JP2009531281A5 - - Google Patents

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Publication number
JP2009531281A5
JP2009531281A5 JP2008552645A JP2008552645A JP2009531281A5 JP 2009531281 A5 JP2009531281 A5 JP 2009531281A5 JP 2008552645 A JP2008552645 A JP 2008552645A JP 2008552645 A JP2008552645 A JP 2008552645A JP 2009531281 A5 JP2009531281 A5 JP 2009531281A5
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JP
Japan
Prior art keywords
inhibitor
tubulin polymerization
kit
compound
inhibition
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JP2008552645A
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English (en)
Japanese (ja)
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JP2009531281A (ja
JP5315060B2 (ja
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Priority claimed from PCT/AU2007/000101 external-priority patent/WO2007087684A1/en
Publication of JP2009531281A publication Critical patent/JP2009531281A/ja
Publication of JP2009531281A5 publication Critical patent/JP2009531281A5/ja
Application granted granted Critical
Publication of JP5315060B2 publication Critical patent/JP5315060B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2008552645A 2006-02-03 2007-02-02 置換ベンゾフラン、ベンゾチオフェン、ベンゾセレノフェンおよびインドールおよびそれらのチューブリン重合阻害剤としての使用 Expired - Fee Related JP5315060B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US76533706P 2006-02-03 2006-02-03
US60/765,337 2006-02-03
PCT/AU2007/000101 WO2007087684A1 (en) 2006-02-03 2007-02-02 Substituted benzofurans, benzothiophenes, benzoselenophenes and indoles and their use as tubulin polymerisation inhibitors

Publications (3)

Publication Number Publication Date
JP2009531281A JP2009531281A (ja) 2009-09-03
JP2009531281A5 true JP2009531281A5 (https=) 2011-03-10
JP5315060B2 JP5315060B2 (ja) 2013-10-16

Family

ID=38327089

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008552645A Expired - Fee Related JP5315060B2 (ja) 2006-02-03 2007-02-02 置換ベンゾフラン、ベンゾチオフェン、ベンゾセレノフェンおよびインドールおよびそれらのチューブリン重合阻害剤としての使用

Country Status (11)

