JP5280600B2 - 分裂中の細胞を破壊するための方法および装置 - Google Patents

分裂中の細胞を破壊するための方法および装置 Download PDF

Info

Publication number
JP5280600B2
JP5280600B2 JP2001560365A JP2001560365A JP5280600B2 JP 5280600 B2 JP5280600 B2 JP 5280600B2 JP 2001560365 A JP2001560365 A JP 2001560365A JP 2001560365 A JP2001560365 A JP 2001560365A JP 5280600 B2 JP5280600 B2 JP 5280600B2
Authority
JP
Japan
Prior art keywords
electric field
cells
cell
potential
dividing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2001560365A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004505604A (ja
JP2004505604A5 (enExample
Inventor
パルティ、ヨーラム
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of JP2004505604A publication Critical patent/JP2004505604A/ja
Publication of JP2004505604A5 publication Critical patent/JP2004505604A5/ja
Application granted granted Critical
Publication of JP5280600B2 publication Critical patent/JP5280600B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/326—Applying electric currents by contact electrodes alternating or intermittent currents for promoting growth of cells, e.g. bone cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/205—Applying electric currents by contact electrodes continuous direct currents for promoting a biological process
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00613—Irreversible electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B2018/147—Electrodes transferring energy by capacitive coupling, i.e. with a dielectricum between electrode and target tissue

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2001560365A 2000-02-17 2001-02-16 分裂中の細胞を破壊するための方法および装置 Expired - Lifetime JP5280600B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18329500P 2000-02-17 2000-02-17
US60/183,295 2000-02-17
PCT/IB2001/000202 WO2001060994A1 (en) 2000-02-17 2001-02-16 Method and apparatus for destroying dividing cells

Publications (3)

Publication Number Publication Date
JP2004505604A JP2004505604A (ja) 2004-02-26
JP2004505604A5 JP2004505604A5 (enExample) 2011-08-04
JP5280600B2 true JP5280600B2 (ja) 2013-09-04

Family

ID=22672230

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001560365A Expired - Lifetime JP5280600B2 (ja) 2000-02-17 2001-02-16 分裂中の細胞を破壊するための方法および装置

Country Status (7)

Country Link
US (2) US7333852B2 (enExample)
EP (2) EP2335776A1 (enExample)
JP (1) JP5280600B2 (enExample)
CN (1) CN1416466A (enExample)
AU (1) AU3399801A (enExample)
CA (1) CA2400526C (enExample)
WO (1) WO2001060994A1 (enExample)

