc105的方法 |
| NZ738406A (en) * | 2015-06-11 | 2023-04-28 | Bionomics Ltd | Pharmaceutical combination of a tubulin polymerization inhibitor with an inhibitor of pd-l1, pd-1, or ctla-4 and uses and compositions thereof |
| LT3386500T (lt) | 2015-12-09 | 2022-12-27 | The Board Of Trustees Of The University Of Illinois | Selektyvūs estrogenų receptorių slopintojai benzotiofeno pagrindu |
| EP3454856B1 (en) | 2016-05-10 | 2024-09-11 | C4 Therapeutics, Inc. | Heterocyclic degronimers for target protein degradation |
| ES2990061T3 (es) | 2016-05-10 | 2024-11-28 | C4 Therapeutics Inc | Degronímeros espirocíclicos para la degradación de proteínas diana |
| CN109641874A (zh) | 2016-05-10 | 2019-04-16 | C4医药公司 | 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体 |
| CN109790143A (zh) | 2016-05-10 | 2019-05-21 | C4医药公司 | 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体 |
| RU2019102647A (ru) | 2016-07-01 | 2020-08-03 | Г1 Терапьютикс, Инк. | Антипролиферационные средства на основе пиримидина |
| CN107586284B (zh) * | 2016-07-06 | 2021-03-26 | 中国药科大学 | 一种2-芳基苯并呋喃类衍生物在制备痛风药物中的用途 |
| WO2018049474A1 (en) | 2016-09-16 | 2018-03-22 | Bionomics Limited | Antibody and checkpoint inhibitor combination therapy |
| WO2018081168A2 (en) | 2016-10-24 | 2018-05-03 | The Board Of Trustees Of The University Of Illinois | Benzothiophene-based selective mixed estrogen receptor downregulators |
| MX2019008158A (es) | 2017-01-06 | 2019-12-09 | G1 Therapeutics Inc | Terapia de combinacion para el tratamiento del cancer. |
| KR20190117582A (ko) | 2017-02-10 | 2019-10-16 | 쥐원 쎄라퓨틱스, 인크. | 벤조티오펜 에스트로겐 수용체 조정제 |
| CN110769822A (zh) | 2017-06-20 | 2020-02-07 | C4医药公司 | 用于蛋白降解的n/o-连接的降解决定子和降解决定子体 |
| WO2019006393A1 (en) | 2017-06-29 | 2019-01-03 | G1 Therapeutics, Inc. | Morphic forms of git38 and methods of manufacture thereof |
| CN120698983A (zh) | 2018-12-20 | 2025-09-26 | C4医药公司 | 靶向蛋白降解 |
| KR20220119415A (ko) | 2019-12-20 | 2022-08-29 | 씨4 테라퓨틱스, 인코포레이티드 | Egfr 분해를 위한 이소인돌리논 및 인다졸 화합물 |
| JP7726628B2 (ja) * | 2020-01-30 | 2025-08-20 | エイムドバイオ株式会社 | ベンゾセレノフェン系化合物、これを含む薬学的組成物及び抗体-薬物複合体 |
| TW202146412A (zh) | 2020-03-05 | 2021-12-16 | 美商C4醫藥公司 | 用於標靶降解brd9之化合物 |
| IL300397A (en) | 2020-08-05 | 2023-04-01 | C4 Therapeutics Inc | Compounds for targeted knockdown of RET |
| MX2023014059A (es) | 2021-06-08 | 2024-03-12 | C4 Therapeutics Inc | Terapeuticos para la degradacion de una proteina quiinasa de serina/ treonina mutante. |
| KR20240058859A (ko) | 2021-08-12 | 2024-05-03 | 쿨레온 엘엘씨 | 환각성 및 비환각성 세로토닌 수용체 작용제 및 이의 제조 및 사용 방법 |
| US12575874B2 (en) | 2021-09-10 | 2026-03-17 | Covidien Lp | Cutting blade for vessel sealer with knife return |
| WO2024030968A1 (en) | 2022-08-03 | 2024-02-08 | Brystol-Myers Squibb Company | Compounds for modulating ret protein |
| WO2024097980A1 (en) | 2022-11-04 | 2024-05-10 | Bristol-Myers Squibb Company | Ret-ldd protein inhibitors |
| EP4611901A1 (en) | 2022-11-04 | 2025-09-10 | Bristol-Myers Squibb Company | Ret-ldd protein degraders |
| EP4735452A2 (en) | 2023-06-30 | 2026-05-06 | Merck Patent GmbH | Heterobifunctional compounds for the degradation of kras protein |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07508039A (ja) | 1992-05-20 | 1995-09-07 | メルク エンド カンパニー インコーポレーテッド | 4−アザステロイドのエステル誘導体 |
| US5536727A (en) | 1992-05-20 | 1996-07-16 | Merck & Co., Inc. | 17-Ethers and thioethers of 4-aza-steroids |
| NZ248573A (en) | 1992-09-10 | 1996-02-27 | Lilly Co Eli | 5-arylmethyl (and methylidene) thiazolidin-4-one derivatives; their preparation and pharmaceutical compositions |
| WO1995014003A1 (en) * | 1993-11-17 | 1995-05-26 | Kyowa Hakko Kogyo Co., Ltd. | Propenone derivative |