Country Link
US (5) US8198466B2 (https=)
EP (2) EP2460793A1 (https=)
JP (1) JP5315060B2 (https=)
AT (1) ATE555091T1 (https=)
AU (1) AU2007211840B2 (https=)
CA (1) CA2640678C (https=)
DK (1) DK1984333T3 (https=)
ES (1) ES2386299T3 (https=)
NZ (1) NZ570014A (https=)
PT (1) PT1984333E (https=)
WO (1) WO2007087684A1 (https=)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA009875B1 (ru) 2003-11-20 2008-04-28 Янссен Фармацевтика Н.В. 6-алкенил и 6-фенилалкил замещенные 2-хинолиноны и 2-хиноксалиноны в качестве ингибиторов поли(адф-рибоза) полимеразы
EA011211B1 (ru) 2003-11-20 2009-02-27 Янссен Фармацевтика Н. В. 7-фенилалкилзамещённые 2-хинолиноны и 2-хиноксалиноны в качестве ингибиторов поли(адф-рибоза)полимеразы
MXPA06014933A (es) 2004-06-30 2007-02-28 Janssen Pharmaceutica Nv Derivados de 2-alquil quinazolinona sustituidos como inhibidores de poli(adp-ribosa) polimerasa-1.
SG154433A1 (en) 2004-06-30 2009-08-28 Janssen Pharmaceutica Nv Phthalazine derivatives as parp inhibitors
MXPA06014541A (es) 2004-06-30 2007-03-23 Janssen Pharmaceutica Nv Derivados de quinazolindiona como inhibidores de la poli(adp-ribosa) polimerasa.
AU2007211840B2 (en) 2006-02-03 2012-03-01 Bionomics Limited Substituted benzofurans, benzothiophenes, benzoselenophenes and indoles and their use as tubulin polymerisation inhibitors
US8299256B2 (en) 2007-03-08 2012-10-30 Janssen Pharmaceutica Nv Quinolinone derivatives as PARP and TANK inhibitors
US8404713B2 (en) 2007-10-26 2013-03-26 Janssen Pharmaceutica Nv Quinolinone derivatives as PARP inhibitors
CA2716726C (en) 2008-03-27 2017-01-24 Janssen Pharmaceutica Nv Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as parp and tubulin polymerization inhibitors
JP5464609B2 (ja) 2008-03-27 2014-04-09 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ チューブリン重合阻害剤としてのキナゾリノン誘導体
CN102596197A (zh) * 2009-08-27 2012-07-18 生物学特性有限公司 用于治疗增生性疾病的联合疗法
JP2013502440A (ja) * 2009-08-27 2013-01-24 バイオノミックス リミテッド 黄斑変性の治療
AU2009240878B2 (en) * 2009-11-27 2016-05-26 Bionomics Limited Combination Therapy for Treating Proliferative Diseases
WO2011063469A1 (en) * 2009-11-27 2011-06-03 Bionomics Limited Tubulin biomarker assay
US20110130367A1 (en) * 2009-11-27 2011-06-02 Bionomics Limited Combination Therapy for Treating Proliferative Diseases
US20130131018A1 (en) 2010-06-04 2013-05-23 Exonhit S.A. Substituted isoquinolines and their use as tubulin polymerization inhibitors
WO2012006686A1 (en) 2010-07-16 2012-01-19 Bionomics Limited Chemical processes for the manufacture of substituted benzofurans
FR2962731B1 (fr) * 2010-07-19 2012-08-17 Sanofi Aventis Procede de preparation de derives d'amino-benzoyl-benzofurane
US10005750B2 (en) 2010-10-06 2018-06-26 J-Pharma Co., Ltd. Developing potent urate transporter inhibitors: compounds designed for their uricosuric action
US9090633B2 (en) 2010-11-18 2015-07-28 Kasina Laila Innova Pharmaceuticals Private Limited Substituted 4-(arylamino) selenophenopyrimidine compounds and methods of use thereof
CN103221048A (zh) 2010-11-18 2013-07-24 卡斯纳莱拉创新药物私人有限公司 取代的4-(硒吩-2(或3)-基氨基)嘧啶化合物及其使用方法
EP2648509B1 (en) * 2010-12-09 2015-04-29 Kasina Laila Innova Pharmaceuticals Private Ltd. Substituted 4-(arylamino) selenophenopyrimidine compounds and methods of use thereof
US9039732B2 (en) 2011-07-11 2015-05-26 Covidien Lp Surgical forceps
WO2013048177A2 (ko) * 2011-09-28 2013-04-04 세종대학교산학협력단 셀레노펜-접합 방향족 화합물, 및 이의 제조 방법
AU2013204313C1 (en) * 2012-06-01 2016-04-07 Bionomics Limited Combination Therapy
CN103058988B (zh) * 2012-12-31 2015-09-02 中国人民大学 苯并噻吩及其衍生物及其制备方法与应用