Families Citing this family (146)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7016725B2 (en) 2001-11-06 2006-03-21 Standen Ltd. Method and apparatus for destroying dividing cells
US7599746B2 (en) 2000-02-17 2009-10-06 Standen Ltd Apparatus and method for preventing the spread of cancerous metastases and for elimination of metastases
US6868289B2 (en) * 2002-10-02 2005-03-15 Standen Ltd. Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor
US8175698B2 (en) 2000-02-17 2012-05-08 Novocure Ltd. Treating bacteria with electric fields
US7136699B2 (en) 2002-10-02 2006-11-14 Standen, Ltd. Apparatus for destroying dividing cells
JP5280600B2 (ja) 2000-02-17 2013-09-04 パルティ、ヨーラム 分裂中の細胞を破壊するための方法および装置
US7146210B2 (en) 2000-02-17 2006-12-05 Standen Ltd. Apparatus and method for optimizing tumor treatment efficiency by electric fields
US8447395B2 (en) 2000-02-17 2013-05-21 Novocure Ltd Treating bacteria with electric fields
US7089054B2 (en) 2002-10-02 2006-08-08 Standen Ltd. Apparatus and method for treating a tumor or the like
JP4750784B2 (ja) 2004-04-23 2011-08-17 ノヴォキュアー・リミテッド 異なる周波数の電界による腫瘍等の治療
WO2006061688A1 (en) 2004-12-07 2006-06-15 Standen Ltd. Electrodes for applying an electric field in-vivo over an extended period of time
JP5559460B2 (ja) * 2004-12-27 2014-07-23 スタンデン・リミテッド 異なる配向の電界を用いて腫瘍またはその類似物を処理する方法
US20070021803A1 (en) 2005-07-22 2007-01-25 The Foundry Inc. Systems and methods for neuromodulation for treatment of pain and other disorders associated with nerve conduction
DK1933937T3 (en) * 2005-10-03 2015-04-07 Novocure Ltd OPTIMIZATION OF THE CHARACTERISTICS OF AN ELECTRIC FIELD FOR ENHANCING FIELD EFFECT ON proliferating cells
US8019414B2 (en) 2006-04-05 2011-09-13 Novocure Ltd. Treating cancer using electromagnetic fields in combination with other treatment regimens
US8109926B2 (en) 2006-09-14 2012-02-07 Lazure Scientific, Inc. Ablation probe with deployable electrodes
WO2008098298A1 (en) * 2007-02-16 2008-08-21 Iogenyx Pty Ltd Methods for improving the cultivation of aquatic organisms
US8465533B2 (en) 2007-03-06 2013-06-18 Novocure Limited Treating cancer using electromagnetic fields in combination with photodynamic therapy
EP2183024B1 (en) 2007-08-14 2019-05-15 Novocure Ltd. Treating parasites with electric fields
US20090076500A1 (en) * 2007-09-14 2009-03-19 Lazure Technologies, Llc Multi-tine probe and treatment by activation of opposing tines
WO2009036457A1 (en) 2007-09-14 2009-03-19 Lazure Technologies, Llc Multi-layer electrode ablation probe and related methods
WO2009036468A1 (en) 2007-09-14 2009-03-19 Lazure Technologies, Llc Transurethral systems and methods for ablation treatment of prostate tissue
US20100100093A1 (en) * 2008-09-16 2010-04-22 Lazure Technologies, Llc. System and method for controlled tissue heating for destruction of cancerous cells
US8728139B2 (en) 2009-04-16 2014-05-20 Lazure Technologies, Llc System and method for energy delivery to a tissue using an electrode array
US9526911B1 (en) 2010-04-27 2016-12-27 Lazure Scientific, Inc. Immune mediated cancer cell destruction, systems and methods
US9233257B1 (en) 2010-11-22 2016-01-12 Jacob Zabara Electromagnetic radiation treatment
US8684901B1 (en) 2010-11-22 2014-04-01 Jacob Zabara Electromagnetic radiation treatment for cancer and pathological genetic regulations
CA2826770C (en) 2011-02-15 2020-06-23 Hemosonics, Llc Characterization of blood hemostasis and oxygen transport parameters
US9757582B2 (en) * 2012-10-26 2017-09-12 Robert E. Sandstrom Tumor treatment with free radical lifetimes enhanced by persistant low strength magnetic field
US9789328B2 (en) * 2012-10-26 2017-10-17 Robert E. Sandstrom Tumor treatment with free radical lifetimes enhanced by persistent low strength magnetic field
US9655669B2 (en) 2013-05-06 2017-05-23 Novocure Limited Optimizing treatment using TTFields by changing the frequency during the course of long term tumor treatment
US10779875B2 (en) 2013-05-06 2020-09-22 Novocure Gmbh Optimizing treatment using TTfields by changing the frequency during the course of long term tumor treatment
US20190117963A1 (en) 2014-07-25 2019-04-25 Loyalty Based Innovations, LLC Apparatus and method for treating multiple tumors in patients with metastatic disease by electric fields
US9833617B2 (en) 2014-07-25 2017-12-05 Loyalty Based Innovations, LLC Apparatus and method for treating multiple tumors in patients with metastatic disease by electric fields
US9726647B2 (en) 2015-03-17 2017-08-08 Hemosonics, Llc Determining mechanical properties via ultrasound-induced resonance
US10188851B2 (en) 2015-10-28 2019-01-29 Novocure Limited TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements
