JP5301465B2 - インスリン抵抗性改善薬および治療方法 - Google Patents

インスリン抵抗性改善薬および治療方法 Download PDF

Info

Publication number
JP5301465B2
JP5301465B2 JP2009546616A JP2009546616A JP5301465B2 JP 5301465 B2 JP5301465 B2 JP 5301465B2 JP 2009546616 A JP2009546616 A JP 2009546616A JP 2009546616 A JP2009546616 A JP 2009546616A JP 5301465 B2 JP5301465 B2 JP 5301465B2
Authority
JP
Japan
Prior art keywords
alkyl
alkoxy
halo
nhc
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2009546616A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010516711A (ja
Inventor
グレゴリー・ロイス・コリアー
ケネス・ラッセル・ワルダー
ジェイムズ・アレクサンダー・キャンベル
フアン−カルロス・モレロ−ナバハス
ニッキー・コンスタントポーロス
ガイ・ヨーマン・クリップナー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Verva Pharmaceuticals Ltd
Original Assignee
Verva Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2007902013A external-priority patent/AU2007902013A0/en
Application filed by Verva Pharmaceuticals Ltd filed Critical Verva Pharmaceuticals Ltd
Publication of JP2010516711A publication Critical patent/JP2010516711A/ja
Application granted granted Critical
Publication of JP5301465B2 publication Critical patent/JP5301465B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2009546616A 2007-01-25 2008-01-25 インスリン抵抗性改善薬および治療方法 Expired - Fee Related JP5301465B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US89776907P 2007-01-25 2007-01-25
US60/897,769 2007-01-25
AU2007902013A AU2007902013A0 (en) 2007-04-17 Inhibitory compounds
AU2007902013 2007-04-17
US98433507P 2007-10-31 2007-10-31
US60/984,335 2007-10-31
US737607P 2007-12-11 2007-12-11
US61/007,376 2007-12-11
PCT/AU2008/000089 WO2008089521A1 (en) 2007-01-25 2008-01-25 Insulin sensitisers and methods of treatment

Publications (2)

Publication Number Publication Date
JP2010516711A JP2010516711A (ja) 2010-05-20
JP5301465B2 true JP5301465B2 (ja) 2013-09-25

Family

ID=39644028

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009546616A Expired - Fee Related JP5301465B2 (ja) 2007-01-25 2008-01-25 インスリン抵抗性改善薬および治療方法

Country Status (12)

Country Link
US (3) US8455432B2 (enExample)
EP (1) EP2106260B8 (enExample)
JP (1) JP5301465B2 (enExample)
CN (1) CN101801375B (enExample)
AU (1) AU2008209320B2 (enExample)
CA (1) CA2676051C (enExample)
ES (1) ES2660170T3 (enExample)
NO (1) NO2106260T3 (enExample)
NZ (1) NZ579229A (enExample)
PL (1) PL2106260T3 (enExample)
PT (1) PT2106260T (enExample)
WO (1) WO2008089521A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2660170T3 (es) 2007-01-25 2018-03-21 NAIA Metabolic, Inc. Sensibilizadores a la insulina y métodos de tratamiento
US20200155558A1 (en) * 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
NZ702666A (en) * 2012-05-24 2016-08-26 Verva Pharmaceuticals Ltd A method of weight reduction
BR112014029308A2 (pt) * 2012-05-24 2017-06-27 Verva Pharmaceuticals Ltd um método de melhorar a função hepática
AU2013202988B2 (en) * 2012-06-29 2016-04-21 NAIA Metabolic, Inc. Method of improving liver function
US8652527B1 (en) 2013-03-13 2014-02-18 Upsher-Smith Laboratories, Inc Extended-release topiramate capsules
US9101545B2 (en) 2013-03-15 2015-08-11 Upsher-Smith Laboratories, Inc. Extended-release topiramate capsules