| US5728724A (en) * | 1995-08-17 | 1998-03-17 | Eli Lilly And Company | Benzothiophene compounds |
| US5886025A (en) * | 1997-03-06 | 1999-03-23 | Baylor University | Anti-mitotic agents which inhibit tubulin polymerization |
| CA2260499A1 (en) | 1998-01-29 | 1999-07-29 | Sumitomo Pharmaceuticals Company Limited | Pharmaceutical compositions for the treatment of ischemic brain damage |
| CA2348740A1 (en) | 1998-12-23 | 2000-07-06 | Ruth R. Wexler | Thrombin or factor xa inhibitors |
| WO2000048606A1 (en) * | 1999-02-18 | 2000-08-24 | Oxigene, Inc. | Compositions and methods for use in targeting vascular destruction |
| WO2004099139A1 (en) * | 2000-09-15 | 2004-11-18 | Baylor University | Indole-containing compounds with anti-tubulin and vascular targeting activity |
| EP1214298B1 (en) | 1999-09-17 | 2012-05-30 | Baylor University | Indole-containing and combretastatin-related anti-mitotic and anti-tubulin polymerization agents |
| CA2387138A1 (en) | 1999-10-18 | 2001-04-26 | University Of Connecticut | Cannabimimetic indole derivatives |
| CA2397575A1 (en) | 2000-01-13 | 2001-07-19 | Tularik Inc. | Antibacterial agents |
| US7091240B2 (en) * | 2000-03-10 | 2006-08-15 | Oxigene, Inc. | Tubulin binding ligands and corresponding prodrug constructs |
| CA2407967C (en) | 2000-03-10 | 2010-10-05 | Baylor University | Tubulin binding ligands and corresponding prodrug constructs |
| DE10017947A1 (de) | 2000-04-11 | 2001-10-25 | Merck Patent Gmbh | Verfahren zur Herstellung benzo-annelierter Heterocyclen |
| AU2001273040A1 (en) | 2000-06-27 | 2002-01-08 | Du Pont Pharmaceuticals Company | Factor xa inhibitors |
| FR2813308B1 (fr) | 2000-08-23 | 2005-07-01 | Sanofi Synthelabo | Aminoalkoxybenzoyl-benzofurannes ou benzothiophenes, leur procede de preparation ainsi que les compositions les contenant |
| EP1347963B1 (en) | 2000-12-05 | 2004-08-25 | F. Hoffmann-La Roche Ag | Benzofuran and benzothiophene derivatives as selective cox-2 inhibitors |
| AUPR283801A0 (en) * | 2001-02-01 | 2001-03-01 | Australian National University, The | Chemical compounds and methods |
| GB0106586D0 (en) | 2001-03-16 | 2001-05-09 | Smithkline Beecham Plc | Novel compounds |
| ATE527247T1 (de) | 2001-07-05 | 2011-10-15 | Takeda Pharmaceutical | Benzokondensierte 5gliedrige heterocyclische verbindungen, verfahren zu deren herstellung und deren verwendung |
| TWI317634B (en) * | 2001-12-13 | 2009-12-01 | Nat Health Research Institutes | Aroyl indoles compounds |
| US7528165B2 (en) * | 2001-12-13 | 2009-05-05 | National Health Research Institutes | Indole compounds |
| EP1400244A1 (en) | 2002-09-17 | 2004-03-24 | Warner-Lambert Company LLC | New spirocondensed quinazolinones and their use as phosphodiesterase inhibitors |
| EP1622886A2 (en) | 2003-04-30 | 2006-02-08 | The Institutes for Pharmaceutical Discovery, LLC | Substituted amino carboxylic acids as inhibitors of protein tyrosine phosphatase-1b |
| US7456214B2 (en) | 2004-05-03 | 2008-11-25 | Baylor University | Chromene-containing compounds with anti-tubulin and vascular targeting activity |
| US20050245489A1 (en) * | 2004-05-03 | 2005-11-03 | Pinney Kevin G | Chromene-containing compounds with anti-tubulin and vascular targeting activity |
| US7456289B2 (en) * | 2004-12-31 | 2008-11-25 | National Health Research Institutes | Anti-tumor compounds |
| AU2006212726C1 (en) * | 2005-02-14 | 2013-05-16 | Bionomics Limited | Novel tubulin polymerisation inhibitors |
| JP5315060B2 (ja) | 2006-02-03 | 2013-10-16 | バイオノミックス リミテッド | 置換ベンゾフラン、ベンゾチオフェン、ベンゾセレノフェンおよびインドールおよびそれらのチューブリン重合阻害剤としての使用 |
-
2007
- 2007-02-02 JP JP2008552645A patent/JP5315060B2/ja not_active Expired - Fee Related
- 2007-02-02 PT PT07701434T patent/PT1984333E/pt unknown