US10821283B2 (en) 2016-04-04 2020-11-03 Novocure Gmbh Reducing motility of cancer cells using tumor treating fields (TTFields)
AU2017289870B2 (en) 2016-06-30 2021-12-23 Novocure Gmbh Arrays for longitudinal delivery of TTFields to a body
WO2018134733A1 (en) 2017-01-19 2018-07-26 Moshe Giladi System for viewing cell cultures under a microscope whilst applying ttfields
US12403306B2 (en) 2017-10-23 2025-09-02 Cardiac Pacemakers, Inc. Electric field shaping leads for treatment of cancer
US11338135B2 (en) 2017-10-23 2022-05-24 Cardiac Pacemakers, Inc. Medical devices for cancer therapy with electric field shaping elements
CO2018001283A1 (es) 2018-02-07 2019-08-09 Panacea Quantum Leap Tech Llc Método de estimulación de tejidos con campos eléctricos y magnéticos por barrido en frecuencia
US10953209B2 (en) 2018-03-28 2021-03-23 Board Of Regents Of The University Of Texas System Treating tumors using TTFields combined with a PARP inhibitor
US11298422B2 (en) 2018-04-09 2022-04-12 Novocure Gmbh Treating tumors with TTFields and an aurora kinase inhibitor
PL3775956T3 (pl) 2018-04-10 2022-10-10 Novocure Gmbh Szacunki przewodności ac o niskiej częstotliwości (< 1 mhz) pozyskane z dwóch obrazów mri o różnych czasach repetycji
CN116603165A (zh) 2018-07-03 2023-08-18 斯坦福大学托管董事会 使用交变电场提高细胞膜通透性
US11179322B2 (en) 2018-07-10 2021-11-23 Novocure Gmbh Methods and compositions for treating tumors with TTFields and sorafenib
CA3103070C (en) 2018-07-10 2024-01-09 Novocure Gmbh Inhibiting viral infection using alternating electric fields
MX2020013431A (es) 2018-07-18 2021-05-27 Novocure Gmbh Uso de densidad de perdida de potencia y mediciones relacionadas para cuantificar la dosis de campos de tratamiento de tumores (ttfield).
KR20250069692A (ko) 2018-08-23 2025-05-19 카스텐 하게만 뇌-혈액 장벽 투과성을 향상시키기 위한 교번 전기장의 이용
US11160977B2 (en) 2018-09-04 2021-11-02 Novocure Gmbh Delivering tumor treating fields (TTFields) to the infratentorial brain
CN112770806B (zh) 2018-09-07 2025-12-05 诺沃库勒有限责任公司 使用交变电场治疗自身免疫性疾病以减少t细胞的增殖
US11986647B2 (en) 2018-09-07 2024-05-21 Novocure Gmbh Treating autoinflammatory and mitochondrial diseases using an alternating electric field
CN118925056A (zh) 2018-10-15 2024-11-12 诺沃库勒有限责任公司 生成遍及大脑具有高均匀性的肿瘤治疗场（ttfields）
US11369790B2 (en) 2018-10-25 2022-06-28 Novocure Gmbh Delivering alternating electric fields (e.g., TTFields) to a subject's spinal anatomy
EP3880299B1 (en) 2018-11-13 2025-09-24 The Methodist Hospital Device for oncomagnetic treatment
KR102747887B1 (ko) 2018-11-19 2024-12-27 노보큐어 게엠베하 선택적으로 주소 지정 가능한 하위 요소를 하지는 종양 치료장 제공을 위한 어레이
SG11202101810SA (en) 2018-11-29 2021-03-30 Novocure Gmbh Enhanced-flexibility transducer arrays for delivering ttfields (tumor treating fields)
CN113330485B (zh) 2019-01-08 2025-09-26 诺沃库勒有限责任公司 评估将图像分割成不同类型组织的质量，用于使用肿瘤治疗场（TTField）来计划治疗
US11554262B2 (en) 2019-02-26 2023-01-17 Novocure Gmbh Determining a frequency for TTFields treatment based on an electrical characteristic of targeted cancer cells
EP3954314B1 (en) 2019-02-27 2025-01-08 Novocure GmbH Delivering tumor treating fields (ttfields) using implantable transducer arrays
EP3988099B1 (en) 2019-03-29 2023-06-07 Novocure GmbH Methods for restoring sensitivity to ttfields in ttfields-resistant cancer cells with ptger3 inhibitors
EP3924039B1 (en) 2019-04-17 2023-11-22 Novocure GmbH Uploading data from an isolated system without compromising isolation
JP7410176B2 (ja) 2019-04-22 2024-01-09 ボストン サイエンティフィック サイムド，インコーポレイテッド 癌を治療するために電気刺激を与えるためのシステム
CN113766948B (zh) 2019-04-22 2025-02-07 波士顿科学国际有限公司 对癌症的电与化学组合治疗
JP7593942B2 (ja) 2019-04-22 2024-12-03 ボストン サイエンティフィック サイムド，インコーポレイテッド 癌治療のための電気刺激機器
WO2020219517A2 (en) 2019-04-23 2020-10-29 Boston Scientific Scimed, Inc. Electrical stimulation for cancer treatment with internal and external electrodes
JP7476231B2 (ja) 2019-04-23 2024-04-30 ボストン サイエンティフィック サイムド，インコーポレイテッド 温熱療法又は熱モニタと共に行われる電気刺激
EP3958956B1 (en) 2019-04-23 2024-02-28 Boston Scientific Scimed Inc. Electrodes for electrical stimulation to treat cancer
CN114364432B (zh) 2019-07-31 2025-10-31 诺沃库勒有限责任公司 经由埋入颅骨植入物中的电极施加肿瘤治疗场（TTField）
US12343336B2 (en) 2019-08-05 2025-07-01 Novocure Gmbh Increasing cancer cells' sensitivity to tumor treating fields (TTFields) by inhibiting IL11 activity
US11890467B2 (en) 2019-08-30 2024-02-06 Novocure Gmbh Delivering tumor treating fields (TTFields) to the neck
EP4038035A1 (de) 2019-09-30 2022-08-10 TDK Electronics AG Polykristalliner keramischer festkörper, dielektrische elektrode mit dem festkörper, vorrichtung mit der elektrode und verfahren zur herstellung
