JP2009531281A5 - - Google Patents
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- Publication number
- JP2009531281A5 JP2009531281A5 JP2008552645A JP2008552645A JP2009531281A5 JP 2009531281 A5 JP2009531281 A5 JP 2009531281A5 JP 2008552645 A JP2008552645 A JP 2008552645A JP 2008552645 A JP2008552645 A JP 2008552645A JP 2009531281 A5 JP2009531281 A5 JP 2009531281A5
- Authority
- JP
- Japan
- Prior art keywords
- inhibitor
- tubulin polymerization
- kit
- compound
- inhibition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003112 inhibitor Substances 0.000 claims 9
- MQLACMBJVPINKE-UHFFFAOYSA-N 10-[(3-hydroxy-4-methoxyphenyl)methylidene]anthracen-9-one Chemical compound C1=C(O)C(OC)=CC=C1C=C1C2=CC=CC=C2C(=O)C2=CC=CC=C21 MQLACMBJVPINKE-UHFFFAOYSA-N 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 8
- 230000005764 inhibitory process Effects 0.000 claims 5
- 229940122530 Tubulin polymerization inhibitor Drugs 0.000 claims 4
- 229940124572 antihypotensive agent Drugs 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 231100000433 cytotoxic Toxicity 0.000 claims 4
- 230000001472 cytotoxic effect Effects 0.000 claims 4
- 239000005555 hypertensive agent Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76533706P | 2006-02-03 | 2006-02-03 | |
| US60/765,337 | 2006-02-03 | ||
| PCT/AU2007/000101 WO2007087684A1 (en) | 2006-02-03 | 2007-02-02 | Substituted benzofurans, benzothiophenes, benzoselenophenes and indoles and their use as tubulin polymerisation inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009531281A JP2009531281A (ja) | 2009-09-03 |
| JP2009531281A5 true JP2009531281A5 (https=) | 2011-03-10 |
| JP5315060B2 JP5315060B2 (ja) | 2013-10-16 |
Family
ID=38327089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008552645A Expired - Fee Related JP5315060B2 (ja) | 2006-02-03 | 2007-02-02 | 置換ベンゾフラン、ベンゾチオフェン、ベンゾセレノフェンおよびインドールおよびそれらのチューブリン重合阻害剤としての使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US8198466B2 (https=) |
| EP (2) | EP2460793A1 (https=) |
| JP (1) | JP5315060B2 (https=) |
| AT (1) | ATE555091T1 (https=) |
| AU (1) | AU2007211840B2 (https=) |
| CA (1) | CA2640678C (https=) |
| DK (1) | DK1984333T3 (https=) |
| ES (1) | ES2386299T3 (https=) |
| NZ (1) | NZ570014A (https=) |
| PT (1) | PT1984333E (https=) |
| WO (1) | WO2007087684A1 (https=) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA009875B1 (ru) | 2003-11-20 | 2008-04-28 | Янссен Фармацевтика Н.В. | 6-алкенил и 6-фенилалкил замещенные 2-хинолиноны и 2-хиноксалиноны в качестве ингибиторов поли(адф-рибоза) полимеразы |
| EA011211B1 (ru) | 2003-11-20 | 2009-02-27 | Янссен Фармацевтика Н. В. | 7-фенилалкилзамещённые 2-хинолиноны и 2-хиноксалиноны в качестве ингибиторов поли(адф-рибоза)полимеразы |
| MXPA06014933A (es) | 2004-06-30 | 2007-02-28 | Janssen Pharmaceutica Nv | Derivados de 2-alquil quinazolinona sustituidos como inhibidores de poli(adp-ribosa) polimerasa-1. |
| SG154433A1 (en) | 2004-06-30 | 2009-08-28 | Janssen Pharmaceutica Nv | Phthalazine derivatives as parp inhibitors |