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2994701A (en) 1961-08-01 Z-sulfamyr
US2783241A (en) 1957-02-26 S-acylimino-x-substituted-az-i
US2554816A (en) 1950-04-04 1951-05-29 American Cyanamid Co Heterocyclic sulfonamides and methods of preparation thereof
GB795174A (en) 1954-10-13 1958-05-21 Upjohn Co Heterocyclic sulphonamides
US2835702A (en) 1956-05-02 1958-05-20 Merck & Co Inc Benzene 1, 3 disulfonamides possessing diuretic properties
US2978457A (en) 1959-04-06 1961-04-04 Merck & Co Inc 5-acylamido-4-substituted-thiazole-2-sulfonamides having diuretic properties
US3157572A (en) 1961-01-06 1964-11-17 American Cyanamid Co Parenteral diuretic compositions of 5-acylimino-4-substituted-delta2-1, 3, 4-thiadiazolidine-2-sulfonamides
US3668248A (en) 1964-09-30 1972-06-06 Lilly Co Eli 5-chloro-2,4-bis(sulfamoyl)fluorobenzene and 5-chloro-2,4-bis(chlorosulfonyl)fluorobenzene
FR2468366A1 (fr) 1979-10-31 1981-05-08 Stoclet Alain Medicament antiglaucomateux a base d'acetazolamide ou de methazolamide
DE3377130D1 (en) 1982-05-28 1988-07-28 Ciba Geigy Ag Sulfonyl(thio)ureas, process for their preparation and their use as herbicides and/or growth regulating agents
IT1224860B (it) 1988-07-29 1990-10-24 Istituto Chimico Internazional Composti correlati all'acetozolammi de con attivita' inibitrice dell'anidrasi carbonica, utili in particolare nel trattamento del glaucoma
GB2223166B (en) 1988-09-29 1992-03-18 American Cyanamid Co Stable ophthalmic preparations containing methazolamide
US4990523A (en) 1989-06-19 1991-02-05 A. H. Robins Company, Incorporated Treatment of chronic inflammatory joint disease with arylsulfonamides
US5153192A (en) 1990-04-09 1992-10-06 Alcon Laboratories, Inc. Thiophene sulfonamides useful as carbonic anhydrase inhibitors
US5378703A (en) 1990-04-09 1995-01-03 Alcon Laboratories, Inc. Sulfonamides useful as carbonic anhydrase inhibitors
US5585377A (en) 1990-04-09 1996-12-17 Alcon Laboratories, Inc. Sulfonamides useful as carbonic anhydrase inhibitors
US5225424A (en) 1992-10-21 1993-07-06 University Of Iowa Research Foundation Methazolamide-derived carbonic anhydrase inhibitors
US5519040A (en) 1994-04-29 1996-05-21 Allergan Substituted thiazole sulfonamides as antiglaucoma agents
TW438587B (en) 1995-06-20 2001-06-07 Takeda Chemical Industries Ltd A pharmaceutical composition for prophylaxis and treatment of diabetes
EP0869785B1 (en) 1995-11-17 2002-08-28 PHARMACIA & UPJOHN COMPANY 4-hydroxycoumarin-3-carboxamides for the treatment of non-insulin dependent diabetes mellitus
JP2000080047A (ja) 1998-06-30 2000-03-21 Takeda Chem Ind Ltd 医 薬
US6214381B1 (en) 1998-09-08 2001-04-10 Effcon, Inc. Methazolamide composition and method of use
GB9930688D0 (en) * 1999-12-24 2000-02-16 Smithkline Beecham Plc Novel method of treatment
AU2382601A (en) * 1999-12-24 2001-07-09 Smithkline Beecham Plc Novel method of treatment
CA2415093A1 (en) 2000-07-07 2002-01-17 Carlos Plata-Salaman Anticonvulsant derivatives useful for preventing the development of type ii diabetes mellitus and syndrome x
DE10035227A1 (de) 2000-07-20 2002-01-31 Solvay Pharm Gmbh Verfahren zum Auffinden von Verbindungen, welche zur Behandlung und/oder Prophylaxe von Fettleibigkeit geeignet sind