US11534601B2 (en) 2019-11-08 2022-12-27 Novocure Gmbh Perforated hydrogel configurations and methods of production and use thereof
WO2021111186A1 (en) 2019-12-02 2021-06-10 Novocure Gmbh Methods and apparatuses for optimizing transducer array placement
CA3163315A1 (en) 2019-12-31 2021-07-08 Novocure Gmbh High voltage, high efficiency sine wave generator that prevents spikes during amplitude adjustments and switching of channels
TWI902740B (zh) 2019-12-31 2025-11-01 瑞士商諾沃庫勒有限責任公司 用於影像分割之方法、系統和設備
CN114830248A (zh) 2019-12-31 2022-07-29 诺沃库勒有限责任公司 用于电场分布的快速近似的方法、系统和装置
US12121739B2 (en) 2019-12-31 2024-10-22 Novocure Gmbh Methods, systems, and apparatuses for managing temperatures induced by alternating fields
DK4074367T3 (da) 2019-12-31 2023-05-22 Novocure Gmbh Arrays til levering af tumorbehandlingsfelter (tt-felter) med individuelt tilgængelige elektrodeelementer og temperatursensorer
WO2021150877A1 (en) 2020-01-22 2021-07-29 Novocure Gmbh Assemblies containing two conductive gel compositions and methods of production and use thereof
EP4110455B1 (en) 2020-02-24 2024-05-22 Boston Scientific Scimed, Inc. Systems for treatment of pancreatic cancer
US20210299440A1 (en) 2020-03-30 2021-09-30 Novocure Gmbh Intravenous / Intra-Spinal / Intra-Cavity / Intraventricular Delivery of TTFields (Tumor Treating Fields) for Treating Cancer and Metastases
WO2021214693A1 (en) 2020-04-24 2021-10-28 Novocure Gmbh Using alternating electric fields to increase permeability of the blood brain barrier
WO2021223684A1 (zh) * 2020-05-02 2021-11-11 电冷科学有限公司 一种避免活性非消融电极附近组织损伤的装置
TW202537657A (zh) 2020-05-06 2025-10-01 瑞士商諾沃庫勒有限責任公司 用於產生腫瘤治療電場之導電襯墊以及生產和使用其之方法
EP4168108A4 (en) 2020-06-19 2024-07-17 The Methodist Hospital dba Houston Methodist Hospital METHOD AND APPARATUS FOR ONCOMAGNETIC TREATMENT
US11818943B2 (en) 2020-06-25 2023-11-14 Novocure Gmbh Fabricating organic light emitting diodes (OLEDs) using tubulin
EP4188380A1 (en) * 2020-08-03 2023-06-07 Novocure GmbH Compositions and methods for increasing cancer cell sensitivity to alternating electric fields
CN114075508A (zh) * 2020-08-14 2022-02-22 上海必修福企业管理有限公司 电场发生装置及其在影响细胞的分裂周期中的用途和方法
EP4223364B1 (en) 2020-09-25 2024-04-24 Novocure GmbH Varying the metallization area on individual electrode elements in a tumor treating fields system to maximize current without overheating
DE102020133165B9 (de) 2020-12-11 2024-06-06 Tdk Electronics Ag Keramikelektrode, Baugruppe mit der Keramikelektrode, Anordnung mit der Keramikelektrode und Verfahren zur Herstellung einer Keramikelektrode
CN116782980A (zh) 2020-12-21 2023-09-19 诺沃库勒有限责任公司 复合电极的优化
WO2022175803A1 (en) 2021-02-17 2022-08-25 Novocure Gmbh Arrays for delivering tumor treating fields (ttfields) with sets of electrode elements having individually adjustable active areas
WO2022190068A1 (en) 2021-03-12 2022-09-15 Novocure Gmbh Methods of treating disease by skewing macrophage phenotype with alternating electric fields
JP2024514045A (ja) 2021-03-12 2024-03-28 ノボキュア ゲーエムベーハー 電極アレイ、ならびにその製造および使用方法
WO2022195542A2 (en) 2021-03-18 2022-09-22 Novocure Gmbh Constructing a 3d phantom with liquid hydrogel
JP2024513854A (ja) 2021-03-31 2024-03-27 ノボキュア ゲーエムベーハー 腫瘍治療電場（ＴＴＦｉｅｌｄｓ）システムの電極を使用したインピーダンス断層撮影法
JP2024523598A (ja) 2021-06-30 2024-06-28 ノボキュア ゲーエムベーハー 腫瘍治療電場（ＴＴｆｉｅｌｄｓ）を印加するためのトランスデューサアレイにおける電流を調整するためのキャパシタの使用
CN117813131A (zh) 2021-07-21 2024-04-02 诺沃库勒有限责任公司 生成肿瘤治疗场的导电衬垫及其生产和使用的方法
US11877838B2 (en) * 2021-08-14 2024-01-23 Nano Hesgarsazan Salamat Arya Preventing cytokine storm in COVID-19 patients by suppressing clonal expansion in activated lymphocytes using alternating electric fields
EP4376939A1 (en) 2021-09-14 2024-06-05 Novocure GmbH Temperature independent method and system for applying ttfields
US12527954B2 (en) 2021-09-30 2026-01-20 Novocure Gmbh Method and system for applying tumor treating fields interfacing with hair follicles
US20230168242A1 (en) 2021-11-29 2023-06-01 Novocure Gmbh Methods of Reducing Ciliogenesis with Alternating Electric Fields
WO2023105391A1 (en) 2021-12-07 2023-06-15 Novocure Gmbh Compact dc system for delivering a square wave ac signal
US20230173265A1 (en) 2021-12-10 2023-06-08 Novocure Gmbh Garment providing a biasing force on a transducer array
CN118317809A (zh) 2021-12-10 2024-07-09 诺沃库勒有限责任公司 用于应用ttfield的压缩服装组件及其制造和使用方法
US12434051B2 (en) 2021-12-10 2025-10-07 Novocure Gmbh Compression garment assembly for applying TTFields and methods of production and use thereof
US12502548B2 (en) 2021-12-29 2025-12-23 Novocure Gmbh Reducing electrosensation whilst treating a subject using alternating electric fields by using larger cathodes and smaller anodes
JP2024545019A (ja) 2021-12-30 2024-12-05 ノボキュア ゲーエムベーハー 腫瘍治療フィールド（ｔｔｆｉｅｌｄ）を使用した治療のためのパラメータ値の選択