| MXPA06014541A (es) | 2004-06-30 | 2007-03-23 | Janssen Pharmaceutica Nv | Derivados de quinazolindiona como inhibidores de la poli(adp-ribosa) polimerasa. |
| AU2007211840B2 (en) | 2006-02-03 | 2012-03-01 | Bionomics Limited | Substituted benzofurans, benzothiophenes, benzoselenophenes and indoles and their use as tubulin polymerisation inhibitors |
| US8299256B2 (en) | 2007-03-08 | 2012-10-30 | Janssen Pharmaceutica Nv | Quinolinone derivatives as PARP and TANK inhibitors |
| US8404713B2 (en) | 2007-10-26 | 2013-03-26 | Janssen Pharmaceutica Nv | Quinolinone derivatives as PARP inhibitors |
| CA2716726C (en) | 2008-03-27 | 2017-01-24 | Janssen Pharmaceutica Nv | Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as parp and tubulin polymerization inhibitors |
| JP5464609B2 (ja) | 2008-03-27 | 2014-04-09 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | チューブリン重合阻害剤としてのキナゾリノン誘導体 |
| CN102596197A (zh) * | 2009-08-27 | 2012-07-18 | 生物学特性有限公司 | 用于治疗增生性疾病的联合疗法 |
| JP2013502440A (ja) * | 2009-08-27 | 2013-01-24 | バイオノミックス リミテッド | 黄斑変性の治療 |
| AU2009240878B2 (en) * | 2009-11-27 | 2016-05-26 | Bionomics Limited | Combination Therapy for Treating Proliferative Diseases |
| WO2011063469A1 (en) * | 2009-11-27 | 2011-06-03 | Bionomics Limited | Tubulin biomarker assay |
| US20110130367A1 (en) * | 2009-11-27 | 2011-06-02 | Bionomics Limited | Combination Therapy for Treating Proliferative Diseases |
| US20130131018A1 (en) | 2010-06-04 | 2013-05-23 | Exonhit S.A. | Substituted isoquinolines and their use as tubulin polymerization inhibitors |
| WO2012006686A1 (en) | 2010-07-16 | 2012-01-19 | Bionomics Limited | Chemical processes for the manufacture of substituted benzofurans |
| FR2962731B1 (fr) * | 2010-07-19 | 2012-08-17 | Sanofi Aventis | Procede de preparation de derives d'amino-benzoyl-benzofurane |
| US10005750B2 (en) | 2010-10-06 | 2018-06-26 | J-Pharma Co., Ltd. | Developing potent urate transporter inhibitors: compounds designed for their uricosuric action |
| US9090633B2 (en) | 2010-11-18 | 2015-07-28 | Kasina Laila Innova Pharmaceuticals Private Limited | Substituted 4-(arylamino) selenophenopyrimidine compounds and methods of use thereof |
| CN103221048A (zh) | 2010-11-18 | 2013-07-24 | 卡斯纳莱拉创新药物私人有限公司 | 取代的4-(硒吩-2(或3)-基氨基)嘧啶化合物及其使用方法 |
| EP2648509B1 (en) * | 2010-12-09 | 2015-04-29 | Kasina Laila Innova Pharmaceuticals Private Ltd. | Substituted 4-(arylamino) selenophenopyrimidine compounds and methods of use thereof |
| US9039732B2 (en) | 2011-07-11 | 2015-05-26 | Covidien Lp | Surgical forceps |
| WO2013048177A2 (ko) * | 2011-09-28 | 2013-04-04 | 세종대학교산학협력단 | 셀레노펜-접합 방향족 화합물, 및 이의 제조 방법 |
| AU2013204313C1 (en) * | 2012-06-01 | 2016-04-07 | Bionomics Limited | Combination Therapy |
| CN103058988B (zh) * | 2012-12-31 | 2015-09-02 | 中国人民大学 | 苯并噻吩及其衍生物及其制备方法与应用 |
| WO2014175623A1 (ko) * | 2013-04-26 | 2014-10-30 | 한국생명공학연구원 | 신규 튜불린 중합 저해제 및 그 합성방법 |
| KR101584731B1 (ko) | 2013-04-26 | 2016-01-12 | 한국생명공학연구원 | 신규 튜불린 중합 저해제 및 그 합성방법 |
