JP5301465B2 - インスリン抵抗性改善薬および治療方法 - Google Patents
インスリン抵抗性改善薬および治療方法 Download PDFInfo
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- JP5301465B2 JP5301465B2 JP2009546616A JP2009546616A JP5301465B2 JP 5301465 B2 JP5301465 B2 JP 5301465B2 JP 2009546616 A JP2009546616 A JP 2009546616A JP 2009546616 A JP2009546616 A JP 2009546616A JP 5301465 B2 JP5301465 B2 JP 5301465B2
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- OUDSBRTVNLOZBN-UHFFFAOYSA-N tolazamide Chemical compound C1=CC(C)=CC=C1S(=O)(=O)NC(=O)NN1CCCCCC1 OUDSBRTVNLOZBN-UHFFFAOYSA-N 0.000 description 1
- 229960005371 tolbutamide Drugs 0.000 description 1
- 125000005425 toluyl group Chemical group 0.000 description 1
- 229960005461 torasemide Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- 125000003866 trichloromethyl group Chemical group ClC(Cl)(Cl)* 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 125000005455 trithianyl group Chemical group 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
- 125000000297 undecanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 229940005605 valeric acid Drugs 0.000 description 1
- 125000003774 valeryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000000304 vasodilatating effect Effects 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- MTZBBNMLMNBNJL-UHFFFAOYSA-N xipamide Chemical compound CC1=CC=CC(C)=C1NC(=O)C1=CC(S(N)(=O)=O)=C(Cl)C=C1O MTZBBNMLMNBNJL-UHFFFAOYSA-N 0.000 description 1
- 229960000537 xipamide Drugs 0.000 description 1
- 229940093612 zein Drugs 0.000 description 1
- 239000005019 zein Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 230000004572 zinc-binding Effects 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89776907P | 2007-01-25 | 2007-01-25 | |
| US60/897,769 | 2007-01-25 | ||
| AU2007902013A AU2007902013A0 (en) | 2007-04-17 | Inhibitory compounds | |
| AU2007902013 | 2007-04-17 | ||
| US98433507P | 2007-10-31 | 2007-10-31 | |
| US60/984,335 | 2007-10-31 | ||
| US737607P | 2007-12-11 | 2007-12-11 | |
| US61/007,376 | 2007-12-11 | ||
| PCT/AU2008/000089 WO2008089521A1 (en) | 2007-01-25 | 2008-01-25 | Insulin sensitisers and methods of treatment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010516711A JP2010516711A (ja) | 2010-05-20 |
| JP5301465B2 true JP5301465B2 (ja) | 2013-09-25 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009546616A Expired - Fee Related JP5301465B2 (ja) | 2007-01-25 | 2008-01-25 | インスリン抵抗性改善薬および治療方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US8455432B2 (enExample) |
| EP (1) | EP2106260B8 (enExample) |
| JP (1) | JP5301465B2 (enExample) |
| CN (1) | CN101801375B (enExample) |
| AU (1) | AU2008209320B2 (enExample) |
| CA (1) | CA2676051C (enExample) |
| ES (1) | ES2660170T3 (enExample) |
| NO (1) | NO2106260T3 (enExample) |
| NZ (1) | NZ579229A (enExample) |
| PL (1) | PL2106260T3 (enExample) |
| PT (1) | PT2106260T (enExample) |
| WO (1) | WO2008089521A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO2106260T3 (enExample) | 2007-01-25 | 2018-05-05 | ||
| US20200155558A1 (en) * | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
| HK1209041A1 (en) * | 2012-05-24 | 2016-03-24 | Verva Pharmaceuticals Ltd | A method of weight reduction |
| CN109498623A (zh) * | 2012-05-24 | 2019-03-22 | 纳亚代谢有限公司 | 改善肝功能的方法 |
| AU2013202988B2 (en) * | 2012-06-29 | 2016-04-21 | NAIA Metabolic, Inc. | Method of improving liver function |
| US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
| US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
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| US2978457A (en) | 1959-04-06 | 1961-04-04 | Merck & Co Inc | 5-acylamido-4-substituted-thiazole-2-sulfonamides having diuretic properties |
| US3157572A (en) | 1961-01-06 | 1964-11-17 | American Cyanamid Co | Parenteral diuretic compositions of 5-acylimino-4-substituted-delta2-1, 3, 4-thiadiazolidine-2-sulfonamides |
| US3668248A (en) | 1964-09-30 | 1972-06-06 | Lilly Co Eli | 5-chloro-2,4-bis(sulfamoyl)fluorobenzene and 5-chloro-2,4-bis(chlorosulfonyl)fluorobenzene |
| FR2468366A1 (fr) | 1979-10-31 | 1981-05-08 | Stoclet Alain | Medicament antiglaucomateux a base d'acetazolamide ou de methazolamide |
| ATE35265T1 (de) | 1982-05-28 | 1988-07-15 | Ciba Geigy Ag | Neue sulfonyl(thio)harnstoffe, verfahren zu deren herstellung und deren verwendung als herbizide und/oder wachstumsregulatoren. |