WO2014175623A1 (ko) * 2013-04-26 2014-10-30 한국생명공학연구원 신규 튜불린 중합 저해제 및 그 합성방법
KR101584731B1 (ko) 2013-04-26 2016-01-12 한국생명공학연구원 신규 튜불린 중합 저해제 및 그 합성방법
NZ724796A (en) * 2014-04-04 2019-04-26 Bionomics Ltd Method for treating chronic lymphocytic leukemia
US20170119727A1 (en) * 2014-05-30 2017-05-04 Bionomics Limited A therapeutic protocol for treating ovarian cancer
AU2015283811A1 (en) * 2014-07-02 2017-02-09 Bionomics Limited Predictive biomarkers
US10159659B2 (en) * 2014-07-02 2018-12-25 Bionomics Limited Predicting response to cancer therapy
CN104860908B (zh) * 2015-04-28 2017-03-22 广东颐正达医药科技有限公司 一种合成bnc105的方法
AU2016275574B2 (en) * 2015-06-11 2019-07-11 Bionomics Limited Pharmaceutical combination and uses thereof
SMT202300018T1 (it) 2015-12-09 2023-03-17 Univ Illinois Downregolatori del recettore degli estrogeni a base di benzotiofene
CN109790143A (zh) 2016-05-10 2019-05-21 C4医药公司 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体
EP4491236A3 (en) 2016-05-10 2025-04-02 C4 Therapeutics, Inc. Heterocyclic degronimers for target protein degradation
EP3454862B1 (en) 2016-05-10 2024-09-11 C4 Therapeutics, Inc. Spirocyclic degronimers for target protein degradation
CN109641874A (zh) 2016-05-10 2019-04-16 C4医药公司 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体
EP3858835A1 (en) 2016-07-01 2021-08-04 G1 Therapeutics, Inc. Pyrimidine-based antiproliferative agents
CN107586284B (zh) * 2016-07-06 2021-03-26 中国药科大学 一种2-芳基苯并呋喃类衍生物在制备痛风药物中的用途
KR20190053909A (ko) * 2016-09-16 2019-05-20 바이오노믹스 리미티드 항체와 체크포인트 면역 억제제의 병용 요법
WO2018081168A2 (en) 2016-10-24 2018-05-03 The Board Of Trustees Of The University Of Illinois Benzothiophene-based selective mixed estrogen receptor downregulators
EP3565558B1 (en) 2017-01-06 2023-12-06 G1 Therapeutics, Inc. Combination therapy with a serd compound and a cdk4/6 inhibitor for the treatment of cancer
KR20190117582A (ko) 2017-02-10 2019-10-16 쥐원 쎄라퓨틱스, 인크. 벤조티오펜 에스트로겐 수용체 조정제
EP4717317A2 (en) 2017-06-20 2026-04-01 C4 Therapeutics, Inc. N/o-linked degrons and degronimers for protein degradation
FI3645001T3 (fi) 2017-06-29 2024-09-25 G1 Therapeutics Inc Git38:n morfisia muotoja ja niiden valmistusmenetelmiä
CN120698983A (zh) 2018-12-20 2025-09-26 C4医药公司 靶向蛋白降解
BR112022011827A2 (pt) 2019-12-20 2022-08-30 C4 Therapeutics Inc Composto, composição farmacêutica, uso de um composto, métodos para tratamento ou profilaxia de câncer e para tratar um paciente com um distúrbio mediado por receptor do fator de crescimento epidérmico, e, invenção
KR102894542B1 (ko) * 2020-01-30 2025-12-03 (주)에임드바이오 벤조셀레노펜계 화합물, 이를 포함하는 약학적 조성물 및 항체-약물 결합체
AU2021231898A1 (en) 2020-03-05 2022-10-27 C4 Therapeutics, Inc. Compounds for targeted degradation of BRD9
EP4192458A4 (en) 2020-08-05 2024-09-04 C4 Therapeutics, Inc. COMPOUNDS FOR TARGETED DEGRADATION OF RET
WO2022261250A1 (en) 2021-06-08 2022-12-15 C4 Therapeutics, Inc. Therapeutics for the degradation of mutant braf
WO2023018864A1 (en) 2021-08-12 2023-02-16 Psilosterics, Llc Hallucinogenic and non-hallucinogenic serotonin receptor agonists and methods of making and using the same
US12575874B2 (en) 2021-09-10 2026-03-17 Covidien Lp Cutting blade for vessel sealer with knife return
JP2025525917A (ja) 2022-08-03 2025-08-07 ブリストル-マイヤーズ スクイブ カンパニー Retタンパク質を調節するための化合物
CN120569388A (zh) 2022-11-04 2025-08-29 百时美施贵宝公司 Ret-ldd蛋白降解剂
CN120530116A (zh) 2022-11-04 2025-08-22 百时美施贵宝公司 Ret-ldd蛋白抑制剂
WO2025006753A2 (en) 2023-06-30 2025-01-02 Merck Patent Gmbh Heterobifunctional compounds for the degradation of kras protein