| NZ724796A (en) * | 2014-04-04 | 2019-04-26 | Bionomics Ltd | Method for treating chronic lymphocytic leukemia |
| US20170119727A1 (en) * | 2014-05-30 | 2017-05-04 | Bionomics Limited | A therapeutic protocol for treating ovarian cancer |
| AU2015283811A1 (en) * | 2014-07-02 | 2017-02-09 | Bionomics Limited | Predictive biomarkers |
| US10159659B2 (en) * | 2014-07-02 | 2018-12-25 | Bionomics Limited | Predicting response to cancer therapy |
| CN104860908B (zh) * | 2015-04-28 | 2017-03-22 | 广东颐正达医药科技有限公司 | 一种合成bnc105的方法 |
| AU2016275574B2 (en) * | 2015-06-11 | 2019-07-11 | Bionomics Limited | Pharmaceutical combination and uses thereof |
| SMT202300018T1 (it) | 2015-12-09 | 2023-03-17 | Univ Illinois | Downregolatori del recettore degli estrogeni a base di benzotiofene |
| CN109790143A (zh) | 2016-05-10 | 2019-05-21 | C4医药公司 | 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体 |
| EP4491236A3 (en) | 2016-05-10 | 2025-04-02 | C4 Therapeutics, Inc. | Heterocyclic degronimers for target protein degradation |
| EP3454862B1 (en) | 2016-05-10 | 2024-09-11 | C4 Therapeutics, Inc. | Spirocyclic degronimers for target protein degradation |
| CN109641874A (zh) | 2016-05-10 | 2019-04-16 | C4医药公司 | 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体 |
| EP3858835A1 (en) | 2016-07-01 | 2021-08-04 | G1 Therapeutics, Inc. | Pyrimidine-based antiproliferative agents |
| CN107586284B (zh) * | 2016-07-06 | 2021-03-26 | 中国药科大学 | 一种2-芳基苯并呋喃类衍生物在制备痛风药物中的用途 |
| KR20190053909A (ko) * | 2016-09-16 | 2019-05-20 | 바이오노믹스 리미티드 | 항체와 체크포인트 면역 억제제의 병용 요법 |
| WO2018081168A2 (en) | 2016-10-24 | 2018-05-03 | The Board Of Trustees Of The University Of Illinois | Benzothiophene-based selective mixed estrogen receptor downregulators |
| EP3565558B1 (en) | 2017-01-06 | 2023-12-06 | G1 Therapeutics, Inc. | Combination therapy with a serd compound and a cdk4/6 inhibitor for the treatment of cancer |
| KR20190117582A (ko) | 2017-02-10 | 2019-10-16 | 쥐원 쎄라퓨틱스, 인크. | 벤조티오펜 에스트로겐 수용체 조정제 |
| EP4717317A2 (en) | 2017-06-20 | 2026-04-01 | C4 Therapeutics, Inc. | N/o-linked degrons and degronimers for protein degradation |
| FI3645001T3 (fi) | 2017-06-29 | 2024-09-25 | G1 Therapeutics Inc | Git38:n morfisia muotoja ja niiden valmistusmenetelmiä |
| CN120698983A (zh) | 2018-12-20 | 2025-09-26 | C4医药公司 | 靶向蛋白降解 |
| BR112022011827A2 (pt) | 2019-12-20 | 2022-08-30 | C4 Therapeutics Inc | Composto, composição farmacêutica, uso de um composto, métodos para tratamento ou profilaxia de câncer e para tratar um paciente com um distúrbio mediado por receptor do fator de crescimento epidérmico, e, invenção |
| KR102894542B1 (ko) * | 2020-01-30 | 2025-12-03 | (주)에임드바이오 | 벤조셀레노펜계 화합물, 이를 포함하는 약학적 조성물 및 항체-약물 결합체 |
| AU2021231898A1 (en) | 2020-03-05 | 2022-10-27 | C4 Therapeutics, Inc. | Compounds for targeted degradation of BRD9 |
| EP4192458A4 (en) | 2020-08-05 | 2024-09-04 | C4 Therapeutics, Inc. | COMPOUNDS FOR TARGETED DEGRADATION OF RET |
| WO2022261250A1 (en) | 2021-06-08 | 2022-12-15 | C4 Therapeutics, Inc. | Therapeutics for the degradation of mutant braf |