US12478779B2 (en) 2022-03-29 2025-11-25 Novocure Gmbh Electrode array having a semi-liquid conductive gel
CA3255022A1 (en) 2022-03-30 2023-10-05 Novocure Gmbh USE OF INTERLACED COOLING PERIODS TO INCREASE THE MAXIMUM INTENSITY OF TUMOR TREATMENT FIELDS
CN119013076A (zh) 2022-03-30 2024-11-22 诺沃库勒有限责任公司 通过将换能器阵列配对在一起来使用交流电场治疗受试者的同时减少电敏
WO2023193012A2 (en) 2022-04-01 2023-10-05 The Board Of Regents Of The University Of Texas System Methods and apparatus for applying tumor treating fields combined with personalized ultra-fractionated stereotactic adaptive radiotherapy
WO2023242741A1 (en) 2022-06-13 2023-12-21 Novocure Gmbh Systems and methods for increasing intestinal absorption of therapeutic agents
JP2025520608A (ja) 2022-06-20 2025-07-03 ノボキュア ゲーエムベーハー 癌を治療するための組成物、システム、および方法、腫瘍治療場およびｖｅｇｆ阻害剤
JP2025520663A (ja) 2022-06-21 2025-07-03 ノボキュア ゲーエムベーハー 交流電場とｃｒｉｓｐｒ－ｃａｓシステムを用いた症状および疾患の治療システムおよび方法
WO2024052877A1 (en) 2022-09-08 2024-03-14 Novocure Gmbh Constructing a 3d phantom with a matrix material having conductive particles dispersed therein
EP4554661A1 (en) 2022-09-27 2025-05-21 Novocure GmbH Ingestible implantable device to measure internal ttfield intensity
JP2025532765A (ja) 2022-09-29 2025-10-03 ノボキュア ゲーエムベーハー 電池交換中にｔｔ場を維持するためのシステムおよび方法
CA3180284A1 (en) 2022-09-29 2024-03-29 Novocure Gmbh Transducer array having a temperature sensor isolation layer between a temperature sensor and external environment
CN119968221A (zh) 2022-09-30 2025-05-09 诺沃库勒有限责任公司 用于减少电感应和/或皮肤刺激的组合物、系统和方法
CN119968209A (zh) 2022-09-30 2025-05-09 诺沃库勒有限责任公司 使用交变电场和树突状细胞治疗癌症的组合物、系统和方法
JP2025533794A (ja) 2022-09-30 2025-10-09 ノボキュア ゲーエムベーハー Ｔｔ場用途システム用のシングルワイヤ温度測定ソリューション、ならびにその製造方法および使用方法
JP2025532048A (ja) 2022-09-30 2025-09-29 ノボキュア ゲーエムベーハー 交流電場およびアポトーシスがん細胞ワクチンを用いたがん治療のための組成物、システムおよび方法
CN115845254B (zh) * 2022-11-23 2024-02-02 湖南安泰康成生物科技有限公司 小细胞肺癌治疗系统以及交变电场发生装置
JP2025539300A (ja) 2022-11-30 2025-12-05 ノボキュア ゲーエムベーハー 代替アレイ材料を有するトランスデューサアレイ
WO2024127192A1 (en) 2022-12-13 2024-06-20 Novocure Gmbh Wireless transducer arrays applying tumor treating fields and systems and methods of use thereof
JP2026500634A (ja) 2022-12-28 2026-01-08 ノボキュア ゲーエムベーハー 癌を治療するための組成物、システム、および方法、腫瘍治療場及び抗ｖｅｇｆｒ－２抗体
US12268863B2 (en) 2023-02-06 2025-04-08 Novocure Gmbh Shiftable transducer array with anisotropic material layer
WO2024201344A1 (en) 2023-03-30 2024-10-03 Novocure Gmbh Compositions, systems, and methods for treating cancer using tumor treating fields and chimeric antigen receptor (car)-immune cells
AU2024246741A1 (en) 2023-03-30 2025-10-16 Novocure Gmbh Compositions, systems, and methods for treating cancer using tumor treating fields and killer cells
US20240399141A1 (en) 2023-03-31 2024-12-05 Novocure Gmbh Microneedles to overcome contact resistance
WO2024257051A1 (en) 2023-06-15 2024-12-19 Novocure Gmbh Compositions, systems, and methods for treating cancer using tumor treating fields (ttfields) and thioredoxin/glutathione inhibitors
US20250099545A1 (en) 2023-09-21 2025-03-27 Novocure Gmbh Compositions, systems, and methods for treating cancer using tumor treating fields with immune checkpoint inhibitors and mhc class i activators
WO2025068982A1 (en) 2023-09-28 2025-04-03 Novocure Gmbh Transducer array having subarrays
WO2025068877A1 (en) 2023-09-29 2025-04-03 Novocure Gmbh Low frequency rf ablation system
WO2025068918A1 (en) 2023-09-29 2025-04-03 Novocure Gmbh Apparatus and method of reapplying transducer arrays to a patient
TW202528013A (zh) 2023-09-29 2025-07-16 瑞士商諾沃庫勒有限責任公司 使用振幅和頻率的交錯變化來改善交變電場治療期間的電感覺
WO2025088586A1 (en) 2023-10-27 2025-05-01 Brown University Compositions, systems, and methods for treating cancer using tumor treating fields with inhibitors of mif, mica, and/or micb
WO2025186743A1 (en) 2024-03-05 2025-09-12 Novocure Gmbh Combinations for treating cancer in standard of care and/or profibrotic chemotherapeutic agent-naive patients using tumor treating fields and chemotherapeutic agents
TW202547574A (zh) 2024-03-15 2025-12-16 瑞士商諾沃庫勒有限責任公司 用於施加交流電場之降低阻抗轉換器陣列及其生產與使用方法
US20250367138A1 (en) 2024-05-31 2025-12-04 Novocure Gmbh Compositions, systems, and methods for treating cancer using tumor treating fields (ttfields) and methylglyoxal
WO2026003783A1 (en) 2024-06-27 2026-01-02 Novocure Gmbh Compositions, systems, and methods for treating cancer using tumor treating fields (ttfields) and nf-κb inhibitors
WO2026033423A1 (en) 2024-08-05 2026-02-12 Novocure Gmbh Flexible layer for use in a tumor treating fields transducer
US20260034376A1 (en) 2024-08-05 2026-02-05 Novocure Gmbh Shiftable transducer array with anisotropic material layer and foam layer