US6946243B2 (en) 2000-07-20 2005-09-20 Solvay Pharmaceuticals Gmbh Method of identifying compounds suitable for treatment and/or prophylaxis of obesity
DE10038022A1 (de) 2000-08-04 2002-02-14 Bayer Ag Inverse Thiazolylamid-Derivate
WO2002013800A2 (en) 2000-08-11 2002-02-21 Einar Stefansson Method for the prevention and treatment of retinopathy
FR2816841B1 (fr) 2000-11-22 2004-02-06 Lipha Nouvelles compositions pharmaceutiques a action antidiabetique et leur procede de preparation
US6800669B2 (en) 2000-12-22 2004-10-05 Dow Global Technologies Inc. Propylene copolymer foams
EP1695716A2 (en) 2000-12-26 2006-08-30 Sankyo Company, Limited Medicinal compositions containing diuretics and insulin sensitizers
CA2364985A1 (en) 2001-12-14 2003-06-14 John W. Gillard Imidazo(2,1-b)thiadiazole sulfonamides
EG24716A (en) * 2002-05-17 2010-06-07 Novartis Ag Combination of organic compounds
WO2004063194A1 (en) * 2003-01-06 2004-07-29 Eli Lilly And Company Heteroaryl compounds
CA2516142A1 (en) 2003-03-18 2004-09-30 Novartis Ag Compositions comprising fatty acids and amino acids
KR101167579B1 (ko) 2003-04-29 2012-07-27 오렉시젠 세러퓨틱스 인크. 체중감량용 조성물
WO2005012243A2 (en) 2003-08-01 2005-02-10 Janssen Pharmaceutica N.V. Substituted indole-o-glucosides
ES2385219T3 (es) * 2003-09-12 2012-07-19 Merck Serono Sa Derivados de sulfonamida para el tratamiento de diabetes
TW200533336A (en) 2004-03-02 2005-10-16 Fujisawa Pharmaceutical Co Concomitant drugs
RU2395503C2 (ru) 2004-05-19 2010-07-27 Зольвай Фармасьютиклз Гмбх Лекарственные средства, содержащие n-сульфамоил-n'-арилпиперазины, предназначенные для профилактики или лечения ожирения и связанных с ним состояний
US20090297496A1 (en) 2005-09-08 2009-12-03 Childrens Hospital Medical Center Lysosomal Acid Lipase Therapy for NAFLD and Related Diseases
US20070110707A1 (en) * 2005-11-04 2007-05-17 Washington University Method of treating diseases involving non-enzymatic glycation
US7670794B2 (en) 2005-11-04 2010-03-02 Washington University Managing glycemia status in diabetic patients
TW200804393A (en) 2005-11-14 2008-01-16 Solvay Pharm Gmbh Novel N-sulfamoyl-N'-benzopyranpiperidines for medical use
JP2009515928A (ja) 2005-11-14 2009-04-16 ゾルファイ ファーマスーティカルズ ゲゼルシャフト ミット ベシュレンクテル ハフツング カルボニックアンヒドラーゼの阻害剤としてのn−スルファモイル−n’−ベンゾピランピペリジン
WO2007065948A1 (en) * 2005-12-09 2007-06-14 Solvay Pharmaceuticals Gmbh Novel n-sulfamoyl-piperidineamides for the prophylaxis or treatment of obesity and related conditions
WO2007114948A2 (en) 2006-04-04 2007-10-11 The Brigham And Women's Hospital, Inc. Methods and compositions for inhibiting cell death
ES2660170T3 (es) 2007-01-25 2018-03-21 NAIA Metabolic, Inc. Sensibilizadores a la insulina y métodos de tratamiento
TW201105338A (en) 2009-07-01 2011-02-16 Kissei Pharmaceutical Medicine derived from a combination of SGLT1-inhibitor and DPP-IV inhibitor
CN103068400A (zh) 2010-06-25 2013-04-24 阿斯顿大学 具有脂类动员性质的糖蛋白及其治疗用途
JP5722892B2 (ja) 2010-07-15 2015-05-27 武田薬品工業株式会社 複素環化合物
BR112014029308A2 (pt) 2012-05-24 2017-06-27 Verva Pharmaceuticals Ltd um método de melhorar a função hepática
NZ702666A (en) 2012-05-24 2016-08-26 Verva Pharmaceuticals Ltd A method of weight reduction