| WO2023018864A1 (en) | 2021-08-12 | 2023-02-16 | Psilosterics, Llc | Hallucinogenic and non-hallucinogenic serotonin receptor agonists and methods of making and using the same |
| US12575874B2 (en) | 2021-09-10 | 2026-03-17 | Covidien Lp | Cutting blade for vessel sealer with knife return |
| JP2025525917A (ja) | 2022-08-03 | 2025-08-07 | ブリストル-マイヤーズ スクイブ カンパニー | Retタンパク質を調節するための化合物 |
| CN120569388A (zh) | 2022-11-04 | 2025-08-29 | 百时美施贵宝公司 | Ret-ldd蛋白降解剂 |
| CN120530116A (zh) | 2022-11-04 | 2025-08-22 | 百时美施贵宝公司 | Ret-ldd蛋白抑制剂 |
| WO2025006753A2 (en) | 2023-06-30 | 2025-01-02 | Merck Patent Gmbh | Heterobifunctional compounds for the degradation of kras protein |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2135173A1 (en) | 1992-05-20 | 1993-11-25 | Bruce E. Witzel | Ester derivatives of 4-aza-steroids |
| EP0641204B1 (en) | 1992-05-20 | 2000-08-16 | Merck & Co. Inc. | 17-ethers and thioethers of 4-aza-steroids |
| EP0915090A1 (en) | 1992-09-10 | 1999-05-12 | Eli Lilly And Company | Compounds useful as hypoglycemic agents and for treating Alzheimer's disease |
| DE69427283T2 (de) * | 1993-11-17 | 2001-09-13 | Kyowa Hakko Kogyo Co., Ltd. | Propenon-derivate |
| US5728724A (en) * | 1995-08-17 | 1998-03-17 | Eli Lilly And Company | Benzothiophene compounds |
| US5886025A (en) | 1997-03-06 | 1999-03-23 | Baylor University | Anti-mitotic agents which inhibit tubulin polymerization |
| CA2260499A1 (en) | 1998-01-29 | 1999-07-29 | Sumitomo Pharmaceuticals Company Limited | Pharmaceutical compositions for the treatment of ischemic brain damage |
| WO2000038683A1 (en) | 1998-12-23 | 2000-07-06 | Du Pont Pharmaceuticals Company | THROMBIN OR FACTOR Xa INHIBITORS |
| WO2000048606A1 (en) * | 1999-02-18 | 2000-08-24 | Oxigene, Inc. | Compositions and methods for use in targeting vascular destruction |
| WO2004099139A1 (en) * | 2000-09-15 | 2004-11-18 | Baylor University | Indole-containing compounds with anti-tubulin and vascular targeting activity |
| JP4187441B2 (ja) | 1999-09-17 | 2008-11-26 | ベイラー・ユニバーシテイ | インドール含有およびコンブレタスタチン関連の抗有糸分裂および抗チューブリン重合薬剤 |
| DE60030303T2 (de) | 1999-10-18 | 2007-10-11 | The University Of Connecticut, Farmington | Cannabimimetische indolderivate |
| WO2001051456A2 (en) | 2000-01-13 | 2001-07-19 | Tularik Inc. | Antibacterial agents |
| WO2001068654A2 (en) | 2000-03-10 | 2001-09-20 | Baylor University | Tubulin binding ligands and corresponding prodrug constructs |
| US7091240B2 (en) * | 2000-03-10 | 2006-08-15 | Oxigene, Inc. | Tubulin binding ligands and corresponding prodrug constructs |
| DE10017947A1 (de) | 2000-04-11 | 2001-10-25 | Merck Patent Gmbh | Verfahren zur Herstellung benzo-annelierter Heterocyclen |
| WO2002000651A2 (en) | 2000-06-27 | 2002-01-03 | Bristol-Myers Squibb Pharma Company | Factor xa inhibitors |
| FR2813308B1 (fr) | 2000-08-23 | 2005-07-01 | Sanofi Synthelabo | Aminoalkoxybenzoyl-benzofurannes ou benzothiophenes, leur procede de preparation ainsi que les compositions les contenant |