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR446660A (fr) 1911-09-02 1912-12-12 Gottlieb Schuettel Dispositif pour métiers continus à anneaux pour monter les curseurs sur les anneaux
BE794566A (fr) 1972-01-28 1973-07-26 Esb Inc Regenerateur et stimulateur bioelectrochimique et procedes d'application in vivo d'energie electrique a des cellules et des tissus.
US3991770A (en) 1974-01-24 1976-11-16 Leveen Harry H Method for treating benign and malignant tumors utilizing radio frequency, electromagnetic radiation
US4016886A (en) 1974-11-26 1977-04-12 The United States Of America As Represented By The United States Energy Research And Development Administration Method for localizing heating in tumor tissue
US4121592A (en) 1975-08-04 1978-10-24 Critical Systems, Inc. Apparatus for heating tissue
DE2907013A1 (de) 1978-02-24 1979-08-30 American Med Syst Verfahren und vorrichtung zum beguenstigen der heilung von verletzten knochenknorpeln und geweben im gesichtsbereich
DE2813068A1 (de) 1978-03-25 1979-10-04 Philips Patentverwaltung Verfahren und vorrichtung zur ermittlung von inneren koerperstrukturen
GB2043453A (en) 1979-02-22 1980-10-08 Electrochem Tech Corp Improvements in or relating to an electrode
US4472506A (en) 1981-01-13 1984-09-18 Liburdy Robert P Method for determining cell membrane dielectric breakdown
US4467809A (en) 1982-09-17 1984-08-28 Biolectron, Inc. Method for non-invasive electrical stimulation of epiphyseal plate growth
US4622952A (en) * 1983-01-13 1986-11-18 Gordon Robert T Cancer treatment method
CA1244889A (en) * 1983-01-24 1988-11-15 Kureha Chemical Ind Co Ltd HYPERTHERMIA DEVICE
DE3323415C2 (de) 1983-06-29 1985-04-25 Kernforschungsanlage Jülich GmbH, 5170 Jülich Verwendung eines Verfahrens und einer Vorrichtung zur Bestimmung von Zellinhaltstoffe sezernierenden Zellen
SE455920B (sv) 1986-01-29 1988-08-22 Hans Wiksell Anordning for hypertermibehandling av tumorer
US4923814A (en) * 1986-05-09 1990-05-08 Electropore, Inc. High speed, high power apparatus for vesicle prealignment, poration, loading and fusion in uniform electric fields and method therefor
CN86103803B (zh) 1986-06-05 1987-11-18 北京信息工程学院 静电场治疗装置
US4822470A (en) * 1987-10-09 1989-04-18 Baylor College Of Medicine Method of and apparatus for cell poration and cell fusion using radiofrequency electrical pulses
US4936303A (en) 1987-11-20 1990-06-26 Ultrathermics Ultrasonic heating apparatus and method
JPH0629196B2 (ja) 1987-12-01 1994-04-20 甲子郎 梅村 超音波による腫瘍治療用生理作用増強剤
US5389069A (en) 1988-01-21 1995-02-14 Massachusetts Institute Of Technology Method and apparatus for in vivo electroporation of remote cells and tissue
FR2627987B3 (fr) 1988-03-04 1990-02-02 Indiba Sa Appareil electronique pour la therapie medicale et cosmetique
US5158071A (en) * 1988-07-01 1992-10-27 Hitachi, Ltd. Ultrasonic apparatus for therapeutical use
GB8904998D0 (en) 1989-03-04 1989-04-19 Matthews Tony Anaesthetising apparatus
US5099756A (en) * 1989-06-01 1992-03-31 Harry H. Leveen Radio frequency thermotherapy
US5441746A (en) * 1989-12-22 1995-08-15 Molecular Bioquest, Inc. Electromagnetic wave absorbing, surface modified magnetic particles for use in medical applications, and their method of production
US5236410A (en) * 1990-08-02 1993-08-17 Ferrotherm International, Inc. Tumor treatment method
JPH06501410A (ja) * 1990-11-05 1994-02-17 ビーエスディ・メディカル・コーポレイション 前立腺過形成治療用電磁容量結合アプリケータ装置
WO1992019286A1 (en) * 1991-05-03 1992-11-12 University Technologies International, Inc. Biofilm reduction method
US5441532A (en) 1991-06-26 1995-08-15 Massachusetts Institute Of Technology Adaptive focusing and nulling hyperthermia annular and monopole phased array applicators
US5697909A (en) * 1992-01-07 1997-12-16 Arthrocare Corporation Methods and apparatus for surgical cutting
US5468223A (en) 1992-11-30 1995-11-21 C.N.R.S. Paris Electrochemotherapy
US5386837A (en) * 1993-02-01 1995-02-07 Mmtc, Inc. Method for enhancing delivery of chemotherapy employing high-frequency force fields
FR2703253B1 (fr) * 1993-03-30 1995-06-23 Centre Nat Rech Scient Applicateur d'impulsions electriques pour traitement de tissus biologiques.
US5458597A (en) * 1993-11-08 1995-10-17 Zomed International Device for treating cancer and non-malignant tumors and methods