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2135173A1 (en) 1992-05-20 1993-11-25 Bruce E. Witzel Ester derivatives of 4-aza-steroids
EP0641204B1 (en) 1992-05-20 2000-08-16 Merck & Co. Inc. 17-ethers and thioethers of 4-aza-steroids
EP0915090A1 (en) 1992-09-10 1999-05-12 Eli Lilly And Company Compounds useful as hypoglycemic agents and for treating Alzheimer's disease
DE69427283T2 (de) * 1993-11-17 2001-09-13 Kyowa Hakko Kogyo Co., Ltd. Propenon-derivate
US5728724A (en) * 1995-08-17 1998-03-17 Eli Lilly And Company Benzothiophene compounds
US5886025A (en) 1997-03-06 1999-03-23 Baylor University Anti-mitotic agents which inhibit tubulin polymerization
CA2260499A1 (en) 1998-01-29 1999-07-29 Sumitomo Pharmaceuticals Company Limited Pharmaceutical compositions for the treatment of ischemic brain damage
WO2000038683A1 (en) 1998-12-23 2000-07-06 Du Pont Pharmaceuticals Company THROMBIN OR FACTOR Xa INHIBITORS
WO2000048606A1 (en) * 1999-02-18 2000-08-24 Oxigene, Inc. Compositions and methods for use in targeting vascular destruction
WO2004099139A1 (en) * 2000-09-15 2004-11-18 Baylor University Indole-containing compounds with anti-tubulin and vascular targeting activity
JP4187441B2 (ja) 1999-09-17 2008-11-26 ベイラー・ユニバーシテイ インドール含有およびコンブレタスタチン関連の抗有糸分裂および抗チューブリン重合薬剤
DE60030303T2 (de) 1999-10-18 2007-10-11 The University Of Connecticut, Farmington Cannabimimetische indolderivate
WO2001051456A2 (en) 2000-01-13 2001-07-19 Tularik Inc. Antibacterial agents
WO2001068654A2 (en) 2000-03-10 2001-09-20 Baylor University Tubulin binding ligands and corresponding prodrug constructs
US7091240B2 (en) * 2000-03-10 2006-08-15 Oxigene, Inc. Tubulin binding ligands and corresponding prodrug constructs
DE10017947A1 (de) 2000-04-11 2001-10-25 Merck Patent Gmbh Verfahren zur Herstellung benzo-annelierter Heterocyclen
WO2002000651A2 (en) 2000-06-27 2002-01-03 Bristol-Myers Squibb Pharma Company Factor xa inhibitors
FR2813308B1 (fr) 2000-08-23 2005-07-01 Sanofi Synthelabo Aminoalkoxybenzoyl-benzofurannes ou benzothiophenes, leur procede de preparation ainsi que les compositions les contenant
AU2002224890B2 (en) 2000-12-05 2007-03-22 F. Hoffmann-La Roche Ag Benzofuran and benzothiophene derivatives as selective COX-2 inhibitors
AUPR283801A0 (en) 2001-02-01 2001-03-01 Australian National University, The Chemical compounds and methods
GB0106586D0 (en) 2001-03-16 2001-05-09 Smithkline Beecham Plc Novel compounds
WO2003004485A1 (fr) 2001-07-05 2003-01-16 Takeda Chemical Industries, Ltd. Composes heterocycles a 5 chainons condenses avec un benzo, leur procede de preparation et leur utilisation
TWI317634B (en) * 2001-12-13 2009-12-01 Nat Health Research Institutes Aroyl indoles compounds
US7528165B2 (en) * 2001-12-13 2009-05-05 National Health Research Institutes Indole compounds
EP1400244A1 (en) 2002-09-17 2004-03-24 Warner-Lambert Company LLC New spirocondensed quinazolinones and their use as phosphodiesterase inhibitors
CA2523718A1 (en) 2003-04-30 2004-11-18 The Institutes For Pharmaceutical Discovery, Llc Substituted amino carboxylic acids as inhibitors of protein tyrosine phosphatase-1b
US20050245489A1 (en) * 2004-05-03 2005-11-03 Pinney Kevin G Chromene-containing compounds with anti-tubulin and vascular targeting activity
US7456214B2 (en) 2004-05-03 2008-11-25 Baylor University Chromene-containing compounds with anti-tubulin and vascular targeting activity
US7456289B2 (en) * 2004-12-31 2008-11-25 National Health Research Institutes Anti-tumor compounds
US8278290B2 (en) 2005-02-14 2012-10-02 Biononics Limited Tubulin polymerisation inhibitors
AU2007211840B2 (en) 2006-02-03 2012-03-01 Bionomics Limited Substituted benzofurans, benzothiophenes, benzoselenophenes and indoles and their use as tubulin polymerisation inhibitors

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