Also Published As

Publication number Publication date
US10172837B2 (en) 2019-01-08
US20140011848A1 (en) 2014-01-09
US20110003740A1 (en) 2011-01-06
CA2676051C (en) 2017-06-06
US9452148B2 (en) 2016-09-27
AU2008209320B2 (en) 2013-05-30
CA2676051A1 (en) 2008-07-31
EP2106260B1 (en) 2017-12-06
EP2106260B8 (en) 2018-04-04
EP2106260A4 (en) 2010-05-26
NO2106260T3 (enExample) 2018-05-05
EP2106260A1 (en) 2009-10-07
CN101801375A (zh) 2010-08-11
ES2660170T3 (es) 2018-03-21
NZ579229A (en) 2011-07-29
CN101801375B (zh) 2014-01-01
WO2008089521A1 (en) 2008-07-31
PL2106260T3 (pl) 2018-06-29
US20170079960A1 (en) 2017-03-23
US8455432B2 (en) 2013-06-04
AU2008209320A1 (en) 2008-07-31
JP2010516711A (ja) 2010-05-20
PT2106260T (pt) 2018-03-05

Similar Documents

Publication Publication Date Title
US10172837B2 (en) Insulin sensitisers and methods of treatment
US20100222304A1 (en) Methods of Treating Neuropathic Pain by Modulation of Glycogenolysis or Glycolysis
US20050250794A1 (en) Methods of treating a disorder
CN1313769A (zh) 含有COX-2抑制剂和iNOS抑制剂的药物组合
CZ297386B6 (cs) N-[2-hydroxy-3-(1-piperidinyl)propoxy]pyridin-1-oxid-3-karboximidoylchlorid, N-[2-hydroxy-3-(1-piperidinyl)propoxy]pyridin-1-oxid-3-karboximidoylchlorid pro pouzití pri lécbe rezistence vuci inzulínua farmaceutický prípravek ho obsahující
EP0777469A1 (en) Use of insulin sensitisers for treating renal diseases
JPWO2008075741A1 (ja) 糖尿病治療剤及び予防剤
US10245255B2 (en) Compositions and methods for the treatment of obesity and related disorders
CA2443031A1 (en) Use of selective cox-2 inhibitors for the treatment of urinary incontinence
JP2024509265A (ja) 赤血球増加症を処置するための組成物および方法
US6399658B1 (en) Composition containing ascorbic acid
WO2005016339A1 (en) Methods for the treatment of parkinson's disease
US12414927B2 (en) CXCR5 antagonists and methods of treating diseases or disorders using same
HK1132198B (en) Insulin sensitisers and methods of treatment
HK1132198A (en) Insulin sensitisers and methods of treatment
WO2019031425A1 (ja) 運動ニューロン疾患治療剤
JP2000500490A (ja) 糖尿病治療用の4−ヒドロキシクマリン−3−カルボキシアミド
US20020156106A1 (en) Use of insulin sensitisers for treating renal diseases
MX2014014316A (es) Método de reducción de peso.
KR101898608B1 (ko) PPARδ 활성물질의 태자 재프로그래밍 용도
KR101934074B1 (ko) PPARδ 활성물질의 태자 재프로그래밍 용도
WO2021107122A1 (ja) 特定アミノ酸またはアミノ酸様物質による低酸素応答制御

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20101115

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120911

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20121210

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20121217

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20130110

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20130118

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130308

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20130604

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20130619

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

LAPS Cancellation because of no payment of annual fees