IL108775A (en) 1994-02-25 2003-09-17 Univ Ramot Method for efficient incorporation of molecules into cells
US5704355A (en) 1994-07-01 1998-01-06 Bridges; Jack E. Non-invasive system for breast cancer detection
AU6639596A (en) 1995-07-28 1997-02-26 James R. Gray Use of a polarizing field to modify the efficacy of a bioactive agent
US5606971A (en) * 1995-11-13 1997-03-04 Artann Corporation, A Nj Corp. Method and device for shear wave elasticity imaging
US5718246A (en) 1996-01-03 1998-02-17 Preferential, Inc. Preferential induction of electrically mediated cell death from applied pulses
US5984882A (en) * 1996-08-19 1999-11-16 Angiosonics Inc. Methods for prevention and treatment of cancer and other proliferative diseases with ultrasonic energy
US5869326A (en) 1996-09-09 1999-02-09 Genetronics, Inc. Electroporation employing user-configured pulsing scheme
US6055453A (en) * 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
AU9472998A (en) * 1997-09-04 1999-03-22 Science Research Laboratory, Inc. Cell separation using electric fields
US6027488A (en) * 1998-06-03 2000-02-22 Genetronics, Inc. Flow-through electroporation system for ex vivo gene therapy
US5976092A (en) * 1998-06-15 1999-11-02 Chinn; Douglas O. Combination stereotactic surgical guide and ultrasonic probe
US6319901B1 (en) 1998-10-15 2001-11-20 Ichor Medical Systems, Inc. Methods for prolonging cell membrane permeability
CA2364098C (en) 1999-03-09 2010-11-16 Thermage, Inc. Apparatus and method for treatment of tissue
US6678558B1 (en) * 1999-03-25 2004-01-13 Genetronics, Inc. Method and apparatus for reducing electroporation-mediated muscle reaction and pain response
US6366808B1 (en) 2000-03-13 2002-04-02 Edward A. Schroeppel Implantable device and method for the electrical treatment of cancer
US6853864B2 (en) * 2000-02-02 2005-02-08 Catholic University Of America, The Use of electromagnetic fields in cancer and other therapies
US6868289B2 (en) 2002-10-02 2005-03-15 Standen Ltd. Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor
US7089054B2 (en) 2002-10-02 2006-08-08 Standen Ltd. Apparatus and method for treating a tumor or the like
JP5280600B2 (ja) 2000-02-17 2013-09-04 パルティ、ヨーラム 分裂中の細胞を破壊するための方法および装置
US8175698B2 (en) 2000-02-17 2012-05-08 Novocure Ltd. Treating bacteria with electric fields
US7146210B2 (en) 2000-02-17 2006-12-05 Standen Ltd. Apparatus and method for optimizing tumor treatment efficiency by electric fields
US7136699B2 (en) 2002-10-02 2006-11-14 Standen, Ltd. Apparatus for destroying dividing cells
US7016725B2 (en) 2001-11-06 2006-03-21 Standen Ltd. Method and apparatus for destroying dividing cells
US7599746B2 (en) 2000-02-17 2009-10-06 Standen Ltd Apparatus and method for preventing the spread of cancerous metastases and for elimination of metastases
US6546290B1 (en) 2000-04-12 2003-04-08 Roamitron Holding S.A. Method and apparatus for electromedical therapy
US6994706B2 (en) 2001-08-13 2006-02-07 Minnesota Medical Physics, Llc Apparatus and method for treatment of benign prostatic hyperplasia
JP4750784B2 (ja) 2004-04-23 2011-08-17 ノヴォキュアー・リミテッド 異なる周波数の電界による腫瘍等の治療
DE102004028156A1 (de) 2004-06-09 2006-01-05 Kalbe, Jochen, Dr. Kombination von Radiowellen mit pharmakologisch aktiven Substanzen
WO2006061688A1 (en) 2004-12-07 2006-06-15 Standen Ltd. Electrodes for applying an electric field in-vivo over an extended period of time
JP5559460B2 (ja) 2004-12-27 2014-07-23 スタンデン・リミテッド 異なる配向の電界を用いて腫瘍またはその類似物を処理する方法
US20060282122A1 (en) 2005-06-08 2006-12-14 Yoram Palti Treating cancer with electric fields that are guided to desired locations within a body
DK1933937T3 (en) 2005-10-03 2015-04-07 Novocure Ltd OPTIMIZATION OF THE CHARACTERISTICS OF AN ELECTRIC FIELD FOR ENHANCING FIELD EFFECT ON proliferating cells
US8019414B2 (en) 2006-04-05 2011-09-13 Novocure Ltd. Treating cancer using electromagnetic fields in combination with other treatment regimens
US8465533B2 (en) 2007-03-06 2013-06-18 Novocure Limited Treating cancer using electromagnetic fields in combination with photodynamic therapy
EP2183024B1 (en) 2007-08-14 2019-05-15 Novocure Ltd. Treating parasites with electric fields
US8715203B2 (en) 2007-09-17 2014-05-06 Novocure Limited Composite electrode