| AU2002224890B2 (en) | 2000-12-05 | 2007-03-22 | F. Hoffmann-La Roche Ag | Benzofuran and benzothiophene derivatives as selective COX-2 inhibitors |
| AUPR283801A0 (en) | 2001-02-01 | 2001-03-01 | Australian National University, The | Chemical compounds and methods |
| GB0106586D0 (en) | 2001-03-16 | 2001-05-09 | Smithkline Beecham Plc | Novel compounds |
| WO2003004485A1 (fr) | 2001-07-05 | 2003-01-16 | Takeda Chemical Industries, Ltd. | Composes heterocycles a 5 chainons condenses avec un benzo, leur procede de preparation et leur utilisation |
| TWI317634B (en) * | 2001-12-13 | 2009-12-01 | Nat Health Research Institutes | Aroyl indoles compounds |
| US7528165B2 (en) * | 2001-12-13 | 2009-05-05 | National Health Research Institutes | Indole compounds |
| EP1400244A1 (en) | 2002-09-17 | 2004-03-24 | Warner-Lambert Company LLC | New spirocondensed quinazolinones and their use as phosphodiesterase inhibitors |
| CA2523718A1 (en) | 2003-04-30 | 2004-11-18 | The Institutes For Pharmaceutical Discovery, Llc | Substituted amino carboxylic acids as inhibitors of protein tyrosine phosphatase-1b |
| US20050245489A1 (en) * | 2004-05-03 | 2005-11-03 | Pinney Kevin G | Chromene-containing compounds with anti-tubulin and vascular targeting activity |
| US7456214B2 (en) | 2004-05-03 | 2008-11-25 | Baylor University | Chromene-containing compounds with anti-tubulin and vascular targeting activity |
| US7456289B2 (en) * | 2004-12-31 | 2008-11-25 | National Health Research Institutes | Anti-tumor compounds |
| US8278290B2 (en) | 2005-02-14 | 2012-10-02 | Biononics Limited | Tubulin polymerisation inhibitors |
| AU2007211840B2 (en) | 2006-02-03 | 2012-03-01 | Bionomics Limited | Substituted benzofurans, benzothiophenes, benzoselenophenes and indoles and their use as tubulin polymerisation inhibitors |
-
2007
- 2007-02-02 AU AU2007211840A patent/AU2007211840B2/en not_active Ceased
- 2007-02-02 EP EP12153534A patent/EP2460793A1/en not_active Withdrawn
- 2007-02-02 JP JP2008552645A patent/JP5315060B2/ja not_active Expired - Fee Related
- 2007-02-02 US US12/162,917 patent/US8198466B2/en active Active
- 2007-02-02 DK DK07701434.8T patent/DK1984333T3/da active
- 2007-02-02 NZ NZ570014A patent/NZ570014A/en not_active IP Right Cessation
- 2007-02-02 AT AT07701434T patent/ATE555091T1/de active
- 2007-02-02 WO PCT/AU2007/000101 patent/WO2007087684A1/en not_active Ceased
- 2007-02-02 CA CA2640678A patent/CA2640678C/en active Active
- 2007-02-02 ES ES07701434T patent/ES2386299T3/es active Active
- 2007-02-02 EP EP07701434A patent/EP1984333B1/en active Active
- 2007-02-02 PT PT07701434T patent/PT1984333E/pt unknown
-
2012
- 2012-05-01 US US13/461,213 patent/US8716335B2/en active Active
- 2012-10-22 US US13/657,160 patent/US8680135B2/en not_active Expired - Fee Related
-
2014
- 2014-02-19 US US14/183,908 patent/US9346842B2/en active Active
-
2016
- 2016-04-28 US US15/141,170 patent/US10213409B2/en active Active
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