| IT1224860B (it) | 1988-07-29 | 1990-10-24 | Istituto Chimico Internazional | Composti correlati all'acetozolammi de con attivita' inibitrice dell'anidrasi carbonica, utili in particolare nel trattamento del glaucoma |
| GB2223166B (en) | 1988-09-29 | 1992-03-18 | American Cyanamid Co | Stable ophthalmic preparations containing methazolamide |
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| US5723476A (en) * | 1995-11-17 | 1998-03-03 | Pharmacia & Upjohn Company | 4-hydroxycoumarin-3-carboxamides for the treatment of diabetes mellitus |
| JP2000080047A (ja) | 1998-06-30 | 2000-03-21 | Takeda Chem Ind Ltd | 医 薬 |
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| GB9930688D0 (en) * | 1999-12-24 | 2000-02-16 | Smithkline Beecham Plc | Novel method of treatment |
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| DE10035227A1 (de) | 2000-07-20 | 2002-01-31 | Solvay Pharm Gmbh | Verfahren zum Auffinden von Verbindungen, welche zur Behandlung und/oder Prophylaxe von Fettleibigkeit geeignet sind |
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| JP2009515928A (ja) * | 2005-11-14 | 2009-04-16 | ゾルファイ ファーマスーティカルズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | カルボニックアンヒドラーゼの阻害剤としてのn−スルファモイル−n’−ベンゾピランピペリジン |
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| WO2007065948A1 (en) * | 2005-12-09 | 2007-06-14 | Solvay Pharmaceuticals Gmbh | Novel n-sulfamoyl-piperidineamides for the prophylaxis or treatment of obesity and related conditions |
| WO2007114948A2 (en) | 2006-04-04 | 2007-10-11 | The Brigham And Women's Hospital, Inc. | Methods and compositions for inhibiting cell death |
| NO2106260T3 (enExample) * | 2007-01-25 | 2018-05-05 | ||
| WO2011002011A1 (ja) | 2009-07-01 | 2011-01-06 | キッセイ薬品工業株式会社 | Sglt1阻害薬とdpp-iv阻害薬を組み合わせてなる医薬 |
| ES2706913T3 (es) | 2010-06-25 | 2019-04-01 | Univ Aston | Glucoproteínas que tienen propiedades de movilización de lípidos y usos terapéuticos de las mismas |
| EP2583965B1 (en) | 2010-07-15 | 2017-01-25 | Takeda Pharmaceutical Company Limited | Heterocyclic ring compound |
| HK1209041A1 (en) | 2012-05-24 | 2016-03-24 | Verva Pharmaceuticals Ltd | A method of weight reduction |
| CN109498623A (zh) | 2012-05-24 | 2019-03-22 | 纳亚代谢有限公司 | 改善肝功能的方法 |
-
2008
- 2008-01-25 NO NO08700385A patent/NO2106260T3/no unknown
- 2008-01-25 PT PT87003851T patent/PT2106260T/pt unknown
- 2008-01-25 WO PCT/AU2008/000089 patent/WO2008089521A1/en not_active Ceased
- 2008-01-25 CN CN200880005674.3A patent/CN101801375B/zh not_active Expired - Fee Related
- 2008-01-25 PL PL08700385T patent/PL2106260T3/pl unknown
- 2008-01-25 EP EP08700385.1A patent/EP2106260B8/en not_active Not-in-force
- 2008-01-25 NZ NZ579229A patent/NZ579229A/en not_active IP Right Cessation
- 2008-01-25 ES ES08700385.1T patent/ES2660170T3/es active Active
- 2008-01-25 US US12/524,146 patent/US8455432B2/en not_active Expired - Fee Related
- 2008-01-25 AU AU2008209320A patent/AU2008209320B2/en not_active Ceased
- 2008-01-25 CA CA2676051A patent/CA2676051C/en not_active Expired - Fee Related
- 2008-01-25 JP JP2009546616A patent/JP5301465B2/ja not_active Expired - Fee Related
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2013
- 2013-05-31 US US13/907,717 patent/US9452148B2/en not_active Expired - Fee Related
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2016
- 2016-09-26 US US15/276,013 patent/US10172837B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NZ579229A (en) | 2011-07-29 |
| PL2106260T3 (pl) | 2018-06-29 |
| AU2008209320B2 (en) | 2013-05-30 |
| CN101801375A (zh) | 2010-08-11 |
| EP2106260A1 (en) | 2009-10-07 |
| EP2106260B8 (en) | 2018-04-04 |
| PT2106260T (pt) | 2018-03-05 |
| US20110003740A1 (en) | 2011-01-06 |
| NO2106260T3 (enExample) | 2018-05-05 |
| US20140011848A1 (en) | 2014-01-09 |
| US20170079960A1 (en) | 2017-03-23 |
| US10172837B2 (en) | 2019-01-08 |
| WO2008089521A1 (en) | 2008-07-31 |
| CA2676051C (en) | 2017-06-06 |
| CN101801375B (zh) | 2014-01-01 |
| CA2676051A1 (en) | 2008-07-31 |
| EP2106260B1 (en) | 2017-12-06 |
| US9452148B2 (en) | 2016-09-27 |
| JP2010516711A (ja) | 2010-05-20 |
| ES2660170T3 (es) | 2018-03-21 |
| EP2106260A4 (en) | 2010-05-26 |
| US8455432B2 (en) | 2013-06-04 |
| AU2008209320A1 (en) | 2008-07-31 |
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