Also Published As

Publication number Publication date
AU3399801A (en) 2001-08-27
JP2004505604A (ja) 2004-02-26
USRE43618E1 (en) 2012-08-28
EP2335776A1 (en) 2011-06-22
WO2001060994A1 (en) 2001-08-23
US20030150372A1 (en) 2003-08-14
CN1416466A (zh) 2003-05-07
CA2400526A1 (en) 2001-08-23
EP1259596A4 (en) 2004-12-22
EP1259596A1 (en) 2002-11-27
CA2400526C (en) 2013-04-23
US7333852B2 (en) 2008-02-19

Similar Documents

Publication Publication Date Title
JP5280600B2 (ja) 分裂中の細胞を破壊するための方法および装置
JP2004505604A5 (enExample)
US7016725B2 (en) Method and apparatus for destroying dividing cells
US10994133B2 (en) Methods for enhancing and modulating reversible and irreversible electroporation lesions by manipulating pulse waveforms
EP2183024B1 (en) Treating parasites with electric fields
US7519420B2 (en) Apparatus for selectively destroying dividing cells
JP4750784B2 (ja) 異なる周波数の電界による腫瘍等の治療
Stacey et al. Differential effects in cells exposed to ultra-short, high intensity electric fields: cell survival, DNA damage, and cell cycle analysis
CA2697012C (en) Treating bacteria with electric fields
CN101124011B (zh) 利用电场从不同方向治疗肿瘤等
US20060237019A1 (en) Hat for treating a tumor or the like
US20230149708A1 (en) Tumor treating fields (ttf) for cancer treatment
Joshi et al. Review of developments in bioelectrics as an application of pulsed power technology
CN111803792A (zh) 空间电场的发生装置
HK1139089A (en) Treating parasites with electric fields
HK1139089B (en) Treating parasites with electric fields
Miyakoshi Experimental Results: In vitro

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20071204

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20090326

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20101220

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20110322

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20110329

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20110620

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120228

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20120528

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20120604

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120828

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20130423

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20130523

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

Ref document number: 5280600

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313113

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313113

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

EXPY Cancellation because of completion of term