- 2007-02-02 CA CA2640678A patent/CA2640678C/en active Active
- 2007-02-02 ES ES07701434T patent/ES2386299T3/es active Active
- 2007-02-02 EP EP07701434A patent/EP1984333B1/en active Active
- 2007-02-02 US US12/162,917 patent/US8198466B2/en active Active
- 2007-02-02 AT AT07701434T patent/ATE555091T1/de active
- 2007-02-02 DK DK07701434.8T patent/DK1984333T3/da active
- 2007-02-02 NZ NZ570014A patent/NZ570014A/en not_active IP Right Cessation
- 2007-02-02 EP EP12153534A patent/EP2460793A1/en not_active Withdrawn
- 2007-02-02 WO PCT/AU2007/000101 patent/WO2007087684A1/en not_active Ceased
- 2007-02-02 AU AU2007211840A patent/AU2007211840B2/en not_active Ceased
-
2012
- 2012-05-01 US US13/461,213 patent/US8716335B2/en active Active
- 2012-10-22 US US13/657,160 patent/US8680135B2/en not_active Expired - Fee Related
-
2014
- 2014-02-19 US US14/183,908 patent/US9346842B2/en active Active
-
2016
- 2016-04-28 US US15/141,170 patent/US10213409B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009531281A5 (https=) | ||
| WO2008033798A3 (en) | A pyrrolopyrazin as syk-kinase inhibitor | |
| WO2008075068A3 (en) | Acylaminopyrazoles as fgfr inhibitors | |
| WO2007087395A3 (en) | UNSATURATED mTOR INHIBITORS | |
| EA201290397A1 (ru) | 1,3,4-оксадиазол-2-карбоксамидное соединение | |
| WO2008142055A3 (en) | Antiviral agents | |
| CL2009000914A1 (es) | Compuestos derivados de 1-ciano-3-pirrolidinil-n-sustituidas-sulfonamidas, inhibidores de catepsina c; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de una enfermedad pulmonar obstructiva cronica. | |
| CL2009000915A1 (es) | Compuestos derivados de 1-ciano-3-pirrolidinil-bencenosulfonamidas, inhibidores de catepsina c; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de una enfermedad pulmonar obstructiva cronica (copd). | |
| MX2009011578A (es) | 6-fenilpirimidinonas como moduladores de pim. | |
| GEP20125650B (en) | Thiophene or thiazole derivatives and use thereof as pi3k inhibitors | |
| UA98141C2 (ru) | Способы лечения с применением хинаксолиновых ингибиторов pi3k-альфа | |
| UA106748C2 (uk) | Похідні проліну як інгібітори катепсину | |
| CL2008001095A1 (es) | Uso de compuesto derivados de pirazolopirimidinas, inhibidores de quinasas dependientes de ciclinas para inhibir el crecimiento de un tumor. | |
| CL2008002369A1 (es) | Compuestos derivados de piridin-3-il-oxipiridin-2-il-amino, inhibidores de alk5; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto en el tratamiento del cancer. | |
| MX2009008506A (es) | Derivados del pirazol como inhibidores de 11-b-hsd1. | |
| IL202505A (en) | 2-oxo-3-benzyl-benzoxazole-2-one derivatives and related compounds as met kinase inhibitors for the treatment of tumors, drugs containing them and their uses | |
| TN2010000038A1 (en) | Organic compounds | |
| ZA201002475B (en) | Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents,and methods of use | |
| WO2008055068A3 (en) | Inhibitors of histone deacetylase | |
| MX2009011579A (es) | Pirimidinonas como moduladores de caseina cinasa ii (ck2). | |
| CL2008001024A1 (es) | Compuestos derivados de ftalazinona; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de enfermedades cardiovasculares, parkinson, enfermedades inflamatorias, esclerosis multiple, cancer, entre otras | |
| EP2620145A3 (en) | 2,5-dihydroxybenzene compounds for the treatment of of cancer of an organ | |
| IL201064A0 (en) | Janus kinase inhibitor compounds, compositions comprising the same and uses thereof | |
| EP2639229A3 (en) | Thiazole Derivative and use thereof as VAP-1 Inhibitor | |
| WO2011058027A3 (en) | N-9-substituted purine compounds, compositions and methods of use |